DK1686119T3 - Pyrimidin-5-on-derivater som LDL-PLA2 inhibitorer - Google Patents

Pyrimidin-5-on-derivater som LDL-PLA2 inhibitorer

Info

Publication number: DK1686119T3
Authority: DK; Denmark
Prior art keywords: ldl; pyrimidin; derivatives; pla2 inhibitors; inhibitors
Prior art date: 2000-02-16

Application number

DK06075890T

Other languages

English (en)

Inventor

Deidre Mary Hickey

Robert John Ife

Colin Andrew Leach

Ivan Leo Pinto

Stephen Allan Smith

Steven James Stanway

Original Assignee

Smithkline Beecham Plc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-02-16

Filing date

2001-02-13

Publication date

2009-11-09

2000-02-16 Priority claimed from GB0003636A external-priority patent/GB0003636D0/en

2001-01-19 Priority claimed from GB0101437A external-priority patent/GB0101437D0/en

2001-02-13 Application filed by Smithkline Beecham Plc filed Critical Smithkline Beecham Plc

2009-11-09 Application granted granted Critical

2009-11-09 Publication of DK1686119T3 publication Critical patent/DK1686119T3/da

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/56—One oxygen atom and one sulfur atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/60—Three or more oxygen or sulfur atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/95—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in positions 2 and 4
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Medicinal Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Diabetes (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Obesity (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Hematology (AREA)
Rheumatology (AREA)
Dermatology (AREA)
Physical Education & Sports Medicine (AREA)
Urology & Nephrology (AREA)
Endocrinology (AREA)
Immunology (AREA)
Orthopedic Medicine & Surgery (AREA)
Emergency Medicine (AREA)
Vascular Medicine (AREA)
Hospice & Palliative Care (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

DK06075890T 2000-02-16 2001-02-13 Pyrimidin-5-on-derivater som LDL-PLA2 inhibitorer DK1686119T3 (da)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
GB0003636A GB0003636D0 (en)	2000-02-16	2000-02-16	Novel compounds
GB0101437A GB0101437D0 (en)	2001-01-19	2001-01-19	Novel Compounds
PCT/EP2001/001515 WO2001060805A1 (en)	2000-02-16	2001-02-13	Pyrimidine-4-one derivatives as ldl-pla2 inhibitors

Publications (1)

Publication Number	Publication Date
DK1686119T3 true DK1686119T3 (da)	2009-11-09

Family

ID=26243663

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
DK01907522T DK1263740T3 (da)	2000-02-16	2001-02-13	Pyrimidin-4-on-derivat som LDL-PLA2-inhibitor
DK06075890T DK1686119T3 (da)	2000-02-16	2001-02-13	Pyrimidin-5-on-derivater som LDL-PLA2 inhibitorer

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
DK01907522T DK1263740T3 (da)	2000-02-16	2001-02-13	Pyrimidin-4-on-derivat som LDL-PLA2-inhibitor

Country Status (31)

Country	Link
US (10)	US20020103213A1 (da)
EP (2)	EP1686119B1 (da)
JP (1)	JP4095804B2 (da)
KR (1)	KR100781425B1 (da)
CN (1)	CN1179952C (da)
AR (1)	AR030190A1 (da)
AT (2)	ATE437862T1 (da)
AU (2)	AU3546601A (da)
BG (1)	BG66014B1 (da)
BR (1)	BRPI0108396B1 (da)
CA (1)	CA2400554C (da)
CO (1)	CO5271661A1 (da)
CY (2)	CY1105649T1 (da)
CZ (1)	CZ304450B6 (da)
DE (2)	DE60121550T2 (da)
DK (2)	DK1263740T3 (da)
ES (2)	ES2330552T3 (da)
GC (1)	GC0000221A (da)
HU (1)	HU229479B1 (da)
IL (2)	IL151236A (da)
MX (1)	MXPA02008062A (da)
MY (1)	MY135732A (da)
NO (1)	NO324691B1 (da)
NZ (1)	NZ520752A (da)
PL (1)	PL209824B1 (da)
PT (2)	PT1686119E (da)
SI (2)	SI1263740T1 (da)
SK (1)	SK287296B6 (da)
TW (1)	TW550259B (da)
UA (1)	UA73762C2 (da)
WO (1)	WO2001060805A1 (da)

