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WO2004097041A3 - Methodes de criblage - Google Patents

Methodes de criblage Download PDF

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Publication number
WO2004097041A3
WO2004097041A3 PCT/EP2004/004387 EP2004004387W WO2004097041A3 WO 2004097041 A3 WO2004097041 A3 WO 2004097041A3 EP 2004004387 W EP2004004387 W EP 2004004387W WO 2004097041 A3 WO2004097041 A3 WO 2004097041A3
Authority
WO
WIPO (PCT)
Prior art keywords
binding molecules
screening method
molecule
target
binds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2004/004387
Other languages
English (en)
Other versions
WO2004097041A2 (fr
Inventor
Helena Persson
Mats Ohlin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bioinvent International AB
Original Assignee
Bioinvent International AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bioinvent International AB filed Critical Bioinvent International AB
Publication of WO2004097041A2 publication Critical patent/WO2004097041A2/fr
Publication of WO2004097041A3 publication Critical patent/WO2004097041A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/005—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies constructed by phage libraries
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/44—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material not provided for elsewhere, e.g. haptens, metals, DNA, RNA, amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • Genetics & Genomics (AREA)
  • Physics & Mathematics (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Virology (AREA)
  • Analytical Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Microbiology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Peptides Or Proteins (AREA)
  • Information Retrieval, Db Structures And Fs Structures Therefor (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

L'invention concerne une méthode pour identifier une molécule de liaison permettant une liaison avec le site cible d'une molécule cible.
PCT/EP2004/004387 2003-04-25 2004-04-23 Methodes de criblage Ceased WO2004097041A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0309397.8 2003-04-25
GB0309397A GB2400851B (en) 2003-04-25 2003-04-25 Identifying binding of a polypeptide to a polypeptide target

Publications (2)

Publication Number Publication Date
WO2004097041A2 WO2004097041A2 (fr) 2004-11-11
WO2004097041A3 true WO2004097041A3 (fr) 2005-02-03

Family

ID=9957209

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2004/004387 Ceased WO2004097041A2 (fr) 2003-04-25 2004-04-23 Methodes de criblage

Country Status (2)

Country Link
GB (1) GB2400851B (fr)
WO (1) WO2004097041A2 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9334331B2 (en) 2010-11-17 2016-05-10 Chugai Seiyaku Kabushiki Kaisha Bispecific antibodies

