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EA200200673A1 - Оксазолидиноновые эфиры бензойной кислоты, содержащие гидроксиацетилпиперазиновый заместитель - Google Patents

Оксазолидиноновые эфиры бензойной кислоты, содержащие гидроксиацетилпиперазиновый заместитель

Info

Publication number
EA200200673A1
EA200200673A1 EA200200673A EA200200673A EA200200673A1 EA 200200673 A1 EA200200673 A1 EA 200200673A1 EA 200200673 A EA200200673 A EA 200200673A EA 200200673 A EA200200673 A EA 200200673A EA 200200673 A1 EA200200673 A1 EA 200200673A1
Authority
EA
Eurasian Patent Office
Prior art keywords
hydroxyacetylpyperazine
nitten
deputy
oxazolidine
ethers
Prior art date
Application number
EA200200673A
Other languages
English (en)
Inventor
Джексон Б. Мл. Хестер
Original Assignee
Фармация Энд Апджон Компани
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Фармация Энд Апджон Компани filed Critical Фармация Энд Апджон Компани
Publication of EA200200673A1 publication Critical patent/EA200200673A1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/18—Oxygen atoms
    • C07D263/20—Oxygen atoms attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Ophthalmology & Optometry (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Настоящее изобретение относится к соединению формулы (I), которое обладает сильным действием против грамположительных и грамотрицательных бактерий.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA200200673A 1999-12-14 2000-12-06 Оксазолидиноновые эфиры бензойной кислоты, содержащие гидроксиацетилпиперазиновый заместитель EA200200673A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US17067599P 1999-12-14 1999-12-14
PCT/US2000/032432 WO2001044212A1 (en) 1999-12-14 2000-12-06 Benzoic acid esters of oxazolidinones having a hydroxyacetylpiperazine substituent

Publications (1)

Publication Number Publication Date
EA200200673A1 true EA200200673A1 (ru) 2002-12-26

Family

ID=22620832

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200200673A EA200200673A1 (ru) 1999-12-14 2000-12-06 Оксазолидиноновые эфиры бензойной кислоты, содержащие гидроксиацетилпиперазиновый заместитель

Country Status (26)

