DK2258870T3 - Fremgangsmåde til at identificere forbindelser der binder til et biologisk target-molekyle - Google Patents

Fremgangsmåde til at identificere forbindelser der binder til et biologisk target-molekyle

Info

Publication number: DK2258870T3
Authority: DK; Denmark
Prior art keywords: bind; target molecule; identifying compounds; biological target; biological
Prior art date: 2005-06-09

Application number

DK10075295.5T

Other languages

English (en)

Inventor

Barry Morgan

Stephen Hale

Christopher C Arico-Muendel

Matthew Clark

Richard Wagner

Steffen Phillip Creaser

Paolo A Centrella

David I Israel

Malcolm L Gefter

Dennis Benjamin

Nils Jakob Vest Hansen

Raksha A Acharya

Malcolm J Kavarana

George J Franklin

Original Assignee

Glaxosmithkline Llc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2005-06-09

Filing date

2006-06-09

Publication date

2013-03-18

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=36930432&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK2258870(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2006-06-09 Application filed by Glaxosmithkline Llc filed Critical Glaxosmithkline Llc

2013-03-18 Application granted granted Critical

2013-03-18 Publication of DK2258870T3 publication Critical patent/DK2258870T3/da

Links

150000001875 compounds Chemical class 0.000 title 1
108091034117 Oligonucleotide Proteins 0.000 abstract 1
JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 abstract 1
230000002194 synthesizing effect Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B61/00—Other general methods
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1068—Template (nucleic acid) mediated chemical library synthesis, e.g. chemical and enzymatical DNA-templated organic molecule synthesis, libraries prepared by non ribosomal polypeptide synthesis [NRPS], DNA/RNA-polymerase mediated polypeptide synthesis

Landscapes

Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Genetics & Genomics (AREA)
Engineering & Computer Science (AREA)
Biochemistry (AREA)
Biotechnology (AREA)
Molecular Biology (AREA)
General Health & Medical Sciences (AREA)
Zoology (AREA)
Wood Science & Technology (AREA)
Bioinformatics & Cheminformatics (AREA)
Biomedical Technology (AREA)
General Engineering & Computer Science (AREA)
Plant Pathology (AREA)
Physics & Mathematics (AREA)
Microbiology (AREA)
Crystallography & Structural Chemistry (AREA)
Biophysics (AREA)
Bioinformatics & Computational Biology (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Steroid Compounds (AREA)
Polyurethanes Or Polyureas (AREA)
Saccharide Compounds (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Compounds Of Unknown Constitution (AREA)
Investigating Or Analysing Biological Materials (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)

DK10075295.5T 2005-06-09 2006-06-09 Fremgangsmåde til at identificere forbindelser der binder til et biologisk target-molekyle DK2258870T3 (da)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US68946605P	2005-06-09	2005-06-09
US73104105P	2005-10-28	2005-10-28
EP06784718A EP1910538B1 (en)	2005-06-09	2006-06-09	Methods for synthesis of encoded libraries

Publications (1)

Publication Number	Publication Date
DK2258870T3 true DK2258870T3 (da)	2013-03-18

Family

ID=36930432

Family Applications (4)

Application Number	Title	Priority Date	Filing Date
DK06784718.6T DK1910538T3 (da)	2005-06-09	2006-06-09	Fremgangsmåder til syntese af kodede biblioteker
DK10075295.5T DK2258870T3 (da)	2005-06-09	2006-06-09	Fremgangsmåde til at identificere forbindelser der binder til et biologisk target-molekyle
DKPA200800005A DK177345B1 (da)	2005-06-09	2008-01-03	Fremgangsmåder til syntese af kodede biblioteker
DKPA201170734A DK179064B1 (da)	2005-06-09	2011-12-20	Fremgangsmåder til syntese af kodede biblioteker

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
DK06784718.6T DK1910538T3 (da)	2005-06-09	2006-06-09	Fremgangsmåder til syntese af kodede biblioteker

Family Applications After (2)

Application Number	Title	Priority Date	Filing Date
DKPA200800005A DK177345B1 (da)	2005-06-09	2008-01-03	Fremgangsmåder til syntese af kodede biblioteker
DKPA201170734A DK179064B1 (da)	2005-06-09	2011-12-20	Fremgangsmåder til syntese af kodede biblioteker

Country Status (23)

