DK1542970T3 - Pyrrolidinderivater som MAOB-inhibitorer - Google Patents

Pyrrolidinderivater som MAOB-inhibitorer

Info

Publication number: DK1542970T3
Authority: DK; Denmark
Prior art keywords: pyrrolidine derivatives; maob inhibitors; maob; inhibitors; pyrrolidine
Prior art date: 2002-09-20

Application number

DK03750564.1T

Other languages

English (en)

Inventor

Wolfgang Wostl

Synese Jolidon

Daniela Krummenacher

Rosa Maria Rodriguez-Sarmiento

Andrew William Thomas

Beat Wirz

Rene Wyler

Hans Iding

Original Assignee

Hoffmann La Roche

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-09-20

Filing date

2003-09-18

Publication date

2010-08-02

2003-09-18 Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche

2010-08-02 Application granted granted Critical

2010-08-02 Publication of DK1542970T3 publication Critical patent/DK1542970T3/da

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
- C07D207/273—2-Pyrrolidones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/4015—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having oxo groups directly attached to the heterocyclic ring, e.g. piracetam, ethosuximide
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/34—Tobacco-abuse
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
- C07D207/273—2-Pyrrolidones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
- C07D207/277—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Neurosurgery (AREA)
Chemical Kinetics & Catalysis (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Psychiatry (AREA)
Addiction (AREA)
Diabetes (AREA)
Epidemiology (AREA)
Hematology (AREA)
Child & Adolescent Psychology (AREA)
Psychology (AREA)
Pain & Pain Management (AREA)
Hospice & Palliative Care (AREA)
Obesity (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Pyrrole Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

DK03750564.1T 2002-09-20 2003-09-18 Pyrrolidinderivater som MAOB-inhibitorer DK1542970T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP02021319		2002-09-20
PCT/EP2003/010356 WO2004026825A1 (en)	2002-09-20	2003-09-18	Pyrrolidone derivatives as maob inhibitors

Publications (1)

Publication Number	Publication Date
DK1542970T3 true DK1542970T3 (da)	2010-08-02

Family

ID=32010924

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK03750564.1T DK1542970T3 (da)	2002-09-20	2003-09-18	Pyrrolidinderivater som MAOB-inhibitorer

Country Status (31)

Country	Link
US (4)	US7037935B2 (da)
EP (3)	EP1542969B1 (da)
JP (3)	JP4335141B2 (da)
KR (3)	KR100676014B1 (da)
CN (3)	CN100400509C (da)
AR (3)	AR041297A1 (da)
AT (2)	ATE459601T1 (da)
AU (3)	AU2003270213B8 (da)
BR (4)	BR0314299A (da)
CA (3)	CA2496756C (da)
CY (1)	CY1110745T1 (da)
DE (2)	DE60331559D1 (da)
DK (1)	DK1542970T3 (da)
ES (2)	ES2338646T3 (da)
GT (3)	GT200300205A (da)
HR (3)	HRP20050262A2 (da)
JO (2)	JO2605B1 (da)
MX (3)	MXPA05002880A (da)
MY (3)	MY134480A (da)
NO (3)	NO330012B1 (da)
NZ (3)	NZ538048A (da)
PA (3)	PA8583001A1 (da)
PE (3)	PE20050077A1 (da)
PL (3)	PL216030B1 (da)
PT (1)	PT1542970E (da)
RU (3)	RU2336267C2 (da)
SI (1)	SI1542970T1 (da)
TW (3)	TWI286132B (da)
UY (3)	UY27991A1 (da)
WO (3)	WO2004026826A1 (da)
ZA (3)	ZA200501137B (da)

