[go: up one dir, main page]

EA200200699A1 - Оксазолидиноны, обладающие сульфоксиминовой функциональностью - Google Patents

Оксазолидиноны, обладающие сульфоксиминовой функциональностью

Info

Publication number
EA200200699A1
EA200200699A1 EA200200699A EA200200699A EA200200699A1 EA 200200699 A1 EA200200699 A1 EA 200200699A1 EA 200200699 A EA200200699 A EA 200200699A EA 200200699 A EA200200699 A EA 200200699A EA 200200699 A1 EA200200699 A1 EA 200200699A1
Authority
EA
Eurasian Patent Office
Prior art keywords
sulphoximin
oxazolidinones
functionality
gram
positive
Prior art date
Application number
EA200200699A
Other languages
English (en)
Other versions
EA005567B1 (ru
Inventor
Джексон Б. мл. Хестер
Дэвид Л. Александер
Original Assignee
Фармация Энд Апджон Компани
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Фармация Энд Апджон Компани filed Critical Фармация Энд Апджон Компани
Publication of EA200200699A1 publication Critical patent/EA200200699A1/ru
Publication of EA005567B1 publication Critical patent/EA005567B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Ophthalmology & Optometry (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Данное изобретение представляет соединение формулы Iкоторое обладает высокой активностью против грамположительных и грамотрицательных бактерий.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA200200699A 1999-12-21 2000-12-12 Оксазолидиноны, обладающие сульфоксиминовой функциональностью EA005567B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US17191699P 1999-12-21 1999-12-21
PCT/US2000/032451 WO2001046185A1 (en) 1999-12-21 2000-12-12 Oxazolidinones having a sulfoximine functionality and their use as antimicrobial agents

Publications (2)

Publication Number Publication Date
EA200200699A1 true EA200200699A1 (ru) 2003-02-27
EA005567B1 EA005567B1 (ru) 2005-04-28

Family

ID=22625632

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200200699A EA005567B1 (ru) 1999-12-21 2000-12-12 Оксазолидиноны, обладающие сульфоксиминовой функциональностью

Country Status (22)