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AU2014210259B2 (en)	2013-01-25	2016-11-03	Glaxosmithkline Intellectual Property Development Limited	Compounds
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EP0673426B1 (en) *	1993-10-06	2001-06-06	Icos Corporation	Platelet-activating factor acetylhydrolase
GB9421816D0 (en)	1994-10-29	1994-12-14	Smithkline Beecham Plc	Novel compounds
NZ298416A (en)	1994-12-22	1999-03-29	Smithkline Beecham Plc	Substituted azetidin-2-one derivatives and medicaments thereof
CH690264A5 (fr)	1995-06-30	2000-06-30	Symphar Sa	Dérivés aminophosphonates substitués, leur procédé de préparation et leur utilisation pour la préparation de compositions pharmaceutiques.
IL122650A0 (en)	1995-07-01	1998-08-16	Smithkline Beecham Plc	Azetidinone derivatives for the treatment of atherosclerosis
WO1997012963A2 (en)	1995-09-29	1997-04-10	Smithkline Beecham Plc	A paf-acetylhydrolase and use in therapy
JP2000505063A (ja)	1995-12-08	2000-04-25	スミスクライン・ビーチャム・パブリック・リミテッド・カンパニー	アテローム性動脈硬化症の治療のためのアゼチジノン化合物
JP2000502079A (ja)	1995-12-08	2000-02-22	スミスクライン・ビーチャム・パブリック・リミテッド・カンパニー	アテローム性動脈硬化症の治療のための単環β―ラクタム誘導体
AU2698697A (en)	1996-04-26	1997-11-19	Smithkline Beecham Plc	Azetidinone derivatives for the treatment of atherosclerosis
GB9608649D0 (en)	1996-04-26	1996-07-03	Smithkline Beecham Plc	Novel compounds
GB9626616D0 (en)	1996-12-20	1997-02-05	Symphar Sa	Novel compounds
GB9626615D0 (en)	1996-12-20	1997-02-05	Symphar Sa	Novel compounds
GB9626536D0 (en)	1996-12-20	1997-02-05	Symphar Sa	Novel compounds
JP2001522844A (ja)	1997-11-06	2001-11-20	スミスクライン・ビーチャム・パブリック・リミテッド・カンパニー	ピリミジノン化合物およびそれを含有する医薬組成物
ATE251613T1 (de) *	1998-08-21	2003-10-15	Smithkline Beecham Plc	Pyrimidinonderivate zur behandlung von atheroscleros
PT1175408E (pt) *	1999-05-01	2005-04-29	Smithkline Beecham Plc	Derivados sulfonamida
GB9910079D0 (en)	1999-05-01	1999-06-30	Smithkline Beecham Plc	Novel compounds
GB9910378D0 (en)	1999-05-05	1999-06-30	Smithkline Beecham Plc	Novel compounds
ATE437862T1 (de)	2000-02-16	2009-08-15	Smithkline Beecham Plc	Pyrimidin-5-onderivate als ldl-pla2 inhibitoren
GB0024808D0 (en) *	2000-10-10	2000-11-22	Smithkline Beecham Plc	Novel compounds
GB0024807D0 (en) *	2000-10-10	2000-11-22	Smithkline Beecham Plc	Novel compounds

2001
- 2001-02-13 AT AT06075890T patent/ATE437862T1/de active
- 2001-02-13 AU AU3546601A patent/AU3546601A/xx active Pending
- 2001-02-13 CA CA002400554A patent/CA2400554C/en not_active Expired - Fee Related
- 2001-02-13 KR KR1020027010662A patent/KR100781425B1/ko not_active Expired - Fee Related
- 2001-02-13 PT PT06075890T patent/PT1686119E/pt unknown
- 2001-02-13 PT PT01907522T patent/PT1263740E/pt unknown
- 2001-02-13 AU AU2001235466A patent/AU2001235466B2/en not_active Ceased
- 2001-02-13 HU HU0204410A patent/HU229479B1/hu not_active IP Right Cessation
- 2001-02-13 BR BRPI0108396-1A patent/BRPI0108396B1/pt not_active IP Right Cessation
- 2001-02-13 ES ES06075890T patent/ES2330552T3/es not_active Expired - Lifetime
- 2001-02-13 DK DK01907522T patent/DK1263740T3/da active
- 2001-02-13 PL PL357382A patent/PL209824B1/pl unknown
- 2001-02-13 CZ CZ2002-2768A patent/CZ304450B6/cs not_active IP Right Cessation
- 2001-02-13 AT AT01907522T patent/ATE333446T1/de active
- 2001-02-13 ES ES01907522T patent/ES2267714T3/es not_active Expired - Lifetime
- 2001-02-13 UA UA2002097389A patent/UA73762C2/uk unknown
- 2001-02-13 SI SI200130614T patent/SI1263740T1/sl unknown
- 2001-02-13 NZ NZ520752A patent/NZ520752A/en not_active IP Right Cessation
- 2001-02-13 DE DE60121550T patent/DE60121550T2/de not_active Expired - Lifetime
- 2001-02-13 SI SI200130941T patent/SI1686119T1/sl unknown
- 2001-02-13 WO PCT/EP2001/001515 patent/WO2001060805A1/en not_active Ceased
- 2001-02-13 EP EP06075890A patent/EP1686119B1/en not_active Expired - Lifetime
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- 2001-02-13 SK SK1177-2002A patent/SK287296B6/sk not_active IP Right Cessation
- 2001-02-13 DE DE60139429T patent/DE60139429D1/de not_active Expired - Lifetime
- 2001-02-13 DK DK06075890T patent/DK1686119T3/da active
- 2001-02-13 MX MXPA02008062A patent/MXPA02008062A/es active IP Right Grant
- 2001-02-13 EP EP01907522A patent/EP1263740B1/en not_active Expired - Lifetime
- 2001-02-13 CN CNB01806521XA patent/CN1179952C/zh not_active Expired - Fee Related
- 2001-02-14 GC GCP20011178 patent/GC0000221A/en active
- 2001-02-14 MY MYPI20010671A patent/MY135732A/en unknown
- 2001-02-14 US US09/782,930 patent/US20020103213A1/en not_active Abandoned
- 2001-02-14 AR ARP010100659A patent/AR030190A1/es not_active Application Discontinuation
- 2001-02-15 TW TW090103332A patent/TW550259B/zh not_active IP Right Cessation
- 2001-02-15 CO CO01011957A patent/CO5271661A1/es active IP Right Grant
2002
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- 2002-08-13 NO NO20023828A patent/NO324691B1/no not_active IP Right Cessation
- 2002-08-26 BG BG107034A patent/BG66014B1/bg unknown
2003
- 2003-02-03 US US10/357,238 patent/US6649619B1/en not_active Expired - Lifetime
- 2003-10-27 US US10/694,561 patent/US7153861B2/en not_active Expired - Fee Related
2006
- 2006-10-06 CY CY20061101441T patent/CY1105649T1/el unknown
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- 2006-11-21 US US11/561,926 patent/US7638520B2/en not_active Expired - Fee Related
2007
- 2007-03-15 IL IL181957A patent/IL181957A0/en unknown
2009
- 2009-01-06 US US12/349,086 patent/US7652019B2/en not_active Expired - Fee Related
- 2009-02-18 US US12/372,837 patent/US20090170877A1/en not_active Abandoned
- 2009-10-12 CY CY20091101045T patent/CY1109484T1/el unknown
2010
- 2010-02-18 US US12/707,838 patent/US20100144765A1/en not_active Abandoned
2011
- 2011-12-02 US US13/309,941 patent/US8871775B2/en not_active Expired - Fee Related
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Also Published As

