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MX2022005615A - Derivado triciclico de dihidroimidazopirimidona, metodo de preparacion del mismo, composicion farmaceutica y uso del mismo. - Google Patents

Derivado triciclico de dihidroimidazopirimidona, metodo de preparacion del mismo, composicion farmaceutica y uso del mismo.

Info

Publication number
MX2022005615A
MX2022005615A MX2022005615A MX2022005615A MX2022005615A MX 2022005615 A MX2022005615 A MX 2022005615A MX 2022005615 A MX2022005615 A MX 2022005615A MX 2022005615 A MX2022005615 A MX 2022005615A MX 2022005615 A MX2022005615 A MX 2022005615A
Authority
MX
Mexico
Prior art keywords
preparation
pharmaceutical composition
dihydroimidazopyrimidone
tricyclic
derivative
Prior art date
Application number
MX2022005615A
Other languages
English (en)
Inventor
Yun Jin
Yong Sun
Jinhua Wu
Jun Peng
Original Assignee
Shanghai Simr Biotechnology Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=75750506&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX2022005615(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Shanghai Simr Biotechnology Co Ltd filed Critical Shanghai Simr Biotechnology Co Ltd
Publication of MX2022005615A publication Critical patent/MX2022005615A/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
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    • C07D487/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/18—Bridged systems
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    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
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    • C07D487/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains four or more hetero rings
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    • C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
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    • C07D513/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains three hetero rings
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Abstract

Se desvelan un compuesto representado por la fórmula general (I), un isómero cis-trans del mismo, un enantiómero del mismo, un diastereómero del mismo, un racemato del mismo, un solvato del mismo, un hidrato del mismo, o una sal farmacéuticamente aceptable del mismo o un profármaco del mismo, un método de preparación para el mismo, una composición farmacéutica que comprende el compuesto y el uso del compuesto como inhibidor de Lp-PLA2. (ver Fórmula).
MX2022005615A 2019-11-09 2020-11-09 Derivado triciclico de dihidroimidazopirimidona, metodo de preparacion del mismo, composicion farmaceutica y uso del mismo. MX2022005615A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN201911104067 2019-11-09
PCT/CN2020/127426 WO2021089032A1 (zh) 2019-11-09 2020-11-09 三环二氢咪唑并嘧啶酮衍生物、其制备方法、药物组合物和用途

Publications (1)

Publication Number Publication Date
MX2022005615A true MX2022005615A (es) 2022-07-27

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ID=75750506

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MX2022005615A MX2022005615A (es) 2019-11-09 2020-11-09 Derivado triciclico de dihidroimidazopirimidona, metodo de preparacion del mismo, composicion farmaceutica y uso del mismo.

Country Status (15)

Country Link
US (1) US20230044787A1 (es)
EP (1) EP4056571A4 (es)
JP (2) JP7564872B2 (es)
KR (1) KR102816614B1 (es)
CN (2) CN112778331B (es)
AU (1) AU2020379796C1 (es)
BR (1) BR112022008786A2 (es)
CA (1) CA3156783A1 (es)
CO (1) CO2022008171A2 (es)
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