[go: up one dir, main page]

DE60330406D1 - Durch quasizufallsstrukturen und funktionen geführte synthesemethode - Google Patents

Durch quasizufallsstrukturen und funktionen geführte synthesemethode

Info

Publication number
DE60330406D1
DE60330406D1 DE60330406T DE60330406T DE60330406D1 DE 60330406 D1 DE60330406 D1 DE 60330406D1 DE 60330406 T DE60330406 T DE 60330406T DE 60330406 T DE60330406 T DE 60330406T DE 60330406 D1 DE60330406 D1 DE 60330406D1
Authority
DE
Germany
Prior art keywords
ccpns
cpns
formation
functional entities
cpn
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60330406T
Other languages
English (en)
Inventor
Alex Haahr Gouliaev
Anette Holtmann
Henrik Pedersen
Thomas Franch
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nuevolution AS
Original Assignee
Nuevolution AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nuevolution AS filed Critical Nuevolution AS
Application granted granted Critical
Publication of DE60330406D1 publication Critical patent/DE60330406D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B30/00—Methods of screening libraries
    • C40B30/04—Methods of screening libraries by measuring the ability to specifically bind a target molecule, e.g. antibody-antigen binding, receptor-ligand binding
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1068—Template (nucleic acid) mediated chemical library synthesis, e.g. chemical and enzymatical DNA-templated organic molecule synthesis, libraries prepared by non ribosomal polypeptide synthesis [NRPS], DNA/RNA-polymerase mediated polypeptide synthesis
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B20/00—Methods specially adapted for identifying library members
    • C40B20/04—Identifying library members by means of a tag, label, or other readable or detectable entity associated with the library members, e.g. decoding processes
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/04—Libraries containing only organic compounds
    • C40B40/06—Libraries containing nucleotides or polynucleotides, or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B50/00—Methods of creating libraries, e.g. combinatorial synthesis
    • C40B50/08—Liquid phase synthesis, i.e. wherein all library building blocks are in liquid phase or in solution during library creation; Particular methods of cleavage from the liquid support
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B50/00—Methods of creating libraries, e.g. combinatorial synthesis
    • C40B50/04—Methods of creating libraries, e.g. combinatorial synthesis using dynamic combinatorial chemistry techniques
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/14—Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
    • Y10T436/145555—Hetero-N

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Analytical Chemistry (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Structural Engineering (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • External Artificial Organs (AREA)
  • Automatic Cycles, And Cycles In General (AREA)
  • Steroid Compounds (AREA)
DE60330406T 2002-12-19 2003-12-19 Durch quasizufallsstrukturen und funktionen geführte synthesemethode Expired - Lifetime DE60330406D1 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US43438602P 2002-12-19 2002-12-19
DKPA200201948 2002-12-19
DKPA200301424 2003-09-30
US50711103P 2003-10-01 2003-10-01
PCT/DK2003/000921 WO2004056994A2 (en) 2002-12-19 2003-12-19 Quasirandom structure and function guided synthesis methods

Publications (1)

Publication Number Publication Date
DE60330406D1 true DE60330406D1 (de) 2010-01-14

Family

ID=32686139

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60330406T Expired - Lifetime DE60330406D1 (de) 2002-12-19 2003-12-19 Durch quasizufallsstrukturen und funktionen geführte synthesemethode

Country Status (6)

