PE20010851A1 - Esteres del acido benzoico de oxazolidinonas que tienen un substituyente hidroxiacetilpiperazina - Google Patents
Esteres del acido benzoico de oxazolidinonas que tienen un substituyente hidroxiacetilpiperazinaInfo
- Publication number
- PE20010851A1 PE20010851A1 PE2000001220A PE0012202000A PE20010851A1 PE 20010851 A1 PE20010851 A1 PE 20010851A1 PE 2000001220 A PE2000001220 A PE 2000001220A PE 0012202000 A PE0012202000 A PE 0012202000A PE 20010851 A1 PE20010851 A1 PE 20010851A1
- Authority
- PE
- Peru
- Prior art keywords
- alkyl
- methyl
- piperazinyl
- benzoic acid
- oxazolidinones
- Prior art date
Links
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical class OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 title abstract 4
- IZXIZTKNFFYFOF-UHFFFAOYSA-N 2-Oxazolidone Chemical compound O=C1NCCO1 IZXIZTKNFFYFOF-UHFFFAOYSA-N 0.000 title abstract 2
- WCYWZMWISLQXQU-UHFFFAOYSA-N methyl Chemical class [CH3] WCYWZMWISLQXQU-UHFFFAOYSA-N 0.000 abstract 4
- -1 HYDROXYACETYL Chemical class 0.000 abstract 3
- ROSDSFDQCJNGOL-UHFFFAOYSA-N Dimethylamine Chemical compound CNC ROSDSFDQCJNGOL-UHFFFAOYSA-N 0.000 abstract 2
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical compound [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- WPZSAUFQHYFIPG-UHFFFAOYSA-N propanethioamide Chemical compound CCC(N)=S WPZSAUFQHYFIPG-UHFFFAOYSA-N 0.000 abstract 2
- YKZWLZLFBNIZCC-UHFFFAOYSA-N 2-hydroxy-1-piperazin-1-ylethanone Chemical group OCC(=O)N1CCNCC1 YKZWLZLFBNIZCC-UHFFFAOYSA-N 0.000 abstract 1
- NPCLRBQYESMUPD-UHFFFAOYSA-N 2-methylpropanethioamide Chemical compound CC(C)C(N)=S NPCLRBQYESMUPD-UHFFFAOYSA-N 0.000 abstract 1
- 208000035143 Bacterial infection Diseases 0.000 abstract 1
- 208000022362 bacterial infectious disease Diseases 0.000 abstract 1
- 229940052296 esters of benzoic acid for local anesthesia Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D263/18—Oxygen atoms
- C07D263/20—Oxygen atoms attached in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Ophthalmology & Optometry (AREA)
- Dermatology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
SE REFIERE A ESTERES DEL ACIDO BENZOICO DE OXAZOLIDINONAS SUSTITUIDO CON HIDROXIACETILPIPERAZINA DE FORMULA I, DONDE A ES UN ANILLO DE FORMULA i, ii, iii; X ES O, S; R1 ES H, NH2, NH-ALQUILO C1-C4, ALQUILO C1-C4, ENTRE OTROS; R2 Y R3 SON H, F, Cl, ALQUILO C1-C2; R4 ES -N(R5)-CO-CH(R6)-N(R7)(R8); CH(R5)N(R7)(R8); R5 ES H, CH3; R6 ES H, ALQUILO C1-C4; R7 Y R8 SON H, ALQUILO C1-C4 O JUNTO A N FORMAN UN HETEROCICLO DE 5-7 MIEMBROS; CUANDO X ES O; R4 NO ES -N(R5)-CO-CH(R6)-N(R7)(R8). SON COMPUESTOS PREFERIDOS 4-[(DIMETILAMINO)METIL]BENZOATO DE (S)-N-[[3-[3-FLUORO-4-[4-(HIDROXIACETIL)-1-PIPERAZINIL]-FENIL]-2-OXO-5-OXAZOLIDINIL]METILPROPANOTIOAMIDA; 4-(MORFOLINOMETIL)BENZOATO DE (S)-N-[[3-[3-FLUORO-4-[4-(HIDROXIACETIL)-1-PIPERAZINIL]FENIL]-2-OXO-5-OXAZOLIDINIL]METIL]PROPANOTIOAMIDA; 4-[(4-METIL-1-PIPERAZINIL)METIL]BENZOATO DE (S)-N-[[3-[3-FLUORO-4-[4-(HIDROXIACETIL)-1-PIPERAZINIL]FENIL]-2-OXO-5-OXAZOLIDINIL]METIL]PROPANOTIOAMIDA. EL COMPUESTO PUEDE SER UTIL PARA EL TRATAMIENTO DE INFECCIONES BACTERIANAS CUTANEA, OCULAR
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US17067599P | 1999-12-14 | 1999-12-14 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20010851A1 true PE20010851A1 (es) | 2001-08-17 |
Family
ID=22620832
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2000001220A PE20010851A1 (es) | 1999-12-14 | 2000-11-15 | Esteres del acido benzoico de oxazolidinonas que tienen un substituyente hidroxiacetilpiperazina |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US6281210B1 (es) |
