[go: up one dir, main page]

MX2019011904A - Composicion farmaceutica que contiene agonista de mor y agonista de kor, y sus usos. - Google Patents

Composicion farmaceutica que contiene agonista de mor y agonista de kor, y sus usos.

Info

Publication number
MX2019011904A
MX2019011904A MX2019011904A MX2019011904A MX2019011904A MX 2019011904 A MX2019011904 A MX 2019011904A MX 2019011904 A MX2019011904 A MX 2019011904A MX 2019011904 A MX2019011904 A MX 2019011904A MX 2019011904 A MX2019011904 A MX 2019011904A
Authority
MX
Mexico
Prior art keywords
agonist
pharmaceutical composition
composition containing
kor
mor
Prior art date
Application number
MX2019011904A
Other languages
English (en)
Other versions
MX388643B (es
Inventor
Cao Guoqing
Zhang Lianshan
Yang Changyong
Niu Zhuolu
Original Assignee
Jiangsu Hengrui Medicine Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Jiangsu Hengrui Medicine Co filed Critical Jiangsu Hengrui Medicine Co
Publication of MX2019011904A publication Critical patent/MX2019011904A/es
Publication of MX388643B publication Critical patent/MX388643B/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/443—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with oxygen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4433—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with oxygen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4436—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/45—Non condensed piperidines, e.g. piperocaine having oxo groups directly attached to the heterocyclic ring, e.g. cycloheximide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/07—Tetrapeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Se proporcionan usos de la combinación de un agonista del receptor de opioides µ (MOR) y un agonista del receptor de opioides ? ( KO R) e n l a p r e p a r a c i ó n d e f á rma c o s p a r a a l i v i a r y / o t r a t a r e l d o l o r. El agonista de MOR se selecciona del compuesto representado en la fórmula ( I ) o un tautómero, mesómero, racemato, enant iómero o diaestereómero de él , o una mezcla de el los, o una sal de el los aceptable farmacéut icamente. También se proporciona una composición farmacéut ica que cont iene el agonista de MOR y el agonista de KOR.
MX2019011904A 2017-04-14 2018-04-13 Composicion farmaceutica que contiene agonista de mor y agonista de kor, y sus usos MX388643B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN201710242435 2017-04-14
PCT/CN2018/082912 WO2018188641A1 (zh) 2017-04-14 2018-04-13 一种mor激动剂与kor激动剂的药物组合物及其用途

Publications (2)

Publication Number Publication Date
MX2019011904A true MX2019011904A (es) 2019-11-25
MX388643B MX388643B (es) 2025-03-20

Family

ID=63792284

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2019011904A MX388643B (es) 2017-04-14 2018-04-13 Composicion farmaceutica que contiene agonista de mor y agonista de kor, y sus usos

Country Status (11)

Country Link
US (1) US20200054594A1 (es)
EP (1) EP3610874A4 (es)
JP (1) JP2020516591A (es)
KR (1) KR20190133047A (es)
CN (1) CN109982699A (es)
AU (1) AU2018251118A1 (es)
BR (1) BR112019020691A2 (es)
CA (1) CA3058272A1 (es)
MX (1) MX388643B (es)
TW (1) TW201836606A (es)
WO (1) WO2018188641A1 (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2021505547A (ja) * 2017-12-06 2021-02-18 江蘇恒瑞医薬股▲ふん▼有限公司 疼痛を治療するための薬物の製造におけるｍｏｒアゴニストと組み合わせたｋｏｒアゴニストの使用
CN111836807A (zh) * 2018-04-28 2020-10-27 四川科伦博泰生物医药股份有限公司 氧杂螺环类化合物及其制备方法和用途
WO2020147848A1 (zh) * 2019-01-17 2020-07-23 上海海雁医药科技有限公司 三环取代的氧杂螺环衍生物、其制法与医药上的用途
CN111662284B (zh) * 2019-03-06 2021-08-10 上海海雁医药科技有限公司 双杂环取代的氧杂螺环衍生物、其制法与医药上的用途
WO2021026492A1 (en) * 2019-08-07 2021-02-11 Humanwell Pharmaceutical US Kappa opioid receptor peptide amide agonists
WO2021027304A1 (zh) * 2019-08-14 2021-02-18 上海海雁医药科技有限公司 镇痛化合物、其制法与医药上的用途
CN112552374B (zh) * 2019-09-10 2024-06-04 西藏海思科制药有限公司 一种肽酰胺类化合物及其中间体的制备方法
US20230128062A1 (en) * 2020-01-17 2023-04-27 Shanghai Haiyan Pharmaceutical Technology Co., Ltd. Azabicyclic substituted oxaspiro derivative, preparation method therefor and medical use thereof
AU2021207143B2 (en) * 2020-01-17 2023-12-14 Shanghai Haiyan Pharmaceutical Technology Co., Ltd. Optically pure oxaspiro-substituted pyrrolopyrazole derivative, preparation method therefor and pharmaceutical use thereof
CN113214264B (zh) * 2020-01-21 2022-08-09 上海海雁医药科技有限公司 二氢吡咯并五元杂芳基取代的氧杂螺环衍生物、其制法与医药上的用途
AU2020454871A1 (en) 2020-06-25 2023-01-19 Humanwell Pharmaceutical US Peptides for treatment of medical disorders
EP4302779A1 (en) * 2021-03-04 2024-01-10 Socium Inc. Cancer therapeutic agent

