PL1910538T3 - Sposób syntezy kodowanych bibliotek - Google Patents

Sposób syntezy kodowanych bibliotek

Info

Publication number: PL1910538T3
Authority: PL; Poland
Prior art keywords: synthesis; methods; encoded libraries; libraries; encoded
Prior art date: 2005-06-09

Application number

PL06784718T

Other languages

English (en)

Inventor

Barry Morgan

Stephen Hale

Christopher C Arico-Muendel

Matthew Clark

Richard Wagner

Malcolm J Kavarana

Steffen Phillip Creaser

George J Franklin

Paolo A Centrella

David I Israel

Malcolm L Gefter

Dennis Benjamin

Nils Jakob Vest Hansen

Raksha A Acharya

Original Assignee

Praecis Pharm Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2005-06-09

Filing date

2006-06-09

Publication date

2011-12-30

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=36930432&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PL1910538(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2006-06-09 Application filed by Praecis Pharm Inc filed Critical Praecis Pharm Inc

2011-12-30 Publication of PL1910538T3 publication Critical patent/PL1910538T3/pl

Links

238000000034 method Methods 0.000 title abstract 2
230000015572 biosynthetic process Effects 0.000 title 1
238000003786 synthesis reaction Methods 0.000 title 1
108091034117 Oligonucleotide Proteins 0.000 abstract 1
JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 abstract 1
230000002194 synthesizing effect Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B61/00—Other general methods
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1068—Template (nucleic acid) mediated chemical library synthesis, e.g. chemical and enzymatical DNA-templated organic molecule synthesis, libraries prepared by non ribosomal polypeptide synthesis [NRPS], DNA/RNA-polymerase mediated polypeptide synthesis

Landscapes

Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Genetics & Genomics (AREA)
Engineering & Computer Science (AREA)
Biochemistry (AREA)
Biotechnology (AREA)
Molecular Biology (AREA)
General Health & Medical Sciences (AREA)
Zoology (AREA)
Wood Science & Technology (AREA)
Bioinformatics & Cheminformatics (AREA)
Biomedical Technology (AREA)
General Engineering & Computer Science (AREA)
Plant Pathology (AREA)
Biophysics (AREA)
Physics & Mathematics (AREA)
Microbiology (AREA)
Crystallography & Structural Chemistry (AREA)
Bioinformatics & Computational Biology (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Steroid Compounds (AREA)
Compounds Of Unknown Constitution (AREA)
Investigating Or Analysing Biological Materials (AREA)
Saccharide Compounds (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Polyurethanes Or Polyureas (AREA)
Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

PL06784718T 2005-06-09 2006-06-09 Sposób syntezy kodowanych bibliotek PL1910538T3 (pl)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
US68946605P	2005-06-09	2005-06-09
US73104105P	2005-10-28	2005-10-28
PCT/US2006/022555 WO2006135786A2 (en)	2005-06-09	2006-06-09	Methods for synthesis of encoded libraries
EP06784718A EP1910538B1 (en)	2005-06-09	2006-06-09	Methods for synthesis of encoded libraries

Publications (1)

Publication Number	Publication Date
PL1910538T3 true PL1910538T3 (pl)	2011-12-30

Family

ID=36930432

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
PL06784718T PL1910538T3 (pl)	2005-06-09	2006-06-09	Sposób syntezy kodowanych bibliotek
PL10075295T PL2258870T3 (pl)	2005-06-09	2006-06-09	Sposób identyfikacji związków, które wiążą się z docelową cząsteczką biologiczną

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
PL10075295T PL2258870T3 (pl)	2005-06-09	2006-06-09	Sposób identyfikacji związków, które wiążą się z docelową cząsteczką biologiczną

Country Status (23)

Country	Link
EP (4)	EP1910538B1 (pl)
JP (2)	JP5508711B2 (pl)
KR (1)	KR101346432B1 (pl)
CN (2)	CN101233235B (pl)
AT (1)	ATE507292T1 (pl)
AU (1)	AU2006257915B2 (pl)
BR (1)	BRPI0613566B1 (pl)
CA (1)	CA2611512C (pl)
CY (1)	CY1112036T1 (pl)
DE (1)	DE602006021580D1 (pl)
DK (4)	DK1910538T3 (pl)
ES (2)	ES2365534T3 (pl)
HR (1)	HRP20110528T1 (pl)
IL (1)	IL187977A (pl)
NO (1)	NO343698B1 (pl)
NZ (1)	NZ564545A (pl)
PL (2)	PL1910538T3 (pl)
PT (2)	PT2258870E (pl)
RS (1)	RS51868B (pl)
RU (2)	RU2459869C2 (pl)
SI (1)	SI1910538T1 (pl)
WO (1)	WO2006135786A2 (pl)
ZA (2)	ZA200800190B (pl)

