SI1910538T1 - POSTOPKI ZA SINTEZO KODIRANIH KNJIĹľNIC - Google Patents

POSTOPKI ZA SINTEZO KODIRANIH KNJIĹľNIC

Info

Publication number: SI1910538T1
Authority: SI; Slovenia
Prior art keywords: synthesis; methods; encoded libraries; libraries; encoded
Prior art date: 2005-06-09

Application number

SI200631057T

Other languages

English (en)

Inventor

Barry Morgan

Stephen Hale

Christopher C Arico-Muendel

Matthew Clark

Richard Wagner

Malcolm J Kavarana

Steffen Phillip Creaser

George J Franklin

Paolo A Centrella

David I Israel

Malcolm L Gefter

Dennis Benjamin

Nils Jakob Vest Hansen

Raksha A Acharya

Original Assignee

Praecis Pharm Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2005-06-09

Filing date

2006-06-09

Publication date

2011-09-30

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=36930432&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SI1910538(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2006-06-09 Application filed by Praecis Pharm Inc filed Critical Praecis Pharm Inc

2011-09-30 Publication of SI1910538T1 publication Critical patent/SI1910538T1/sl

Links

238000000034 method Methods 0.000 title abstract 2
230000015572 biosynthetic process Effects 0.000 title 1
238000003786 synthesis reaction Methods 0.000 title 1
108091034117 Oligonucleotide Proteins 0.000 abstract 1
JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 abstract 1
230000002194 synthesizing effect Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B61/00—Other general methods
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1068—Template (nucleic acid) mediated chemical library synthesis, e.g. chemical and enzymatical DNA-templated organic molecule synthesis, libraries prepared by non ribosomal polypeptide synthesis [NRPS], DNA/RNA-polymerase mediated polypeptide synthesis

Landscapes

Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Genetics & Genomics (AREA)
Engineering & Computer Science (AREA)
Biochemistry (AREA)
Biotechnology (AREA)
Molecular Biology (AREA)
General Health & Medical Sciences (AREA)
Zoology (AREA)
Wood Science & Technology (AREA)
Bioinformatics & Cheminformatics (AREA)
Biomedical Technology (AREA)
General Engineering & Computer Science (AREA)
Plant Pathology (AREA)
Biophysics (AREA)
Physics & Mathematics (AREA)
Microbiology (AREA)
Crystallography & Structural Chemistry (AREA)
Bioinformatics & Computational Biology (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Steroid Compounds (AREA)
Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Saccharide Compounds (AREA)
Investigating Or Analysing Biological Materials (AREA)
Compounds Of Unknown Constitution (AREA)
Polyurethanes Or Polyureas (AREA)

SI200631057T 2005-06-09 2006-06-09 POSTOPKI ZA SINTEZO KODIRANIH KNJIĹľNIC SI1910538T1 (sl)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
US68946605P	2005-06-09	2005-06-09
US73104105P	2005-10-28	2005-10-28
PCT/US2006/022555 WO2006135786A2 (en)	2005-06-09	2006-06-09	Methods for synthesis of encoded libraries
EP06784718A EP1910538B1 (en)	2005-06-09	2006-06-09	Methods for synthesis of encoded libraries

Publications (1)

Publication Number	Publication Date
SI1910538T1 true SI1910538T1 (sl)	2011-09-30

Family

ID=36930432

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SI200631057T SI1910538T1 (sl)	2005-06-09	2006-06-09	POSTOPKI ZA SINTEZO KODIRANIH KNJIĹľNIC

Country Status (23)

Country	Link
EP (4)	EP2338990A3 (sl)
JP (2)	JP5508711B2 (sl)
KR (1)	KR101346432B1 (sl)
CN (2)	CN102392014A (sl)
AT (1)	ATE507292T1 (sl)
AU (1)	AU2006257915B2 (sl)
BR (1)	BRPI0613566B1 (sl)
CA (1)	CA2611512C (sl)
CY (1)	CY1112036T1 (sl)
DE (1)	DE602006021580D1 (sl)
DK (4)	DK1910538T3 (sl)
ES (2)	ES2401485T3 (sl)
HR (1)	HRP20110528T1 (sl)
IL (1)	IL187977A (sl)
NO (1)	NO343698B1 (sl)
NZ (1)	NZ564545A (sl)
PL (2)	PL2258870T3 (sl)
PT (2)	PT2258870E (sl)
RS (1)	RS51868B (sl)
RU (2)	RU2459869C2 (sl)
SI (1)	SI1910538T1 (sl)
WO (1)	WO2006135786A2 (sl)
ZA (2)	ZA200800190B (sl)

