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DK2258870T3 - Process for identifying compounds that bind to a biological target molecule - Google Patents

Process for identifying compounds that bind to a biological target molecule

Info

Publication number
DK2258870T3
DK2258870T3 DK10075295.5T DK10075295T DK2258870T3 DK 2258870 T3 DK2258870 T3 DK 2258870T3 DK 10075295 T DK10075295 T DK 10075295T DK 2258870 T3 DK2258870 T3 DK 2258870T3
Authority
DK
Denmark
Prior art keywords
bind
target molecule
identifying compounds
biological target
biological
Prior art date
Application number
DK10075295.5T
Other languages
Danish (da)
Inventor
Barry Morgan
Stephen Hale
Christopher C Arico-Muendel
Matthew Clark
Richard Wagner
Steffen Phillip Creaser
Paolo A Centrella
David I Israel
Malcolm L Gefter
Dennis Benjamin
Nils Jakob Vest Hansen
Raksha A Acharya
Malcolm J Kavarana
George J Franklin
Original Assignee
Glaxosmithkline Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=36930432&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK2258870(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Glaxosmithkline Llc filed Critical Glaxosmithkline Llc
Application granted granted Critical
Publication of DK2258870T3 publication Critical patent/DK2258870T3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B61/00—Other general methods
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1068—Template (nucleic acid) mediated chemical library synthesis, e.g. chemical and enzymatical DNA-templated organic molecule synthesis, libraries prepared by non ribosomal polypeptide synthesis [NRPS], DNA/RNA-polymerase mediated polypeptide synthesis

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Steroid Compounds (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Saccharide Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Polyurethanes Or Polyureas (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

The present invention provides a method of synthesizing libraries of molecules which include an encoding oligonucleotides tag.
DK10075295.5T 2005-06-09 2006-06-09 Process for identifying compounds that bind to a biological target molecule DK2258870T3 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US68946605P 2005-06-09 2005-06-09
US73104105P 2005-10-28 2005-10-28
EP06784718A EP1910538B1 (en) 2005-06-09 2006-06-09 Methods for synthesis of encoded libraries

Publications (1)

Publication Number Publication Date
DK2258870T3 true DK2258870T3 (en) 2013-03-18

Family

ID=36930432

Family Applications (4)

Application Number Title Priority Date Filing Date
DK06784718.6T DK1910538T3 (en) 2005-06-09 2006-06-09 Methods for synthesizing encoded libraries
DK10075295.5T DK2258870T3 (en) 2005-06-09 2006-06-09 Process for identifying compounds that bind to a biological target molecule
DKPA200800005A DK177345B1 (en) 2005-06-09 2008-01-03 Methods for synthesizing encoded libraries
DKPA201170734A DK179064B1 (en) 2005-06-09 2011-12-20 Methods for synthesizing encoded libraries

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DK06784718.6T DK1910538T3 (en) 2005-06-09 2006-06-09 Methods for synthesizing encoded libraries

Family Applications After (2)

Application Number Title Priority Date Filing Date
DKPA200800005A DK177345B1 (en) 2005-06-09 2008-01-03 Methods for synthesizing encoded libraries
DKPA201170734A DK179064B1 (en) 2005-06-09 2011-12-20 Methods for synthesizing encoded libraries

Country Status (23)