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US7727713B2 (en)	2001-06-20	2010-06-01	Nuevolution A/S	Templated molecules and methods for using such molecules
NZ535144A (en)	2002-03-15	2006-03-31	Nuevolution As	An improved method for synthesising templated molecules
US10730906B2 (en)	2002-08-01	2020-08-04	Nuevolutions A/S	Multi-step synthesis of templated molecules
PT1558744E (pt)	2002-10-30	2011-09-22	Nuevolution As	Codificação enzimática
DE60330406D1 (de)	2002-12-19	2010-01-14	Nuevolution As	Durch quasizufallsstrukturen und funktionen geführte synthesemethode
EP1597395A2 (en)	2003-02-21	2005-11-23	Nuevolution A/S	Method for producing second-generation library
DK1670939T3 (da)	2003-09-18	2010-03-01	Nuevolution As	Fremgangsmåde til opnåelse af strukturel information om et kodet molekyle og fremgangsmåde til udvælgelse af forbindelser
EP1910538B1 (en)	2005-06-09	2011-04-27	Praecis Pharmaceuticals Inc.	Methods for synthesis of encoded libraries
DK2336315T3 (da) *	2005-12-01	2017-11-06	Nuevolution As	Fremgangsmåde til enzymatisk kodning ved effektiv syntese af store biblioteker
AP3396A (en) *	2009-02-13	2015-08-31	Chem Inc X	Methods of creating and screening DNA-encoded libraries
US11225655B2 (en)	2010-04-16	2022-01-18	Nuevolution A/S	Bi-functional complexes and methods for making and using such complexes
BR112014005205A2 (pt) *	2011-09-07	2017-03-21	X-Chem Inc	métodos para etiquetar bibliotecas codificadas com dna
SG10201907347YA (en)	2012-07-13	2019-09-27	X Chem Inc	Dna-encoded libraries having encoding oligonucleotide linkages not readable by polymerases
JP6911248B2 (ja) *	2017-03-17	2021-07-28	成都先導薬物開発股▲フン▼有限公司ＨｉｔｇｅｎＩｎｃ．	エンコードライブラリの合成方法及び組成物
WO2019149198A1 (zh) *	2018-01-31	2019-08-08	成都先导药物开发股份有限公司	一种dna编码化合物库及化合物筛选方法
GB201821109D0 (en) *	2018-12-21	2019-02-06	Philochem Ag	Nucleic acid encoded chemical libraries
CN110041390B (zh) *	2019-04-26	2022-05-27	上海药明康德新药开发有限公司	DNA编码化合物库中On-DNA的1,2,3-三氮唑化合物的合成方法
CN112779606A (zh) *	2019-11-06	2021-05-11	成都先导药物开发股份有限公司	一种On-DNA曼尼希反应的方法
CN113089104B (zh) *	2019-12-23	2023-03-28	成都先导药物开发股份有限公司	一种On-DNA二胺化合物关环反应的合成方法
CN115506036B (zh) *	2021-06-22	2024-07-02	中国科学院上海药物研究所	Dna编码化合物文库起始片段及其制备和应用
DK4201951T3 (da) *	2021-12-21	2024-01-15	Bachem Holding Ag	Fremgangsmåde til syntese af et peptid
CN114920791B (zh) *	2022-04-28	2024-06-18	康龙化成(宁波)科技发展有限公司	一种寡聚核酸-琥珀酰亚胺化合物的合成方法

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EP2366705A1 (en) *	2003-12-17	2011-09-21	Praecis Pharmaceuticals Incorporated	Methods for synthesis of encoded libraries
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EP1828381B1 (en) *	2004-11-22	2009-01-07	Peter Birk Rasmussen	Template directed split and mix systhesis of small molecule libraries
EP1910538B1 (en)	2005-06-09	2011-04-27	Praecis Pharmaceuticals Inc.	Methods for synthesis of encoded libraries

