[go: up one dir, main page]

UA100835C2 - СПОСОБ СИНТЕЗА (3R,3aS,6aR)-ГЕКСАГИДРОФУРО[2,3-b]ФУРАН-3-ОЛА, ПРОМЕЖУТОЧНОЕ СОЕДИНЕНИЕ И СПОСОБ ЕГО ПОЛУЧЕНИЯ - Google Patents

СПОСОБ СИНТЕЗА (3R,3aS,6aR)-ГЕКСАГИДРОФУРО[2,3-b]ФУРАН-3-ОЛА, ПРОМЕЖУТОЧНОЕ СОЕДИНЕНИЕ И СПОСОБ ЕГО ПОЛУЧЕНИЯ

Info

Publication number
UA100835C2
UA100835C2 UAA200610289A UAA200610289A UA100835C2 UA 100835 C2 UA100835 C2 UA 100835C2 UA A200610289 A UAA200610289 A UA A200610289A UA A200610289 A UAA200610289 A UA A200610289A UA 100835 C2 UA100835 C2 UA 100835C2
Authority
UA
Ukraine
Prior art keywords
furo
furan
hexahydro
preparation
synthesis
Prior art date
Application number
UAA200610289A
Other languages
English (en)
Ukrainian (uk)
Inventor
Питер Ян Леонар Кваедфлиег
Барт Рудольф Романи Кестелин
Роберт Ян Виджн
Константинус Симон Мария Лиэбрегтс
Якоб Херманус Матеус Херо Кооистра
Францискус Альфонс Мари Ломмен
Original Assignee
Тиботек Фармасьютикелз Лтд.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34928933&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=UA100835(C2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Тиботек Фармасьютикелз Лтд. filed Critical Тиботек Фармасьютикелз Лтд.
Publication of UA100835C2 publication Critical patent/UA100835C2/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D307/18—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/20—Oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Furan Compounds (AREA)
  • Polyesters Or Polycarbonates (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
UAA200610289A 2004-03-31 2005-03-31 СПОСОБ СИНТЕЗА (3R,3aS,6aR)-ГЕКСАГИДРОФУРО[2,3-b]ФУРАН-3-ОЛА, ПРОМЕЖУТОЧНОЕ СОЕДИНЕНИЕ И СПОСОБ ЕГО ПОЛУЧЕНИЯ UA100835C2 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP04101336 2004-03-31
PCT/EP2005/051452 WO2005095410A1 (en) 2004-03-31 2005-03-31 METHODS FOR THE PREPARATION OF (3R,3aS,6aR) HEXAHYDRO-FURO[2,3-b]FURAN-3-OL

Publications (1)

Publication Number Publication Date
UA100835C2 true UA100835C2 (ru) 2013-02-11

Family

ID=34928933

Family Applications (1)

Application Number Title Priority Date Filing Date
UAA200610289A UA100835C2 (ru) 2004-03-31 2005-03-31 СПОСОБ СИНТЕЗА (3R,3aS,6aR)-ГЕКСАГИДРОФУРО[2,3-b]ФУРАН-3-ОЛА, ПРОМЕЖУТОЧНОЕ СОЕДИНЕНИЕ И СПОСОБ ЕГО ПОЛУЧЕНИЯ

Country Status (28)