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PE20050077A1 (es) *	2002-09-20	2005-03-01	Hoffmann La Roche	Derivados de 4-pirrolidino-fenil-bencil-eter
GB0314373D0 (en)	2003-06-19	2003-07-23	Glaxo Group Ltd	Chemical compounds
AU2005268894B2 (en) *	2004-08-02	2010-12-16	F. Hoffmann-La Roche Ag	Benzyloxy derivatives as MAOB inhibitors
KR100845366B1 (ko) *	2004-08-02	2008-07-09	에프. 호프만-라 로슈 아게	모노아민 산화효소 ｂ 억제제로서 벤질옥시 유도체
RU2007129642A (ru)	2005-02-25	2009-03-27	Ф.Хоффманн-Ля Рош Аг (Ch)	Таблетки с улучшенным распределением лекарственного вещества
CN101142181B (zh) *	2005-03-15	2011-05-04	弗·哈夫曼-拉罗切有限公司	对映异构纯的4-吡咯烷子基苯基苄基醚衍生物的制备方法
US7501528B2 (en) *	2005-03-15	2009-03-10	Hoffmann-La Roche Inc.	Method for preparing enantiomerically pure 4-pyrrolidino phenylbenzyl ether derivatives
TW200728258A (en) *	2005-10-10	2007-08-01	Glaxo Group Ltd	Novel compounds
TW200730494A (en) *	2005-10-10	2007-08-16	Glaxo Group Ltd	Novel compounds
EP1943216B1 (en) *	2005-10-10	2010-06-30	Glaxo Group Limited	Prolinamide derivatives as sodium channel modulators
EP2171478A4 (en) *	2007-03-30	2013-01-30	Univ California	IN VIVO IMAGING METHOD FOR SULPHOTRANSFERASES
KR101220182B1 (ko) *	2009-02-25	2013-01-11	에스케이바이오팜 주식회사	치환된 아졸 유도체 화합물, 이를 포함하는 약제학적 조성물 및 이를 이용한 파킨슨씨 병 치료방법
CZ304053B6 (cs) *	2011-08-22	2013-09-04	Farmak, A. S.	Zpusob prípravy 2-[4-[(methylamino)karbonyl]-1-H-pyrazol-1-yl]adenosinu monohydrátu
KR102018284B1 (ko) *	2013-02-28	2019-09-05	삼성디스플레이 주식회사	박막 트랜지스터 어레이 기판 및 이를 포함하는 유기 발광 표시 장치
BR112015022202A2 (pt)	2013-03-14	2017-07-18	Dart Neuroscience Cayman Ltd	compostos substituídos de naftiridina e quinolina como inibidores da mao
CZ305213B6 (cs) *	2013-04-29	2015-06-10	Farmak, A. S.	Polymorf E 2-[4-[(methylamino)karbonyl]-1H-pyrazol-1-yl]adenosinu a způsob jeho přípravy
BR112016003288A8 (pt) *	2013-10-29	2020-02-04	Hoffmann La Roche	processos para sintetizar n-[(3s)-1-[4-[(3-fluorofenil)metóxi]fenil]-5-oxo-pirrolidin-3-il]acetamida cristalina, e seu intermediário
EP3237379B1 (en)	2014-12-23	2022-04-06	Convergence Pharmaceuticals Limited	Process for preparing alpha-carboxamide pyrrolidine derivatives
EP3273946A1 (en) *	2015-03-27	2018-01-31	F. Hoffmann-La Roche AG	Pharmaceutical formulation comprising sembragiline
JP7169592B2 (ja)	2017-09-27	2022-11-11	国立大学法人鹿児島大学	Ｐａｃ１受容体拮抗薬を用いた鎮痛薬
CA3076823A1 (en)	2017-10-05	2019-04-11	Biogen Inc.	Process for preparing alpha-carboxamide pyrrolidine derivatives
CN108299272B (zh) *	2018-01-31	2019-10-18	福州大学	一种合成1-氯-2,2,2-三氟亚乙基取代咯酮化合物的方法
US11225460B2 (en)	2018-03-08	2022-01-18	Sunshine Lake Pharma Co., Ltd.	Pyrrolidineamide derivatives and uses thereof
EP3932490B1 (en)	2019-02-27	2025-04-02	Kagoshima University	Antipruritic agent using pac1 receptor antagonist
WO2021225161A1 (ja)	2020-05-08	2021-11-11	国立大学法人鹿児島大学	Ｐａｃ１受容体拮抗薬を用いた抗うつ・抗不安薬
CN112851561A (zh) *	2021-01-29	2021-05-28	南京艾美斐生物医药科技有限公司	一种nr6a1蛋白受体抑制剂及其制备和应用
WO2022268520A1 (de)	2021-06-21	2022-12-29	Bayer Aktiengesellschaft	Verwendung von substituierten pyrrolidinonen oder deren salzen zur steigerung der stresstoleranz in pflanzen.

