GR3032198T3 - Androstenones - Google Patents

Androstenones

Info

Publication number: GR3032198T3
Authority: GR; Greece
Prior art keywords: hydrogen; member ring; chem; halogen; joined
Prior art date: 1993-09-17

Application number

GR990403332T

Other languages

English (en)

Inventor

Kenneth William Batchelor

Stephen Vernon Frye

Original Assignee

Glaxo Wellcome Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-09-17

Filing date

1999-12-22

Publication date

2000-04-27

1999-12-22 Application filed by Glaxo Wellcome Inc filed Critical Glaxo Wellcome Inc

2000-04-27 Publication of GR3032198T3 publication Critical patent/GR3032198T3/el

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J3/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom
- C07J3/005—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom the carbon atom being part of a carboxylic function
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/26—Androgens
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/70—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/82—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0066—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by a carbon atom forming part of an amide group
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J73/00—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms
- C07J73/001—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom
- C07J73/005—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom by nitrogen as hetero atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2603/00—Systems containing at least three condensed rings
- C07C2603/02—Ortho- or ortho- and peri-condensed systems
- C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
- C07C2603/06—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members
- C07C2603/10—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings
- C07C2603/12—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings only one five-membered ring
- C07C2603/14—Benz[f]indenes; Hydrogenated benz[f]indenes

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Public Health (AREA)
Bioinformatics & Cheminformatics (AREA)
Endocrinology (AREA)
Diabetes (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Steroid Compounds (AREA)
Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicinal Preparation (AREA)

GR990403332T 1993-09-17 1999-12-22 Androstenones GR3032198T3 (en)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US12328093A	1993-09-17	1993-09-17
US13651593A	1993-10-12	1993-10-12
EP94928605A EP0719277B1 (en)	1993-09-17	1994-09-16	Androstenones

Publications (1)

Publication Number	Publication Date
GR3032198T3 true GR3032198T3 (en)	2000-04-27

Family

ID=26821398

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
GR970403304T GR3025717T3 (en)	1993-09-17	1997-12-18	Androstenones
GR990403332T GR3032198T3 (en)	1993-09-17	1999-12-22	Androstenones

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
GR970403304T GR3025717T3 (en)	1993-09-17	1997-12-18	Androstenones

Country Status (19)

Country	Link
US (1)	US5977126A (el)
EP (2)	EP0783001B1 (el)
CN (1)	CN1041939C (el)
AT (2)	ATE161268T1 (el)
AU (1)	AU685167B2 (el)
CA (3)	CA2449679C (el)
DE (2)	DE69421726T2 (el)
DK (2)	DK0783001T3 (el)
ES (2)	ES2110260T3 (el)
FI (1)	FI961232A7 (el)
GR (2)	GR3025717T3 (el)
HU (1)	HUT74445A (el)
IL (1)	IL110979A (el)
IS (1)	IS1726B (el)
NO (1)	NO306510B1 (el)
NZ (1)	NZ274059A (el)
RU (1)	RU2144037C1 (el)
TW (1)	TW408127B (el)
WO (1)	WO1995007926A1 (el)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
TW369521B (en) *	1993-09-17	1999-09-11	Smithkline Beecham Corp	Androstenone derivative
USRE39056E1 (en) *	1995-09-15	2006-04-04	Merck & Co, Inc.	4-Azasteroids for treatment of hyperandrogenic conditions
US5935968A (en) *	1997-03-17	1999-08-10	Merck & Co., Inc.	Methods for treating polycystic ovary syndrome
GB9717428D0 (en) *	1997-08-19	1997-10-22	Glaxo Group Ltd	Pharmaceutical composition
GB9717444D0 (en) *	1997-08-19	1997-10-22	Glaxo Group Ltd	Pharmaceutical composition
WO2001023405A2 (en)	1999-09-30	2001-04-05	Hollis-Eden Pharmaceuticals, Inc.	Therapeutic treatment of androgen receptor driven conditions
AU2002210768B2 (en)	2000-11-03	2008-01-10	The University Of Manchester	Selective glucocorticoid receptor agonists
GB0026876D0 (en) *	2000-11-03	2000-12-20	Glaxo Group Ltd	Process
US6645974B2 (en)	2001-07-31	2003-11-11	Merck & Co., Inc.	Androgen receptor modulators and methods for use thereof
JP4490689B2 (ja) *	2001-10-03	2010-06-30	メルク・シャープ・エンド・ドーム・コーポレイション	アンドロゲン受容体調節剤としてのアンドロスタン１７β−カルボキサミド類
US7186838B2 (en) *	2002-03-13	2007-03-06	Merck & Co., Inc.	Fluorinated 4-azasteroid derivatives as androgen receptor modulators
WO2003092588A2 (en) *	2002-04-30	2003-11-13	Merck & Co., Inc.	4-azasteroid derivatives as androgen receptor modulators
CU23256A1 (es) *	2003-03-20	2008-01-24	Dalmer Lab Sa	EXTRACTO OBTENIDO A PARTIR DE FRUTOS DE ROYSTONEA REGIA UTILIZADO CONTRA LA HIPERPLASIA PROSTáTICA Y LA PROSTATITIS
JP2007534757A (ja) *	2004-04-28	2007-11-29	メルク　エンド　カムパニー　インコーポレーテッド	アンドロゲン受容体モジュレーターとしてのフッ素付加４−アザステロイド
HU230730B1 (hu)	2011-06-30	2017-12-28	Richter Gedeon Nyrt	Eljárás (5alfa,17béta)-N-[2,5-bisz-(trifluormetil)-fenil]-3-oxo-4-aza-5-androszt-1-én-17-karbonsavamid előállítására
CN103554213A (zh) *	2012-01-05	2014-02-05	中国药科大学	4-氧杂-雄甾-3-酮-17β-酰胺类衍生物、其制备方法及其医药用途
CN102532236B (zh) *	2012-01-05	2014-04-16	中国药科大学	甾体类5α-还原酶抑制剂、其制备方法及其医药用途
CN103570796A (zh) *	2012-07-24	2014-02-12	重庆医药工业研究院有限责任公司	一种度他雄胺ⅰ型晶的制备方法

