SI2152667T1 - Postopki za pripravo N-izobutil-N(2-hidroksi-3-amino-4-fenilbutil)-p- nitrobenzensulfonilamidnih derivatov - Google Patents
Postopki za pripravo N-izobutil-N(2-hidroksi-3-amino-4-fenilbutil)-p- nitrobenzensulfonilamidnih derivatovInfo
- Publication number
- SI2152667T1 SI2152667T1 SI200830232T SI200830232T SI2152667T1 SI 2152667 T1 SI2152667 T1 SI 2152667T1 SI 200830232 T SI200830232 T SI 200830232T SI 200830232 T SI200830232 T SI 200830232T SI 2152667 T1 SI2152667 T1 SI 2152667T1
- Authority
- SI
- Slovenia
- Prior art keywords
- hydroxy
- phenylbutyl
- isobutyl
- amino
- preparation
- Prior art date
Links
- RXZQKCYDYRLICS-UHFFFAOYSA-N [3-hydroxy-4-(2-methylpropylamino)-1-phenylbutan-2-yl]carbamic acid Chemical class CC(C)CNCC(O)C(NC(O)=O)CC1=CC=CC=C1 RXZQKCYDYRLICS-UHFFFAOYSA-N 0.000 abstract 1
- -1 p-nitrophenylsulfonyl halide Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
- C07C303/36—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of amides of sulfonic acids
- C07C303/38—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of amides of sulfonic acids by reaction of ammonia or amines with sulfonic acids, or with esters, anhydrides, or halides thereof
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP07107177 | 2007-04-27 | ||
| PCT/EP2008/055042 WO2008132154A1 (en) | 2007-04-27 | 2008-04-25 | Methods for the preparation of n-isobutyl-n-(2-hydroxy-3-amino-4-phenylbutyl)-p-nitrobenzenesulfonylamide derivatives |
| EP08749718A EP2152667B1 (en) | 2007-04-27 | 2008-04-25 | Methods for the preparation of n-isobutyl-n-(2-hydroxy-3-amino-4-phenylbutyl)-p-nitrobenzenesulfonylamide derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SI2152667T1 true SI2152667T1 (sl) | 2011-06-30 |
Family
ID=38924830
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SI200830232T SI2152667T1 (sl) | 2007-04-27 | 2008-04-25 | Postopki za pripravo N-izobutil-N(2-hidroksi-3-amino-4-fenilbutil)-p- nitrobenzensulfonilamidnih derivatov |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US8076513B2 (sl) |
| EP (1) | EP2152667B1 (sl) |
| JP (1) | JP2010525029A (sl) |
| CN (1) | CN101668734A (sl) |
| AT (1) | ATE498606T1 (sl) |
| AU (1) | AU2008244306A1 (sl) |
| BR (1) | BRPI0810609A2 (sl) |
| CA (1) | CA2682616A1 (sl) |
| CY (1) | CY1111457T1 (sl) |
| DE (1) | DE602008005012D1 (sl) |
| DK (1) | DK2152667T3 (sl) |
| ES (1) | ES2360654T3 (sl) |
| HR (1) | HRP20110290T1 (sl) |
| IL (1) | IL200811A0 (sl) |
| MX (1) | MX2009011574A (sl) |
| PL (1) | PL2152667T3 (sl) |
| PT (1) | PT2152667E (sl) |
| RU (1) | RU2009143867A (sl) |
| SI (1) | SI2152667T1 (sl) |
| WO (1) | WO2008132154A1 (sl) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8921415B2 (en) | 2009-01-29 | 2014-12-30 | Mapi Pharma Ltd. | Polymorphs of darunavir |
| ES2516916T3 (es) | 2010-01-28 | 2014-10-31 | Mapi Pharma Limited | Procedimiento para la preparación de darunavir e intermedios de darunavir |
| US20130211108A1 (en) * | 2010-06-18 | 2013-08-15 | Mylan Laboratories Ltd | Novel process for the preparation of (3s)-tetrahydrofuran-3-yl (is, 2r)-3-[[(4-aminophenyl) sulfonyl] (isobutyl) amino]-1-benzyl-2-(phosphonooxy) propylcarbamate and its pharmaceutically acceptable salts |
