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CY1119150T1 - ΜΕΘΟΔΟΙ ΓΙΑ ΤΗΝ ΠΑΡΑΣΚΕΥΗ (3R,3aS,6aR) ΕΞΑΫΔΡΟ-ΦΟΥΡΟ[2,3-b]ΦΟΥΡΑΝ-3-ΟΛΗΣ - Google Patents

ΜΕΘΟΔΟΙ ΓΙΑ ΤΗΝ ΠΑΡΑΣΚΕΥΗ (3R,3aS,6aR) ΕΞΑΫΔΡΟ-ΦΟΥΡΟ[2,3-b]ΦΟΥΡΑΝ-3-ΟΛΗΣ

Info

Publication number
CY1119150T1
CY1119150T1 CY20161100809T CY161100809T CY1119150T1 CY 1119150 T1 CY1119150 T1 CY 1119150T1 CY 20161100809 T CY20161100809 T CY 20161100809T CY 161100809 T CY161100809 T CY 161100809T CY 1119150 T1 CY1119150 T1 CY 1119150T1
Authority
CY
Cyprus
Prior art keywords
furo
furan
methods
preparation
hydro
Prior art date
Application number
CY20161100809T
Other languages
English (en)
Inventor
Peter Jan Leonard Mario Quaedflieg
Bart Rudolf Romanie Kesteleyn
Robert Jan Vijn
Constantinus Simon Maria Liebregts
Jacob Hermanus Matheus Hero Kooistra
Franciscus Alphons Marie Lommen
Original Assignee
Janssen Sciences Ireland Uc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34928933&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CY1119150(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Janssen Sciences Ireland Uc filed Critical Janssen Sciences Ireland Uc
Publication of CY1119150T1 publication Critical patent/CY1119150T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D307/18—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/20—Oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Furan Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polyesters Or Polycarbonates (AREA)

Abstract

Η παρούσα εφεύρεση αφορά μεθόδους για την παρασκευή διαστερεομερικώς καθαρής (3R,3aS,6aR) εξαϋδρο-φουρο[2,3-b]φουραν-3-όλης (6) καθώς επίσης ενός νέου ενδιαμέσου, (3aR,4S,6aS) 4-μεθοξυ-τετραϋδρο-φουρο[3,4-b]φουραν-2-όνης (4) για χρήση στις εν λόγω μεθόδους. Πιο συγκεκριμένα η εφεύρεση αφορά μια στερεοεκλεκτική μέθοδο για την παρασκευή διαστερεομερικώς καθαρής (3R,3aS,6aR) εξαϋδρο-φουρο[2,3-b]φουραν-3-όλης, καθώς επίσης μεθόδους για την κρυστάλλωση (3aR,4S,6aS) 4-μεθοξυ-τετραϋδρο-φουρο[3,4-b]φουραν- 2-όνης και για τον επιμερισμό (3aR,4R,6aS) 4-μεθοξυ-τετραϋδρο-φουρο[3,4-b]-φουραν-2-όνης προς τo (3aR,4S,6aS) 4-μεθοξυ-τετραϋδρο-φουρο[3,4-b]φουραν-2-όνη.
CY20161100809T 2004-03-31 2016-08-17 ΜΕΘΟΔΟΙ ΓΙΑ ΤΗΝ ΠΑΡΑΣΚΕΥΗ (3R,3aS,6aR) ΕΞΑΫΔΡΟ-ΦΟΥΡΟ[2,3-b]ΦΟΥΡΑΝ-3-ΟΛΗΣ CY1119150T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP04101336 2004-03-31
PCT/EP2005/051452 WO2005095410A1 (en) 2004-03-31 2005-03-31 METHODS FOR THE PREPARATION OF (3R,3aS,6aR) HEXAHYDRO-FURO[2,3-b]FURAN-3-OL

Publications (1)

Publication Number Publication Date
CY1119150T1 true CY1119150T1 (el) 2018-01-10

Family

ID=34928933

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20161100809T CY1119150T1 (el) 2004-03-31 2016-08-17 ΜΕΘΟΔΟΙ ΓΙΑ ΤΗΝ ΠΑΡΑΣΚΕΥΗ (3R,3aS,6aR) ΕΞΑΫΔΡΟ-ΦΟΥΡΟ[2,3-b]ΦΟΥΡΑΝ-3-ΟΛΗΣ

Country Status (28)

