EA200200355A1 - Тиеноизоксазолил- и тиенилпирразолилфеноксизамещенные пролилпроизводные, используемые в качестве антагонистов рецептора d - Google Patents
Тиеноизоксазолил- и тиенилпирразолилфеноксизамещенные пролилпроизводные, используемые в качестве антагонистов рецептора dInfo
- Publication number
- EA200200355A1 EA200200355A1 EA200200355A EA200200355A EA200200355A1 EA 200200355 A1 EA200200355 A1 EA 200200355A1 EA 200200355 A EA200200355 A EA 200200355A EA 200200355 A EA200200355 A EA 200200355A EA 200200355 A1 EA200200355 A1 EA 200200355A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- antagonists
- receptor
- compounds
- disorder
- derivatives used
- Prior art date
Links
- 239000005557 antagonist Substances 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 3
- 208000011117 substance-related disease Diseases 0.000 abstract 2
- 208000027448 Attention Deficit and Disruptive Behavior disease Diseases 0.000 abstract 1
- 206010013654 Drug abuse Diseases 0.000 abstract 1
- 201000004311 Gilles de la Tourette syndrome Diseases 0.000 abstract 1
- 208000021384 Obsessive-Compulsive disease Diseases 0.000 abstract 1
- 208000018737 Parkinson disease Diseases 0.000 abstract 1
- 208000027089 Parkinsonian disease Diseases 0.000 abstract 1
- 206010034010 Parkinsonism Diseases 0.000 abstract 1
- 208000028017 Psychotic disease Diseases 0.000 abstract 1
- 206010043118 Tardive Dyskinesia Diseases 0.000 abstract 1
- 208000000323 Tourette Syndrome Diseases 0.000 abstract 1
- 208000016620 Tourette disease Diseases 0.000 abstract 1
- 230000006735 deficit Effects 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 206010013663 drug dependence Diseases 0.000 abstract 1
- 208000013403 hyperactivity Diseases 0.000 abstract 1
- 230000005764 inhibitory process Effects 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- 208000024196 oppositional defiant disease Diseases 0.000 abstract 1
- 230000001575 pathological effect Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000012450 pharmaceutical intermediate Substances 0.000 abstract 1
- 125000001500 prolyl group Chemical class [H]N1C([H])(C(=O)[*])C([H])([H])C([H])([H])C1([H])[H] 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Neurology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- Neurosurgery (AREA)
- Psychology (AREA)
- Psychiatry (AREA)
- Addiction (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Abstract
Соединения представляют класс тиеноизоксазолил- и тиенилпирразолилфеноксизамещенных пролилпроизводных, используемых в качестве антагонистов D. Названные соединения используются для лечения патологических состояний, опосредованных ингибированием рецептора D. Упомянутые состояния включают в себя, например, дефицит внимания/гиперактивность, обсессивно-компульсивное расстройство, психозы, злоупотребление лекарством, лекарственную зависимость, болезнь Паркинсона, паркинсонизм, позднюю дискинезию, синдром Жиля де ля Туретта, кондуктивное расстройство и оппозиционное вызывающее расстройство. Следующий аспект изобретения заключается в обеспечении фармацевтической композицией, промежуточными соединениями и способом получения названного класса соединений.Международная заявка была опубликована вместе с отчетом о международном поиске.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US39608199A | 1999-09-14 | 1999-09-14 | |
| PCT/US2000/024962 WO2001019833A1 (en) | 1999-09-14 | 2000-09-13 | Thienoisoxazolyl- and thienylpyrrazolyl-phenoxy substituted propyl derivatives useful as d4 antagonists |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| EA200200355A1 true EA200200355A1 (ru) | 2002-10-31 |