Country Link
US (1) US9121110B2 (de)
EP (2) EP1756277B1 (de)
AT (1) ATE450609T1 (de)
AU (1) AU2003291964A1 (de)
DE (1) DE60330406D1 (de)
WO (1) WO2004056994A2 (de)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1832567A3 (de) 2001-03-19 2009-08-26 President And Fellows Of Harvard College Entwicklung neuer molekularer Funktionen
EP1401850A1 (de) * 2001-06-20 2004-03-31 Nuevolution A/S Nukleosidderivate zur herstellung einer verbindungsbibliothek
US7413854B2 (en) * 2002-03-15 2008-08-19 Nuevolution A/S Method for synthesising templated molecules
US10730906B2 (en) 2002-08-01 2020-08-04 Nuevolutions A/S Multi-step synthesis of templated molecules
CA2495881C (en) 2002-08-19 2014-07-08 The President And Fellows Of Harvard College Evolving new molecular function
AU2003266932B2 (en) 2002-09-27 2009-04-09 Mpm-Holding Aps Spatially encoded polymer matrix
EP1558744B1 (de) 2002-10-30 2011-06-15 Nuevolution A/S Enzymatisches codieren
WO2004056994A2 (en) 2002-12-19 2004-07-08 Nuevolution A/S Quasirandom structure and function guided synthesis methods
US20070026397A1 (en) 2003-02-21 2007-02-01 Nuevolution A/S Method for producing second-generation library
EP2236606B1 (de) 2003-03-20 2013-11-06 Nuevolution A/S Ligationsvermittelnde Codierung von kleinen Molekülen
EP1670939B1 (de) * 2003-09-18 2009-11-04 Nuevolution A/S Methode zur Gewinnung struktureller Informationen kodierter Moleküle und zur Selektion von Verbindungen
US7972992B2 (en) 2003-12-17 2011-07-05 Praecis Pharmaceuticals, Inc. Methods for synthesis of encoded libraries
US7972994B2 (en) 2003-12-17 2011-07-05 Glaxosmithkline Llc Methods for synthesis of encoded libraries
WO2005078122A2 (en) * 2004-02-17 2005-08-25 Nuevolution A/S Method for enrichment involving elimination by mismatch hybridisation
DK1730277T3 (da) 2004-03-22 2010-03-01 Nuevolution As Kodning ved ligering under anvendelse af byggebloksoligonukleotider
CN101914528B (zh) * 2004-11-08 2013-04-03 威泊根私人有限公司 结构型核酸指导的化学合成
US20090149347A1 (en) * 2005-06-07 2009-06-11 President And Fellows Of Harvard College Ordered Multi-Step Synthesis by Nucleic Acid-Mediated Chemistry
US7989395B2 (en) 2005-10-28 2011-08-02 Glaxosmithkline Llc Methods for identifying compounds of interest using encoded libraries
EP2341140B1 (de) 2005-12-01 2017-07-19 Nuevolution A/S Enzymvermittelnde Kodierungsmethoden für eine effiziente Synthese von grossen Bibliotheken
EP2021470A1 (de) 2006-05-03 2009-02-11 Vipergen APS Verfahren zur herstellung von verbindungen durch nukleinsäuregesteuerte synthese
ES2638324T3 (es) 2009-02-13 2017-10-19 X-Chem, Inc. Métodos de creación y examen de bibliotecas codificadas por ADN
US11225655B2 (en) 2010-04-16 2022-01-18 Nuevolution A/S Bi-functional complexes and methods for making and using such complexes
EP3828271A1 (de) 2011-09-07 2021-06-02 X-Chem, Inc. Verfahren zur markierung dna-codierter bibliotheken
ES2675167T3 (es) 2012-07-13 2018-07-09 X-Chem, Inc. Bibliotecas codificadas por ADN que tienen enlaces oligonucleotídicos codificantes no legibles por polimerasas
WO2014186874A1 (en) 2013-05-23 2014-11-27 Yyz Pharmatech, Inc. Methods and compositions for enzyme linked immuno and hybridization mass spectrometric assay
GB201322692D0 (en) 2013-12-20 2014-02-05 Philochem Ag Production of encoded chemical libraries
US20180340174A1 (en) 2014-11-11 2018-11-29 Nanocore Aps Method for identification of molecules with desired characteristics
EP3472376A4 (de) 2016-06-16 2019-12-18 Richard Edward Watts Oligonukleotidgesteuerte und aufgezeichnete kombinatorische synthese von codierten sondenmolekülen
WO2018204420A1 (en) 2017-05-02 2018-11-08 Haystack Sciences Corporation Molecules for verifying oligonucleotide directed combinatorial synthesis and methods of making and using the same