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AU2003247266A1 (en)	2002-08-01	2004-02-23	Nuevolution A/S	Multi-step synthesis of templated molecules
CN106337046B (zh)	2002-10-30	2021-03-23	纽韦卢森公司	合成双功能复合物的方法
ATE450609T1 (de)	2002-12-19	2009-12-15	Nuevolution As	Durch quasizufallsstrukturen und funktionen geführte synthesemethode
US20070026397A1 (en)	2003-02-21	2007-02-01	Nuevolution A/S	Method for producing second-generation library
ATE447626T1 (de)	2003-09-18	2009-11-15	Nuevolution As	Methode zur gewinnung struktureller informationen kodierter moleküle und zur selektion von verbindungen
CA2611512C (en)	2005-06-09	2018-05-22	Praecis Pharmaceuticals, Inc.	Methods for synthesis of encoded libraries
LT3018206T (lt)	2005-12-01	2021-12-10	Nuevolution A/S	Fermentiniai kodavimo būdai, skirti didelių bibliotekų efektyviai sintezei
WO2010094036A1 (en) *	2009-02-13	2010-08-19	X-Chem, Inc.	Methods of creating and screening dna-encoded libraries
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KR102146721B1 (ko)	2012-07-13	2020-08-21	엑스-켐, 인크.	폴리머라제에 의해 판독가능하지 않은 코딩 올리고뉴클레오티드 연결을 갖는 dna-코딩된 라이브러리
CN110325491B (zh) *	2017-03-17	2022-04-19	成都先导药物开发股份有限公司	编码库的合成方法及组合物
WO2019149198A1 (zh) *	2018-01-31	2019-08-08	成都先导药物开发股份有限公司	一种dna编码化合物库及化合物筛选方法
GB201821109D0 (en) *	2018-12-21	2019-02-06	Philochem Ag	Nucleic acid encoded chemical libraries
CN110041390B (zh) *	2019-04-26	2022-05-27	上海药明康德新药开发有限公司	DNA编码化合物库中On-DNA的1,2,3-三氮唑化合物的合成方法
CN112779606A (zh) *	2019-11-06	2021-05-11	成都先导药物开发股份有限公司	一种On-DNA曼尼希反应的方法
CN113089104B (zh) *	2019-12-23	2023-03-28	成都先导药物开发股份有限公司	一种On-DNA二胺化合物关环反应的合成方法
CN115506036B (zh) *	2021-06-22	2024-07-02	中国科学院上海药物研究所	Dna编码化合物文库起始片段及其制备和应用
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CN114920791B (zh) *	2022-04-28	2024-06-18	康龙化成(宁波)科技发展有限公司	一种寡聚核酸-琥珀酰亚胺化合物的合成方法