Country	Link
EP (4)	EP1910538B1 (da)
JP (2)	JP5508711B2 (da)
KR (1)	KR101346432B1 (da)
CN (2)	CN102392014A (da)
AT (1)	ATE507292T1 (da)
AU (1)	AU2006257915B2 (da)
BR (1)	BRPI0613566B1 (da)
CA (1)	CA2611512C (da)
CY (1)	CY1112036T1 (da)
DE (1)	DE602006021580D1 (da)
DK (4)	DK1910538T3 (da)
ES (2)	ES2365534T3 (da)
HR (1)	HRP20110528T1 (da)
IL (1)	IL187977A (da)
NO (1)	NO343698B1 (da)
NZ (1)	NZ564545A (da)
PL (2)	PL1910538T3 (da)
PT (2)	PT2258870E (da)
RS (1)	RS51868B (da)
RU (2)	RU2459869C2 (da)
SI (1)	SI1910538T1 (da)
WO (1)	WO2006135786A2 (da)
ZA (2)	ZA200800190B (da)

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EP1401850A1 (en)	2001-06-20	2004-03-31	Nuevolution A/S	Nucleoside derivatives for library preparation
US7413854B2 (en)	2002-03-15	2008-08-19	Nuevolution A/S	Method for synthesising templated molecules
US10730906B2 (en)	2002-08-01	2020-08-04	Nuevolutions A/S	Multi-step synthesis of templated molecules
EP1558744B1 (en)	2002-10-30	2011-06-15	Nuevolution A/S	Enzymatic encoding
WO2004056994A2 (en)	2002-12-19	2004-07-08	Nuevolution A/S	Quasirandom structure and function guided synthesis methods
US20070026397A1 (en)	2003-02-21	2007-02-01	Nuevolution A/S	Method for producing second-generation library
EP1670939B1 (en)	2003-09-18	2009-11-04	Nuevolution A/S	A method for obtaining structural information concerning an encoded molecule and method for selecting compounds
SI1910538T1 (sl)	2005-06-09	2011-09-30	Praecis Pharm Inc	POSTOPKI ZA SINTEZO KODIRANIH KNJIĹľNIC
EP2341140B1 (en) *	2005-12-01	2017-07-19	Nuevolution A/S	Enzymatic encoding methods for efficient synthesis of large libraries
ES2638324T3 (es) *	2009-02-13	2017-10-19	X-Chem, Inc.	Métodos de creación y examen de bibliotecas codificadas por ADN
US11225655B2 (en)	2010-04-16	2022-01-18	Nuevolution A/S	Bi-functional complexes and methods for making and using such complexes
EP3828271A1 (en) *	2011-09-07	2021-06-02	X-Chem, Inc.	Methods for tagging dna-encoded libraries
ES2675167T3 (es)	2012-07-13	2018-07-09	X-Chem, Inc.	Bibliotecas codificadas por ADN que tienen enlaces oligonucleotídicos codificantes no legibles por polimerasas
US20200149034A1 (en) *	2017-03-17	2020-05-14	Hitgen Ltd.	Methods and Compositions for Synthesis of Encoded Libraries
WO2019149198A1 (zh) *	2018-01-31	2019-08-08	成都先导药物开发股份有限公司	一种dna编码化合物库及化合物筛选方法
GB201821109D0 (en) *	2018-12-21	2019-02-06	Philochem Ag	Nucleic acid encoded chemical libraries
CN110041390B (zh) *	2019-04-26	2022-05-27	上海药明康德新药开发有限公司	DNA编码化合物库中On-DNA的1,2,3-三氮唑化合物的合成方法
CN112779606A (zh) *	2019-11-06	2021-05-11	成都先导药物开发股份有限公司	一种On-DNA曼尼希反应的方法
CN113089104B (zh) *	2019-12-23	2023-03-28	成都先导药物开发股份有限公司	一种On-DNA二胺化合物关环反应的合成方法
CN115506036B (zh) *	2021-06-22	2024-07-02	中国科学院上海药物研究所	Dna编码化合物文库起始片段及其制备和应用
DK4201951T3 (da) *	2021-12-21	2024-01-15	Bachem Holding Ag	Fremgangsmåde til syntese af et peptid
CN114920791B (zh) *	2022-04-28	2024-06-18	康龙化成(宁波)科技发展有限公司	一种寡聚核酸-琥珀酰亚胺化合物的合成方法