Family Cites Families (38)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4377584A (en) *	1978-04-13	1983-03-22	Merck & Co., Inc.	4-Aza-17β-substituted-5α-androstan-3-one-reductase inhibitors
AU527030B2 (en) *	1978-04-13	1983-02-10	Merck & Co., Inc.	4-aza-17-substituted-5a-androstan-3-ones
US4760071A (en) *	1984-02-27	1988-07-26	Merck & Co., Inc.	17β-N-monosubstituted carbamoyl-4-aza-5α-androst-1-en-3-ones which are active as testosterone 5α-reductase inhibitors
US5049562A (en) *	1984-02-27	1991-09-17	Merck & Co., Inc.	17β-acyl-4-aza-5α-androst-1-ene-3-ones as 5α-reductase inhibitors
US4845104A (en) *	1986-11-20	1989-07-04	Merck & Co., Inc.	Oxidized analogs of 17β-N-monosubstituted-carbamoyl-4-aza-5-α-androstan-3-ones
ATE78827T1 (de) *	1986-11-20	1992-08-15	Merck & Co Inc	Topisches arzneimittel enthaltend 17-beta-methoxy-carbonyl-4-methyl-4-aza-5-alpha androst-1-en-3- one.
US4888336A (en) *	1987-01-28	1989-12-19	Smithkline Beckman Corporation	Steroid 5-alpha-reductase inhibitors
DE3888378T2 (de) *	1987-04-03	1994-09-29	Merck & Co Inc	Behandlung von Prostatacarcinoma mit 17-beta-n-monosubstituierten-Carbamoyl-4-aza-5-alpha-Androst-1-en-3-onen.
ZA883034B (en) *	1987-04-29	1989-03-29	Smithkline Beckman Corp	Steroid 5-alpha-reductase inhibitors
US5084574A (en) *	1988-04-18	1992-01-28	Merck & Co., Inc.	Dehydrogenation process
CA2023157A1 (en) *	1989-08-21	1991-02-22	Gary H. Rasmusson	17 beta-acyl-4-aza-5 alpha-androst-1-ene-3-ones as 5 alpha-reductase inhibitors
US5021575A (en) *	1989-11-13	1991-06-04	Merck & Co., Inc.	Method for introducing a 1,2 double bond into azasteroids
EP0462662A3 (en) *	1990-06-20	1992-08-19	Merck & Co. Inc.	17beta-n-monosubstituted adamantyl/norbornanyl carbamoyl-4-aza-5alpha-androst-1-en-3-ones and androstan-3-ones
US5098908A (en) *	1990-06-20	1992-03-24	Merck & Co., Inc.	17β-hydroxybenzoyl-4-aza-5α-androst-1-en-3-ones as testosterone reductase inhibitors
EP0462664A3 (en) *	1990-06-20	1992-11-25	Merck & Co. Inc.	Specific 17beta-thiobenzoyl-4-aza-5alpha-androst-1-en-3-ones as antiandrogenic agents
IE76452B1 (en) *	1990-10-29	1997-10-22	Sankyo Co	Azasteroid compounds for the treatment of prostatic hypertrophy their preparation and use
NZ241979A (en) *	1991-03-20	1996-01-26	Merck & Co Inc	Treatment of benign prostatic hyperplasia using 5alpha-reductase inhibitor and an alpha1-adrenergic recepter blocker
IL101245A0 (en) *	1991-03-20	1992-11-15	Merck & Co Inc	Pharmaceutical compositions for the treatment of prostatic cancer
AU1893492A (en) *	1991-04-17	1992-11-17	Merck & Co., Inc.	Pharmaceutical combination for the treatment of benign prostatic hyperplasia comtaining a 5 alpha-reductase inhibitor
US5304562A (en) *	1991-10-09	1994-04-19	Ciba-Geigy Corporation	17β-substituted Aza-androstane derivatives
EP0547687A1 (en) *	1991-12-18	1993-06-23	Merck & Co. Inc.	17B-N-Substituted adamantyl/norbonanyl carbamoyl-4-aza-5a-and-rost-1-en-3-ones and androstan-3 ones
JP3164389B2 (ja) *	1991-12-25	2001-05-08	三共株式会社	４−アザステロイド類
US5215894A (en) *	1992-02-25	1993-06-01	Merck & Co., Inc.	Biological process for producing 17β-N-monosubstituted carbamoyl-11-oxo-4-aza-5-α-androst-3-one testosterone-5-α reductase inhibitors
HUT71484A (en) *	1992-05-20	1995-11-28	Merck & Co Inc	Process for producing of 7beta-substituted-4-aza-5alpha-cholestan-ones as 5-alpha-reductase inhibitors and pharmaceuticals compositions containing them
AU668180B2 (en) *	1992-05-20	1996-04-26	Merck & Co., Inc.	17-ethers and thioethers of 4-aza-steroids
ES2149208T3 (es) *	1992-05-20	2000-11-01	Merck & Co Inc	Inhibidores 4-azaesteroides de 5-alfa-reductasa.
DE69326008T2 (de) *	1992-05-20	2000-03-02	Merck & Co., Inc.	17-amino-substituierte 4-azasteroide als 5-alpha-reductase inhibitoren
ATE198601T1 (de) *	1992-05-20	2001-01-15	Merck & Co Inc	Ester derivate von 4-aza-steroiden
AU674145B2 (en) *	1992-05-20	1996-12-12	Merck & Co., Inc.	New 17-ester, amide, and ketone derivatives of 3-oxo-4-azasteroids as 5a-reductase inhibitors
WO1993023039A1 (en) *	1992-05-20	1993-11-25	Merck & Co., Inc.	Substituted 4-aza-5a-androstan-ones as 5a-reductase inhibitors
US5710275A (en) *	1992-05-20	1998-01-20	Merck & Co., Inc.	7β-substituted-4-aza-5α-androstan-3-ones as 5α-reductase inhibitors
US5510351A (en) *	1992-05-20	1996-04-23	Merck & Co., Inc.	Delta-17 and delta-20 olefinic and saturated 17 beta-substituted 4-aza-5 alpha-androstan-ones as 5 alpha reductase inhibitors useful in the prevention and treatment of hyperandrogenic disorders
GB9210880D0 (en) *	1992-05-21	1992-07-08	Smithkline Beecham Corp	Compounds
TW239145B (el) *	1992-05-21	1995-01-21	Endorech Inc
US5693810A (en) *	1992-10-06	1997-12-02	Merck & Co., Inc.	17 β-carboxanilides of 4-aza-5α-androstan-3-ones as 5α-reductase inhibitors
US5468860A (en) *	1992-11-19	1995-11-21	Merck & Co., Inc.	New finasteride processes
TW369521B (en) *	1993-09-17	1999-09-11	Smithkline Beecham Corp	Androstenone derivative
US5512555A (en) *	1994-07-21	1996-04-30	Merck & Co., Inc.	Method of treating sweat-related conditions using finasteride, epristeride and a cholestan-3-one