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2006
- 2006-06-09 CA CA2611512A patent/CA2611512C/en active Active
- 2006-06-09 EP EP10012326A patent/EP2338990A3/en not_active Withdrawn
- 2006-06-09 EP EP06784718A patent/EP1910538B1/en active Active
- 2006-06-09 BR BRPI0613566-8A patent/BRPI0613566B1/pt active IP Right Grant
- 2006-06-09 WO PCT/US2006/022555 patent/WO2006135786A2/en not_active Ceased
- 2006-06-09 HR HR20110528T patent/HRP20110528T1/hr unknown
- 2006-06-09 RU RU2008100035/10A patent/RU2459869C2/ru active
- 2006-06-09 SI SI200631057T patent/SI1910538T1/sl unknown
- 2006-06-09 JP JP2008515983A patent/JP5508711B2/ja active Active
- 2006-06-09 PL PL10075295T patent/PL2258870T3/pl unknown
- 2006-06-09 DK DK06784718.6T patent/DK1910538T3/da active
- 2006-06-09 RS RS20110327A patent/RS51868B/sr unknown
- 2006-06-09 AU AU2006257915A patent/AU2006257915B2/en not_active Ceased
- 2006-06-09 DK DK10075295.5T patent/DK2258870T3/da active
- 2006-06-09 DE DE602006021580T patent/DE602006021580D1/de active Active
- 2006-06-09 CN CN2011102198704A patent/CN102392014A/zh active Pending
- 2006-06-09 EP EP10075295A patent/EP2258870B1/en active Active
- 2006-06-09 PT PT100752955T patent/PT2258870E/pt unknown
- 2006-06-09 PT PT06784718T patent/PT1910538E/pt unknown
- 2006-06-09 PL PL06784718T patent/PL1910538T3/pl unknown
- 2006-06-09 ES ES10075295T patent/ES2401485T3/es active Active
- 2006-06-09 EP EP10075296.3A patent/EP2311786A3/en not_active Withdrawn
- 2006-06-09 CN CN2006800276157A patent/CN101233235B/zh active Active
- 2006-06-09 KR KR1020087000511A patent/KR101346432B1/ko active Active
- 2006-06-09 AT AT06784718T patent/ATE507292T1/de active
- 2006-06-09 NZ NZ564545A patent/NZ564545A/en unknown
- 2006-06-09 ES ES06784718T patent/ES2365534T3/es active Active
2007
- 2007-12-06 IL IL187977A patent/IL187977A/en active IP Right Grant
- 2007-12-12 NO NO20076362A patent/NO343698B1/no unknown
2008
- 2008-01-03 DK DKPA200800005A patent/DK177345B1/da active
- 2008-01-08 ZA ZA2008/00190A patent/ZA200800190B/en unknown
2010
- 2010-07-07 ZA ZA2010/04791A patent/ZA201004791B/en unknown
2011
- 2011-01-19 RU RU2011101778/10A patent/RU2011101778A/ru not_active Application Discontinuation
- 2011-07-14 CY CY20111100688T patent/CY1112036T1/el unknown
- 2011-12-20 DK DKPA201170734A patent/DK179064B1/da active
2013
- 2013-09-19 JP JP2013194319A patent/JP2014039550A/ja active Pending

Also Published As

Publication number	Publication date
CA2611512A1 (en)	2006-12-21
PT2258870E (pt)	2013-04-01
NZ564545A (en)	2011-03-31
AU2006257915A1 (en)	2006-12-21
RU2459869C2 (ru)	2012-08-27
PL2258870T3 (pl)	2013-05-31
EP2311786A2 (en)	2011-04-20
NO343698B1 (no)	2019-05-13
ES2401485T3 (es)	2013-04-22
CY1112036T1 (el)	2015-11-04
AU2006257915B2 (en)	2011-09-08
DK1910538T3 (da)	2011-08-08
JP2014039550A (ja)	2014-03-06
CA2611512C (en)	2018-05-22
BRPI0613566A2 (pt)	2011-01-18
EP2258870B1 (en)	2013-01-02
DK200800005A (da)	2008-03-04
ZA201004791B (en)	2012-06-27
JP5508711B2 (ja)	2014-06-04
EP2258870A2 (en)	2010-12-08
WO2006135786A3 (en)	2007-06-21
JP2008543289A (ja)	2008-12-04
DE602006021580D1 (de)	2011-06-09
DK179064B1 (da)	2017-10-02
IL187977A (en)	2013-02-28
ATE507292T1 (de)	2011-05-15
ZA200800190B (en)	2010-11-24
EP2311786A3 (en)	2014-04-02
EP2338990A3 (en)	2011-10-19
WO2006135786A2 (en)	2006-12-21
RU2011101778A (ru)	2012-07-27
PL1910538T3 (pl)	2011-12-30
EP1910538A2 (en)	2008-04-16
EP1910538B1 (en)	2011-04-27
RU2008100035A (ru)	2009-07-20
KR20080036577A (ko)	2008-04-28
CN101233235B (zh)	2012-10-03
NO20076362L (no)	2008-03-07
DK2258870T3 (da)	2013-03-18
HK1120546A1 (en)	2009-04-03
HRP20110528T1 (hr)	2011-09-30
PT1910538E (pt)	2011-07-28
KR101346432B1 (ko)	2014-02-14
RS51868B (sr)	2012-02-29
HK1150454A1 (en)	2011-12-30
BRPI0613566B1 (pt)	2020-01-07
EP2258870A3 (en)	2011-11-30
CN102392014A (zh)	2012-03-28
DK201170734A (en)	2011-12-20
DK177345B1 (da)	2013-01-28
IL187977A0 (en)	2008-03-20
CN101233235A (zh)	2008-07-30
ES2365534T3 (es)	2011-10-06
EP2338990A2 (en)	2011-06-29

Publication	Publication Date	Title
ZA201004791B (en)	2012-06-27	Methods for synthesis of encoded libraries
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