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EA200700617A1 - Новые пиридиновые производные и их применение в качестве позитивных аллостерических модуляторов mglur2-рецепторов - Google Patents

Новые пиридиновые производные и их применение в качестве позитивных аллостерических модуляторов mglur2-рецепторов

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Publication number
EA200700617A1
EA200700617A1 EA200700617A EA200700617A EA200700617A1 EA 200700617 A1 EA200700617 A1 EA 200700617A1 EA 200700617 A EA200700617 A EA 200700617A EA 200700617 A EA200700617 A EA 200700617A EA 200700617 A1 EA200700617 A1 EA 200700617A1
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EA
Eurasian Patent Office
Prior art keywords
mglur2
compounds
application
positive allosteric
modules
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Application number
EA200700617A
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English (en)
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EA013740B1 (ru
Inventor
Хассан Жюльен Имогай
Хосе Мария Сид-Нуньес
Гийом Альбер Жак Дювей
Кристелль Мартин Болеа
Вантеа Нем
Терри Патрик Финн
Эмманюэль Кристиан Ле Пуль
Жан-Филипп Франсуа Кристиан Роше
Роберт Иоганнес Лютьенс
Original Assignee
Янссен Фармасьютика Н.В.
Аддекс Фармасьютикалз С.А.
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Application filed by Янссен Фармасьютика Н.В., Аддекс Фармасьютикалз С.А. filed Critical Янссен Фармасьютика Н.В.
Publication of EA200700617A1 publication Critical patent/EA200700617A1/ru
Publication of EA013740B1 publication Critical patent/EA013740B1/ru

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Abstract

Настоящее изобретение относится к новым соединениям, в частности к новым пиридиноновым производным, соответствующим формуле (I), где все радикалы X, R, N, Y, R, Rопределены в данной заявке. Соединения по изобретению представляют собой позитивные аллостерические модуляторы метаботропных рецепторов 2 подтипа («mGluR2»), полезные для лечения или предупреждения неврологических и психиатрических расстройств, ассоциированных с глутаматной дисфункцией, и заболеваний, в которые вовлечен mGluR2-подтип метаботропных рецепторов. В особенности такими заболеваниями являются расстройства центральной нервной системы, выбранные из группы, состоящей из тревоги, шизофрении, мигрени, депрессии и эпилепсии. Изобретение также относится к фармацевтическим композициям и способам получения таких соединений и композиций, а также к применению таких соединений для предупреждения и лечения таких заболеваний, в которые вовлечен mGluR2.
EA200700617A 2004-09-17 2005-09-16 Новые пиридиноновые производные и их применение в качестве позитивных аллостерических модуляторов mglur2-рецепторов EA013740B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0420722A GB0420722D0 (en) 2004-09-17 2004-09-17 Novel allosteric modulators
PCT/EP2005/054636 WO2006030032A1 (en) 2004-09-17 2005-09-16 Novel pyridinone derivatives and their use as positive allosteric modulators of mglur2-receptors

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EA200700617A1 true EA200700617A1 (ru) 2007-10-26
EA013740B1 EA013740B1 (ru) 2010-06-30

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