Country Link
EP (4) EP1910538B1 (en)
JP (2) JP5508711B2 (en)
KR (1) KR101346432B1 (en)
CN (2) CN101233235B (en)
AT (1) ATE507292T1 (en)
AU (1) AU2006257915B2 (en)
BR (1) BRPI0613566B1 (en)
CA (1) CA2611512C (en)
CY (1) CY1112036T1 (en)
DE (1) DE602006021580D1 (en)
DK (4) DK1910538T3 (en)
ES (2) ES2365534T3 (en)
HR (1) HRP20110528T1 (en)
IL (1) IL187977A (en)
NO (1) NO343698B1 (en)
NZ (1) NZ564545A (en)
PL (2) PL1910538T3 (en)
PT (2) PT2258870E (en)
RS (1) RS51868B (en)
RU (2) RU2459869C2 (en)
SI (1) SI1910538T1 (en)
WO (1) WO2006135786A2 (en)
ZA (2) ZA200800190B (en)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7727713B2 (en) 2001-06-20 2010-06-01 Nuevolution A/S Templated molecules and methods for using such molecules
NZ535144A (en) 2002-03-15 2006-03-31 Nuevolution As An improved method for synthesising templated molecules
US10730906B2 (en) 2002-08-01 2020-08-04 Nuevolutions A/S Multi-step synthesis of templated molecules
PT1558744E (en) 2002-10-30 2011-09-22 Nuevolution As Enzymatic encoding
DE60330406D1 (en) 2002-12-19 2010-01-14 Nuevolution As THROUGH QUASIZATIONAL STRUCTURES AND FUNCTIONS OF SYNTHESIS METHOD
EP1597395A2 (en) 2003-02-21 2005-11-23 Nuevolution A/S Method for producing second-generation library
DK1670939T3 (en) 2003-09-18 2010-03-01 Nuevolution As Method for obtaining structural information on a coded molecule and method for selecting compounds
EP1910538B1 (en) 2005-06-09 2011-04-27 Praecis Pharmaceuticals Inc. Methods for synthesis of encoded libraries
DK2336315T3 (en) * 2005-12-01 2017-11-06 Nuevolution As Method for enzymatic coding by efficient synthesis of large libraries
AP3396A (en) * 2009-02-13 2015-08-31 Chem Inc X Methods of creating and screening DNA-encoded libraries
US11225655B2 (en) 2010-04-16 2022-01-18 Nuevolution A/S Bi-functional complexes and methods for making and using such complexes
BR112014005205A2 (en) * 2011-09-07 2017-03-21 X-Chem Inc methods for tagging dna encoded libraries
SG10201907347YA (en) 2012-07-13 2019-09-27 X Chem Inc Dna-encoded libraries having encoding oligonucleotide linkages not readable by polymerases
JP6911248B2 (en) * 2017-03-17 2021-07-28 成都先導薬物開発股▲フン▼有限公司Ｈｉｔｇｅｎ Ｉｎｃ． Encoding library synthesis method and composition
WO2019149198A1 (en) * 2018-01-31 2019-08-08 成都先导药物开发股份有限公司 Dna-encoded compound library and compound screening method
GB201821109D0 (en) * 2018-12-21 2019-02-06 Philochem Ag Nucleic acid encoded chemical libraries
CN110041390B (en) * 2019-04-26 2022-05-27 上海药明康德新药开发有限公司 Method for synthesizing On-DNA 1,2, 3-triazole compound in DNA coding compound library
CN112779606A (en) * 2019-11-06 2021-05-11 成都先导药物开发股份有限公司 Method for On-DNA Mannich reaction
CN113089104B (en) * 2019-12-23 2023-03-28 成都先导药物开发股份有限公司 Synthetic method of On-DNA diamine compound ring closure reaction
CN115506036B (en) * 2021-06-22 2024-07-02 中国科学院上海药物研究所 DNA coding compound library initial fragment and preparation and application thereof
DK4201951T3 (en) * 2021-12-21 2024-01-15 Bachem Holding Ag Method for the synthesis of a peptide
CN114920791B (en) * 2022-04-28 2024-06-18 康龙化成(宁波)科技发展有限公司 Synthesis method of oligonucleotide-succinimide compound