Family
ID=23565772
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA200200355A EA200200355A1 (ru) | 1999-09-14 | 2000-09-13 | Тиеноизоксазолил- и тиенилпирразолилфеноксизамещенные пролилпроизводные, используемые в качестве антагонистов рецептора d |
Country Status (26)
| Country | Link |
|---|---|
| EP (1) | EP1216250B1 (ru) |
| JP (1) | JP4847662B2 (ru) |
| KR (1) | KR20020027647A (ru) |
| AR (1) | AR032134A1 (ru) |
| AT (1) | ATE254621T1 (ru) |
| AU (1) | AU7577400A (ru) |
| BR (1) | BR0014515A (ru) |
| CA (1) | CA2383340C (ru) |
| CY (1) | CY1101692T1 (ru) |
| CZ (1) | CZ2002897A3 (ru) |
| DE (1) | DE60006699T2 (ru) |
| DK (1) | DK1216250T3 (ru) |
| EA (1) | EA200200355A1 (ru) |
| EE (1) | EE200200135A (ru) |
| ES (1) | ES2209995T3 (ru) |
| HR (1) | HRP20020220A2 (ru) |
| HU (1) | HUP0203526A3 (ru) |
| IL (1) | IL148623A0 (ru) |
| MX (1) | MXPA02002695A (ru) |
| NO (1) | NO20021251L (ru) |
| PL (1) | PL354515A1 (ru) |
| PT (1) | PT1216250E (ru) |
| SK (1) | SK3512002A3 (ru) |
| TW (1) | TW530060B (ru) |
| WO (1) | WO2001019833A1 (ru) |
| ZA (1) | ZA200201762B (ru) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7253165B2 (en) | 1999-09-14 | 2007-08-07 | Aventis Pharmaceuticals Inc. | Benzisoxazolyl-, pyridoisoxazolyl-and benzthienyl-phenoxy derivatives useful as D4 antagonists |
| US7125903B1 (en) | 1999-09-14 | 2006-10-24 | Aventis Pharmaceuticals Inc. | Thienoisoxazolyl-and thienylpyrrazolyl-phenoxy substituted propyl derivatives useful as D4 antagonists |
| US7091199B1 (en) | 1999-09-14 | 2006-08-15 | Aventis Pharmaceuticals Inc. | Thienoisoxazole phenoxy unsubstituted ethyl and propyl derivatives useful as d4 antagonists |
| IL157412A0 (en) * | 2001-02-16 | 2004-03-28 | Aventis Pharmaceuticals Inc Av | Novel heterocyclic amide derivatives and their use as dopamine d3 receptor ligands |
| WO2002083648A1 (fr) * | 2001-04-16 | 2002-10-24 | Eisai Co., Ltd. | Nouveau compose a base de 1h-indazole |
| KR20040020457A (ko) * | 2002-08-30 | 2004-03-09 | 주식회사 대웅 | 3-｛2-[4-(6-플루오로벤조[ｄ]이속사졸-3-일)피페리디노]에틸｝-2-메틸-6,7,8,9-테트라하이드로-4Ｈ-피리도[1,2-ａ]피리미딘-4-온 또는 그 산부가염의 제조방법 |
| KR20050092424A (ko) * | 2003-01-17 | 2005-09-21 | 씨브이 쎄러퓨틱스, 인코포레이티드 | 심혈관 질환의 치료에 유용한 치환된 헤테로고리 화합물 |
| JP2007297321A (ja) * | 2006-04-28 | 2007-11-15 | Daiso Co Ltd | アリール２−メチルグリシジルエーテル類の製造法 |
| JP2007297330A (ja) * | 2006-04-28 | 2007-11-15 | Daiso Co Ltd | ２−メチルグリシジル誘導体の製造法 |
| CA2899363A1 (en) | 2012-12-21 | 2014-06-26 | Epizyme, Inc. | Prmt5 inhibitors and uses thereof |
| US8906900B2 (en) | 2012-12-21 | 2014-12-09 | Epizyme, Inc. | PRMT5 inhibitors and uses thereof |
| CA2894157A1 (en) | 2012-12-21 | 2014-06-26 | Epizyme, Inc. | Prmt5 inhibitors and uses thereof |
| EP2935243B1 (en) | 2012-12-21 | 2018-03-14 | Epizyme, Inc. | Prmt5 inhibitors containing a dihydro- or tetrahydroisoquinoline and uses thereof |
| SI2935222T1 (sl) | 2012-12-21 | 2019-02-28 | Epizyme Inc. | Inhibitorji PRMT5 in njihove uporabe |
| EP3160477A4 (en) * | 2014-06-25 | 2018-07-04 | Epizyme, Inc. | Prmt5 inhibitors and uses thereof |
| EP3177288A4 (en) | 2014-08-04 | 2018-04-04 | Epizyme, Inc. | Prmt5 inhibitors and uses thereof |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4728651A (en) * | 1985-10-24 | 1988-03-01 | Hoechst-Roussel Pharmaceuticals Inc. | Antihypertensive thieno-isoxazoles and -pyrazoles |