1994
- 1994-09-03 TW TW083108128A patent/TW408127B/zh active
- 1994-09-13 IS IS4206A patent/IS1726B/is unknown
- 1994-09-16 RU RU96108412A patent/RU2144037C1/ru active
- 1994-09-16 ES ES94928605T patent/ES2110260T3/es not_active Expired - Lifetime
- 1994-09-16 HU HU9600643A patent/HUT74445A/hu unknown
- 1994-09-16 DE DE69421726T patent/DE69421726T2/de not_active Expired - Lifetime
- 1994-09-16 AU AU77980/94A patent/AU685167B2/en not_active Expired
- 1994-09-16 DK DK97200658T patent/DK0783001T3/da active
- 1994-09-16 WO PCT/US1994/010479 patent/WO1995007926A1/en not_active Ceased
- 1994-09-16 EP EP97200658A patent/EP0783001B1/en not_active Expired - Lifetime
- 1994-09-16 FI FI961232A patent/FI961232A7/fi unknown
- 1994-09-16 CN CN94193959A patent/CN1041939C/zh not_active Expired - Fee Related
- 1994-09-16 EP EP94928605A patent/EP0719277B1/en not_active Expired - Lifetime
- 1994-09-16 DK DK94928605T patent/DK0719277T3/da active
- 1994-09-16 DE DE69407422T patent/DE69407422T2/de not_active Expired - Lifetime
- 1994-09-16 CA CA002449679A patent/CA2449679C/en not_active Expired - Fee Related
- 1994-09-16 NZ NZ274059A patent/NZ274059A/en unknown
- 1994-09-16 ES ES97200658T patent/ES2140181T3/es not_active Expired - Lifetime
- 1994-09-16 CA CA002171329A patent/CA2171329C/en not_active Expired - Lifetime
- 1994-09-16 IL IL11097994A patent/IL110979A/xx not_active IP Right Cessation
- 1994-09-16 AT AT94928605T patent/ATE161268T1/de not_active IP Right Cessation
- 1994-09-16 CA CA002478971A patent/CA2478971C/en not_active Expired - Fee Related
- 1994-09-16 AT AT97200658T patent/ATE186733T1/de not_active IP Right Cessation
1996
- 1996-03-15 NO NO961085A patent/NO306510B1/no not_active IP Right Cessation
1997
- 1997-12-18 GR GR970403304T patent/GR3025717T3/el unknown
1998
- 1998-05-14 US US09/079,002 patent/US5977126A/en not_active Expired - Lifetime
1999
- 1999-12-22 GR GR990403332T patent/GR3032198T3/el unknown