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100648133B1 (ko) 2005-04-25 2006-11-23 일동제약주식회사 펩티드 데포르밀라제 저해제로서 신규의 히드록사믹 산유도체 및 그 제조방법
PL2064228T3 (pl) * 2006-11-10 2013-01-31 Cara Therapeutics Inc Syntetyczne amidy peptydowe
US7842662B2 (en) 2006-11-10 2010-11-30 Cara Therapeutics, Inc. Synthetic peptide amide dimers
US8906859B2 (en) 2006-11-10 2014-12-09 Cera Therapeutics, Inc. Uses of kappa opioid synthetic peptide amides
PL2688403T3 (pl) * 2011-03-23 2017-09-29 Trevena, Inc. Ligandy receptora opioidowego oraz sposoby ich stosowania i wytwarzania
HK1205809A1 (en) * 2012-03-04 2015-12-24 Adam JEFFRIES Data systems processing
WO2015065867A2 (en) 2013-10-28 2015-05-07 Cara Therapeutics, Inc. Peripheral kappa opioid receptor agonists for preventing, inhibiting or treating nausea and vomiting
WO2016073443A2 (en) 2014-11-05 2016-05-12 Cara Therapeutics, Inc. Peripheral kappa opioid receptor agonists for hard tissue pain
WO2016187537A1 (en) * 2015-05-21 2016-11-24 The Arizona Board Of Regents On Behalf Of The University Of Arizona Multifunctional opioid receptor ligands and methods of treating pain
DK3354649T3 (da) 2015-10-15 2020-02-24 Jiangsu Hengrui Medicine Co Oxaspiroderivat, fremstillingsmetode derfor og anvendelser deraf i lægemidler
CN107098871B (zh) * 2016-02-23 2021-07-02 江苏恒瑞医药股份有限公司 苯基丙酰胺类衍生物、其制备方法及其在医药上的应用
PL3610875T3 (pl) * 2017-04-14 2021-04-19 Jiangsu Hengrui Medicine Co., Ltd. Sól agonisty receptora opioidowego (MOR), postać krystaliczna I jego soli fumaranowej i sposób jej wytwarzania
JP2021505547A (ja) * 2017-12-06 2021-02-18 江蘇恒瑞医薬股▲ふん▼有限公司 疼痛を治療するための薬物の製造におけるｍｏｒアゴニストと組み合わせたｋｏｒアゴニストの使用

Also Published As

Publication number Publication date
AU2018251118A8 (en) 2019-10-31
CA3058272A1 (en) 2018-10-18
EP3610874A4 (en) 2021-01-06
WO2018188641A1 (zh) 2018-10-18
KR20190133047A (ko) 2019-11-29
MX388643B (es) 2025-03-20
BR112019020691A2 (pt) 2020-05-12
EP3610874A1 (en) 2020-02-19
CN109982699A (zh) 2019-07-05
JP2020516591A (ja) 2020-06-11
TW201836606A (zh) 2018-10-16
AU2018251118A1 (en) 2019-10-17
US20200054594A1 (en) 2020-02-20

Similar Documents

Publication Publication Date Title
MX2019011904A (es) Composicion farmaceutica que contiene agonista de mor y agonista de kor, y sus usos.
MX2020012967A (es) Combinacion farmaceutica que contiene activador de glucosacinasa y activador del receptor ppar, composicion, preparacion del compuesto, metodo de preparacion para el mismo y usos del mismo.
CO2022002842A2 (es) Degradadores bifuncionales de brd9 y sus métodos de uso
ECSP20070854A (es) Compuestos heteroaril tetracíclicos
MX2019003887A (es) Compuestos, dispositivos y usos de los mismos.
MX2018003432A (es) Compuestos heterociclicos y usos de los mismos.
AR093705A1 (es) Depsipeptido y sus usos
MX381707B (es) Nuevos derivados biciclicos, un proceso para su preparacion y composiciones farmaceuticas que los contienen.
SV2016005351A (es) Derivados de indano e indolina y el uso de los mismos como activadores de la guanilato ciclasa soluble
NI202000058A (es) Moduladores de sting (estimulador de genes de interferón) a base de ciclopentano
AR101414A1 (es) Derivados de pirrolidinona como inhibidores de metap-2
DOP2019000070A (es) Compuestos de aza–indazol para usar en lesiones de tendones y/o ligamentos
SV2016005313A (es) Derivados de carboxamida
ECSP19062381A (es) Moduladores del receptor de estrógeno
UY36123A (es) Derivados de carboxamida
CO2019004143A2 (es) Compuestos azaheterocíclicos fusionados y su uso como moduladores de los receptores ampa
CL2019000727A1 (es) Compuestos de indazol para usar en lesiones de tendones y/o ligamentos.
UY38006A (es) Inhibidores de la quinasa mtor, composiciones farmacéuticas que los contienen, y al uso en terapia de tales compuestos y composiciones
UY36084A (es) Activadores de herg policíclicos
MX2022005415A (es) Compuesto de imidazolidinona, metodo de preparacion del mismo y uso del mismo.
CR20190545A (es) Compuestos bicíclicos 5,6-fusionados y composiciones para el tratamiento de enfermedades parasitarias
NZ741384A (en) Dopamine d3 receptor antagonists having a morpholine moiety
MX2017007926A (es) Derivados de fumagilol.
EA201990506A1 (ru) Фармацевтическая композиция
AR088201A1 (es) Inhibidores seleccionados de la actividad de proteina tirosina quinasa y composiciones que los contienen