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SI1910538T1 (sl)	2005-06-09	2011-09-30	Praecis Pharm Inc	POSTOPKI ZA SINTEZO KODIRANIH KNJIĹľNIC

2006
- 2006-06-09 SI SI200631057T patent/SI1910538T1/sl unknown
- 2006-06-09 RU RU2008100035/10A patent/RU2459869C2/ru active
- 2006-06-09 ES ES06784718T patent/ES2365534T3/es active Active
- 2006-06-09 PT PT100752955T patent/PT2258870E/pt unknown
- 2006-06-09 HR HR20110528T patent/HRP20110528T1/hr unknown
- 2006-06-09 PL PL06784718T patent/PL1910538T3/pl unknown
- 2006-06-09 KR KR1020087000511A patent/KR101346432B1/ko active Active
- 2006-06-09 EP EP06784718A patent/EP1910538B1/en active Active
- 2006-06-09 WO PCT/US2006/022555 patent/WO2006135786A2/en not_active Ceased
- 2006-06-09 EP EP10012326A patent/EP2338990A3/en not_active Withdrawn
- 2006-06-09 PL PL10075295T patent/PL2258870T3/pl unknown
- 2006-06-09 CN CN2011102198704A patent/CN102392014A/zh active Pending
- 2006-06-09 AT AT06784718T patent/ATE507292T1/de active
- 2006-06-09 DK DK06784718.6T patent/DK1910538T3/da active
- 2006-06-09 DE DE602006021580T patent/DE602006021580D1/de active Active
- 2006-06-09 EP EP10075295A patent/EP2258870B1/en active Active
- 2006-06-09 EP EP10075296.3A patent/EP2311786A3/en not_active Withdrawn
- 2006-06-09 RS RS20110327A patent/RS51868B/sr unknown
- 2006-06-09 AU AU2006257915A patent/AU2006257915B2/en not_active Ceased
- 2006-06-09 CA CA2611512A patent/CA2611512C/en active Active
- 2006-06-09 NZ NZ564545A patent/NZ564545A/en unknown
- 2006-06-09 DK DK10075295.5T patent/DK2258870T3/da active
- 2006-06-09 CN CN2006800276157A patent/CN101233235B/zh active Active
- 2006-06-09 BR BRPI0613566-8A patent/BRPI0613566B1/pt active IP Right Grant
- 2006-06-09 ES ES10075295T patent/ES2401485T3/es active Active
- 2006-06-09 JP JP2008515983A patent/JP5508711B2/ja not_active Expired - Fee Related
- 2006-06-09 PT PT06784718T patent/PT1910538E/pt unknown
2007
- 2007-12-06 IL IL187977A patent/IL187977A/en active IP Right Grant
- 2007-12-12 NO NO20076362A patent/NO343698B1/no unknown
2008
- 2008-01-03 DK DKPA200800005A patent/DK177345B1/da active
- 2008-01-08 ZA ZA2008/00190A patent/ZA200800190B/en unknown
2010
- 2010-07-07 ZA ZA2010/04791A patent/ZA201004791B/en unknown
2011
- 2011-01-19 RU RU2011101778/10A patent/RU2011101778A/ru not_active Application Discontinuation
- 2011-07-14 CY CY20111100688T patent/CY1112036T1/el unknown
- 2011-12-20 DK DKPA201170734A patent/DK179064B1/da active
2013
- 2013-09-19 JP JP2013194319A patent/JP2014039550A/ja active Pending