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7601351B1 (en) 2002-06-26 2009-10-13 Human Genome Sciences, Inc. Antibodies against protective antigen
AU2003256299A1 (en) 2002-07-01 2004-01-19 Human Genome Sciences, Inc. Antibodies that specifically bind to reg iv
EP3050963B1 (fr) 2005-03-31 2019-09-18 Chugai Seiyaku Kabushiki Kaisha Procédé pour la production de polypeptide au moyen de la régulation d'un ensemble
JP4917024B2 (ja) * 2005-04-08 2012-04-18 中外製薬株式会社 血液凝固第ｖｉｉｉ因子の機能代替抗体
IN2014DN10515A (fr) 2006-03-31 2015-08-21 Chugai Pharmaceutical Co Ltd
ES2654040T3 (es) 2006-03-31 2018-02-12 Chugai Seiyaku Kabushiki Kaisha Método de modificación de anticuerpos para la purificación de anticuerpos biespecíficos
MX369784B (es) 2007-09-26 2019-11-21 Chugai Pharmaceutical Co Ltd Metodo de modificacion del punto isoelectrico de anticuerpos mediante la sustitucion de aminoacidos en region de determinacion de complementariedad (cdr).
CA2794851A1 (fr) * 2010-04-02 2011-10-06 Kalobios Pharmaceuticals, Inc. Generation d'anticorps d'un epitope d'interet
KR102441231B1 (ko) 2013-09-27 2022-09-06 추가이 세이야쿠 가부시키가이샤 폴리펩티드 이종 다량체의 제조방법
TWI701435B (zh) 2014-09-26 2020-08-11 日商中外製藥股份有限公司 測定ｆｖｉｉｉ的反應性之方法
MA40764A (fr) 2014-09-26 2017-08-01 Chugai Pharmaceutical Co Ltd Agent thérapeutique induisant une cytotoxicité
TWI700300B (zh) 2014-09-26 2020-08-01 日商中外製藥股份有限公司 中和具有第ｖｉｉｉ凝血因子（ｆｖｉｉｉ）機能替代活性的物質之抗體
US11142587B2 (en) 2015-04-01 2021-10-12 Chugai Seiyaku Kabushiki Kaisha Method for producing polypeptide hetero-oligomer
JP6954842B2 (ja) 2015-12-25 2021-10-27 中外製薬株式会社 増強された活性を有する抗体及びその改変方法
SG11201803989WA (en) 2015-12-28 2018-06-28 Chugai Pharmaceutical Co Ltd Method for promoting efficiency of purification of fc region-containing polypeptide
PE20181889A1 (es) 2016-04-28 2018-12-11 Chugai Pharmaceutical Co Ltd Preparaciones que contienen anticuerpos
RU2766233C2 (ru) 2016-09-06 2022-02-10 Чугаи Сейяку Кабусики Кайся Способы применения биспецифического антитела, которое распознает фактор свертывания ix и/или активированный фактор свертывания ix и фактор свертывания x и/или активированный фактор свертывания x
MY204641A (en) 2017-09-29 2024-09-06 Chugai Pharmaceutical Co Ltd Multispecific antigen-binding molecule having blood coagulation factor viii (fviii) cofactor function-substituting activity, and pharmaceutical formulation containing said molecule as active ingredient
EP3705496A4 (fr) 2017-11-01 2021-12-08 Chugai Seiyaku Kabushiki Kaisha Variant d'anticorps et isoforme à activité biologique réduite

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5712089A (en) * 1993-12-06 1998-01-27 Bioinvent International Ab Method of selecting specific bacteriophages
WO2001075091A2 (fr) * 2000-04-05 2001-10-11 Bioinvent International Ab Procede d'evolution moleculaire in vitro de la fonction d'anticorps

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4778751A (en) * 1986-05-12 1988-10-18 Diagnostic Products Corporation Method for measuring antigens or antibodies in biological fluids using ligand labeled antigens or ligand labeled antibodies
US6653067B1 (en) * 2001-02-22 2003-11-25 Isis Pharmaceuticals, Inc. Methods for identifying ligand binding sites in a biomolecule

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5712089A (en) * 1993-12-06 1998-01-27 Bioinvent International Ab Method of selecting specific bacteriophages
WO2001075091A2 (fr) * 2000-04-05 2001-10-11 Bioinvent International Ab Procede d'evolution moleculaire in vitro de la fonction d'anticorps

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
HALLBORN J ET AL: "AUTOMATED SCREENING PROCEDURE FOR HIGH-THROUGHPUT GENERATION OF ANTIBODY FRAGMENTS", BIOTECHNIQUES, EATON PUBLISHING, NATICK, US, vol. 33, no. SUPPL, December 2002 (2002-12-01), pages S30 - S37, XP001155909, ISSN: 0736-6205 *
MANDECKI W ET AL: "A Mathematical Model for Biopanning (Affinity Selection) Using Peptide Libraries on Filamentous Phage", JOURNAL OF THEORETICAL BIOLOGY, ACADEMIC PRESS, LONDON, GB, vol. 176, 1995, pages 523 - 530, XP002267100, ISSN: 0022-5193 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9334331B2 (en) 2010-11-17 2016-05-10 Chugai Seiyaku Kabushiki Kaisha Bispecific antibodies

Also Published As

Publication number Publication date
GB0309397D0 (en) 2003-06-04
WO2004097041A2 (fr) 2004-11-11
GB2400851B (en) 2004-12-15
GB2400851A (en) 2004-10-27

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