| EP (1) | EP1242395B1 (es) |
| JP (1) | JP2003516977A (es) |
| KR (1) | KR20020062332A (es) |
| CN (1) | CN1390211A (es) |
| AR (1) | AR026547A1 (es) |
| AT (1) | ATE288423T1 (es) |
| AU (1) | AU1805801A (es) |
| BR (1) | BR0015177A (es) |
| CA (1) | CA2387047A1 (es) |
| CO (1) | CO5261527A1 (es) |
| CZ (1) | CZ20022389A3 (es) |
| DE (1) | DE60017941T2 (es) |
| EA (1) | EA200200673A1 (es) |
| ES (1) | ES2236006T3 (es) |
| HU (1) | HUP0203787A3 (es) |
| IL (1) | IL150031A0 (es) |
| MX (1) | MXPA02005909A (es) |
| NO (1) | NO20022811D0 (es) |
| PE (1) | PE20010851A1 (es) |
| PL (1) | PL355369A1 (es) |
| PT (1) | PT1242395E (es) |
| SK (1) | SK5972002A3 (es) |
| TW (1) | TW544449B (es) |
| WO (1) | WO2001044212A1 (es) |
| ZA (1) | ZA200202953B (es) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9928568D0 (en) | 1999-12-03 | 2000-02-02 | Zeneca Ltd | Chemical compounds |
| DE19962924A1 (de) | 1999-12-24 | 2001-07-05 | Bayer Ag | Substituierte Oxazolidinone und ihre Verwendung |
| GB0009803D0 (en) | 2000-04-25 | 2000-06-07 | Astrazeneca Ab | Chemical compounds |
| ES2256318T3 (es) * | 2000-10-17 | 2006-07-16 | PHARMACIA & UPJOHN COMPANY LLC | Metodos de produccion de compuestos de oxazolidinona. |
| DE10129725A1 (de) | 2001-06-20 | 2003-01-02 | Bayer Ag | Kombinationstherapie substituierter Oxazolidinone |
| TW200403240A (en) * | 2002-06-28 | 2004-03-01 | Upjohn Co | Difluorothioacetamides of oxazolidinones as antibacterial agents |
| TW200404069A (en) * | 2002-06-28 | 2004-03-16 | Upjohn Co | Difluorothioacetamides of oxazolidinones with a glycoloylpiperazine substituent |
| MXPA05005472A (es) | 2002-11-21 | 2005-07-25 | Pharmacia & Upjohn Co Llc | Derivados de n-(4-piparazin-1-il)-fenil-2-oxazolidinona-5-carboxamida y compuestos relacionados como agentes antibacterianos. |
| DE10300111A1 (de) * | 2003-01-07 | 2004-07-15 | Bayer Healthcare Ag | Verfahren zur Herstellung von 5-Chlor-N-({(5S)-2-oxo-3-[4-(3-oxo-4-morpholinyl)-phenyl]-1,3-oxazolidin-5-yl}-methyl)-2-thiophencarboxamid |
| DE10355461A1 (de) | 2003-11-27 | 2005-06-23 | Bayer Healthcare Ag | Verfahren zur Herstellung einer festen, oral applizierbaren pharmazeutischen Zusammensetzung |
| DE102004062475A1 (de) * | 2004-12-24 | 2006-07-06 | Bayer Healthcare Ag | Feste, oral applizierbare pharmazeutische Darreichungsformen mit modifizierter Freisetzung |
| EP1685841A1 (en) * | 2005-01-31 | 2006-08-02 | Bayer Health Care Aktiengesellschaft | Prevention and treatment of thromboembolic disorders |
| DE102005045518A1 (de) * | 2005-09-23 | 2007-03-29 | Bayer Healthcare Ag | 2-Aminoethoxyessigsäure-Derivate und ihre Verwendung |
| WO2007039132A1 (de) | 2005-10-04 | 2007-04-12 | Bayer Healthcare Ag | Neue polymorphe form und die amorphe form von 5-chlor-n- ( { ( 5s ) -2-0x0-3-[4-( 3-oxo-4-morpholinyl) - phenyl] -1,3-oxazolidin-5-yl} -methyl) -2- thiophencarboxamid |
| DE102005047561A1 (de) | 2005-10-04 | 2007-04-05 | Bayer Healthcare Ag | Feste, oral applizierbare pharmazeutische Darreichungsformen mit schneller Wirkstofffreisetzung |
| US20100210602A1 (en) * | 2006-12-12 | 2010-08-19 | The Johns Hopkins University | PhoU (PerF), A PERSISTENCE SWITCH INVOLVED IN PERSISTER FORMATION AND TOLERANCE TO MULTIPLE ANTIBIOTICS AND STRESSES AS A DRUG TARGET FOR PERSISTER BACTERIA |
| EP2170874A4 (en) * | 2007-06-22 | 2011-08-31 | Orchid Res Lab Ltd | NEW COMPOUNDS AND THEIR USE |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE69419523T2 (de) * | 1993-11-22 | 1999-11-25 | Pharmacia & Upjohn Co., Kalamazoo | Substituierte hydroxyacetyl piperazine phenyl oxazolidinonsäureester |