Also Published As

Publication number	Publication date
EP2311786A3 (en)	2014-04-02
AU2006257915A1 (en)	2006-12-21
HK1120546A1 (en)	2009-04-03
PT2258870E (pt)	2013-04-01
EP2338990A2 (en)	2011-06-29
WO2006135786A2 (en)	2006-12-21
RU2008100035A (ru)	2009-07-20
DK200800005A (da)	2008-03-04
KR20080036577A (ko)	2008-04-28
DK179064B1 (da)	2017-10-02
EP2311786A2 (en)	2011-04-20
NO343698B1 (no)	2019-05-13
CY1112036T1 (el)	2015-11-04
EP2258870A2 (en)	2010-12-08
JP2014039550A (ja)	2014-03-06
ATE507292T1 (de)	2011-05-15
EP1910538A2 (en)	2008-04-16
PL2258870T3 (pl)	2013-05-31
ZA201004791B (en)	2012-06-27
IL187977A0 (en)	2008-03-20
PL1910538T3 (pl)	2011-12-30
JP5508711B2 (ja)	2014-06-04
BRPI0613566A2 (pt)	2011-01-18
NO20076362L (no)	2008-03-07
DK201170734A (en)	2011-12-20
PT1910538E (pt)	2011-07-28
AU2006257915B2 (en)	2011-09-08
EP2338990A3 (en)	2011-10-19
JP2008543289A (ja)	2008-12-04
RU2459869C2 (ru)	2012-08-27
ES2401485T3 (es)	2013-04-22
CN101233235B (zh)	2012-10-03
SI1910538T1 (sl)	2011-09-30
IL187977A (en)	2013-02-28
HK1150454A1 (en)	2011-12-30
DK177345B1 (da)	2013-01-28
ZA200800190B (en)	2010-11-24
CA2611512A1 (en)	2006-12-21
CA2611512C (en)	2018-05-22
NZ564545A (en)	2011-03-31
CN102392014A (zh)	2012-03-28
EP2258870B1 (en)	2013-01-02
EP2258870A3 (en)	2011-11-30
RU2011101778A (ru)	2012-07-27
KR101346432B1 (ko)	2014-02-14
RS51868B (sr)	2012-02-29
EP1910538B1 (en)	2011-04-27
CN101233235A (zh)	2008-07-30
DE602006021580D1 (de)	2011-06-09
BRPI0613566B1 (pt)	2020-01-07
HRP20110528T1 (hr)	2011-09-30
ES2365534T3 (es)	2011-10-06
DK1910538T3 (da)	2011-08-08
WO2006135786A3 (en)	2007-06-21

Publication	Publication Date	Title
DK2258870T3 (da)	2013-03-18	Fremgangsmåde til at identificere forbindelser der binder til et biologisk target-molekyle
WO2007053358A3 (en)	2007-11-01	Methods for identifying compounds of interest using encoded libraries
EA201492135A1 (ru)	2015-06-30	Способы создания и скрининга библиотек, кодируемых днк
EA200401107A1 (ru)	2005-04-28	Закодированные самособирающиеся химические библиотеки
DK1875239T3 (da)	2012-01-23	Fremgangsmåde til fremstilling af billeddannelsessonder under anvendelse af klik-kemi
EP2329045A4 (en)	2012-09-19	DEVICE FOR RAPID IDENTIFICATION OF NUCLEIC ACIDS FOR BINDING TO SPECIFIC CHEMICAL TARGETS
DK2292607T3 (da)	2014-06-30	Fremgangsmåde til syntese af organiske forbindelser
ATE431426T1 (de)	2009-05-15	Verfahren zur identifizierung von lrrk2 interagierenden molekülen und zur reinigung von lrrk2
WO2004097041A3 (en)	2005-02-03	Screening method for binding molecules
DE602005009827D1 (de)	2008-10-30	Verfahren zur aufreinigung von il-18-bindendem protein
DE602006012585D1 (de)	2010-04-15	Verfahren zur Förderung von Michael-additionsreaktionen
ATE496914T1 (de)	2011-02-15	Verfahren zur synthese von triazolen
ATE529433T1 (de)	2011-11-15	Verfahren zur reinigung eines il-18-bindenden proteins
EA200701578A1 (ru)	2008-10-30	Способ конъюгирования молекул, содержащих аминотиол, к носителям
CY1114172T1 (el)	2016-08-31	Μεθοδοι για ταυτοποιηση ενωσεων οι οποιες δεσμευονται σε βιολογικο μοριο στοχο
SI2258870T1 (sl)	2013-06-28	Postopek za identifikacijo spojin, ki se veĹľejo na bioloĹˇko ciljano molekulo
WO2025042899A3 (en)	2025-04-17	Methods for identifying compounds binding to a target molecule using mirror-imaging of the target molecule
DE502006006113D1 (de)	2010-03-25	Selektion von phosphatase kodierenden nukleinsäuremolekülen
WO2007106413A3 (en)	2008-12-04	Extended length borane phosphonate nucleic acid compounds
TH87312A (th)	2007-10-31	สารประกอบเบนซิมิแดโซลไธโอฟีน