Family Cites Families (204)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6361943B1 (en) 1996-10-17 2002-03-26 Mitsubishi Chemical Corporation Molecule that homologizes genotype and phenotype and utilization thereof
US6040166A (en) 1985-03-28 2000-03-21 Roche Molecular Systems, Inc. Kits for amplifying and detecting nucleic acid sequences, including a probe
US4822731A (en) 1986-01-09 1989-04-18 Cetus Corporation Process for labeling single-stranded nucleic acids and hybridizaiton probes
US5047519A (en) 1986-07-02 1991-09-10 E. I. Du Pont De Nemours And Company Alkynylamino-nucleotides
US5449602A (en) 1988-01-13 1995-09-12 Amoco Corporation Template-directed photoligation
US5025388A (en) 1988-08-26 1991-06-18 Cramer Richard D Iii Comparative molecular field analysis (CoMFA)
WO1990005785A1 (en) 1988-11-18 1990-05-31 The Regents Of The University Of California Method for site-specifically incorporating unnatural amino acids into proteins
US5324829A (en) * 1988-12-16 1994-06-28 Ortho Diagnostic Systems, Inc. High specific activity nucleic acid probes having target recognition and signal generating moieties
AU638762B2 (en) 1989-10-05 1993-07-08 Optein Inc Cell-free synthesis and isolation of novel genes and polypeptides
CA2039517C (en) * 1990-04-03 2006-11-07 David Segev Dna probe signal amplification
US5723289A (en) 1990-06-11 1998-03-03 Nexstar Pharmaceuticals, Inc. Parallel selex
US5723286A (en) 1990-06-20 1998-03-03 Affymax Technologies N.V. Peptide library and screening systems
US5650489A (en) 1990-07-02 1997-07-22 The Arizona Board Of Regents Random bio-oligomer library, a method of synthesis thereof, and a method of use thereof
US5843701A (en) 1990-08-02 1998-12-01 Nexstar Pharmaceticals, Inc. Systematic polypeptide evolution by reverse translation
WO1992002536A1 (en) 1990-08-02 1992-02-20 The Regents Of The University Of Colorado Systematic polypeptide evolution by reverse translation
US5432272A (en) 1990-10-09 1995-07-11 Benner; Steven A. Method for incorporating into a DNA or RNA oligonucleotide using nucleotides bearing heterocyclic bases
JPH08268B2 (ja) 1991-04-05 1996-01-10 アイダエンジニアリング株式会社 プレス機械のブランク材供給装置
WO1993003172A1 (en) * 1991-08-01 1993-02-18 University Research Corporation Systematic polypeptide evolution by reverse translation
US5474796A (en) 1991-09-04 1995-12-12 Protogene Laboratories, Inc. Method and apparatus for conducting an array of chemical reactions on a support surface
JP2780572B2 (ja) 1991-09-13 1998-07-30 株式会社島津製作所 オリゴヌクレオチドの酵素的合成法及びオリゴヌクレオチドのプライマーとしての使用
ES2097925T3 (es) 1991-09-18 1997-04-16 Affymax Tech Nv Metodo para sintetizar diversas colecciones de oligomeros.
US5639603A (en) 1991-09-18 1997-06-17 Affymax Technologies N.V. Synthesizing and screening molecular diversity
US6197556B1 (en) 1991-12-20 2001-03-06 The University Of Chicago Nucleic acid amplification using modular branched primers
US5424413A (en) 1992-01-22 1995-06-13 Gen-Probe Incorporated Branched nucleic acid probes
US5573905A (en) 1992-03-30 1996-11-12 The Scripps Research Institute Encoded combinatorial chemical libraries
US5541061A (en) 1992-04-29 1996-07-30 Affymax Technologies N.V. Methods for screening factorial chemical libraries
US5565324A (en) 1992-10-01 1996-10-15 The Trustees Of Columbia University In The City Of New York Complex combinatorial chemical libraries encoded with tags
PT665897E (pt) 1992-10-01 2003-11-28 Trustees Of Columbia U In The Bibliotecas quimicas combinatorias complexas codificadas com etiquetas
US6503759B1 (en) 1992-10-01 2003-01-07 The Trustees Of Columbia University In The City Of New York Complex combinatorial chemical libraries encoded with tags
US5684169A (en) 1992-11-27 1997-11-04 Ensuiko Sugar Refining Co., Ltd. Cyclodextrin inclusion complex of taxol, and method for its production and its use
EP0675873A4 (de) 1992-12-11 2000-03-29 Chiron Corp Herstellung von kodierten polymeren
WO1994024143A1 (en) 1993-04-12 1994-10-27 Northwestern University Method of forming oligonucleotides
US5681943A (en) 1993-04-12 1997-10-28 Northwestern University Method for covalently linking adjacent oligonucleotides
US5840485A (en) 1993-05-27 1998-11-24 Selectide Corporation Topologically segregated, encoded solid phase libraries
DK0705279T3 (da) 1993-05-27 2003-06-10 Selectide Corp Topologisk adskilte, kodende fastfase-biblioteker
JPH09500378A (ja) 1993-07-02 1997-01-14 リンクス セラピューティクス，インコーポレイティド 枝分れされそして複雑に結合された高分子構造体の集中的合成
US5473060A (en) 1993-07-02 1995-12-05 Lynx Therapeutics, Inc. Oligonucleotide clamps having diagnostic applications
US5571903A (en) 1993-07-09 1996-11-05 Lynx Therapeutics, Inc. Auto-ligating oligonucleotide compounds
US6087186A (en) 1993-07-16 2000-07-11 Irori Methods and apparatus for synthesizing labeled combinatorial chemistry libraries
GB9315847D0 (en) 1993-07-30 1993-09-15 Isis Innovation Tag reagent and assay method
DK96093D0 (da) 1993-08-25 1993-08-25 Symbicom Ab Improvements in molecular modelling and drug design
