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AR069309A1 - Derivados de imidazo[1,2-a] piridina moduladores alostericos positivos de receptores mglur2, composiciones farmaceuticas que los contienen y usos de los mismos en el tratamiento de trastornos neurologicos y psiquiatricos. - Google Patents

Derivados de imidazo[1,2-a] piridina moduladores alostericos positivos de receptores mglur2, composiciones farmaceuticas que los contienen y usos de los mismos en el tratamiento de trastornos neurologicos y psiquiatricos.

Info

Publication number
AR069309A1
AR069309A1 ARP080104955A ARP080104955A AR069309A1 AR 069309 A1 AR069309 A1 AR 069309A1 AR P080104955 A ARP080104955 A AR P080104955A AR P080104955 A ARP080104955 A AR P080104955A AR 069309 A1 AR069309 A1 AR 069309A1
Authority
AR
Argentina
Prior art keywords
alkyl
phenyl
trifluoromethyl
substituted
hydroxyalkyl
Prior art date
Application number
ARP080104955A
Other languages
English (en)
Original Assignee
Addex Pharma Sa
Ortho Mcneil Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Addex Pharma Sa, Ortho Mcneil Pharm Inc filed Critical Addex Pharma Sa
Publication of AR069309A1 publication Critical patent/AR069309A1/es

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    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
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  • Psychology (AREA)
  • Vascular Medicine (AREA)
  • Ophthalmology & Optometry (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Reivindicacion 1: Un compuesto que tiene la formula (1) o una de sus formas estereoquímicamente isoméricas, en donde R1 es alquilo C1-6 cicloalquilo C3-6, trifluorometilo; alquilo C1-3 sustituido con trifluorometilo, 2,2,2-trifluoroetoxi, cicloalquilo C3-7, fenilo o fenilo sustituido con alquilo C1-3, alquil C1-3-oxi, ciano, halo, trifluorometilo o trifluorometoxi; fenilo; fenilo sustituido con 1 o 2 sustituyentes seleccionados del grupo que consiste en alquilo C1-3, alquil C1-3-oxi, ciano, halo, trifluorometilo y trifluorometoxi; o 4-tetrahidropiranilo; R2 es ciano, halo, trifluorometilo, alquilo C1-3 o ciclopropilo; R3 es un radical de la formula (a) o (b) o (c) o (d); R4 es hidrogeno; hidroxicicloalquilo C3-6, piridinilo; piridinilo sustituido con uno o dos grupos alquilo C1-3, pirimidinilo; pirimidinilo sustituido con uno o dos grupos alquilo C1-3, fenilo; fenilo sustituido con 1 o 2 sustituyentes seleccionados del grupo que consiste en halo, alquilo C1-3, hidroxialquilo C1-3, mono- o polihaloalquilo C1-3, ciano, hidroxilo, amino, carboxilo, alquil C1-3-oxialquilo C1-3, alquil C1-3-oxi, mono- o polihalo-alquil C1-3-oxi, alquil C1-3-carbonilo, mono- y di(alquil C1-3)amino y morfolinilo; o fenilo con dos sustituyentes vecinales que, tomados juntos, forman un radical bivalente de la formula -N=CH-NH- (e), -CH=CH-NH- (f), o -O-CH2-CH2-NH- (g); R5 es hidrogeno, fluoro, hidroxilo, hidroxialquilo C1-3, hidroxialquil C1-3-oxi, fluoroalquilo C1-3, fluoroalquil C1-3-oxi, morfolinilo o ciano; X es C o N en cuyo caso R5 representa un par de electrones en N; o R4-X-R5 representa un radical de la formula (h) o (i) o (j) n es 0 o 1; q es 1 o 2; R6 es alquilo C1-3, cicloalquilo C3-6, hidroxialquilo C2-4; cicloalquil C3-6-alquilo C1-3, fenilo; piridinilo; o fenilo o piridinilo sustituido con uno o dos sustituyentes seleccionados del grupo que consiste en halo, alquilo C1-3, alcoxi C1-3, hidroxialquilo C1-3, trifluorometilo y (CH2)m-CO2H, en donde m = 0, 1 o 2; o R6 es un radical cíclico de la formula (k) en donde R8 es hidrogeno, alquilo C1-3, alquil C1-3-oxi, hidroxialquilo C1-3; p es 1 o 2; Z es O, CH2 o CR9(OH) en donde R9 es hidrogeno o alquilo C1-3; o R8 y R9 forman un radical -CH2-CH2-; R7 es hidrogeno, halo o trifluorometilo; Y es un enlace covalente, O, NH, S, SO, SO2, C(OH)(CH3), -CH2-O-, -O-CH2-, CHF o CF2; o R6-Y es morfolinilo, pirrolidinilo o piperidinilo opcionalmente sustituido con hidroxilo o hidroxialquilo C1-3; y A es O o NH; o una sal farmacéuticamente aceptable o uno de sus solvatos.
ARP080104955A 2007-11-14 2008-11-13 Derivados de imidazo[1,2-a] piridina moduladores alostericos positivos de receptores mglur2, composiciones farmaceuticas que los contienen y usos de los mismos en el tratamiento de trastornos neurologicos y psiquiatricos. AR069309A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP07120647 2007-11-14

Publications (1)

Publication Number Publication Date
AR069309A1 true AR069309A1 (es) 2010-01-13

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ARP080104955A AR069309A1 (es) 2007-11-14 2008-11-13 Derivados de imidazo[1,2-a] piridina moduladores alostericos positivos de receptores mglur2, composiciones farmaceuticas que los contienen y usos de los mismos en el tratamiento de trastornos neurologicos y psiquiatricos.

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Country Link
US (1) US8785486B2 (es)
EP (1) EP2220083B1 (es)
JP (1) JP5433582B2 (es)
CN (1) CN101861316B (es)
AR (1) AR069309A1 (es)
AU (1) AU2008323287B2 (es)
CA (1) CA2704436C (es)
CL (1) CL2008003393A1 (es)
ES (1) ES2637794T3 (es)
IL (1) IL205341A0 (es)
MX (1) MX2010005110A (es)
RU (1) RU2492170C9 (es)
TW (1) TW200927103A (es)
WO (1) WO2009062676A2 (es)

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