Also Published As

Publication number	Publication date
CA2449679A1 (en)	1995-03-23
FI961232L (fi)	1996-03-15
DE69421726T2 (de)	2000-06-29
IS4206A (is)	1995-03-18
HU9600643D0 (en)	1996-05-28
ES2110260T3 (es)	1998-02-01
CA2171329C (en)	2004-11-23
US5977126A (en)	1999-11-02
NZ274059A (en)	1997-12-19
GR3025717T3 (en)	1998-03-31
FI961232A0 (fi)	1996-03-15
HUT74445A (en)	1996-12-30
DK0783001T3 (da)	2000-04-10
IS1726B (is)	1999-09-06
DE69421726D1 (de)	1999-12-23
DE69407422T2 (de)	1998-04-09
FI961232A7 (fi)	1996-03-15
NO306510B1 (no)	1999-11-15
DE69407422D1 (en)	1998-01-29
ATE161268T1 (de)	1998-01-15
ATE186733T1 (de)	1999-12-15
ES2140181T3 (es)	2000-02-16
CA2449679C (en)	2007-10-23
WO1995007926A1 (en)	1995-03-23
CN1041939C (zh)	1999-02-03
IL110979A (en)	1999-08-17
IL110979A0 (en)	1994-11-28
CA2478971A1 (en)	1995-03-23
EP0719277B1 (en)	1997-12-17
RU2144037C1 (ru)	2000-01-10
EP0719277A1 (en)	1996-07-03
EP0783001A1 (en)	1997-07-09
NO961085L (no)	1996-04-22
CN1134155A (zh)	1996-10-23
CA2171329A1 (en)	1995-03-23
NO961085D0 (no)	1996-03-15
DK0719277T3 (da)	1998-08-24
TW408127B (en)	2000-10-11
AU685167B2 (en)	1998-01-15
CA2478971C (en)	2007-10-23
EP0783001B1 (en)	1999-11-17
AU7798094A (en)	1995-04-03

Publication	Publication Date	Title
DE69407422D1 (en)	1998-01-29	Androstenone
PT771794E (pt)	2006-09-29	Compostos heterociclicos contendo oxigenio
EA200100310A1 (ru)	2001-10-22	Кислородсодержащие гетероциклические соединения
DE69505470D1 (de)	1998-11-26	Pyrrolocarbazol
FI900461A0 (fi)	1990-01-30	Imidazopyridaziner, deras framstaellning och anvaendning.
ES2068413T3 (es)	1995-04-16	Derivados de 4-fenilftalazina.
NZ221699A (en)	1990-03-27	Pyridazinone derivatives; pharmaceutical compositions and intermediates
AU7733491A (en)	1991-11-28	Isochromane derivatives
DE69116766D1 (de)	1996-03-14	Thienopyridin-Derivate, deren Herstellung und Verwendung
TW198007B (el)	1993-01-11
IL89942A (en)	1993-07-08	Heterotetracyclic lactam derivatives, their preparation and pharmaceutical compositions containing them
EP0755930A4 (en)	1998-06-10	BENZODIAZEPINES DERIVATIVES, SALTS DERIVED FROM SUCH DERIVATIVES, AND MEDICINAL PRODUCTS BASED ON SUCH DERIVATIVES AND SALTS
DE3665063D1 (en)	1989-09-21	Novel prostacyclins
FI853907L (fi)	1986-04-10	Mellanprodukter foer framstaellning av 16-fenoxi- och 16-substituerade fenoxi-prostatriensyraderivat.