CN1154640C (zh) 1993-10-01 2004-06-23 纽约市哥伦比亚大学理事 用标示物编码的多元组合化学库
AU703472B2 (en) 1993-11-02 1999-03-25 Affymax Technologies N.V. Synthesizing and screening molecular diversity
US5503805A (en) 1993-11-02 1996-04-02 Affymax Technologies N.V. Apparatus and method for parallel coupling reactions
US6165778A (en) 1993-11-02 2000-12-26 Affymax Technologies N.V. Reaction vessel agitation apparatus
JPH09506629A (ja) * 1993-12-17 1997-06-30 キュビッチョッティ，ロジャー・エス ヌクレオチドに支配された生体分子および多分子薬物の集合並びに装置
WO1995019567A1 (en) 1994-01-13 1995-07-20 The Trustees Of Columbia University In The City Of New York Synthetic receptors, libraries and uses thereof
US5605793A (en) 1994-02-17 1997-02-25 Affymax Technologies N.V. Methods for in vitro recombination
US5449613A (en) 1994-03-01 1995-09-12 The University Of Iowa Research Foundation Reacting an enzyme in a non-aqueous solvent by adding a lyophilizate of enzyme and salt to the solvent
US6936477B2 (en) 1994-04-13 2005-08-30 The Trustees Of Columbia University In The City Of New York Complex combinatorial chemical libraries encoded with tags
US5643722A (en) 1994-05-11 1997-07-01 Trustees Of Boston University Methods for the detection and isolation of proteins
US5663046A (en) 1994-06-22 1997-09-02 Pharmacopeia, Inc. Synthesis of combinatorial libraries
AU689924B2 (en) 1994-06-23 1998-04-09 Affymax Technologies N.V. Photolabile compounds and methods for their use
US20030059826A1 (en) 1994-07-26 2003-03-27 Kim Janda Soluble combinatorial libraries
US5695934A (en) 1994-10-13 1997-12-09 Lynx Therapeutics, Inc. Massively parallel sequencing of sorted polynucleotides
US5604097A (en) 1994-10-13 1997-02-18 Spectragen, Inc. Methods for sorting polynucleotides using oligonucleotide tags
US5846719A (en) 1994-10-13 1998-12-08 Lynx Therapeutics, Inc. Oligonucleotide tags for sorting and identification
US6045671A (en) 1994-10-18 2000-04-04 Symyx Technologies, Inc. Systems and methods for the combinatorial synthesis of novel materials
US5985356A (en) 1994-10-18 1999-11-16 The Regents Of The University Of California Combinatorial synthesis of novel materials
WO1996024847A1 (en) 1995-02-10 1996-08-15 Smithkline Beecham Corporation A process for identifiying pharmaceutically active agents using an epitope-tagged library
US5843650A (en) 1995-05-01 1998-12-01 Segev; David Nucleic acid detection and amplification by chemical linkage of oligonucleotides
US5679519A (en) * 1995-05-09 1997-10-21 Oprandy; John J. Multi-label complex for enhanced sensitivity in electrochemiluminescence assay
US6210900B1 (en) 1995-05-23 2001-04-03 Smithkline Beecham Corporation Method of encoding a series of combinatorial libraries and developing structure activity relationships
US5830658A (en) 1995-05-31 1998-11-03 Lynx Therapeutics, Inc. Convergent synthesis of branched and multiply connected macromolecular structures
US5824471A (en) 1995-06-05 1998-10-20 Brigham And Women's Hospital Detection of mismatches by cleavage of nucleic acid heteroduplexes
HUP9900910A2 (hu) 1995-06-07 1999-07-28 Lynx Therapeutics, Inc. Oligonukleotid jelzések osztályozáshoz és azonosításhoz
US5958792A (en) 1995-06-07 1999-09-28 Chiron Corporation Combinatorial libraries of substrate-bound cyclic organic compounds
WO1997004131A1 (en) 1995-07-21 1997-02-06 Forsyth Dental Infirmary For Children Single primer amplification of polynucleotide hairpins
US5780613A (en) 1995-08-01 1998-07-14 Northwestern University Covalent lock for self-assembled oligonucleotide constructs
US5795976A (en) 1995-08-08 1998-08-18 The Board Of Trustees Of The Leland Stanford Junior University Detection of nucleic acid heteroduplex molecules by denaturing high-performance liquid chromatography and methods for comparative sequencing
US5723320A (en) 1995-08-29 1998-03-03 Dehlinger; Peter J. Position-addressable polynucleotide arrays
AU7247896A (en) 1995-09-29 1997-04-17 Scripps Research Institute, The Protein signature analysis
DE19646372C1 (de) 1995-11-11 1997-06-19 Evotec Biosystems Gmbh Genotyp und Phänotyp koppelnde Verbindung
US5763175A (en) 1995-11-17 1998-06-09 Lynx Therapeutics, Inc. Simultaneous sequencing of tagged polynucleotides
WO1997019039A1 (en) 1995-11-17 1997-05-29 Novartis Ag Solid phase synthesis of heterocyclic compounds and combinatorial compound library
US5763263A (en) 1995-11-27 1998-06-09 Dehlinger; Peter J. Method and apparatus for producing position addressable combinatorial libraries
US6537776B1 (en) 1999-06-14 2003-03-25 Diversa Corporation Synthetic ligation reassembly in directed evolution
AU2253397A (en) 1996-01-23 1997-08-20 Affymetrix, Inc. Nucleic acid analysis techniques
US6613508B1 (en) 1996-01-23 2003-09-02 Qiagen Genomics, Inc. Methods and compositions for analyzing nucleic acid molecules utilizing sizing techniques
US5880972A (en) 1996-02-26 1999-03-09 Pharmacopeia, Inc. Method and apparatus for generating and representing combinatorial chemistry libraries