Country Link
US (1) US7595408B2 (el)
EP (1) EP1732931B1 (el)
JP (1) JP4778955B2 (el)
KR (1) KR101135156B1 (el)
CN (1) CN1938316B (el)
AP (1) AP2528A (el)
AU (1) AU2005229435B2 (el)
BR (1) BRPI0509514B1 (el)
CA (1) CA2559959C (el)
CY (1) CY1119150T1 (el)
DK (1) DK1732931T3 (el)
ES (1) ES2587571T3 (el)
HR (1) HRP20161031T1 (el)
HU (1) HUE029886T2 (el)
IL (1) IL178019A (el)
LT (1) LT1732931T (el)
ME (1) ME02525B (el)
NO (1) NO338175B1 (el)
NZ (1) NZ549971A (el)
PL (1) PL1732931T3 (el)
PT (1) PT1732931T (el)
RS (1) RS55011B1 (el)
RU (1) RU2421458C2 (el)
SI (1) SI1732931T1 (el)
TW (1) TWI383975B (el)
UA (1) UA100835C2 (el)
WO (1) WO2005095410A1 (el)
ZA (1) ZA200609008B (el)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL2089371T3 (pl) 2006-11-09 2011-06-30 Janssen Sciences Ireland Uc Sposoby wytwarzania heksahydrofuro[2,3-b]furan-3-olu
CN101024646B (zh) * 2007-02-06 2010-07-14 启东东岳药业有限公司 4-甲氧基呋喃并呋喃-2-酮的纯化方法
SI2152667T1 (sl) 2007-04-27 2011-06-30 Tibotec Pharm Ltd Postopki za pripravo N-izobutil-N(2-hidroksi-3-amino-4-fenilbutil)-p- nitrobenzensulfonilamidnih derivatov
WO2009030733A1 (en) * 2007-09-04 2009-03-12 Dsm Ip Assets B.V. Method for the synthesis of 4-alkoxy-, 4-hydroxy- and 4-aryloxy-substituted tetrahydro-furo[3,4-b]furan-2(3h)-one compounds
KR20110099711A (ko) 2008-12-03 2011-09-08 메사추세츠 인스티튜트 오브 테크놀로지 코팅된 나노구조물에 기초한 다기능성 복합체
US8921415B2 (en) 2009-01-29 2014-12-30 Mapi Pharma Ltd. Polymorphs of darunavir
EP2493891A2 (en) 2009-10-30 2012-09-05 Lupin Limited A novel process for preparation of darunavir and darunavir ethanolate of fine particle size
BR112012018862A2 (pt) 2010-01-28 2015-10-13 Mapi Pharma Ltd processo para a preparação de darunavir e intermediários de darunavir
EP3795572B1 (en) 2012-07-24 2023-11-15 Laurus Labs Limited Darunavir propionate solvate
CN103864813B (zh) * 2012-12-18 2017-02-22 上海迪赛诺化学制药有限公司 一种合成六氢呋喃并[2,3‑b]呋喃‑3‑醇及其对映体的方法
CN104628552A (zh) * 2015-02-09 2015-05-20 许昌豪丰化学科技有限公司 一种新淬灭体系及其应用
WO2017041228A1 (zh) * 2015-09-08 2017-03-16 浙江九洲药业股份有限公司 六氢呋喃并呋喃醇衍生物的制备方法、其中间体及其制备方法
US10407438B2 (en) 2016-10-27 2019-09-10 Gilead Sciences, Inc. Crystalline forms of darunavir
CN110272398B (zh) 2018-03-16 2022-11-29 江苏瑞科医药科技有限公司 六氢呋喃并呋喃醇衍生物的制备方法、其中间体及其制备方法
KR20250150160A (ko) 2019-02-15 2025-10-17 디지렌즈 인코포레이티드. 일체형 격자를 이용하여 홀로그래픽 도파관 디스플레이를 제공하기 위한 방법 및 장치
CN115557964A (zh) * 2022-10-18 2023-01-03 启东东岳药业有限公司 一种药物化合物的制备方法
CN117659033A (zh) * 2023-12-05 2024-03-08 南京杰运医药科技有限公司 一种地瑞那韦中间体的制备方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0427693A1 (en) * 1989-10-11 1991-05-15 Monsanto Company Method for azide displacement of alpha-triflates of 1,5-lactones
EP0715618B1 (en) 1993-08-24 1998-12-16 G.D. Searle & Co. Hydroxyethylamino sulphonamides useful as retroviral protease inhibitors
ATE184594T1 (de) 1994-03-07 1999-10-15 Vertex Pharma Sulfonamidderivate als aspartylprotease- inhibitoren
IN188837B (el) * 1998-05-22 2002-11-09 Torrent Pharmaceuticals Ltd
BR9912169A (pt) 1998-06-19 2001-04-10 Vertex Pharma Inibidores de sulfonamida de protease de aspartil
ATE500823T1 (de) 1998-06-23 2011-03-15 Us Of America Represented By The Secretary Dept Of Health And Human Services Arzneimittel zur behandlung von hiv-infizierten säugetieren
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Also Published As

Publication number Publication date
AU2005229435A1 (en) 2005-10-13
TW200602346A (en) 2006-01-16
SI1732931T1 (sl) 2016-10-28
BRPI0509514A (pt) 2007-09-11
JP2007530638A (ja) 2007-11-01
RU2006138228A (ru) 2008-05-10
BRPI0509514B1 (pt) 2022-09-27
CN1938316A (zh) 2007-03-28
DK1732931T3 (en) 2016-08-29
RU2421458C2 (ru) 2011-06-20
CA2559959C (en) 2013-11-19
JP4778955B2 (ja) 2011-09-21
TWI383975B (zh) 2013-02-01
NO20064977L (no) 2006-10-31
LT1732931T (lt) 2016-09-12
ES2587571T3 (es) 2016-10-25
AU2005229435B2 (en) 2011-07-07
CN1938316B (zh) 2012-12-12
RS55011B1 (sr) 2016-11-30
NO338175B1 (no) 2016-08-01
ME02525B (me) 2017-02-20
NZ549971A (en) 2010-12-24
CA2559959A1 (en) 2005-10-13
US7595408B2 (en) 2009-09-29
BRPI0509514A8 (pt) 2016-02-10
US20070208184A1 (en) 2007-09-06
AP2528A (en) 2012-12-10
KR20070026479A (ko) 2007-03-08
PL1732931T3 (pl) 2016-11-30
KR101135156B1 (ko) 2012-04-23
IL178019A0 (en) 2006-12-31
EP1732931B1 (en) 2016-05-18
WO2005095410A1 (en) 2005-10-13
IL178019A (en) 2014-02-27
AP2006003748A0 (en) 2006-10-31
EP1732931A1 (en) 2006-12-20
UA100835C2 (ru) 2013-02-11
PT1732931T (pt) 2016-07-14
HRP20161031T1 (hr) 2016-10-21
HUE029886T2 (en) 2017-04-28
ZA200609008B (en) 2008-07-30

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