Country Link
US (1) US6281210B1 (ru)
EP (1) EP1242395B1 (ru)
JP (1) JP2003516977A (ru)
KR (1) KR20020062332A (ru)
CN (1) CN1390211A (ru)
AR (1) AR026547A1 (ru)
AT (1) ATE288423T1 (ru)
AU (1) AU1805801A (ru)
BR (1) BR0015177A (ru)
CA (1) CA2387047A1 (ru)
CO (1) CO5261527A1 (ru)
CZ (1) CZ20022389A3 (ru)
DE (1) DE60017941T2 (ru)
EA (1) EA200200673A1 (ru)
ES (1) ES2236006T3 (ru)
HU (1) HUP0203787A3 (ru)
IL (1) IL150031A0 (ru)
MX (1) MXPA02005909A (ru)
NO (1) NO20022811L (ru)
PE (1) PE20010851A1 (ru)
PL (1) PL355369A1 (ru)
PT (1) PT1242395E (ru)
SK (1) SK5972002A3 (ru)
TW (1) TW544449B (ru)
WO (1) WO2001044212A1 (ru)
ZA (1) ZA200202953B (ru)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9928568D0 (en) 1999-12-03 2000-02-02 Zeneca Ltd Chemical compounds
DE19962924A1 (de) 1999-12-24 2001-07-05 Bayer Ag Substituierte Oxazolidinone und ihre Verwendung
GB0009803D0 (en) 2000-04-25 2000-06-07 Astrazeneca Ab Chemical compounds
EP1328509B1 (en) 2000-10-17 2006-03-22 Pharmacia & Upjohn Company LLC Methods of producing oxazolidinone compounds
DE10129725A1 (de) 2001-06-20 2003-01-02 Bayer Ag Kombinationstherapie substituierter Oxazolidinone
TW200404069A (en) * 2002-06-28 2004-03-16 Upjohn Co Difluorothioacetamides of oxazolidinones with a glycoloylpiperazine substituent
TW200403240A (en) * 2002-06-28 2004-03-01 Upjohn Co Difluorothioacetamides of oxazolidinones as antibacterial agents
DE60309504T2 (de) 2002-11-21 2007-05-16 Pharmacia & Upjohn Co. Llc, Kalamazoo N-(4-(piperazin-1-yl)-phenyl-2-oxazolidinon-5-carbosäureamid-derivate und verwandte verbindungen als antibakterielle mittel
DE10300111A1 (de) * 2003-01-07 2004-07-15 Bayer Healthcare Ag Verfahren zur Herstellung von 5-Chlor-N-({(5S)-2-oxo-3-[4-(3-oxo-4-morpholinyl)-phenyl]-1,3-oxazolidin-5-yl}-methyl)-2-thiophencarboxamid
DE10355461A1 (de) 2003-11-27 2005-06-23 Bayer Healthcare Ag Verfahren zur Herstellung einer festen, oral applizierbaren pharmazeutischen Zusammensetzung
DE102004062475A1 (de) * 2004-12-24 2006-07-06 Bayer Healthcare Ag Feste, oral applizierbare pharmazeutische Darreichungsformen mit modifizierter Freisetzung
EP1685841A1 (en) 2005-01-31 2006-08-02 Bayer Health Care Aktiengesellschaft Prevention and treatment of thromboembolic disorders
DE102005045518A1 (de) * 2005-09-23 2007-03-29 Bayer Healthcare Ag 2-Aminoethoxyessigsäure-Derivate und ihre Verwendung
DE102005047561A1 (de) 2005-10-04 2007-04-05 Bayer Healthcare Ag Feste, oral applizierbare pharmazeutische Darreichungsformen mit schneller Wirkstofffreisetzung
EP1934208B1 (de) 2005-10-04 2011-03-23 Bayer Schering Pharma Aktiengesellschaft Neue polymorphe form von 5-chlor-n-({ ( 5s )-2-0x0-3-[4-( 3-oxo-4-morpholinyl)-phenyl]-1,3-oxazolidin-5-yl} -methyl)-2-thiophencarboxamid
WO2008073444A2 (en) * 2006-12-12 2008-06-19 The Johns Hopkins University Phou (perf), a persistence switch involved in persister formation as a drug target for persister bacteria
EP2170874A4 (en) * 2007-06-22 2011-08-31 Orchid Res Lab Ltd NEW COMPOUNDS AND THEIR USE

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU698699B2 (en) * 1993-11-22 1998-11-05 Pharmacia & Upjohn Company Esters of substituted-hydroxyacetyl piperazine phenyl oxazolidinones
MY116093A (en) * 1996-02-26 2003-11-28 Upjohn Co Azolyl piperazinyl phenyl oxazolidinone antimicrobials
CN1138765C (zh) * 1997-05-30 2004-02-18 法玛西雅厄普约翰美国公司 带有硫代羰基功能基的噁唑烷酮抗菌剂
GB9812019D0 (en) * 1998-06-05 1998-07-29 Zeneca Ltd Chemical compounds

Also Published As

Publication number Publication date
BR0015177A (pt) 2002-06-18
WO2001044212A1 (en) 2001-06-21
EP1242395B1 (en) 2005-02-02
HUP0203787A3 (en) 2005-06-28
NO20022811D0 (no) 2002-06-13
SK5972002A3 (en) 2003-01-09
MXPA02005909A (es) 2002-10-23
DE60017941T2 (de) 2006-03-30
CO5261527A1 (es) 2003-03-31
ATE288423T1 (de) 2005-02-15
AR026547A1 (es) 2003-02-19
AU1805801A (en) 2001-06-25
NO20022811L (no) 2002-06-13
PT1242395E (pt) 2005-05-31
HUP0203787A2 (hu) 2003-07-28
ZA200202953B (en) 2003-09-23
EP1242395A1 (en) 2002-09-25
JP2003516977A (ja) 2003-05-20
DE60017941D1 (de) 2005-03-10
US6281210B1 (en) 2001-08-28
CN1390211A (zh) 2003-01-08
PE20010851A1 (es) 2001-08-17
CA2387047A1 (en) 2001-06-21
CZ20022389A3 (cs) 2002-10-16
IL150031A0 (en) 2002-12-01
PL355369A1 (en) 2004-04-19
TW544449B (en) 2003-08-01
ES2236006T3 (es) 2005-07-16
KR20020062332A (ko) 2002-07-25

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