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CY1126007T1 - Προαγωγεις αποπτωσης - Google Patents

Προαγωγεις αποπτωσης

Info

Publication number
CY1126007T1
CY1126007T1 CY20141100757T CY141100757T CY1126007T1 CY 1126007 T1 CY1126007 T1 CY 1126007T1 CY 20141100757 T CY20141100757 T CY 20141100757T CY 141100757 T CY141100757 T CY 141100757T CY 1126007 T1 CY1126007 T1 CY 1126007T1
Authority
CY
Cyprus
Prior art keywords
compounds
promoters
removal
family members
protein family
Prior art date
Application number
CY20141100757T
Other languages
English (en)
Inventor
Milan Bruncko
Hong Ding
Steven W. Elmore
Aaron R. Kunzer
Christopher L. Lynch
William J. Mccellan
Cheol-Min Park
Xiaohong Song
Xilu Wang
Original Assignee
Abbvie Bahamas Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=37695179&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CY1126007(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Abbvie Bahamas Ltd. filed Critical Abbvie Bahamas Ltd.
Publication of CY1126007T1 publication Critical patent/CY1126007T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/155—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/08—Bridged systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Indole Compounds (AREA)
  • Pyrrole Compounds (AREA)

Abstract

Αποκαλύπτονται ενώσεις που αναστέλλουν την δραστικότητα μελών οικογένειας αντιαποπτωτικών πρωτεϊνών, συνθέσεις που περιέχουν τις ενώσεις και μέθοδοι θεραπευτικής αγωγής ασθενειών κατά την διάρκεια των οποίων εκφράζονται ένα ή περισσότερα μέλη οικογένειας αντιαποπτωτικών πρωτεϊνών.
CY20141100757T 2005-05-12 2014-09-17 Προαγωγεις αποπτωσης CY1126007T1 (el)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US68010705P 2005-05-12 2005-05-12
US71861805P 2005-09-20 2005-09-20
PCT/US2006/018799 WO2007040650A2 (en) 2005-05-12 2006-05-12 Apoptosis promoters
US11/432,937 US7390799B2 (en) 2005-05-12 2006-05-12 Apoptosis promoters

Publications (1)

Publication Number Publication Date
CY1126007T1 true CY1126007T1 (el) 2024-02-16

Family

ID=37695179

Family Applications (2)

Application Number Title Priority Date Filing Date
CY20141100757T CY1126007T1 (el) 2005-05-12 2014-09-17 Προαγωγεις αποπτωσης
CY20171101191T CY1119601T1 (el) 2005-05-12 2017-11-14 Προαγωγεις αποπτωσης

Family Applications After (1)

Application Number Title Priority Date Filing Date
CY20171101191T CY1119601T1 (el) 2005-05-12 2017-11-14 Προαγωγεις αποπτωσης

Country Status (20)

Country Link
US (3) US7390799B2 (el)
EP (2) EP2757099B1 (el)
JP (1) JP5132550B2 (el)
KR (3) KR101533268B1 (el)
CN (2) CN101175738B (el)
AU (2) AU2006297853B2 (el)
BR (1) BRPI0610108B8 (el)
CA (1) CA2606147C (el)
CY (2) CY1126007T1 (el)
DK (1) DK1888550T3 (el)
ES (1) ES2493466T3 (el)
IL (1) IL186141A (el)
MX (1) MX2007014049A (el)
NZ (2) NZ583758A (el)
PL (2) PL1888550T3 (el)
PT (1) PT1888550E (el)
SI (1) SI1888550T1 (el)
TW (2) TWI337182B (el)
WO (1) WO2007040650A2 (el)
ZA (1) ZA200800279B (el)

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CA2606147C (en) 2011-07-05
TWI337608B (en) 2011-02-21
US7906505B2 (en) 2011-03-15
NZ583758A (en) 2011-02-25
KR20140066798A (ko) 2014-06-02
ZA200800279B (en) 2011-10-26
IL186141A0 (en) 2008-01-20
MX2007014049A (es) 2008-02-11
KR101533268B1 (ko) 2015-07-03
KR20140006086A (ko) 2014-01-15
CY1119601T1 (el) 2018-04-04
TWI337182B (en) 2011-02-11
BRPI0610108B1 (pt) 2020-11-24
AU2006297853B2 (en) 2010-08-19
JP2008540577A (ja) 2008-11-20
AU2010233055B2 (en) 2012-04-26
TW201020248A (en) 2010-06-01
SI1888550T1 (sl) 2014-10-30
CN101928264B (zh) 2012-03-28
EP2757099A1 (en) 2014-07-23
CN101928264A (zh) 2010-12-29
TW200720269A (en) 2007-06-01
US7709467B2 (en) 2010-05-04
WO2007040650A2 (en) 2007-04-12
BRPI0610108A2 (pt) 2010-05-25
PT1888550E (pt) 2014-09-03
PL1888550T3 (pl) 2014-12-31
DK1888550T3 (da) 2014-09-29
PL2757099T3 (pl) 2018-02-28
ES2493466T3 (es) 2014-09-11
CN101175738A (zh) 2008-05-07
EP1888550A2 (en) 2008-02-20
AU2006297853A1 (en) 2007-04-12
IL186141A (en) 2013-08-29
JP5132550B2 (ja) 2013-01-30
KR101391263B1 (ko) 2014-05-02
KR101509440B1 (ko) 2015-04-07
EP2757099B1 (en) 2017-08-23
CN101175738B (zh) 2010-10-27
EP1888550B1 (en) 2014-06-25

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