Country Link
US (1) US7595408B2 (ru)
EP (1) EP1732931B1 (ru)
JP (1) JP4778955B2 (ru)
KR (1) KR101135156B1 (ru)
CN (1) CN1938316B (ru)
AP (1) AP2528A (ru)
AU (1) AU2005229435B2 (ru)
BR (1) BRPI0509514B1 (ru)
CA (1) CA2559959C (ru)
CY (1) CY1119150T1 (ru)
DK (1) DK1732931T3 (ru)
ES (1) ES2587571T3 (ru)
HR (1) HRP20161031T1 (ru)
HU (1) HUE029886T2 (ru)
IL (1) IL178019A (ru)
LT (1) LT1732931T (ru)
ME (1) ME02525B (ru)
NO (1) NO338175B1 (ru)
NZ (1) NZ549971A (ru)
PL (1) PL1732931T3 (ru)
PT (1) PT1732931T (ru)
RS (1) RS55011B1 (ru)
RU (1) RU2421458C2 (ru)
SI (1) SI1732931T1 (ru)
TW (1) TWI383975B (ru)
UA (1) UA100835C2 (ru)
WO (1) WO2005095410A1 (ru)
ZA (1) ZA200609008B (ru)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101541775B (zh) 2006-11-09 2011-12-28 泰博特克药品有限公司 六氢呋喃并[2,3-b]呋喃-3-醇的制备方法
CN101024646B (zh) * 2007-02-06 2010-07-14 启东东岳药业有限公司 4-甲氧基呋喃并呋喃-2-酮的纯化方法
AU2008244306A1 (en) 2007-04-27 2008-11-06 Tibotec Pharmaceuticals Ltd. Methods for the preparation of N-isobutyl-N-(2-hydroxy-3-amino-4-phenylbutyl)-p-nitrobenzenesulfonylamide derivatives
WO2009030733A1 (en) * 2007-09-04 2009-03-12 Dsm Ip Assets B.V. Method for the synthesis of 4-alkoxy-, 4-hydroxy- and 4-aryloxy-substituted tetrahydro-furo[3,4-b]furan-2(3h)-one compounds
WO2010120273A2 (en) 2008-12-03 2010-10-21 Massachusetts Institute Of Technology Multifunctional composites based on coated nanostructures
US8921415B2 (en) 2009-01-29 2014-12-30 Mapi Pharma Ltd. Polymorphs of darunavir
US9062065B2 (en) 2009-10-30 2015-06-23 Lupin Limited Process for preparation of darunavir and darunavir ethanolate of fine particle size
AU2011210349A1 (en) 2010-01-28 2012-07-05 Mapi Pharma Limited Process for the preparation of darunavir and darunavir intermediates
ES2969589T3 (es) 2012-07-24 2024-05-21 Laurus Labs Ltd Solvato de Propionato de Darunavir
CN103864813B (zh) * 2012-12-18 2017-02-22 上海迪赛诺化学制药有限公司 一种合成六氢呋喃并[2,3‑b]呋喃‑3‑醇及其对映体的方法
CN104628552A (zh) * 2015-02-09 2015-05-20 许昌豪丰化学科技有限公司 一种新淬灭体系及其应用
WO2017041228A1 (zh) * 2015-09-08 2017-03-16 浙江九洲药业股份有限公司 六氢呋喃并呋喃醇衍生物的制备方法、其中间体及其制备方法
EP3532478B1 (en) 2016-10-27 2021-05-26 Gilead Sciences, Inc. Crystalline form of darunavir free base
CN116103348A (zh) 2018-03-16 2023-05-12 江苏瑞科医药科技有限公司 六氢呋喃并呋喃醇衍生物的制备方法、其中间体及其制备方法
EP3924759B1 (en) 2019-02-15 2025-07-30 Digilens Inc. Methods and apparatuses for providing a holographic waveguide display using integrated gratings
CN115557964A (zh) * 2022-10-18 2023-01-03 启东东岳药业有限公司 一种药物化合物的制备方法
CN117659033A (zh) * 2023-12-05 2024-03-08 南京杰运医药科技有限公司 一种地瑞那韦中间体的制备方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0427693A1 (en) * 1989-10-11 1991-05-15 Monsanto Company Method for azide displacement of alpha-triflates of 1,5-lactones
EP0715618B1 (en) 1993-08-24 1998-12-16 G.D. Searle & Co. Hydroxyethylamino sulphonamides useful as retroviral protease inhibitors
WO1995024385A1 (en) * 1994-03-07 1995-09-14 Vertex Pharmaceuticals Incorporated Sulphonamide derivatives as aspartyl protease inhibitors
IN188837B (ru) * 1998-05-22 2002-11-09 Torrent Pharmaceuticals Ltd
DK1086076T3 (da) 1998-06-19 2005-03-29 Vertex Pharma Sulfonamidinhibitorer af aspartylprotease
ATE500823T1 (de) 1998-06-23 2011-03-15 Us Of America Represented By The Secretary Dept Of Health And Human Services Arzneimittel zur behandlung von hiv-infizierten säugetieren
ATE311391T1 (de) 1999-02-12 2005-12-15 Vertex Pharma Aspartyl-protease-inhibitoren
AR031520A1 (es) 1999-06-11 2003-09-24 Vertex Pharma Un compuesto inhibidor de aspartilo proteasa, una composicion que lo comprende y un metodo para tratar un paciente con dicha composicion
IL149005A0 (en) 1999-10-06 2002-11-10 Us Gov Health & Human Serv Hexahydrofuro-2', 3-bifuran-3-yl-n-{3'(1, 3-benzodioxol-5-ylsulfonyl) (isobutyl) amino-1-benzyl-2-hydroxypropyl} carbamate as restroviral protease inhibitor
IL160166A0 (en) * 2001-09-10 2004-07-25 Tibotec Pharm Ltd Method for the preparation of hexahydro-furo[2,3-b] furan-3-ol