2006
- 2006-06-09 EP EP06784718A patent/EP1910538B1/en active Active
- 2006-06-09 BR BRPI0613566-8A patent/BRPI0613566B1/pt active IP Right Grant
- 2006-06-09 JP JP2008515983A patent/JP5508711B2/ja active Active
- 2006-06-09 RU RU2008100035/10A patent/RU2459869C2/ru active
- 2006-06-09 EP EP10075295A patent/EP2258870B1/en active Active
- 2006-06-09 CA CA2611512A patent/CA2611512C/en active Active
- 2006-06-09 NZ NZ564545A patent/NZ564545A/en unknown
- 2006-06-09 DK DK06784718.6T patent/DK1910538T3/da active
- 2006-06-09 ES ES06784718T patent/ES2365534T3/es active Active
- 2006-06-09 KR KR1020087000511A patent/KR101346432B1/ko active Active
- 2006-06-09 AT AT06784718T patent/ATE507292T1/de active
- 2006-06-09 PL PL06784718T patent/PL1910538T3/pl unknown
- 2006-06-09 DK DK10075295.5T patent/DK2258870T3/da active
- 2006-06-09 CN CN2006800276157A patent/CN101233235B/zh active Active
- 2006-06-09 RS RS20110327A patent/RS51868B/sr unknown
- 2006-06-09 SI SI200631057T patent/SI1910538T1/sl unknown
- 2006-06-09 ES ES10075295T patent/ES2401485T3/es active Active
- 2006-06-09 HR HR20110528T patent/HRP20110528T1/hr unknown
- 2006-06-09 PL PL10075295T patent/PL2258870T3/pl unknown
- 2006-06-09 PT PT100752955T patent/PT2258870E/pt unknown
- 2006-06-09 EP EP10075296.3A patent/EP2311786A3/en not_active Withdrawn
- 2006-06-09 DE DE602006021580T patent/DE602006021580D1/de active Active
- 2006-06-09 CN CN2011102198704A patent/CN102392014A/zh active Pending
- 2006-06-09 EP EP10012326A patent/EP2338990A3/en not_active Withdrawn
- 2006-06-09 WO PCT/US2006/022555 patent/WO2006135786A2/en not_active Ceased
- 2006-06-09 PT PT06784718T patent/PT1910538E/pt unknown
- 2006-06-09 AU AU2006257915A patent/AU2006257915B2/en active Active
2007
- 2007-12-06 IL IL187977A patent/IL187977A/en active IP Right Grant
- 2007-12-12 NO NO20076362A patent/NO343698B1/no unknown
2008
- 2008-01-03 DK DKPA200800005A patent/DK177345B1/da active
- 2008-01-08 ZA ZA2008/00190A patent/ZA200800190B/en unknown
2010
- 2010-07-07 ZA ZA2010/04791A patent/ZA201004791B/en unknown
2011
- 2011-01-19 RU RU2011101778/10A patent/RU2011101778A/ru not_active Application Discontinuation
- 2011-07-14 CY CY20111100688T patent/CY1112036T1/el unknown
- 2011-12-20 DK DKPA201170734A patent/DK179064B1/da active
2013
- 2013-09-19 JP JP2013194319A patent/JP2014039550A/ja active Pending

Also Published As

Publication number	Publication date
DK177345B1 (da)	2013-01-28
EP2338990A2 (en)	2011-06-29
CY1112036T1 (el)	2015-11-04
DK2258870T3 (da)	2013-03-18
NZ564545A (en)	2011-03-31
DK200800005A (da)	2008-03-04
IL187977A0 (en)	2008-03-20
HK1150454A1 (en)	2011-12-30
EP2338990A3 (en)	2011-10-19
ES2401485T3 (es)	2013-04-22
ZA200800190B (en)	2010-11-24
JP2008543289A (ja)	2008-12-04
PL2258870T3 (pl)	2013-05-31
WO2006135786A2 (en)	2006-12-21
EP1910538A2 (en)	2008-04-16
EP2258870A2 (en)	2010-12-08
CN102392014A (zh)	2012-03-28
EP2258870A3 (en)	2011-11-30
PT2258870E (pt)	2013-04-01
RU2008100035A (ru)	2009-07-20
IL187977A (en)	2013-02-28
DK201170734A (en)	2011-12-20
CA2611512A1 (en)	2006-12-21
EP1910538B1 (en)	2011-04-27
PT1910538E (pt)	2011-07-28
KR101346432B1 (ko)	2014-02-14
RS51868B (sr)	2012-02-29
EP2311786A3 (en)	2014-04-02
NO20076362L (no)	2008-03-07
DK179064B1 (da)	2017-10-02
AU2006257915B2 (en)	2011-09-08
HK1120546A1 (en)	2009-04-03
DK1910538T3 (da)	2011-08-08
RU2459869C2 (ru)	2012-08-27
ES2365534T3 (es)	2011-10-06
BRPI0613566B1 (pt)	2020-01-07
DE602006021580D1 (de)	2011-06-09
BRPI0613566A2 (pt)	2011-01-18
ZA201004791B (en)	2012-06-27
NO343698B1 (no)	2019-05-13
JP2014039550A (ja)	2014-03-06
CN101233235A (zh)	2008-07-30
HRP20110528T1 (hr)	2011-09-30
EP2311786A2 (en)	2011-04-20
EP2258870B1 (en)	2013-01-02
AU2006257915A1 (en)	2006-12-21
CN101233235B (zh)	2012-10-03
WO2006135786A3 (en)	2007-06-21
KR20080036577A (ko)	2008-04-28
CA2611512C (en)	2018-05-22
SI1910538T1 (sl)	2011-09-30
ATE507292T1 (de)	2011-05-15
RU2011101778A (ru)	2012-07-27
JP5508711B2 (ja)	2014-06-04

Publication	Publication Date	Title
ZA200800190B (en)	2010-11-24	Methods for synthesis of encoded libraries
WO2005058479A3 (en)	2005-10-13	Methods for synthesis of encoded libraries
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