| PL2643326T3 (pl) | 2010-11-23 | 2017-06-30 | Mylan Laboratories, Limited | Sposób przygotowania (3R, 3aS, 6aR)-heksahydrofuro[2,3-b]furan-3-olu |
| CN105315178B (zh) * | 2014-07-09 | 2018-07-06 | 浙江九洲药业股份有限公司 | 达芦那韦相关物质及其制备方法 |
| CN114685322B (zh) * | 2020-12-30 | 2023-08-25 | 上海飞腾医药科技有限公司 | 一种抗hiv类药物中间体晶体的生长方法和所得晶体及其应用 |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3000377A1 (de) * | 1980-01-07 | 1981-07-09 | Boehringer Mannheim Gmbh, 6800 Mannheim | Neue sulfonamide, verfahren zu deren herstellung sowie diese verbindungen enthaltende arzneimittel |
| JPH07110846B2 (ja) * | 1987-12-23 | 1995-11-29 | アグロカネショウ株式会社 | 置換ベンジルスルホアミド誘導体、その製法及び選択性除草剤 |
| ES2177868T3 (es) | 1992-08-25 | 2002-12-16 | Searle & Co | Hidroxietilaminosulfonamidas de alfa- y beta-aminoacidos utiles como inhibidores de proteasas retroviricas. |
| IS2334B (is) | 1992-09-08 | 2008-02-15 | Vertex Pharmaceuticals Inc., (A Massachusetts Corporation) | Aspartyl próteasi hemjari af nýjum flokki súlfonamíða |
| ATE174587T1 (de) | 1993-08-24 | 1999-01-15 | Searle & Co | Hydroxyaminosulfonamide verwendbar als inhibitoren retroviraler proteasen |
| JP3665343B2 (ja) | 1995-02-03 | 2005-06-29 | 株式会社カネカ | α−ハロケトン、α−ハロヒドリン及びエポキシドの製造法 |
| CA2236236A1 (en) | 1995-11-15 | 1997-05-22 | G.D. Searle & Co. | Substituted sulfonylalkanoylamino hydroxyethylamino sulfonamide retroviral protease inhibitors |
| PT1086076E (pt) | 1998-06-19 | 2005-05-31 | Vertex Pharma | Inibidores de sulfonamida de aspartil protease |
| WO1999067254A2 (en) | 1998-06-23 | 1999-12-29 | The United States Of America Represented By The Secretary, Department Of Health And Human Services | Multi-drug resistant retroviral protease inhibitors and use thereof |
| ES2362404T5 (es) | 1998-06-23 | 2015-11-25 | The United States Of America, Represented By The Secretary, Department Of Health And Human Services | Ensayo de aptitud y métodos para reducir la resistencia del VIH a terapia |
| ATE269314T1 (de) | 1998-08-25 | 2004-07-15 | Kaneka Corp | Verfahren zur herstellung von (2r, 3s)-amino-1,2- oxiran |
| US6344572B1 (en) | 1999-01-29 | 2002-02-05 | Kaneka Corporation | Processes for the preparation of threo-1,2-epoxy-3-amino-4-phenylbutane derivatives |
| WO2000047551A2 (en) | 1999-02-12 | 2000-08-17 | Vertex Pharmaceuticals Incorporated | Inhibitors of aspartyl protease |
| AR031520A1 (es) | 1999-06-11 | 2003-09-24 | Vertex Pharma | Un compuesto inhibidor de aspartilo proteasa, una composicion que lo comprende y un metodo para tratar un paciente con dicha composicion |
| KR100708221B1 (ko) | 1999-08-31 | 2007-04-17 | 아지노모토 가부시키가이샤 | 에폭사이드 결정의 제조방법 |
| EP2314563A3 (en) * | 1999-12-23 | 2012-04-04 | Ampac Fine Chemicals LLC | Improved preparation of 2S,3S-N-isobutyl-N-(2-hydroxy-3-amino-4-phenylbutyl)-p-nitrobenzenesulfonylamide hydrochloride and other derivatives of 2-hydroxy-1,3-diamines |
| KR20020046948A (ko) | 2000-12-12 | 2002-06-21 | 에가시라 구니오 | 에폭사이드 결정의 제조방법 |
| JP2002332270A (ja) * | 2001-03-07 | 2002-11-22 | Ajinomoto Co Inc | スルホンアミド誘導体の製造方法 |