EP0904540A1 (de) 1996-03-22 1999-03-31 Ontogen Corporation Methoden für die synthese von räumlich verteilten kombinatorischen bibliotheken mit festgelegten positionen
US6294325B1 (en) 1996-07-05 2001-09-25 The Mount Sinai School Of Medicine Of The City University Of New York Cloning and expression of thermostable multi genes and proteins and uses thereof
US5821356A (en) 1996-08-12 1998-10-13 The Perkin Elmer Corporation Propargylethoxyamino nucleotides
US6355490B1 (en) 1996-09-13 2002-03-12 Jill Edie Hochlowski Attached tags for use in combinatorial chemistry synthesis
DE19642751A1 (de) 1996-10-16 1998-04-23 Deutsches Krebsforsch Saccharid-Bibliothek
US5954874A (en) 1996-10-17 1999-09-21 Hunter; Charles Eric Growth of bulk single crystals of aluminum nitride from a melt
US6261804B1 (en) 1997-01-21 2001-07-17 The General Hospital Corporation Selection of proteins using RNA-protein fusions
KR100566859B1 (ko) 1997-01-21 2006-04-03 제너럴 하스피톨 코포레이션 Ｒｎａ-단백질 융합물을 이용한 단백질의 선별
ATE250668T1 (de) 1997-05-28 2003-10-15 Discerna Ltd Ribosom-komplexe als selektionspartikel für die in vitro anzeige und evolution von proteinen
US6969584B2 (en) * 1997-06-12 2005-11-29 Rigel Pharmaceuticals, Inc. Combinatorial enzymatic complexes
AU8147798A (en) 1997-06-16 1999-01-04 University Of North Carolina At Chapel Hill, The Peptido oligonucleotides (pons) and their combinatorial libraries
US6607878B2 (en) 1997-10-06 2003-08-19 Stratagene Collections of uniquely tagged molecules
US6348322B1 (en) 1997-10-17 2002-02-19 Duke University Method of screening for specific binding interactions
US20030004122A1 (en) 1997-11-05 2003-01-02 Leonid Beigelman Nucleotide triphosphates and their incorporation into oligonucleotides
US6232066B1 (en) 1997-12-19 2001-05-15 Neogen, Inc. High throughput assay system
EP1056882A4 (de) 1998-02-21 2002-04-17 Technology Foundation Wisys Eindimensionale anordnung von chemischen verbindungen und methoden zu ihrer analyse
US6316616B1 (en) 1998-04-02 2001-11-13 President And Fellows Of Harvard College Parallel combinatorial approach to the discovery and optimization of catalysts and uses thereof
WO1999051773A1 (en) 1998-04-03 1999-10-14 Phylos, Inc. Addressable protein arrays
EP1073730A1 (de) 1998-04-17 2001-02-07 Whitehead For Biomedical Research Verwendung von ribozym zum verbinden von nukleinsäuren mit polypeptiden
EP1428810A3 (de) 1998-05-15 2004-07-14 Oxford Gene Technology IP Limited Verbindungs-Bibliotheken aus mit verschiedenen Tags markierten Oligomeren
US6287765B1 (en) 1998-05-20 2001-09-11 Molecular Machines, Inc. Methods for detecting and identifying single molecules
US5948648A (en) 1998-05-29 1999-09-07 Khan; Shaheer H. Nucleotide compounds including a rigid linker
US6096875A (en) 1998-05-29 2000-08-01 The Perlein-Elmer Corporation Nucleotide compounds including a rigid linker
MXPA00012237A (es) 1998-06-10 2002-11-15 Glycodesign Inc Biblioteca de compuestos combinatorios derigidos y ensayos de alto rendimiento para seleccionar los mismos.
WO2000020639A1 (en) 1998-10-05 2000-04-13 Lynx Therapeutics, Inc. Enzymatic synthesis of oligonucleotide tags
EP1119530A2 (de) 1998-10-09 2001-08-01 Pharmacopeia, Inc. Auswahl von codes für die codierung von kombinatorischen bibliotheken
US6175001B1 (en) 1998-10-16 2001-01-16 The Scripps Research Institute Functionalized pyrimidine nucleosides and nucleotides and DNA's incorporating same
EP1123305A1 (de) 1998-10-19 2001-08-16 The Board Of Trustees Of The Leland Stanford Junior University Chemie einer dna-templatisierten kombinatorischen bibliothek
EP1124948A1 (de) 1998-10-28 2001-08-22 Novozymes A/S Verfahren zur herstellung einer genbibliothek
US5942609A (en) 1998-11-12 1999-08-24 The Porkin-Elmer Corporation Ligation assembly and detection of polynucleotides on solid-support
ES2280131T3 (es) 1998-12-02 2007-09-01 Adnexus Therapeutics, Inc. Fusiones de adn-proteina y utilizaciones de las mismas.
EP1141301A4 (de) 1999-01-08 2003-04-02 Ceres Inc Sequenzbestimmte dna-fragmente und entsprechende, durch diese kodierte polypeptide
EP1208219A1 (de) * 1999-04-08 2002-05-29 Pavel Sergeev Synthese von biologisch-aktiven zusammensetzungen in zellen
EP2360270B1 (de) 1999-05-20 2016-11-09 Illumina, Inc. Kombinatorische Entschlüsselung von Zufallsnukleinsäurearrays
ATE502117T1 (de) 1999-06-25 2011-04-15 Nanosphere Inc Nanopartikel mit gebundenen oligonukleotiden und deren verwendungen
CA2380145C (en) 1999-07-22 2009-04-28 Cree, Inc. Growth of bulk single crystals of aluminum
HK1045334A1 (zh) 1999-07-27 2002-11-22 Phylos, Inc. 缩氨酸受体结紮方法
EP1125945B1 (de) 1999-08-27 2003-05-21 Japan Science and Technology Corporation Reversibel photokuppelnde nukleinsäure und phosphoramidit
GB9920194D0 (en) 1999-08-27 1999-10-27 Advanced Biotech Ltd A heat-stable thermostable DNA polymerase for use in nucleic acid amplification
