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WO2004097041A3 - Screening method for binding molecules - Google Patents

Screening method for binding molecules Download PDF

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Publication number
WO2004097041A3
WO2004097041A3 PCT/EP2004/004387 EP2004004387W WO2004097041A3 WO 2004097041 A3 WO2004097041 A3 WO 2004097041A3 EP 2004004387 W EP2004004387 W EP 2004004387W WO 2004097041 A3 WO2004097041 A3 WO 2004097041A3
Authority
WO
WIPO (PCT)
Prior art keywords
binding molecules
screening method
molecule
target
binds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2004/004387
Other languages
French (fr)
Other versions
WO2004097041A2 (en
Inventor
Helena Persson
Mats Ohlin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bioinvent International AB
Original Assignee
Bioinvent International AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bioinvent International AB filed Critical Bioinvent International AB
Publication of WO2004097041A2 publication Critical patent/WO2004097041A2/en
Publication of WO2004097041A3 publication Critical patent/WO2004097041A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/005—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies constructed by phage libraries
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/44—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material not provided for elsewhere, e.g. haptens, metals, DNA, RNA, amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • Genetics & Genomics (AREA)
  • Physics & Mathematics (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Virology (AREA)
  • Analytical Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Microbiology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Peptides Or Proteins (AREA)
  • Information Retrieval, Db Structures And Fs Structures Therefor (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

A method is provided for identifying a binding molecule that binds to a target site of a target molecule.
PCT/EP2004/004387 2003-04-25 2004-04-23 Screening method for binding molecules Ceased WO2004097041A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0309397A GB2400851B (en) 2003-04-25 2003-04-25 Identifying binding of a polypeptide to a polypeptide target
GB0309397.8 2003-04-25

Publications (2)

Publication Number Publication Date
WO2004097041A2 WO2004097041A2 (en) 2004-11-11
WO2004097041A3 true WO2004097041A3 (en) 2005-02-03

Family

ID=9957209

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2004/004387 Ceased WO2004097041A2 (en) 2003-04-25 2004-04-23 Screening method for binding molecules

Country Status (2)

Country Link
GB (1) GB2400851B (en)
WO (1) WO2004097041A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9334331B2 (en) 2010-11-17 2016-05-10 Chugai Seiyaku Kabushiki Kaisha Bispecific antibodies

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7601351B1 (en) 2002-06-26 2009-10-13 Human Genome Sciences, Inc. Antibodies against protective antigen
CA2490280A1 (en) 2002-07-01 2004-01-08 Human Genome Sciences, Inc. Antibodies that specifically bind to reg iv
CA2603408C (en) 2005-03-31 2018-08-21 Chugai Seiyaku Kabushiki Kaisha Methods for producing polypeptides by regulating polypeptide association
SI1876236T1 (en) * 2005-04-08 2014-11-28 Chugai Seiyaku Kabushiki Kaisha Antibody substituting for function of blood coagulation factor viii
CN105177091A (en) 2006-03-31 2015-12-23 中外制药株式会社 Antibody modification method for purifying bispecific antibody
EP4001409A1 (en) 2006-03-31 2022-05-25 Chugai Seiyaku Kabushiki Kaisha Methods for controlling blood pharmacokinetics of antibodies
US9096651B2 (en) 2007-09-26 2015-08-04 Chugai Seiyaku Kabushiki Kaisha Method of modifying isoelectric point of antibody via amino acid substitution in CDR
WO2011123857A1 (en) * 2010-04-02 2011-10-06 Kalobios Pharmaceuticals, Inc. Generation of antibodies to an epitope of interest
CA2925256C (en) 2013-09-27 2023-08-15 Chugai Seiyaku Kabushiki Kaisha Method for producing polypeptide heteromultimer
TWI701435B (en) 2014-09-26 2020-08-11 日商中外製藥股份有限公司 Method to determine the reactivity of FVIII
MA40764A (en) 2014-09-26 2017-08-01 Chugai Pharmaceutical Co Ltd THERAPEUTIC AGENT INDUCING CYTOTOXICITY
TWI700300B (en) 2014-09-26 2020-08-01 日商中外製藥股份有限公司 Antibodies that neutralize substances with the function of FVIII coagulation factor (FVIII)
WO2016159213A1 (en) 2015-04-01 2016-10-06 中外製薬株式会社 Method for producing polypeptide hetero-oligomer
EP3395835B1 (en) 2015-12-25 2021-02-03 Chugai Seiyaku Kabushiki Kaisha Antibody having enhanced activity, and method for modifying same
SG11201803989WA (en) 2015-12-28 2018-06-28 Chugai Pharmaceutical Co Ltd Method for promoting efficiency of purification of fc region-containing polypeptide
JP7320943B2 (en) 2016-04-28 2023-08-04 中外製薬株式会社 Antibody-containing formulation
IL265144B2 (en) 2016-09-06 2024-10-01 Chugai Pharmaceutical Co Ltd Methods for using a bispecific antibody that recognizes coagulation factor IX and/or activated coagulation factor IX and coagulation factor X and/or activated coagulation factor X
EA202090641A1 (en) 2017-09-29 2020-08-07 Чугаи Сейяку Кабусики Кайся MULTISPECIFIC ANTIGEN-BINDING MOLECULE WITH A SUBSTITUTE FUNCTIONAL ACTIVITY OF BLOOD COGULATING FACTOR VIII, AND PHARMACEUTICAL COMPOSITION, COMPOSITION
WO2019088143A1 (en) 2017-11-01 2019-05-09 中外製薬株式会社 Antibody variant and isoform with lowered biological activity

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5712089A (en) * 1993-12-06 1998-01-27 Bioinvent International Ab Method of selecting specific bacteriophages
WO2001075091A2 (en) * 2000-04-05 2001-10-11 Bioinvent International Ab A method for in vitro molecular evolution of antibody function

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4778751A (en) * 1986-05-12 1988-10-18 Diagnostic Products Corporation Method for measuring antigens or antibodies in biological fluids using ligand labeled antigens or ligand labeled antibodies
US6653067B1 (en) * 2001-02-22 2003-11-25 Isis Pharmaceuticals, Inc. Methods for identifying ligand binding sites in a biomolecule

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5712089A (en) * 1993-12-06 1998-01-27 Bioinvent International Ab Method of selecting specific bacteriophages
WO2001075091A2 (en) * 2000-04-05 2001-10-11 Bioinvent International Ab A method for in vitro molecular evolution of antibody function

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
HALLBORN J ET AL: "AUTOMATED SCREENING PROCEDURE FOR HIGH-THROUGHPUT GENERATION OF ANTIBODY FRAGMENTS", BIOTECHNIQUES, EATON PUBLISHING, NATICK, US, vol. 33, no. SUPPL, December 2002 (2002-12-01), pages S30 - S37, XP001155909, ISSN: 0736-6205 *
MANDECKI W ET AL: "A Mathematical Model for Biopanning (Affinity Selection) Using Peptide Libraries on Filamentous Phage", JOURNAL OF THEORETICAL BIOLOGY, ACADEMIC PRESS, LONDON, GB, vol. 176, 1995, pages 523 - 530, XP002267100, ISSN: 0022-5193 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9334331B2 (en) 2010-11-17 2016-05-10 Chugai Seiyaku Kabushiki Kaisha Bispecific antibodies

Also Published As

Publication number Publication date
WO2004097041A2 (en) 2004-11-11
GB2400851B (en) 2004-12-15
GB0309397D0 (en) 2003-06-04
GB2400851A (en) 2004-10-27

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