| CN100519561C (zh) | 2001-09-10 | 2009-07-29 | 泰博特克药品有限公司 | 制备六氢-呋喃并[2,3-b]呋喃-3-醇的方法 |
| AU2003287038A1 (en) | 2002-10-09 | 2004-05-04 | The Board Of Trustees Of The University Of Illinois | METHOD OF PREPARING (3R, 3aS, 6aR) -3- HYDROXYHEXAHYDROFURO (2, 3-b) FURAN AND RELATED COMPOUNDS |
| AU2003275675A1 (en) * | 2002-12-27 | 2004-07-29 | Sumitomo Chemical Company, Limited | Process for producing hexahydrofurofuranol derivative, intermediate thereof and process for producing the same |
| UA79404C2 (en) * | 2003-10-02 | 2007-06-11 | Basf Ag | 2-cyanobenzenesulfonamide for controlling pests |
| KR101192859B1 (ko) * | 2003-12-23 | 2012-10-19 | 얀센 알 앤드 디 아일랜드 | （3ｒ,3ａｓ,6ａｒ）-헥사하이드로푸로〔2,3-ｂ〕푸란-3-일（1ｓ,2ｒ）-3-〔〔（4-아미노페닐）설포닐〕（이소부틸）아미노〕-1-벤질-2-하이드록시프로필카바메이트의 제조방법 |
| TWI383975B (zh) | 2004-03-31 | 2013-02-01 | 悌柏泰克醫藥有限公司 | 製備（３Ｒ，３ａＳ，６ａＲ）六氫-呋喃并〔２，３-ｂ〕呋喃-３-醇之方法 |
-
2008
- 2008-04-25 ES ES08749718T patent/ES2360654T3/es active Active
- 2008-04-25 BR BRPI0810609-6A2A patent/BRPI0810609A2/pt not_active IP Right Cessation
- 2008-04-25 DE DE602008005012T patent/DE602008005012D1/de active Active
- 2008-04-25 CA CA002682616A patent/CA2682616A1/en not_active Abandoned
- 2008-04-25 AU AU2008244306A patent/AU2008244306A1/en not_active Abandoned
- 2008-04-25 RU RU2009143867/04A patent/RU2009143867A/ru not_active Application Discontinuation
- 2008-04-25 PT PT08749718T patent/PT2152667E/pt unknown
- 2008-04-25 AT AT08749718T patent/ATE498606T1/de active
- 2008-04-25 HR HR20110290T patent/HRP20110290T1/hr unknown
- 2008-04-25 SI SI200830232T patent/SI2152667T1/sl unknown
- 2008-04-25 DK DK08749718.6T patent/DK2152667T3/da active
- 2008-04-25 JP JP2010504703A patent/JP2010525029A/ja active Pending
- 2008-04-25 MX MX2009011574A patent/MX2009011574A/es active IP Right Grant
- 2008-04-25 PL PL08749718T patent/PL2152667T3/pl unknown
- 2008-04-25 CN CN200880013559A patent/CN101668734A/zh active Pending
- 2008-04-25 WO PCT/EP2008/055042 patent/WO2008132154A1/en not_active Ceased
- 2008-04-25 EP EP08749718A patent/EP2152667B1/en not_active Not-in-force
- 2008-04-25 US US12/597,088 patent/US8076513B2/en not_active Expired - Fee Related
-
2009
- 2009-09-08 IL IL200811A patent/IL200811A0/en unknown
-
2011
- 2011-05-16 CY CY20111100463T patent/CY1111457T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ES2360654T3 (es) | 2011-06-08 |
| PL2152667T3 (pl) | 2011-06-30 |
| EP2152667B1 (en) | 2011-02-16 |
| EP2152667A1 (en) | 2010-02-17 |
| ATE498606T1 (de) | 2011-03-15 |
| HRP20110290T1 (hr) | 2011-05-31 |
| RU2009143867A (ru) | 2011-06-10 |
| US8076513B2 (en) | 2011-12-13 |
| WO2008132154A1 (en) | 2008-11-06 |
| PT2152667E (pt) | 2011-04-06 |
| US20100121094A1 (en) | 2010-05-13 |
| CN101668734A (zh) | 2010-03-10 |
| CY1111457T1 (el) | 2015-08-05 |
| DK2152667T3 (da) | 2011-05-16 |
| BRPI0810609A2 (pt) | 2014-10-21 |
| JP2010525029A (ja) | 2010-07-22 |
| IL200811A0 (en) | 2010-05-17 |
| AU2008244306A1 (en) | 2008-11-06 |
| DE602008005012D1 (de) | 2011-03-31 |
| MX2009011574A (es) | 2009-11-09 |
| CA2682616A1 (en) | 2008-11-06 |
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