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FR2500831A1 (fr) *	1981-02-27	1982-09-03	Delalande Sa	Nouvelles n-aryl-oxazolidinones et -pyrrolidinones
DE69025418T2 (de)	1989-04-19	1996-11-14	Otsuka Pharma Co Ltd	Phenylcarbonsäurederivate mit einem Heterocyclus
WO1996006837A1 (en) *	1994-08-30	1996-03-07	Sankyo Company, Limited	Isoxazoles
US5679715A (en)	1995-06-07	1997-10-21	Harris; Richard Y.	Method for treating multiple sclerosis
JP3258027B2 (ja)	1996-03-15	2002-02-18	サマーセット・ファーマシューティカルズ・インコーポレイテッド	セレジリン投与による末梢ニューロパシーの予防および治療方法
US5683404A (en) *	1996-06-05	1997-11-04	Metagen, Llc	Clamp and method for its use
DE19841895A1 (de)	1998-09-11	2000-03-23	Degussa	Neues Verfahren zur Herstellung von 3-Amino-2-oxo-pyrrolidinen, neue Zwischenprodukte und deren Verwendung
CA2361848A1 (en) *	1999-04-02	2000-10-12	Dupont Pharmaceuticals Company	Novel lactam inhibitors of matrix metalloproteinases, tnf-.alpha., and aggrecanase
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ATE296071T1 (de) *	2000-02-14	2005-06-15	Potencia Medical Ag	Penisprothese
PE20050077A1 (es) *	2002-09-20	2005-03-01	Hoffmann La Roche	Derivados de 4-pirrolidino-fenil-bencil-eter
US20040267291A1 (en) *	2003-06-27	2004-12-30	Byrum Randal T.	Implantable band with non-mechanical attachment mechanism
US20040267292A1 (en) *	2003-06-27	2004-12-30	Byrum Randal T.	Implantable band with transverse attachment mechanism