US20020048760A1 (en) 1999-12-10 2002-04-25 Hyseq, Inc. Use of mismatch cleavage to detect complementary probes
JP2003520050A (ja) 2000-01-24 2003-07-02 フィロス インク． タンパク質分析のための高感度多重化診断アッセイ法
EP1254367A4 (de) 2000-02-03 2006-07-05 Nanoscale Combinatorial Synthe Verfahren zur identifizierung von strukturen durch massenbestimmung
US20020127598A1 (en) 2000-03-27 2002-09-12 Wenqiang Zhou Solution-phase combinatorial library synthesis and pharmaceutically active compounds produced thereby
US7682837B2 (en) 2000-05-05 2010-03-23 Board Of Trustees Of Leland Stanford Junior University Devices and methods to form a randomly ordered array of magnetic beads and uses thereof
AU2001261771B2 (en) 2000-05-19 2005-06-09 Richard B. Williams In vitro evolution of nucleic acids and encoded polypeptide
US7244560B2 (en) 2000-05-21 2007-07-17 Invitrogen Corporation Methods and compositions for synthesis of nucleic acid molecules using multiple recognition sites
ATE360207T1 (de) 2000-06-05 2007-05-15 Novartis Vaccines & Diagnostic Mikroarrays für durchführen von proteomanalyse
US20020115068A1 (en) 2000-06-23 2002-08-22 Ian Tomlinson Matrix screening method
JP2004502705A (ja) 2000-07-03 2004-01-29 メルク　エンド　カムパニー　インコーポレーテッド コンビナトリアルライブラリーにおけるコード化方法
AU2001283056A1 (en) 2000-07-27 2002-02-13 California Institute Of Technology A rapid, quantitative method for the mass spectrometric analysis of nucleic acids for gene expression and genotyping
US20020072887A1 (en) 2000-08-18 2002-06-13 Sandor Szalma Interaction fingerprint annotations from protein structure models
US7718600B2 (en) 2000-09-29 2010-05-18 The Trustees Of Princeton University IAP binding compounds
US20020146723A1 (en) 2000-10-25 2002-10-10 Krontiris Theodore G. Candidate region mismatch scanning for genotyping and mutation detection
JP2002315577A (ja) 2000-11-14 2002-10-29 Gencom Co 核酸ライブラリーの作製方法
WO2002074978A2 (en) 2001-03-19 2002-09-26 President And Fellows Of Harvard College Nucleic acid shuffling
EP1832567A3 (de) 2001-03-19 2009-08-26 President And Fellows Of Harvard College Entwicklung neuer molekularer Funktionen
WO2002083951A1 (en) 2001-04-10 2002-10-24 Northeastern University Multiplexed ligand/protein binding assays with pna labels
AU2003303395A1 (en) 2001-05-22 2004-07-22 Dahl, Gary, A. Target-dependent transcription using deletion mutants of n4 rna polymerase
AU2002312389A1 (en) 2001-06-05 2002-12-16 Irm Llc Functional proteomic profiling
EP1401850A1 (de) 2001-06-20 2004-03-31 Nuevolution A/S Nukleosidderivate zur herstellung einer verbindungsbibliothek
CN1539014A (zh) 2001-06-20 2004-10-20 ŦΤ¬ɭ��˾ 模控分子和使用这种分子的方法
US20060234231A1 (en) 2001-06-20 2006-10-19 Nuevolution A/S Microarrays displaying encoded molecules
US20040161741A1 (en) 2001-06-30 2004-08-19 Elazar Rabani Novel compositions and processes for analyte detection, quantification and amplification
DE10145226A1 (de) 2001-09-13 2003-04-10 Lifebits Ag Herstellung von trägergebundenen Molekülen
WO2003038558A2 (en) 2001-10-30 2003-05-08 Nanomics Biosystems Pty, Ltd. Device and methods for directed synthesis of chemical libraries
WO2003062417A1 (fr) 2002-01-22 2003-07-31 Mitsubishi Chemical Corporation Produit de ligation arn-adn, et utilisation correspondante
WO2003078445A2 (en) 2002-03-15 2003-09-25 Nuevolution A/S A building block forming a c=c double bond upon reaction
EA006965B1 (ru) 2002-03-08 2006-06-30 Айдгенёссише Текнише Хохшуле Цюрих Закодированные самособирающиеся химические библиотеки
US7413854B2 (en) 2002-03-15 2008-08-19 Nuevolution A/S Method for synthesising templated molecules
WO2003078050A2 (en) 2002-03-15 2003-09-25 Nuevolution A/S A building block forming a c-c bond upon reaction
WO2003078627A2 (en) 2002-03-15 2003-09-25 Nuevolution A/S A building block capable of functional entity transfer to nucleophil
WO2003078446A2 (en) 2002-03-15 2003-09-25 Nuevolution A/S A building block forming a c-c or a c-hetero atom bond upon reaction
WO2003082901A2 (en) 2002-03-22 2003-10-09 Emory University Template-driven processes for synthesizing polymers and components related to such processes
GB0213816D0 (en) 2002-06-14 2002-07-24 Univ Aston Method of producing DNA and protein libraries
EP1520040A2 (de) 2002-06-20 2005-04-06 Nuevolution A/S Mikroarrays zur darstellung von kodierten molekülen
AU2003242516A1 (en) 2002-07-23 2004-02-09 Nuevolution A/S Gene shuffling by template switching
US10730906B2 (en) 2002-08-01 2020-08-04 Nuevolutions A/S Multi-step synthesis of templated molecules
CA2495881C (en) 2002-08-19 2014-07-08 The President And Fellows Of Harvard College Evolving new molecular function
US20040197845A1 (en) 2002-08-30 2004-10-07 Arjang Hassibi Methods and apparatus for pathogen detection, identification and/or quantification
WO2004024929A2 (en) 2002-09-12 2004-03-25 Nuevolution A/S Proximity-aided synthesis of templated molecules
US20040110213A1 (en) * 2002-09-30 2004-06-10 Eugeni Namsaraev Polynucleotide synthesis and labeling by kinetic sampling ligation
