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MX2010005110A - Derivados de imidazo[1,2-a]piridina y su uso como moduladores alostericos positivos de los receptores de glutamato metabotropico 2. - Google Patents

Derivados de imidazo[1,2-a]piridina y su uso como moduladores alostericos positivos de los receptores de glutamato metabotropico 2.

Info

Publication number
MX2010005110A
MX2010005110A MX2010005110A MX2010005110A MX2010005110A MX 2010005110 A MX2010005110 A MX 2010005110A MX 2010005110 A MX2010005110 A MX 2010005110A MX 2010005110 A MX2010005110 A MX 2010005110A MX 2010005110 A MX2010005110 A MX 2010005110A
Authority
MX
Mexico
Prior art keywords
mglur2
compounds
imidazo
diseases
positive allosteric
Prior art date
Application number
MX2010005110A
Other languages
English (en)
Inventor
Gary John Tresadern
Juan Antonio Vega Ramiro
Jose Maria Cid-Nunez
Andres Avelino Trabanco-Suarez
Original Assignee
Ortho Mcneil Janssen Pharm
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ortho Mcneil Janssen Pharm filed Critical Ortho Mcneil Janssen Pharm
Publication of MX2010005110A publication Critical patent/MX2010005110A/es

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    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
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    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
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    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
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    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
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    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
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  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
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  • Pharmacology & Pharmacy (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Pain & Pain Management (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Otolaryngology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Ophthalmology & Optometry (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La presente invención se refiere a nuevos compuestos, en particular nuevos derivados de imidazo(1,2-a]piridina de acuerdo con la fórmula (I) (ver fórmula (I)) en donde todos los radicales son como se definieron en la solicitud y las reivindicaciones. Los compuestos de acuerdo con la invención son moduladores alostéricos positivos de los receptores metabotrópicos - subtipo 2 ("mGluR2") que son útiles para el tratamiento o prevención de los trastornos neurológicos y psiquiátricos asociados con disfunción del glutamato y enfermedades en las que participa el subtipo mGluR2 de los receptores metabotrópicos. En particular, las enfermedades son trastornos del sistema nervioso central seleccionados del grupo de ansiedad, esquizofrenia, migraña, depresión y epilepsia. La invención también se dirige a las composiciones farmacéuticas y procesos para preparar los compuestos y composiciones, así como al uso de los compuestos para la prevención y el tratamiento de las enfermedades en que está involucrado mGluR2.
MX2010005110A 2007-11-14 2008-11-12 Derivados de imidazo[1,2-a]piridina y su uso como moduladores alostericos positivos de los receptores de glutamato metabotropico 2. MX2010005110A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP07120647 2007-11-14
PCT/EP2008/009534 WO2009062676A2 (en) 2007-11-14 2008-11-12 Imidazo[1,2-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors

Publications (1)

Publication Number Publication Date
MX2010005110A true MX2010005110A (es) 2010-09-09

Family

ID=39494182

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2010005110A MX2010005110A (es) 2007-11-14 2008-11-12 Derivados de imidazo[1,2-a]piridina y su uso como moduladores alostericos positivos de los receptores de glutamato metabotropico 2.

Country Status (14)

Country Link
US (1) US8785486B2 (es)
EP (1) EP2220083B1 (es)
JP (1) JP5433582B2 (es)
CN (1) CN101861316B (es)
AR (1) AR069309A1 (es)
AU (1) AU2008323287B2 (es)
CA (1) CA2704436C (es)
CL (1) CL2008003393A1 (es)
ES (1) ES2637794T3 (es)
IL (1) IL205341A0 (es)
MX (1) MX2010005110A (es)
RU (1) RU2492170C9 (es)
TW (1) TW200927103A (es)
WO (1) WO2009062676A2 (es)

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