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UA99124C2 - 3-cyano-4-(4-tetrahydropyran-phenyl)-pyridin-2-one derivatives - Google Patents

3-cyano-4-(4-tetrahydropyran-phenyl)-pyridin-2-one derivatives

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Publication number
UA99124C2
UA99124C2 UAA200909452A UAA200909452A UA99124C2 UA 99124 C2 UA99124 C2 UA 99124C2 UA A200909452 A UAA200909452 A UA A200909452A UA A200909452 A UAA200909452 A UA A200909452A UA 99124 C2 UA99124 C2 UA 99124C2
Authority
UA
Ukraine
Prior art keywords
compounds
diseases
involved
prevention
treatment
Prior art date
Application number
UAA200909452A
Other languages
Russian (ru)
Ukrainian (uk)
Inventor
Хосе Мария Сид-Нюнез
Андрес Авелино Трабанко-Суарез
Грегор Джеймс Макдональд
Гийом Альбер Якьюэс Дюве
Original Assignee
Аддекс Фарма С.А.
Орто-Макнеил-Янссен Фармасьютикалз, Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Аддекс Фарма С.А., Орто-Макнеил-Янссен Фармасьютикалз, Инк. filed Critical Аддекс Фарма С.А.
Publication of UA99124C2 publication Critical patent/UA99124C2/en

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Abstract

The present invention relates to novel compounds, in particular novel pyridinone derivatives according to Formula (I) including any stereochemically isomeric form thereof, or a pharmaceutically acceptable salt thereof or a solvate thereof, wherein all radicals are defined in the application and claims. The compounds according to the invention are positive allosteric modulators of metabotropic glutamate receptors subtype 2 (mGluR2) which are useful for the treatment or prevention of neurological and psychiatric disorders associated with glutamate dysfunction and diseases in which the mGluR2 subtype of metabotropic receptors is involved. In particular, such diseases are central nervous system disorders selected from the group of anxiety schizophrenia, migraine, depression, and epilepsy. The invention is also directed to pharmaceutical compositions and processes to prepare such compounds and such compositions, as well as to the use of such compounds for the prevention and treatment of such diseases in which mQluR2 is involved.(I)
UAA200909452A 2007-03-07 2008-03-07 3-cyano-4-(4-tetrahydropyran-phenyl)-pyridin-2-one derivatives UA99124C2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP07103654 2007-03-07

Publications (1)

Publication Number Publication Date
UA99124C2 true UA99124C2 (en) 2012-07-25

Family

ID=44146575

Family Applications (3)

Application Number Title Priority Date Filing Date
UAA200909453A UA99125C2 (en) 2007-03-07 2008-03-07 1,4-disubstituted 3-cyano-pyridone derivatives and their use as positive mglur2 -receptor modulators
UAA200909452A UA99124C2 (en) 2007-03-07 2008-03-07 3-cyano-4-(4-tetrahydropyran-phenyl)-pyridin-2-one derivatives
UAA200909451A UA99123C2 (en) 2007-03-07 2008-03-07 3-cyano-4-(4-phenyl-piperidin-1-yl)-pyridin-2-one derivatives

Family Applications Before (1)

Application Number Title Priority Date Filing Date
UAA200909453A UA99125C2 (en) 2007-03-07 2008-03-07 1,4-disubstituted 3-cyano-pyridone derivatives and their use as positive mglur2 -receptor modulators

Family Applications After (1)

Application Number Title Priority Date Filing Date
UAA200909451A UA99123C2 (en) 2007-03-07 2008-03-07 3-cyano-4-(4-phenyl-piperidin-1-yl)-pyridin-2-one derivatives

Country Status (2)

Country Link
ES (1) ES2362249T3 (en)
UA (3) UA99125C2 (en)

Also Published As

Publication number Publication date
UA99125C2 (en) 2012-07-25
ES2362249T3 (en) 2011-06-30
UA99123C2 (en) 2012-07-25

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