DK0783001T3 - Androstenoner - Google Patents

Androstenoner

Info

Publication number: DK0783001T3
Authority: DK; Denmark
Prior art keywords: hydrogen; member ring; chem; halogen; joined
Prior art date: 1993-09-17

Application number

DK97200658T

Other languages

Danish (da)

English (en)

Inventor

Kenneth William Batchelor

Stephen Vernon Frye

Original Assignee

Glaxo Wellcome Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-09-17

Filing date

1994-09-16

Publication date

2000-04-10

1994-09-16 Application filed by Glaxo Wellcome Inc filed Critical Glaxo Wellcome Inc

2000-04-10 Application granted granted Critical

2000-04-10 Publication of DK0783001T3 publication Critical patent/DK0783001T3/da

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J3/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom
- C07J3/005—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom the carbon atom being part of a carboxylic function
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/26—Androgens
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/70—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/82—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0066—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by a carbon atom forming part of an amide group
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J73/00—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms
- C07J73/001—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom
- C07J73/005—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom by nitrogen as hetero atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2603/00—Systems containing at least three condensed rings
- C07C2603/02—Ortho- or ortho- and peri-condensed systems
- C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
- C07C2603/06—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members
- C07C2603/10—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings
- C07C2603/12—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings only one five-membered ring
- C07C2603/14—Benz[f]indenes; Hydrogenated benz[f]indenes

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Diabetes (AREA)
Endocrinology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Steroid Compounds (AREA)
Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicinal Preparation (AREA)

DK97200658T 1993-09-17 1994-09-16 Androstenoner DK0783001T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US12328093A	1993-09-17	1993-09-17
US13651593A	1993-10-12	1993-10-12

Publications (1)

Publication Number	Publication Date
DK0783001T3 true DK0783001T3 (da)	2000-04-10

Family

ID=26821398

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
DK97200658T DK0783001T3 (da)	1993-09-17	1994-09-16	Androstenoner
DK94928605T DK0719277T3 (da)	1993-09-17	1994-09-16	Androstenoner

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
DK94928605T DK0719277T3 (da)	1993-09-17	1994-09-16	Androstenoner

Country Status (19)

Country	Link
US (1)	US5977126A (el)
EP (2)	EP0783001B1 (el)
CN (1)	CN1041939C (el)
AT (2)	ATE186733T1 (el)
AU (1)	AU685167B2 (el)
CA (3)	CA2478971C (el)
DE (2)	DE69421726T2 (el)
DK (2)	DK0783001T3 (el)
ES (2)	ES2140181T3 (el)
FI (1)	FI961232L (el)
GR (2)	GR3025717T3 (el)
HU (1)	HUT74445A (el)
IL (1)	IL110979A (el)
IS (1)	IS1726B (el)
NO (1)	NO306510B1 (el)
NZ (1)	NZ274059A (el)
RU (1)	RU2144037C1 (el)
TW (1)	TW408127B (el)
WO (1)	WO1995007926A1 (el)

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TW369521B (en) *	1993-09-17	1999-09-11	Smithkline Beecham Corp	Androstenone derivative
US6001844A (en) *	1995-09-15	1999-12-14	Merck & Co., Inc.	4-Azasteroids for treatment of hyperandrogenic conditions
US5935968A (en)	1997-03-17	1999-08-10	Merck & Co., Inc.	Methods for treating polycystic ovary syndrome
GB9717428D0 (en) *	1997-08-19	1997-10-22	Glaxo Group Ltd	Pharmaceutical composition
GB9717444D0 (en) *	1997-08-19	1997-10-22	Glaxo Group Ltd	Pharmaceutical composition
EP1228083A2 (en) *	1999-09-30	2002-08-07	Hollis-Eden Pharmaceuticals Inc.	Therapeutic treatment of androgen receptor driven conditions
NZ526216A (en)	2000-11-03	2005-02-25	Univ Manchester	Selective glucocorticoid receptor agonists
GB0026876D0 (en) *	2000-11-03	2000-12-20	Glaxo Group Ltd	Process
US6645974B2 (en)	2001-07-31	2003-11-11	Merck & Co., Inc.	Androgen receptor modulators and methods for use thereof
WO2003029268A1 (en) *	2001-10-03	2003-04-10	Merck & Co., Inc.	Androstane 17-beta-carboxamides as androgen receptor modulators
CA2478186C (en) *	2002-03-13	2011-08-23	Merck & Co., Inc.	Fluorinated 4-azasteroid derivatives as androgen receptor modulators
US20050131005A1 (en) *	2002-04-30	2005-06-16	Jiabing Wang	4-azasteroid derivatives as androgen receptor modulators
CU23256A1 (es) *	2003-03-20	2008-01-24	Dalmer Lab Sa	EXTRACTO OBTENIDO A PARTIR DE FRUTOS DE ROYSTONEA REGIA UTILIZADO CONTRA LA HIPERPLASIA PROSTáTICA Y LA PROSTATITIS
EP1742631A4 (en) *	2004-04-28	2009-11-11	Merck & Co Inc	FLUORATED 4-AZASTEROIDS AS ANDROGEN RECEPTOR MODULATORS
HU230730B1 (hu)	2011-06-30	2017-12-28	Richter Gedeon Nyrt	Eljárás (5alfa,17béta)-N-[2,5-bisz-(trifluormetil)-fenil]-3-oxo-4-aza-5-androszt-1-én-17-karbonsavamid előállítására
CN102532236B (zh) *	2012-01-05	2014-04-16	中国药科大学	甾体类5α-还原酶抑制剂、其制备方法及其医药用途
CN103554213A (zh) *	2012-01-05	2014-02-05	中国药科大学	4-氧杂-雄甾-3-酮-17β-酰胺类衍生物、其制备方法及其医药用途
CN103570796A (zh) *	2012-07-24	2014-02-12	重庆医药工业研究院有限责任公司	一种度他雄胺ⅰ型晶的制备方法