CA2504443A1 (en) 2002-10-30 2004-05-13 Pointilliste, Inc. Methods for producing polypeptide-tagged collections and capture systems containing the tagged polypeptides
EP1558744B1 (de) 2002-10-30 2011-06-15 Nuevolution A/S Enzymatisches codieren
WO2004056994A2 (en) 2002-12-19 2004-07-08 Nuevolution A/S Quasirandom structure and function guided synthesis methods
EP1594950A4 (de) 2003-01-29 2007-07-25 454 Corp Verfahren zur herstellung von einzelstrang-dna-bibliotheken
EP1597394A2 (de) 2003-02-21 2005-11-23 Nuevolution A/S Eine methode zur erlangung struktureller information über ein kodiertes molekül
US20070026397A1 (en) 2003-02-21 2007-02-01 Nuevolution A/S Method for producing second-generation library
JP4054871B2 (ja) 2003-02-24 2008-03-05 独立行政法人産業技術総合研究所 耐熱性ｄｎａリガーゼ
EP2236606B1 (de) 2003-03-20 2013-11-06 Nuevolution A/S Ligationsvermittelnde Codierung von kleinen Molekülen
WO2004099441A2 (en) 2003-05-09 2004-11-18 Hyscite Discovery As Selection and evolution of chemical libraries
WO2004110964A2 (en) 2003-06-16 2004-12-23 Nuevolution A/S Encoded molecules by translation (emt)
WO2005003778A2 (en) 2003-07-02 2005-01-13 Nuevolution A/S A method for identifying a synthetic molecule having affinity towards a target
US20070134662A1 (en) 2003-07-03 2007-06-14 Juswinder Singh Structural interaction fingerprint
EP1533385A1 (de) 2003-09-05 2005-05-25 Nuevolution A/S Matrizenabhängigen Verbindungen zur Herstellung von kodierten Molekülen und gesteuerten Verfahren unter Verwendung dieser Verbindungen
EP1670939B1 (de) 2003-09-18 2009-11-04 Nuevolution A/S Methode zur Gewinnung struktureller Informationen kodierter Moleküle und zur Selektion von Verbindungen
US7972992B2 (en) 2003-12-17 2011-07-05 Praecis Pharmaceuticals, Inc. Methods for synthesis of encoded libraries
US7972994B2 (en) 2003-12-17 2011-07-05 Glaxosmithkline Llc Methods for synthesis of encoded libraries
WO2005078122A2 (en) 2004-02-17 2005-08-25 Nuevolution A/S Method for enrichment involving elimination by mismatch hybridisation
DK1730277T3 (da) 2004-03-22 2010-03-01 Nuevolution As Kodning ved ligering under anvendelse af byggebloksoligonukleotider
WO2005116213A2 (en) 2004-04-15 2005-12-08 President And Fellows Of Harvard College Directed evolution of proteins
CN101914528B (zh) 2004-11-08 2013-04-03 威泊根私人有限公司 结构型核酸指导的化学合成
WO2006053571A2 (en) 2004-11-22 2006-05-26 Peter Birk Rasmussen Template directed split and mix systhesis of small molecule libraries
KR20120127754A (ko) 2004-12-20 2012-11-23 제넨테크, 인크. Ｉａｐ의 피롤리딘 억제제
CN101107357B (zh) 2005-01-21 2013-01-02 哈佛大学校长及研究员协会 用于以核酸为模板的合成中的游离反应物
US7968289B2 (en) 2005-05-03 2011-06-28 Ensemble Therapeutics Corporation Turn over probes and use thereof for nucleic acid detection
AU2006249340A1 (en) 2005-05-26 2006-11-30 Ensemble Discovery Corportion Biodetection by nucleic acid-templated chemistry
US20090163371A1 (en) 2005-05-31 2009-06-25 Stern Andrew M Anchor-Assisted Fragment Selection and Directed Assembly
US20090149347A1 (en) 2005-06-07 2009-06-11 President And Fellows Of Harvard College Ordered Multi-Step Synthesis by Nucleic Acid-Mediated Chemistry
US20090203530A1 (en) 2005-06-07 2009-08-13 Liu David R Polymer evolution via templated synthesis
SI1910538T1 (sl) 2005-06-09 2011-09-30 Praecis Pharm Inc POSTOPKI ZA SINTEZO KODIRANIH KNJIĹľNIC
US20090035824A1 (en) 2005-06-17 2009-02-05 Liu David R Nucleic acid-templated chemistry in organic solvents
ATE462005T1 (de) 2005-06-17 2010-04-15 Harvard College Iterierte verzweigende reaktionswege über nukleinsäure-vermittelte chemie
WO2007011722A2 (en) 2005-07-15 2007-01-25 President And Fellows Of Harvard College Reaction discovery system
US20090005256A1 (en) 2005-07-29 2009-01-01 Bittker Joshua A Analysis of Encoded Chemical Libraries
US7989395B2 (en) 2005-10-28 2011-08-02 Glaxosmithkline Llc Methods for identifying compounds of interest using encoded libraries
EP2341140B1 (de) 2005-12-01 2017-07-19 Nuevolution A/S Enzymvermittelnde Kodierungsmethoden für eine effiziente Synthese von grossen Bibliotheken
EP2021470A1 (de) 2006-05-03 2009-02-11 Vipergen APS Verfahren zur herstellung von verbindungen durch nukleinsäuregesteuerte synthese
US20100143499A1 (en) 2006-07-24 2010-06-10 Tetralogic Pharmaceuticals Corporation Dimeric iap inhibitors
EP2064348B1 (de) 2006-09-18 2012-02-08 Ensemble Therapeutics Corporation Profilierung einer rezeptorfamilie
WO2008054600A2 (en) 2006-09-28 2008-05-08 Ensemble Discovery Corporation Compositions and methods for biodetection by nucleic acid-templated chemistry
CA2730565A1 (en) 2007-07-27 2009-02-05 Ensemble Discovery Corporation Detection assays and use thereof
WO2009077173A2 (en) 2007-12-19 2009-06-25 Philochem Ag Dna-encoded chemical libraries
TW201011006A (en) 2008-06-16 2010-03-16 Nuevolution As IAP binding compounds
US11225655B2 (en) 2010-04-16 2022-01-18 Nuevolution A/S Bi-functional complexes and methods for making and using such complexes