| US6187774B1 (en) * | 1996-03-04 | 2001-02-13 | Yoshitomi Pharmaceutical Industries, Ltd. | Fused heterocyclic compounds and pharmaceutical applications thereof |
| HUP9603001A3 (en) * | 1996-10-30 | 1999-07-28 | Richter Gedeon Vegyeszet | Heterocycle compounds comprising nitrogen, process for producing them and pharmaceutical compositions containing the same |
| ATE367389T1 (de) * | 1998-02-09 | 2007-08-15 | Duphar Int Res | Benzisoxazolderivate mit d4-antagonistischer wirkung |
-
2000
- 2000-09-13 KR KR1020027003366A patent/KR20020027647A/ko not_active Withdrawn
- 2000-09-13 SK SK351-2002A patent/SK3512002A3/sk unknown
- 2000-09-13 HU HU0203526A patent/HUP0203526A3/hu unknown
- 2000-09-13 PT PT00964969T patent/PT1216250E/pt unknown
- 2000-09-13 PL PL00354515A patent/PL354515A1/xx unknown
- 2000-09-13 JP JP2001523410A patent/JP4847662B2/ja not_active Expired - Fee Related
- 2000-09-13 CA CA2383340A patent/CA2383340C/en not_active Expired - Fee Related
- 2000-09-13 EE EEP200200135A patent/EE200200135A/xx unknown
- 2000-09-13 IL IL14862300A patent/IL148623A0/xx unknown
- 2000-09-13 BR BR0014515-7A patent/BR0014515A/pt not_active IP Right Cessation
- 2000-09-13 HR HR20020220A patent/HRP20020220A2/hr not_active Application Discontinuation
- 2000-09-13 AR ARP000104793A patent/AR032134A1/es not_active Application Discontinuation
- 2000-09-13 ES ES00964969T patent/ES2209995T3/es not_active Expired - Lifetime
- 2000-09-13 AT AT00964969T patent/ATE254621T1/de not_active IP Right Cessation
- 2000-09-13 DE DE60006699T patent/DE60006699T2/de not_active Expired - Lifetime
- 2000-09-13 AU AU75774/00A patent/AU7577400A/en not_active Abandoned
- 2000-09-13 MX MXPA02002695A patent/MXPA02002695A/es active IP Right Grant
- 2000-09-13 WO PCT/US2000/024962 patent/WO2001019833A1/en not_active Ceased
- 2000-09-13 CZ CZ2002897A patent/CZ2002897A3/cs unknown
- 2000-09-13 EA EA200200355A patent/EA200200355A1/ru unknown
- 2000-09-13 DK DK00964969T patent/DK1216250T3/da active
- 2000-09-13 EP EP00964969A patent/EP1216250B1/en not_active Expired - Lifetime
- 2000-09-14 TW TW089118850A patent/TW530060B/zh not_active IP Right Cessation
-
2002
- 2002-03-13 NO NO20021251A patent/NO20021251L/no not_active Application Discontinuation
- 2002-03-21 ZA ZA200201762A patent/ZA200201762B/en unknown
-
2004
- 2004-02-12 CY CY20041100175T patent/CY1101692T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA2383340C (en) | 2010-06-15 |
| AR032134A1 (es) | 2003-10-29 |
| PL354515A1 (en) | 2004-01-26 |
| HRP20020220A2 (en) | 2004-02-29 |
| HUP0203526A3 (en) | 2004-12-28 |
| WO2001019833A1 (en) | 2001-03-22 |
| TW530060B (en) | 2003-05-01 |
| BR0014515A (pt) | 2002-06-25 |
| CZ2002897A3 (cs) | 2002-07-17 |
| DE60006699T2 (de) | 2004-09-30 |
| IL148623A0 (en) | 2002-09-12 |
| JP2003509432A (ja) | 2003-03-11 |
| PT1216250E (pt) | 2004-04-30 |
| HUP0203526A2 (hu) | 2003-01-28 |
| CY1101692T1 (el) | 2010-07-28 |
| ES2209995T3 (es) | 2004-07-01 |
| ATE254621T1 (de) | 2003-12-15 |
| NO20021251L (no) | 2002-05-10 |
| DK1216250T3 (da) | 2004-02-23 |
| MXPA02002695A (es) | 2002-07-30 |
| ZA200201762B (en) | 2003-08-27 |
| CA2383340A1 (en) | 2001-03-22 |
| EE200200135A (et) | 2003-04-15 |
| EP1216250B1 (en) | 2003-11-19 |
| NO20021251D0 (no) | 2002-03-13 |
| KR20020027647A (ko) | 2002-04-13 |
| SK3512002A3 (en) | 2003-03-04 |
| EP1216250A1 (en) | 2002-06-26 |
| DE60006699D1 (en) | 2003-12-24 |
| AU7577400A (en) | 2001-04-17 |
| JP4847662B2 (ja) | 2011-12-28 |
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