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US4845104A (en) *	1986-11-20	1989-07-04	Merck & Co., Inc.	Oxidized analogs of 17β-N-monosubstituted-carbamoyl-4-aza-5-α-androstan-3-ones
DE3780778T2 (de) *	1986-11-20	1993-01-14	Merck & Co Inc	Topisches arzneimittel enthaltend 17-beta-methoxy-carbonyl-4-methyl-4-aza-5-alpha-androst-1-en-3-one.
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IL101243A (en) *	1991-03-20	1999-12-22	Merck & Co Inc	Pharmaceutical preparations for the treatment of benign prostatic hyperplasia containing steroid history
WO1992018132A1 (en) *	1991-04-17	1992-10-29	Merck & Co., Inc.	Pharmaceutical combination for the treatment of benign prostatic hyperplasia comtaining a 5 alpha-reductase inhibitor
US5304562A (en) *	1991-10-09	1994-04-19	Ciba-Geigy Corporation	17β-substituted Aza-androstane derivatives
EP0547687A1 (en) *	1991-12-18	1993-06-23	Merck & Co. Inc.	17B-N-Substituted adamantyl/norbonanyl carbamoyl-4-aza-5a-and-rost-1-en-3-ones and androstan-3 ones
JP3164389B2 (ja) *	1991-12-25	2001-05-08	三共株式会社	４−アザステロイド類
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US5710275A (en) *	1992-05-20	1998-01-20	Merck & Co., Inc.	7β-substituted-4-aza-5α-androstan-3-ones as 5α-reductase inhibitors
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CA2135173A1 (en) *	1992-05-20	1993-11-25	Bruce E. Witzel	Ester derivatives of 4-aza-steroids
WO1993023038A1 (en) *	1992-05-20	1993-11-25	Merck & Co., Inc.	17-AMINO SUBSTITUTED 4-AZASTEROID 5α-REDUCTASE INHIBITORS
RU94046044A (ru) *	1992-05-20	1996-10-10	Мерк Энд Ко.	Новые 7 бета -замещенные 4-аза- 5 альфа -холестан-оны в качестве ингибиторов 5 альфа -редуктазы, фармацевтическая композиция на их основе, способ ее получения
AU4251993A (en) *	1992-05-20	1993-12-13	Merck & Co., Inc.	Substituted 4-aza-5A-androstan-ones as 5A-reductase inhibitors
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ES2149208T3 (es) *	1992-05-20	2000-11-01	Merck & Co Inc	Inhibidores 4-azaesteroides de 5-alfa-reductasa.
AU4258493A (en) *	1992-05-21	1993-12-13	Endorecherche Inc.	Inhibitors of testosterone 5alpha-reductase activity
GB9210880D0 (en) *	1992-05-21	1992-07-08	Smithkline Beecham Corp	Compounds
DE69329933T2 (de) *	1992-10-06	2001-07-19	Merck & Co., Inc.	17-beta-carboxanilid derivate von 4-aza-5-alpha-androstan-3-one als 5-alpha-reduktase-hemmende arzneimittel
US5468860A (en) *	1992-11-19	1995-11-21	Merck & Co., Inc.	New finasteride processes
TW369521B (en) *	1993-09-17	1999-09-11	Smithkline Beecham Corp	Androstenone derivative
US5512555A (en) *	1994-07-21	1996-04-30	Merck & Co., Inc.	Method of treating sweat-related conditions using finasteride, epristeride and a cholestan-3-one