Also Published As

Publication number Publication date
EP1756277A2 (de) 2007-02-28
EP2175019A3 (de) 2011-04-06
US20080193983A1 (en) 2008-08-14
US9121110B2 (en) 2015-09-01
AU2003291964A8 (en) 2004-07-14
AU2003291964A1 (en) 2004-07-14
EP1756277B1 (de) 2009-12-02
WO2004056994A2 (en) 2004-07-08
EP2175019A2 (de) 2010-04-14
WO2004056994A3 (en) 2004-08-12
ATE450609T1 (de) 2009-12-15

Similar Documents

Publication Publication Date Title
DE60330406D1 (de) Durch quasizufallsstrukturen und funktionen geführte synthesemethode
Laue et al. Continuous application of chemzymes in a membrane reactor: asymmetric transfer hydrogenation of acetophenone
Fischler et al. Formation of bimetallic Ag–Au nanowires by metallization of artificial DNA duplexes
FR2833604B1 (fr) Composition polymere thermoplastique comprenant un copolyamide hyperbranche, et articles realises a partir de cette composition
DE60324023D1 (de) Verzweigte polymere aus organohydrogensilizium-verbindungen
DK1730277T3 (da) Kodning ved ligering under anvendelse af byggebloksoligonukleotider
DE50109938D1 (de) N-Propylethoxysiloxane, Verfahren zu deren Herstellung und deren Verwendung
WO1999010358A3 (de) Verfahren zum herstellen von nukleinsäurepolymeren
EP1231281A4 (de) Methode zum nachweis von variationen oder polymorphismen
DK2236606T3 (da) Kodning af små molekyler ved ligering
DE60321218D1 (de) Verzweigte polymere aus organohydrogensilicon-zusammensetzungen
FI960080A0 (fi) Dendriittisen makromolekyylin valmistusmenetelmä
ATE342924T1 (de) Verfahren zur selektiven hydrierung von konjugierten dienpolymeren
BRPI0409735A (pt) composição de revestimento curável, métodos para a produção de um revestimento, de um sistema de múltiplos revestimentos e de um artigo moldado
Shen et al. Facile Synthesis of In‐Chain, Multicomponent, Functionalized Polymers via Living Anionic Copolymerization through the Ugi Four‐Component Reaction (Ugi‐4CR)
Nakatani Recognition of mismatched base pairs in DNA
AU6409399A (en) Improved process for oligonucleotide synthesis
GB2306166A (en) Hydrosilation of olefinic monomers
Zheng et al. Graft copolymerization of water‐soluble monomers containing quaternary ammonium group on poly (vinyl alcohol) using ceric ions
Henkensmeier et al. Synthesis of carbohydrate‐segmented polydimethylsiloxanes by hydrosilylation
BRPI0410628A (pt) veìculos de revestimento redutìveis em água isenta de voc
DE69425678D1 (de) Detektion und differenzierung von mycobacterium tuberculosis komplexen bakterien durch direkte oligotypisierung von verschiedenen repetetiven segmenten
Morgan Conn et al. Template Effects in New Self‐Replicating Molecules
Pathak et al. An Adamantane‐Based Building Block for DNA Networks
JPH08245745A (ja) ポリマー側鎖に結合したジホスフィン及びその金属錯体

Legal Events

Date Code Title Description
8364 No opposition during term of opposition