Country Link
US (1) US20010046987A1 (ru)
EP (1) EP1242417A1 (ru)
JP (1) JP2003518117A (ru)
KR (1) KR20020067557A (ru)
CN (1) CN1221548C (ru)
AR (1) AR029211A1 (ru)
AU (1) AU782078B2 (ru)
BR (1) BR0016605A (ru)
CA (1) CA2389482A1 (ru)
CO (1) CO5251427A1 (ru)
CZ (1) CZ20022142A3 (ru)
EA (1) EA005567B1 (ru)
HU (1) HUP0203869A2 (ru)
IL (1) IL150348A0 (ru)
MX (1) MXPA02006233A (ru)
NO (1) NO20022973L (ru)
NZ (1) NZ519725A (ru)
PE (1) PE20010931A1 (ru)
PL (1) PL356478A1 (ru)
SK (1) SK7572002A3 (ru)
WO (1) WO2001046185A1 (ru)
ZA (1) ZA200204166B (ru)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9928568D0 (en) 1999-12-03 2000-02-02 Zeneca Ltd Chemical compounds
DE19962924A1 (de) 1999-12-24 2001-07-05 Bayer Ag Substituierte Oxazolidinone und ihre Verwendung
GB0009803D0 (en) 2000-04-25 2000-06-07 Astrazeneca Ab Chemical compounds
GB0108764D0 (en) * 2001-04-07 2001-05-30 Astrazeneca Ab Chemical compounds
GB0108793D0 (en) * 2001-04-07 2001-05-30 Astrazeneca Ab Chemical compounds
GB0108794D0 (en) * 2001-04-07 2001-05-30 Astrazeneca Ab Chemical compound
WO2002081470A1 (en) * 2001-04-07 2002-10-17 Astrazeneca Ab Oxazolidinones containing a sulfonimid group as antibiotics
DE10129725A1 (de) 2001-06-20 2003-01-02 Bayer Ag Kombinationstherapie substituierter Oxazolidinone
US7141588B2 (en) 2002-02-25 2006-11-28 Pfizer, Inc. N-aryl-2-oxazolidinone-5-carboxamides and their derivatives
AR038536A1 (es) 2002-02-25 2005-01-19 Upjohn Co N-aril-2-oxazolidinona-5- carboxamidas y sus derivados
TW200403240A (en) 2002-06-28 2004-03-01 Upjohn Co Difluorothioacetamides of oxazolidinones as antibacterial agents
US6875784B2 (en) * 2002-10-09 2005-04-05 Pharmacia & Upjohn Company Antimibicrobial [3.1.0.] bicyclic oxazolidinone derivatives
DE10300111A1 (de) * 2003-01-07 2004-07-15 Bayer Healthcare Ag Verfahren zur Herstellung von 5-Chlor-N-({(5S)-2-oxo-3-[4-(3-oxo-4-morpholinyl)-phenyl]-1,3-oxazolidin-5-yl}-methyl)-2-thiophencarboxamid
BRPI0409217A (pt) * 2003-04-09 2006-03-28 Pharmacia & Upjohn Co Llc derivados e análogos antimicrobianos da [3.1.0]bicicloexilfeniloxazolidinona
US7304050B2 (en) 2003-09-16 2007-12-04 Pfizer Inc. Antibacterial agents
US7265140B2 (en) * 2003-09-23 2007-09-04 Pfizer Inc Acyloxymethylcarbamate prodrugs of oxazolidinones
DE10355461A1 (de) 2003-11-27 2005-06-23 Bayer Healthcare Ag Verfahren zur Herstellung einer festen, oral applizierbaren pharmazeutischen Zusammensetzung
CA2589250A1 (en) * 2004-11-29 2006-06-01 Pharmacia & Upjohn Company Llc Diazepine oxazolidinones as antibacterial agents
DE102004062475A1 (de) * 2004-12-24 2006-07-06 Bayer Healthcare Ag Feste, oral applizierbare pharmazeutische Darreichungsformen mit modifizierter Freisetzung
EP1685841A1 (en) 2005-01-31 2006-08-02 Bayer Health Care Aktiengesellschaft Prevention and treatment of thromboembolic disorders
ATE449773T1 (de) 2005-06-29 2009-12-15 Pharmacia & Upjohn Co Llc Homomorpholinoxazolidinone als antibakterielle mittel
DE102005045518A1 (de) * 2005-09-23 2007-03-29 Bayer Healthcare Ag 2-Aminoethoxyessigsäure-Derivate und ihre Verwendung
DE102005047561A1 (de) 2005-10-04 2007-04-05 Bayer Healthcare Ag Feste, oral applizierbare pharmazeutische Darreichungsformen mit schneller Wirkstofffreisetzung
DE102005047558A1 (de) * 2005-10-04 2008-02-07 Bayer Healthcare Ag Kombinationstherapie substituierter Oxazolidinone zur Prophylaxe und Behandlung von cerebralen Durchblutungsstörungen
RU2578602C2 (ru) 2005-10-04 2016-03-27 Байер Интеллектуэль Проперти Гмбх Способ получения 5-хлор-n-(5s)-2-оксо-3-[4-(3-оксо-морфолинил)-фенил]-1,3-оксазолидин-5-ил}-метил)-2-тиофенкарбоксамида в модификации ii (варианты)
DE102007028319A1 (de) * 2007-06-20 2008-12-24 Bayer Healthcare Ag Substituierte Oxazolidinone und ihre Verwendung
WO2021184339A1 (en) * 2020-03-20 2021-09-23 Merck Sharp & Dohme Corp. Oxazolidinone compound and methods of use thereof as an antibacterial agent

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MY115155A (en) * 1993-09-09 2003-04-30 Upjohn Co Substituted oxazine and thiazine oxazolidinone antimicrobials.
US5688792A (en) * 1994-08-16 1997-11-18 Pharmacia & Upjohn Company Substituted oxazine and thiazine oxazolidinone antimicrobials
ATE233766T1 (de) * 1994-11-15 2003-03-15 Upjohn Co Antibakterielle bizyklische oxazin und thiazin- oxazolidinone
CA2228647A1 (en) * 1995-09-01 1997-03-13 Pharmacia & Upjohn Company Phenyloxazolidinones having a c-c bond to 4-8 membered heterocyclic rings
NZ501412A (en) * 1997-05-30 2001-11-30 Upjohn Co Oxazolidinone antibacterial agents having a thiocarbonyl functionality