1994
- 1994-09-03 TW TW083108128A patent/TW408127B/zh active
- 1994-09-13 IS IS4206A patent/IS1726B/is unknown
- 1994-09-16 CA CA002478971A patent/CA2478971C/en not_active Expired - Fee Related
- 1994-09-16 HU HU9600643A patent/HUT74445A/hu unknown
- 1994-09-16 CN CN94193959A patent/CN1041939C/zh not_active Expired - Fee Related
- 1994-09-16 RU RU96108412A patent/RU2144037C1/ru active
- 1994-09-16 WO PCT/US1994/010479 patent/WO1995007926A1/en not_active Ceased
- 1994-09-16 FI FI961232A patent/FI961232L/fi unknown
- 1994-09-16 DE DE69421726T patent/DE69421726T2/de not_active Expired - Lifetime
- 1994-09-16 CA CA002171329A patent/CA2171329C/en not_active Expired - Lifetime
- 1994-09-16 AT AT97200658T patent/ATE186733T1/de not_active IP Right Cessation
- 1994-09-16 ES ES97200658T patent/ES2140181T3/es not_active Expired - Lifetime
- 1994-09-16 EP EP97200658A patent/EP0783001B1/en not_active Expired - Lifetime
- 1994-09-16 CA CA002449679A patent/CA2449679C/en not_active Expired - Fee Related
- 1994-09-16 ES ES94928605T patent/ES2110260T3/es not_active Expired - Lifetime
- 1994-09-16 AT AT94928605T patent/ATE161268T1/de not_active IP Right Cessation
- 1994-09-16 AU AU77980/94A patent/AU685167B2/en not_active Expired
- 1994-09-16 IL IL11097994A patent/IL110979A/xx not_active IP Right Cessation
- 1994-09-16 DK DK97200658T patent/DK0783001T3/da active
- 1994-09-16 EP EP94928605A patent/EP0719277B1/en not_active Expired - Lifetime
- 1994-09-16 NZ NZ274059A patent/NZ274059A/en unknown
- 1994-09-16 DK DK94928605T patent/DK0719277T3/da active
- 1994-09-16 DE DE69407422T patent/DE69407422T2/de not_active Expired - Lifetime
1996
- 1996-03-15 NO NO961085A patent/NO306510B1/no not_active IP Right Cessation
1997
- 1997-12-18 GR GR970403304T patent/GR3025717T3/el unknown
1998
- 1998-05-14 US US09/079,002 patent/US5977126A/en not_active Expired - Lifetime
1999
- 1999-12-22 GR GR990403332T patent/GR3032198T3/el unknown

Also Published As

Publication number	Publication date
CN1134155A (zh)	1996-10-23
ES2140181T3 (es)	2000-02-16
AU685167B2 (en)	1998-01-15
AU7798094A (en)	1995-04-03
FI961232A7 (fi)	1996-03-15
US5977126A (en)	1999-11-02
DE69421726D1 (de)	1999-12-23
EP0783001A1 (en)	1997-07-09
EP0719277A1 (en)	1996-07-03
IS4206A (is)	1995-03-18
RU2144037C1 (ru)	2000-01-10
DE69407422T2 (de)	1998-04-09
CA2449679A1 (en)	1995-03-23
GR3032198T3 (en)	2000-04-27
NO961085D0 (no)	1996-03-15
CA2478971C (en)	2007-10-23
NZ274059A (en)	1997-12-19
CN1041939C (zh)	1999-02-03
NO306510B1 (no)	1999-11-15
GR3025717T3 (en)	1998-03-31
TW408127B (en)	2000-10-11
ES2110260T3 (es)	1998-02-01
HUT74445A (en)	1996-12-30
WO1995007926A1 (en)	1995-03-23
CA2171329A1 (en)	1995-03-23
FI961232A0 (fi)	1996-03-15
EP0719277B1 (en)	1997-12-17
DK0719277T3 (da)	1998-08-24
CA2171329C (en)	2004-11-23
IS1726B (is)	1999-09-06
HU9600643D0 (en)	1996-05-28
DE69421726T2 (de)	2000-06-29
IL110979A0 (en)	1994-11-28
FI961232L (fi)	1996-03-15
ATE161268T1 (de)	1998-01-15
IL110979A (en)	1999-08-17
DE69407422D1 (en)	1998-01-29
CA2478971A1 (en)	1995-03-23
ATE186733T1 (de)	1999-12-15
NO961085L (no)	1996-04-22
EP0783001B1 (en)	1999-11-17
CA2449679C (en)	2007-10-23

Publication	Publication Date	Title
DK0719277T3 (da)	1998-08-24	Androstenoner
PT771794E (pt)	2006-09-29	Compostos heterociclicos contendo oxigenio
LU91196I2 (fr)	2005-10-31	Picoxystrobin et ses dérivlés pharmaceutiquement acceptables(ACANTO).
EP1130016A4 (en)	2003-01-29	DERIVATIVES OF THIOCARBAMATE ACID
EA200100310A1 (ru)	2001-10-22	Кислородсодержащие гетероциклические соединения
FI953710A0 (fi)	1995-08-03	Uusia pyrrolokarbatsoleja
ES2068413T3 (es)	1995-04-16	Derivados de 4-fenilftalazina.
NZ221699A (en)	1990-03-27	Pyridazinone derivatives; pharmaceutical compositions and intermediates
DK0458387T3 (da)	1996-10-21	Isochromanderivater
NO915010L (no)	1992-06-22	Fremgangsmaate for fremstilling av fenylalkylaminoalkyl-forbindelser
FI853907A0 (fi)	1985-10-08	Mellanprodukter foer framstaellning av 16-fenoxi- och 16-substituerade fenoxi-prostatriensyraderivat.