2003
- 2003-09-17 PE PE2003000952A patent/PE20050077A1/es not_active Application Discontinuation
- 2003-09-17 PA PA20038583001A patent/PA8583001A1/es unknown
- 2003-09-17 MY MYPI20033545A patent/MY134480A/en unknown
- 2003-09-17 TW TW092125618A patent/TWI286132B/zh not_active IP Right Cessation
- 2003-09-18 KR KR1020057004718A patent/KR100676014B1/ko not_active Expired - Fee Related
- 2003-09-18 AT AT03748052T patent/ATE459601T1/de active
- 2003-09-18 AR ARP030103383A patent/AR041297A1/es unknown
- 2003-09-18 RU RU2005111974/04A patent/RU2336267C2/ru not_active IP Right Cessation
- 2003-09-18 DE DE60331559T patent/DE60331559D1/de not_active Expired - Lifetime
- 2003-09-18 KR KR1020057004683A patent/KR100676015B1/ko not_active Expired - Fee Related
- 2003-09-18 MX MXPA05002880A patent/MXPA05002880A/es active IP Right Grant
- 2003-09-18 WO PCT/EP2003/010383 patent/WO2004026826A1/en not_active Ceased
- 2003-09-18 PL PL376021A patent/PL216030B1/pl unknown
- 2003-09-18 UY UY27991A patent/UY27991A1/es not_active Application Discontinuation
- 2003-09-18 CA CA2496756A patent/CA2496756C/en not_active Expired - Fee Related
- 2003-09-18 NZ NZ538048A patent/NZ538048A/en not_active IP Right Cessation
- 2003-09-18 MY MYPI20033558A patent/MY133332A/en unknown
- 2003-09-18 CN CNB038217678A patent/CN100400509C/zh not_active Expired - Fee Related
- 2003-09-18 CN CNB038212560A patent/CN100503562C/zh not_active Expired - Fee Related
- 2003-09-18 CA CA002498335A patent/CA2498335A1/en not_active Abandoned
- 2003-09-18 HR HR20050262A patent/HRP20050262A2/xx not_active Application Discontinuation
- 2003-09-18 PA PA20038583601A patent/PA8583601A1/es unknown
- 2003-09-18 GT GT200300205A patent/GT200300205A/es unknown
- 2003-09-18 BR BR0314299-0A patent/BR0314299A/pt active Search and Examination
- 2003-09-18 EP EP03748052A patent/EP1542969B1/en not_active Expired - Lifetime
- 2003-09-18 PL PL03376019A patent/PL376019A1/xx not_active Application Discontinuation
- 2003-09-18 RU RU2005111969/04A patent/RU2323209C2/ru not_active IP Right Cessation
- 2003-09-18 TW TW092125735A patent/TWI337604B/zh not_active IP Right Cessation
- 2003-09-18 EP EP03750564A patent/EP1542970B1/en not_active Expired - Lifetime
- 2003-09-18 AU AU2003270213A patent/AU2003270213B8/en not_active Ceased
- 2003-09-18 NZ NZ538049A patent/NZ538049A/en unknown
- 2003-09-18 US US10/667,088 patent/US7037935B2/en not_active Expired - Fee Related
- 2003-09-18 AU AU2003273901A patent/AU2003273901B2/en not_active Ceased
- 2003-09-18 BR BR0314314-7A patent/BR0314314A/pt not_active IP Right Cessation
- 2003-09-18 AR ARP030103384A patent/AR041298A1/es unknown
- 2003-09-18 PE PE2003000956A patent/PE20050078A1/es not_active Application Discontinuation
- 2003-09-18 RU RU2005111968/04A patent/RU2336268C2/ru not_active IP Right Cessation
- 2003-09-18 WO PCT/EP2003/010356 patent/WO2004026825A1/en not_active Ceased
- 2003-09-18 US US10/667,087 patent/US7151111B2/en not_active Expired - Lifetime
- 2003-09-18 PA PA20038583501A patent/PA8583501A1/es unknown
- 2003-09-18 DK DK03750564.1T patent/DK1542970T3/da active
- 2003-09-18 KR KR1020057004699A patent/KR100681586B1/ko not_active Expired - Fee Related
- 2003-09-18 ES ES03748052T patent/ES2338646T3/es not_active Expired - Lifetime
- 2003-09-18 JO JO2003116A patent/JO2605B1/en active
- 2003-09-18 CA CA2498785A patent/CA2498785C/en not_active Expired - Fee Related
- 2003-09-18 AU AU2003267381A patent/AU2003267381B2/en not_active Ceased
- 2003-09-18 MY MYPI20033559A patent/MY135696A/en unknown
- 2003-09-18 NZ NZ538046A patent/NZ538046A/en not_active IP Right Cessation
- 2003-09-18 AT AT03750564T patent/ATE472530T1/de active
- 2003-09-18 JP JP2004537120A patent/JP4335141B2/ja not_active Expired - Fee Related
- 2003-09-18 HR HR20050261A patent/HRP20050261A2/hr not_active Application Discontinuation
- 2003-09-18 JO JO2003115A patent/JO2604B1/en active
- 2003-09-18 EP EP03757866A patent/EP1542971A1/en not_active Withdrawn
- 2003-09-18 PT PT03750564T patent/PT1542970E/pt unknown
- 2003-09-18 WO PCT/EP2003/010384 patent/WO2004026827A1/en not_active Ceased
- 2003-09-18 UY UY27990A patent/UY27990A1/es not_active Application Discontinuation
- 2003-09-18 BR BR0314631-6A patent/BR0314631A/pt not_active IP Right Cessation
- 2003-09-18 JP JP2004537121A patent/JP4335142B2/ja not_active Expired - Fee Related
- 2003-09-18 TW TW092125746A patent/TWI331994B/zh not_active IP Right Cessation
- 2003-09-18 US US10/666,594 patent/US7235581B2/en not_active Expired - Fee Related
- 2003-09-18 DE DE60333202T patent/DE60333202D1/de not_active Expired - Lifetime
- 2003-09-18 GT GT200300204A patent/GT200300204A/es unknown
- 2003-09-18 PL PL03376018A patent/PL376018A1/xx not_active Application Discontinuation
- 2003-09-18 HR HRP20050263AA patent/HRP20050263B1/hr not_active IP Right Cessation
- 2003-09-18 BR BRPI0314631-6A patent/BRPI0314631B1/pt unknown
- 2003-09-18 JP JP2004537119A patent/JP4335140B2/ja not_active Expired - Fee Related
- 2003-09-18 AR ARP030103385A patent/AR041299A1/es not_active Application Discontinuation
- 2003-09-18 ES ES03750564T patent/ES2344557T3/es not_active Expired - Lifetime
- 2003-09-18 MX MXPA05002878A patent/MXPA05002878A/es active IP Right Grant
- 2003-09-18 SI SI200331830T patent/SI1542970T1/sl unknown
- 2003-09-18 CN CNB038219522A patent/CN100383118C/zh not_active Expired - Fee Related
- 2003-09-18 GT GT200300206A patent/GT200300206A/es unknown
- 2003-09-18 MX MXPA05002881A patent/MXPA05002881A/es active IP Right Grant
- 2003-09-18 PE PE2003000958A patent/PE20050079A1/es active IP Right Grant
- 2003-09-19 UY UY27993A patent/UY27993A1/es not_active Application Discontinuation
2005
- 2005-02-08 NO NO20050665A patent/NO330012B1/no not_active IP Right Cessation
- 2005-02-08 ZA ZA200501137A patent/ZA200501137B/xx unknown
- 2005-02-08 NO NO20050652A patent/NO329754B1/no not_active IP Right Cessation
- 2005-02-09 NO NO20050701A patent/NO20050701L/no not_active Application Discontinuation
- 2005-02-14 ZA ZA200501311A patent/ZA200501311B/en unknown
- 2005-02-22 ZA ZA200501557A patent/ZA200501557B/xx unknown
2006
- 2006-01-05 US US11/325,747 patent/US7122562B2/en not_active Expired - Fee Related
2010
- 2010-08-20 CY CY20101100770T patent/CY1110745T1/el unknown