Publication number	Publication date
AU2001235466B2 (en)	2004-04-22
AU3546601A (en)	2001-08-27
US20020103213A1 (en)	2002-08-01
US7638520B2 (en)	2009-12-29
KR20030011772A (ko)	2003-02-11
PL357382A1 (en)	2004-07-26
HU229479B1 (en)	2014-01-28
US6649619B1 (en)	2003-11-18
JP2003523335A (ja)	2003-08-05
CN1179952C (zh)	2004-12-15
DE60121550T2 (de)	2007-06-21
IL151236A (en)	2009-02-11
US9266841B2 (en)	2016-02-23
UA73762C2 (uk)	2005-09-15
TW550259B (en)	2003-09-01
HK1053466A1 (en)	2003-10-24
NO20023828D0 (no)	2002-08-13
US7153861B2 (en)	2006-12-26
US20100144765A1 (en)	2010-06-10
US7470694B2 (en)	2008-12-30
SI1263740T1 (sl)	2006-12-31
CZ20022768A3 (cs)	2003-05-14
IL181957A0 (en)	2009-02-11
CY1109484T1 (el)	2014-08-13
DK1263740T3 (da)	2006-11-13
CY1105649T1 (el)	2010-12-22
US20120172378A1 (en)	2012-07-05
US20070155762A1 (en)	2007-07-05
JP4095804B2 (ja)	2008-06-04
ES2330552T3 (es)	2009-12-11
CA2400554A1 (en)	2001-08-23
CA2400554C (en)	2009-04-07
EP1263740B1 (en)	2006-07-19
US20150045375A1 (en)	2015-02-12
ATE437862T1 (de)	2009-08-15
SK11772002A3 (sk)	2003-02-04
MY135732A (en)	2008-06-30
DE60139429D1 (de)	2009-09-10
US7652019B2 (en)	2010-01-26
ES2267714T3 (es)	2007-03-16
SI1686119T1 (sl)	2009-12-31
US20040097525A1 (en)	2004-05-20
PL209824B1 (pl)	2011-10-31
EP1263740A1 (en)	2002-12-11
US8871775B2 (en)	2014-10-28
US20090118313A1 (en)	2009-05-07
US20070123549A1 (en)	2007-05-31
BRPI0108396B1 (pt)	2015-05-19
ATE333446T1 (de)	2006-08-15
BR0108396A (pt)	2003-03-11
EP1686119A1 (en)	2006-08-02
HUP0204410A3 (en)	2003-07-28
CZ304450B6 (cs)	2014-05-14
MXPA02008062A (es)	2002-11-29
WO2001060805A1 (en)	2001-08-23
BG66014B1 (bg)	2010-10-29
KR100781425B1 (ko)	2007-12-03
PT1686119E (pt)	2009-10-06
US20090170877A1 (en)	2009-07-02
SK287296B6 (sk)	2010-06-07
DE60121550D1 (de)	2006-08-31
AR030190A1 (es)	2003-08-13
PT1263740E (pt)	2006-11-30
BG107034A (bg)	2003-04-30
GC0000221A (en)	2006-03-29
NZ520752A (en)	2004-03-26
NO20023828L (no)	2002-09-30
CN1418199A (zh)	2003-05-14
CO5271661A1 (es)	2003-04-30
EP1686119B1 (en)	2009-07-29
HUP0204410A2 (en)	2003-05-28
NO324691B1 (no)	2007-12-03

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