Also Published As

Publication number Publication date
JP2003518117A (ja) 2003-06-03
CN1221548C (zh) 2005-10-05
EP1242417A1 (en) 2002-09-25
CO5251427A1 (es) 2003-02-28
NO20022973L (no) 2002-08-20
NZ519725A (en) 2004-05-28
PL356478A1 (en) 2004-06-28
US20010046987A1 (en) 2001-11-29
CA2389482A1 (en) 2001-06-28
CN1391572A (zh) 2003-01-15
AU782078B2 (en) 2005-06-30
NO20022973D0 (no) 2002-06-20
BR0016605A (pt) 2003-02-25
PE20010931A1 (es) 2001-08-29
AR029211A1 (es) 2003-06-18
IL150348A0 (en) 2002-12-01
MXPA02006233A (es) 2002-12-05
CZ20022142A3 (cs) 2002-11-13
WO2001046185A1 (en) 2001-06-28
KR20020067557A (ko) 2002-08-22
EA005567B1 (ru) 2005-04-28
HUP0203869A2 (hu) 2003-07-28
SK7572002A3 (en) 2002-12-03
ZA200204166B (en) 2003-10-29
AU2050201A (en) 2001-07-03

Similar Documents

Publication Publication Date Title
EA200200699A1 (ru) Оксазолидиноны, обладающие сульфоксиминовой функциональностью
EA200200661A1 (ru) 3-аминохиназолин-2,4-дионовые антибактериальные агенты
TR199902400T2 (xx) Fungusit etkinlik g�steren terkiplerin birle�imleri.
PT1193270E (pt) Pirrolobenzodiazepinas
ATE403429T1 (de) Spiropyrazol-verbindungen
DE60019919D1 (de) Hydrochloride kondensierter heterozyklen
DE69829846D1 (de) Antibakteriell wirksam oxazolidinone mit einer thiocarbonylfunktionalität
NO20054195D0 (no) Isoksazolforbindelser som inhibitorer for varmesjokkproteiner
EA200400489A1 (ru) Препараты, содержащие цефалоспориновое соединение, и их применение в лечении бактериальных инфекций у кошек и собак
EA200001197A1 (ru) Усиление активности оксазолидиноновых антибактериальных агентов в результате применения производных аргинина
PT931788E (pt) Inibidores de metaloprotease
CY1113578T1 (el) 2,3-διυδρο-6-νιτροϊμιδαζο 2,1 -b-οξαζολια
ATE353894T1 (de) Acyloxymethylcarbamat-prodrugs von oxazolidinonen
EA200200819A1 (ru) Кристаллическая форма ii линезолида
EA200200673A1 (ru) Оксазолидиноновые эфиры бензойной кислоты, содержащие гидроксиацетилпиперазиновый заместитель
SV2003000981A (es) Fenil-heterociclil-eteres ref. pcs10973
NZ336091A (en) Aqueous disinfecting cleaning composition
EA200201007A1 (ru) Контейнер для внутривенного раствора линезолида
EA200200042A1 (ru) Стабильный раствор ксилометазолина и оксиметазолина
EA200200749A1 (ru) Производные гетероциклического амида
EA200200160A1 (ru) Аналоги псевдомицина с n-ацильной боковой цепью
ES2175228T3 (es) Metilsulfomicina i, un procedimiento para su produccion y su uso.
AR024797A1 (es) Forma cristalina iii de la n-(4-(5-dimetilaminonaftalen-1-sulfonilamino)fenil)-3-hidroxi-2,2-dimetilpropionamida
ECSP003746A (es) Oxazolidinonas derivadas de sultamas y sultonas
MY120189A (en) Sultam and sultone derived oxazolidinones

Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM RU