Also Published As

Publication number	Publication date
EP1542970B1 (en)	2010-06-30
WO2004026825A1 (en)	2004-04-01
TWI331994B (en)	2010-10-21
SI1542970T1 (sl)	2010-08-31
BRPI0314631B1 (pt)	2018-04-17
KR20050057456A (ko)	2005-06-16
US20040097578A1 (en)	2004-05-20
CY1110745T1 (el)	2015-06-10
UY27990A1 (es)	2004-03-31
NO329754B1 (no)	2010-12-13
HK1083499A1 (zh)	2006-07-07
PE20050079A1 (es)	2005-03-01
CA2496756C (en)	2012-01-10
MXPA05002880A (es)	2005-05-27
RU2005111968A (ru)	2006-11-10
US7151111B2 (en)	2006-12-19
ATE459601T1 (de)	2010-03-15
TW200408624A (en)	2004-06-01
KR100681586B1 (ko)	2007-02-09
HRP20050262A2 (en)	2006-06-30
AU2003273901A1 (en)	2004-04-08
MXPA05002878A (es)	2005-05-27
US20040106650A1 (en)	2004-06-03
RU2336268C2 (ru)	2008-10-20
CA2496756A1 (en)	2004-04-01
KR100676014B1 (ko)	2007-01-30
GT200300205A (es)	2004-04-29
JP2006503834A (ja)	2006-02-02
TWI337604B (en)	2011-02-21
EP1542969A1 (en)	2005-06-22
NZ538046A (en)	2007-08-31
HRP20050263A2 (en)	2006-12-31
WO2004026826A1 (en)	2004-04-01
CN100400509C (zh)	2008-07-09
US7122562B2 (en)	2006-10-17
ATE472530T1 (de)	2010-07-15
BR0314299A (pt)	2005-12-13
RU2336267C2 (ru)	2008-10-20
NO330012B1 (no)	2011-02-07
PE20050078A1 (es)	2005-02-28
TW200413350A (en)	2004-08-01
PT1542970E (pt)	2010-07-19
RU2005111969A (ru)	2006-01-20
ZA200501557B (en)	2005-09-08
UY27993A1 (es)	2004-03-31
DE60331559D1 (de)	2010-04-15
HK1083498A1 (zh)	2006-07-07
PA8583501A1 (es)	2004-04-23
EP1542969B1 (en)	2010-03-03
EP1542970A1 (en)	2005-06-22
AR041297A1 (es)	2005-05-11
PA8583601A1 (es)	2004-09-16
PL376018A1 (en)	2005-12-12
CN1681778A (zh)	2005-10-12
NO20050652L (no)	2005-03-08
DE60333202D1 (de)	2010-08-12
RU2005111974A (ru)	2006-01-20
AU2003270213A1 (en)	2004-04-08
MY134480A (en)	2007-12-31
GT200300204A (es)	2004-04-29
JP4335141B2 (ja)	2009-09-30
ES2344557T3 (es)	2010-08-31
PL376021A1 (en)	2005-12-12
MXPA05002881A (es)	2005-05-27
PL216030B1 (pl)	2014-02-28
KR20050057450A (ko)	2005-06-16
AU2003273901B2 (en)	2008-07-10
ZA200501137B (en)	2006-12-27
NZ538048A (en)	2007-05-31
AR041299A1 (es)	2005-05-11
JO2605B1 (en)	2011-11-01
JP4335140B2 (ja)	2009-09-30
MY135696A (en)	2008-06-30
RU2323209C2 (ru)	2008-04-27
MY133332A (en)	2007-11-30
AU2003270213B8 (en)	2009-03-05
JO2604B1 (en)	2011-11-01
NO20050701L (no)	2005-03-02
PA8583001A1 (es)	2004-04-23
JP4335142B2 (ja)	2009-09-30
HRP20050261A2 (en)	2006-05-31
ZA200501311B (en)	2006-10-25
ES2338646T3 (es)	2010-05-11
CN1681779A (zh)	2005-10-12
NO20050665L (no)	2005-04-18
EP1542971A1 (en)	2005-06-22
BR0314314A (pt)	2005-07-26
KR100676015B1 (ko)	2007-01-30
CN100503562C (zh)	2009-06-24
TWI286132B (en)	2007-09-01
BR0314631A (pt)	2005-08-02
US7235581B2 (en)	2007-06-26
CN100383118C (zh)	2008-04-23
HK1084383A1 (en)	2006-07-28
JP2006503833A (ja)	2006-02-02
WO2004026827A1 (en)	2004-04-01
TW200410935A (en)	2004-07-01
PE20050077A1 (es)	2005-03-01
US7037935B2 (en)	2006-05-02
CA2498785A1 (en)	2004-04-01
CN1681777A (zh)	2005-10-12
AU2003267381A1 (en)	2004-04-08
CA2498785C (en)	2011-07-26
AR041298A1 (es)	2005-05-11
PL376019A1 (en)	2005-12-12
US20040116707A1 (en)	2004-06-17
AU2003267381B2 (en)	2009-08-27
JP2006510596A (ja)	2006-03-30
GT200300206A (es)	2004-04-29
CA2498335A1 (en)	2004-04-01
UY27991A1 (es)	2004-03-31
NZ538049A (en)	2007-05-31
KR20050057466A (ko)	2005-06-16
US20060122235A1 (en)	2006-06-08
AU2003270213B2 (en)	2009-02-12
HRP20050263B1 (hr)	2013-09-30