Also Published As

Publication number Publication date
BRPI0509514B1 (pt) 2022-09-27
AP2528A (en) 2012-12-10
US20070208184A1 (en) 2007-09-06
CA2559959C (en) 2013-11-19
NO338175B1 (no) 2016-08-01
AU2005229435B2 (en) 2011-07-07
JP2007530638A (ja) 2007-11-01
KR101135156B1 (ko) 2012-04-23
BRPI0509514A (pt) 2007-09-11
AU2005229435A1 (en) 2005-10-13
EP1732931B1 (en) 2016-05-18
CN1938316A (zh) 2007-03-28
RU2006138228A (ru) 2008-05-10
NZ549971A (en) 2010-12-24
CN1938316B (zh) 2012-12-12
BRPI0509514A8 (pt) 2016-02-10
WO2005095410A1 (en) 2005-10-13
CY1119150T1 (el) 2018-01-10
CA2559959A1 (en) 2005-10-13
TWI383975B (zh) 2013-02-01
NO20064977L (no) 2006-10-31
AP2006003748A0 (en) 2006-10-31
HUE029886T2 (en) 2017-04-28
JP4778955B2 (ja) 2011-09-21
ES2587571T3 (es) 2016-10-25
RU2421458C2 (ru) 2011-06-20
IL178019A (en) 2014-02-27
SI1732931T1 (sl) 2016-10-28
LT1732931T (lt) 2016-09-12
PT1732931T (pt) 2016-07-14
US7595408B2 (en) 2009-09-29
EP1732931A1 (en) 2006-12-20
DK1732931T3 (en) 2016-08-29
RS55011B1 (sr) 2016-11-30
ZA200609008B (en) 2008-07-30
TW200602346A (en) 2006-01-16
HRP20161031T1 (hr) 2016-10-21
IL178019A0 (en) 2006-12-31
PL1732931T3 (pl) 2016-11-30
ME02525B (me) 2017-02-20
KR20070026479A (ko) 2007-03-08

Similar Documents

Publication Publication Date Title
CY1119150T1 (el) ΜΕΘΟΔΟΙ ΓΙΑ ΤΗΝ ΠΑΡΑΣΚΕΥΗ (3R,3aS,6aR) ΕΞΑΫΔΡΟ-ΦΟΥΡΟ[2,3-b]ΦΟΥΡΑΝ-3-ΟΛΗΣ
IL198270A0 (en) Methods for the preparation of hexahydrofuro[2,3-b]furan-3-ol
IL194122A (en) Process for making (6ar, 3as, 3r) hexahydroporo [3,2– b] furan – 3 – val
WO2003106461A3 (en) Pseudopolymorphic forms of a hiv protease inhibitor
WO2012063126A3 (en) Improved processes for preparing pure (3ar,4s,6r,6as)-6-amino-2,2-dimethyltetrahdro-3ah-cyclopenta[d] [1,3]-dioxol-4-ol and its key starting material
WO2012085665A8 (en) Novel processes for preparing triazolo[4,5-d]pyrimidine derivatives and intermediates thereof
IL211191A (en) Oxalate salt of (3as, 4r, 6s, 6ar) –6– (2– hydroxyethoxy) –2,2 – dimethyl tetrahydro –3 ah– cyclopenta [d] [1,3] dioxol – 4 – amine
MX345562B (es) Analogos de carba-nucleosido para tratamiento antiviral.
HRP20040320A2 (en) Method for the preparation of hexahydro-furo(2,3-b) furan-3-ol
WO2004033462A3 (en) METHOD OF PREPARING (3R, 3aS, 6aR) -3- HYDROXYHEXAHYDROFURO [2, 3-b] FURAN AND RELATED COMPOUNDS
MY155721A (en) A process for the preparation of (3ar, 4s, 6r, 6as)-6-amino-2, 2-dimethyltetrahydro-3ah-cyclopenta[d] [1,3] dioxol-4-ol dibenzoyl-l-tartrate and to products of said process
WO2008034598A8 (en) Method for the synthesis of hexahydrofuro (2, 3-b) furan-3-ol compounds
MY147736A (en) A process and an apparatus for producing episesamin-rich compositions
EP2707363A4 (en) METHOD OF PREPARING BENZYL - [(3AS, 4R, 6S, 6AR-) 6-HYDROXY-2,2-DIMETHYLTETRAHYDRO-3AH-CYCLOPENTA- [D -] [1,3-] DIOXOL -] - 4-YL-] CARBAMATE AND INTERMEDIATE PRODUCTS IN THIS PROCEDURE
FR2876693B1 (fr) Procede de preparation de l-iditol
EP0331404A3 (en) Method for producing tropane alkaloid
EA201400684A1 (ru) Твердые формы (1r,4r)-6'-фтор-(n,n-диметил)-4-фенил-4'9'-дигидро-3'н-спиро-[циклогексан-1,1'-пирано-[3,4,b]индол]-4-амина и серной кислоты
SG166119A1 (en) A process and an apparatus for producing episesamin-rich compositions
WO2010151476A3 (en) Crystalline forms of (3r, 3as, 6ar) - hexahydrofuro [2,3-b] furan-3-yl (1s,2r) - (1-{4-[ (diethoxyphosphoryl) methoxy] pheny1}-3-hydroxy-4- [4-methoxy-n- (2-methylpropyl) benzenesul - fonamido] butan-2-yl) carbamate
LT2643326T (lt) (3r,3as,6ar)-heksahidrofuro[2,3-b]furan-3-olio gavimo būdas
HK1146408A (en) A process for the preparation of (3ar,4s, 6r, 6as)-6-amino-2, 2-dimethyltetrahydro-3ah-cyclopenta[d] [1,3] dioxol-4-ol dibenzoyl-l-tartrate and to products of said process