| MY116093A (en) * | 1996-02-26 | 2003-11-28 | Upjohn Co | Azolyl piperazinyl phenyl oxazolidinone antimicrobials |
| SK156499A3 (en) * | 1997-05-30 | 2000-06-12 | Upjohn Co | Oxazolidinone antibacterial agents having a thiocarbonyl functionality |
| GB9812019D0 (en) * | 1998-06-05 | 1998-07-29 | Zeneca Ltd | Chemical compounds |
-
2000
- 2000-11-15 PE PE2000001220A patent/PE20010851A1/es not_active Application Discontinuation
- 2000-11-20 AR ARP000106119A patent/AR026547A1/es unknown
- 2000-11-24 TW TW089125030A patent/TW544449B/zh not_active IP Right Cessation
- 2000-12-06 EA EA200200673A patent/EA200200673A1/ru unknown
- 2000-12-06 PT PT00980849T patent/PT1242395E/pt unknown
- 2000-12-06 MX MXPA02005909A patent/MXPA02005909A/es not_active Application Discontinuation
- 2000-12-06 AU AU18058/01A patent/AU1805801A/en not_active Abandoned
- 2000-12-06 DE DE60017941T patent/DE60017941T2/de not_active Expired - Fee Related
- 2000-12-06 CN CN00815710A patent/CN1390211A/zh active Pending
- 2000-12-06 WO PCT/US2000/032432 patent/WO2001044212A1/en not_active Ceased
- 2000-12-06 US US09/732,088 patent/US6281210B1/en not_active Expired - Fee Related
- 2000-12-06 EP EP00980849A patent/EP1242395B1/en not_active Expired - Lifetime
- 2000-12-06 ES ES00980849T patent/ES2236006T3/es not_active Expired - Lifetime
- 2000-12-06 IL IL15003100A patent/IL150031A0/xx unknown
- 2000-12-06 HU HU0203787A patent/HUP0203787A3/hu unknown
- 2000-12-06 PL PL00355369A patent/PL355369A1/xx not_active Application Discontinuation
- 2000-12-06 BR BR0015177-7A patent/BR0015177A/pt not_active IP Right Cessation
- 2000-12-06 SK SK597-2002A patent/SK5972002A3/sk unknown
- 2000-12-06 CA CA002387047A patent/CA2387047A1/en not_active Abandoned
- 2000-12-06 AT AT00980849T patent/ATE288423T1/de not_active IP Right Cessation
- 2000-12-06 JP JP2001544702A patent/JP2003516977A/ja active Pending
- 2000-12-06 CZ CZ20022389A patent/CZ20022389A3/cs unknown
- 2000-12-06 KR KR1020027007514A patent/KR20020062332A/ko not_active Withdrawn
- 2000-12-12 CO CO00094338A patent/CO5261527A1/es not_active Application Discontinuation
-
2002
- 2002-04-15 ZA ZA200202953A patent/ZA200202953B/xx unknown
- 2002-06-13 NO NO20022811A patent/NO20022811D0/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| AR026547A1 (es) | 2003-02-19 |
| CN1390211A (zh) | 2003-01-08 |
| KR20020062332A (ko) | 2002-07-25 |
| TW544449B (en) | 2003-08-01 |
| EA200200673A1 (ru) | 2002-12-26 |
| HUP0203787A3 (en) | 2005-06-28 |
| NO20022811L (no) | 2002-06-13 |
| WO2001044212A1 (en) | 2001-06-21 |
| HUP0203787A2 (hu) | 2003-07-28 |
| EP1242395B1 (en) | 2005-02-02 |
| PL355369A1 (en) | 2004-04-19 |
| ES2236006T3 (es) | 2005-07-16 |
| NO20022811D0 (no) | 2002-06-13 |
| AU1805801A (en) | 2001-06-25 |
| DE60017941T2 (de) | 2006-03-30 |
| US6281210B1 (en) | 2001-08-28 |
| JP2003516977A (ja) | 2003-05-20 |
| CA2387047A1 (en) | 2001-06-21 |
| PT1242395E (pt) | 2005-05-31 |
| IL150031A0 (en) | 2002-12-01 |
| MXPA02005909A (es) | 2002-10-23 |
| BR0015177A (pt) | 2002-06-18 |
| CZ20022389A3 (cs) | 2002-10-16 |
| DE60017941D1 (de) | 2005-03-10 |
| SK5972002A3 (en) | 2003-01-09 |
| EP1242395A1 (en) | 2002-09-25 |
| ATE288423T1 (de) | 2005-02-15 |
| ZA200202953B (en) | 2003-09-23 |
| CO5261527A1 (es) | 2003-03-31 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant, registration | ||
| FD | Application declared void or lapsed |