Publication	Publication Date	Title
DK1542970T3 (da)	2010-08-02	Pyrrolidinderivater som MAOB-inhibitorer
DK1492785T3 (da)	2009-03-02	2-hydroxy-3-heteroarylindol-derivater som GSK3-inhibitorer
NO20055680D0 (no)	2005-12-01	Heksahydropyridoisokinoliner som DPP-IV-inhibitorer
NO20043642L (no)	2004-08-31	Heterocykiske tripeptider som hepatitt C inhibitorer
NO20041709L (no)	2004-04-23	N-substituerte pyrrolidinderivater som dipeptidyl peptidase IV inhibitorer
DE60320933D1 (de)	2008-06-26	Rho-kinase inhibitoren
ATE478870T1 (de)	2010-09-15	Spiroindolinpiperidinderivate
DK1556385T3 (da)	2010-06-14	Heterocyclocarboxamid-derivater
DE60330372D1 (de)	2010-01-14	Indol-3-schwefelderivate
ATE467631T1 (de)	2010-05-15	Chinuclidinamidderivate
ATE438644T1 (de)	2009-08-15	Chinazolinderivate
IS7720A (is)	2005-03-01	Píperidín-N-oxíð-afleiður
DK1474408T3 (da)	2012-06-25	N-Phenyl-2-pyrimidinaminderivater
ATE489387T1 (de)	2010-12-15	Pyridoä2,1-aü-isochinolinderivate als dpp-iv inhibitoren
NO20030867L (no)	2003-02-25	Hydroksamderivater anvendelig som deacetylaseinhibitorer
DK1789041T3 (da)	2008-09-08	Aryl-pyridinderivater som 11-beta-HSD1-inhibitorer
DK1585749T3 (da)	2008-09-22	Diazepinoindol-derivater som kinaseinhibitorer
ATE413395T1 (de)	2008-11-15	N-substituierte pyrazolyl-amidyl-benzimidazolyl-c-kit-inhibitor n
DK1797042T3 (da)	2009-03-02	Indozolonderivater som 11B-HSD1-inhibitorer
DE602004018837D1 (de)	2009-02-12	Ptidase-iv-inhibitoren
NO20051236L (no)	2005-04-08	Heterobiarylderivater som matriksmetalloproteinaseinhibitorer
DE60307512D1 (de)	2006-09-21	3h-chinazoline -4-on derivaten
NO20035440D0 (no)	2003-12-05	Pyrrolidinderivater som faktor-XA-inhibitorer
DK1511718T3 (da)	2009-06-22	N-acylaminobenzenderivater som selektive monoaminoxidase B-inhibitorer
ATE423771T1 (de)	2009-03-15	Tetrahydrochinolinderivate