Family Cites Families (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1545804A (en) 1924-12-26 1925-07-14 Warmerdam Nicholas Sash fastener
US4356270A (en) 1977-11-08 1982-10-26 Genentech, Inc. Recombinant DNA cloning vehicle
US4293652A (en) 1979-05-25 1981-10-06 Cetus Corporation Method for synthesizing DNA sequentially
US4458066A (en) 1980-02-29 1984-07-03 University Patents, Inc. Process for preparing polynucleotides
US4416988A (en) 1980-12-23 1983-11-22 Harvey Rubin Detection and isolation of enkephalin mRNA using a synthetic oligodeoxynucleotide
JPS60222842A (en) 1984-04-19 1985-11-07 Fuji Photo Film Co Ltd Silver halide photographic emulsion and its preparation
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
US4965188A (en) 1986-08-22 1990-10-23 Cetus Corporation Process for amplifying, detecting, and/or cloning nucleic acid sequences using a thermostable enzyme
US4800159A (en) 1986-02-07 1989-01-24 Cetus Corporation Process for amplifying, detecting, and/or cloning nucleic acid sequences
US5360928A (en) 1989-10-23 1994-11-01 Research Corporation Technologies, Inc. Synthesis and use of amino acid fluorides as peptide coupling reagents
DK0604552T3 (en) 1991-09-18 1997-08-04 Affymax Tech Nv Process for the synthesis of different assemblies of oligomers
US5573905A (en) 1992-03-30 1996-11-12 The Scripps Research Institute Encoded combinatorial chemical libraries
US5565324A (en) * 1992-10-01 1996-10-15 The Trustees Of Columbia University In The City Of New York Complex combinatorial chemical libraries encoded with tags
EP0675873A4 (en) 1992-12-11 2000-03-29 Chiron Corp Synthesis of encoded polymers
US6537776B1 (en) * 1999-06-14 2003-03-25 Diversa Corporation Synthetic ligation reassembly in directed evolution
US7479472B1 (en) 1998-10-19 2009-01-20 The Board Of Trustees Of The Leland Stanford Junior University DNA-templated combinatorial library chemistry
PT1423400E (en) 2001-03-19 2006-12-29 Harvard College Evolving new molecular function
EP1905829B1 (en) 2001-06-20 2016-02-17 Nuevolution A/S Templated molecules and methods for using such molecules
WO2003101972A1 (en) 2002-05-30 2003-12-11 The Scripps Research Institute Copper-catalysed ligation of azides and acetylenes
US7491494B2 (en) * 2002-08-19 2009-02-17 President And Fellows Of Harvard College Evolving new molecular function
PT1558744E (en) * 2002-10-30 2011-09-22 Nuevolution As Enzymatic encoding
ATE546525T1 (en) 2003-01-29 2012-03-15 454 Life Sciences Corp NUCLEIC ACID AMPLIFICATION BASED ON BEAD EMULSION
GB0304433D0 (en) * 2003-02-27 2003-04-02 Xceleron Ltd Improvements relating to chemical libraries
DE602004019764D1 (en) * 2003-03-20 2009-04-16 Nuevolution As LIGATION-RELATED CODING OF SMALL MOLECULES
DK1670939T3 (en) * 2003-09-18 2010-03-01 Nuevolution As Method for obtaining structural information on a coded molecule and method for selecting compounds
EP2366705A1 (en) * 2003-12-17 2011-09-21 Praecis Pharmaceuticals Incorporated Methods for synthesis of encoded libraries
US7116036B2 (en) 2004-08-02 2006-10-03 General Electric Company Energy harvesting system, apparatus and method
EP1828381B1 (en) * 2004-11-22 2009-01-07 Peter Birk Rasmussen Template directed split and mix systhesis of small molecule libraries
EP1910538B1 (en) 2005-06-09 2011-04-27 Praecis Pharmaceuticals Inc. Methods for synthesis of encoded libraries

Also Published As

Publication number Publication date
DK177345B1 (en) 2013-01-28
EP2338990A2 (en) 2011-06-29
CY1112036T1 (en) 2015-11-04
NZ564545A (en) 2011-03-31
DK200800005A (en) 2008-03-04
IL187977A0 (en) 2008-03-20
HK1150454A1 (en) 2011-12-30
EP2338990A3 (en) 2011-10-19
ES2401485T3 (en) 2013-04-22
ZA200800190B (en) 2010-11-24
JP2008543289A (en) 2008-12-04
PL2258870T3 (en) 2013-05-31
PL1910538T3 (en) 2011-12-30
WO2006135786A2 (en) 2006-12-21
EP1910538A2 (en) 2008-04-16
EP2258870A2 (en) 2010-12-08
CN102392014A (en) 2012-03-28
EP2258870A3 (en) 2011-11-30
PT2258870E (en) 2013-04-01
RU2008100035A (en) 2009-07-20
IL187977A (en) 2013-02-28
DK201170734A (en) 2011-12-20
CA2611512A1 (en) 2006-12-21
EP1910538B1 (en) 2011-04-27
PT1910538E (en) 2011-07-28
KR101346432B1 (en) 2014-02-14
RS51868B (en) 2012-02-29
EP2311786A3 (en) 2014-04-02
NO20076362L (en) 2008-03-07
DK179064B1 (en) 2017-10-02
AU2006257915B2 (en) 2011-09-08
HK1120546A1 (en) 2009-04-03
DK1910538T3 (en) 2011-08-08
RU2459869C2 (en) 2012-08-27
ES2365534T3 (en) 2011-10-06
BRPI0613566B1 (en) 2020-01-07
DE602006021580D1 (en) 2011-06-09
BRPI0613566A2 (en) 2011-01-18
ZA201004791B (en) 2012-06-27
NO343698B1 (en) 2019-05-13
JP2014039550A (en) 2014-03-06
CN101233235A (en) 2008-07-30
HRP20110528T1 (en) 2011-09-30
EP2311786A2 (en) 2011-04-20
EP2258870B1 (en) 2013-01-02
AU2006257915A1 (en) 2006-12-21
CN101233235B (en) 2012-10-03
WO2006135786A3 (en) 2007-06-21
KR20080036577A (en) 2008-04-28
CA2611512C (en) 2018-05-22
SI1910538T1 (en) 2011-09-30
ATE507292T1 (en) 2011-05-15
RU2011101778A (en) 2012-07-27
JP5508711B2 (en) 2014-06-04

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