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CY1111457T1 - Μεθοδοι για την παρασκευη παραγωγων ν-ισοβουτυλ-ν-(2-υδροξυ-3-αμινο-4-φαινυλβουτυλ)-ρ-νιτροβενζολοσουλφονυλαμιδιου - Google Patents

Μεθοδοι για την παρασκευη παραγωγων ν-ισοβουτυλ-ν-(2-υδροξυ-3-αμινο-4-φαινυλβουτυλ)-ρ-νιτροβενζολοσουλφονυλαμιδιου

Info

Publication number
CY1111457T1
CY1111457T1 CY20111100463T CY111100463T CY1111457T1 CY 1111457 T1 CY1111457 T1 CY 1111457T1 CY 20111100463 T CY20111100463 T CY 20111100463T CY 111100463 T CY111100463 T CY 111100463T CY 1111457 T1 CY1111457 T1 CY 1111457T1
Authority
CY
Cyprus
Prior art keywords
hydroxy
isobutyl
preparation
nitrobenzolsulfonylide
fenylbutyl
Prior art date
Application number
CY20111100463T
Other languages
English (en)
Inventor
Hartmut Burghard Zinser
Peter Hermann Hölzle
Original Assignee
Tibotec Pharmaceuticals
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tibotec Pharmaceuticals filed Critical Tibotec Pharmaceuticals
Publication of CY1111457T1 publication Critical patent/CY1111457T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
    • C07C303/36—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of amides of sulfonic acids
    • C07C303/38—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of amides of sulfonic acids by reaction of ammonia or amines with sulfonic acids, or with esters, anhydrides, or halides thereof

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Μία διαδικασία για την παρασκευή παραγώγων Ν-ισοβουτυλ-Ν-(2-υδροξυ-3-αμινο-4-φαινυλβουτυλ)-p-νιτροβενζολοσουλφονυλαμιδίου (I) στα οποία το παράγωγο 1-βενζυλ-2-υδροξυ-3-ισοβουτυλαμίνης (II) αντιδρά μ' ένα p-νιτροφαινυλσουλφονυλ αλογονίδιο (III) σ' ένα διαλύτη που συμπεριλαμβάνει μία δευτεροταγή ή τριτοταγή αλκοόλη.
CY20111100463T 2007-04-27 2011-05-16 Μεθοδοι για την παρασκευη παραγωγων ν-ισοβουτυλ-ν-(2-υδροξυ-3-αμινο-4-φαινυλβουτυλ)-ρ-νιτροβενζολοσουλφονυλαμιδιου CY1111457T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP07107177 2007-04-27
EP08749718A EP2152667B1 (en) 2007-04-27 2008-04-25 Methods for the preparation of n-isobutyl-n-(2-hydroxy-3-amino-4-phenylbutyl)-p-nitrobenzenesulfonylamide derivatives

Publications (1)

Publication Number Publication Date
CY1111457T1 true CY1111457T1 (el) 2015-08-05

Family

ID=38924830

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20111100463T CY1111457T1 (el) 2007-04-27 2011-05-16 Μεθοδοι για την παρασκευη παραγωγων ν-ισοβουτυλ-ν-(2-υδροξυ-3-αμινο-4-φαινυλβουτυλ)-ρ-νιτροβενζολοσουλφονυλαμιδιου

Country Status (20)

Country Link
US (1) US8076513B2 (el)
EP (1) EP2152667B1 (el)
JP (1) JP2010525029A (el)
CN (1) CN101668734A (el)
AT (1) ATE498606T1 (el)
AU (1) AU2008244306A1 (el)
BR (1) BRPI0810609A2 (el)
CA (1) CA2682616A1 (el)
CY (1) CY1111457T1 (el)
DE (1) DE602008005012D1 (el)
DK (1) DK2152667T3 (el)
ES (1) ES2360654T3 (el)
HR (1) HRP20110290T1 (el)
IL (1) IL200811A0 (el)
MX (1) MX2009011574A (el)
PL (1) PL2152667T3 (el)
PT (1) PT2152667E (el)
RU (1) RU2009143867A (el)
SI (1) SI2152667T1 (el)
WO (1) WO2008132154A1 (el)

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Publication number Priority date Publication date Assignee Title
US8921415B2 (en) 2009-01-29 2014-12-30 Mapi Pharma Ltd. Polymorphs of darunavir
BR112012018862A2 (pt) 2010-01-28 2015-10-13 Mapi Pharma Ltd processo para a preparação de darunavir e intermediários de darunavir
WO2011158259A1 (en) * 2010-06-18 2011-12-22 Matrix Laboratories Ltd Novel process for the preparation of (3s)-tetrahydrofuran-3-yl (is, 2r)-3-[[(4-aminophenyl) sulfonyl] (isobutyl) amino]-1-benzyl-2-(phosphonooxy) propylcarbamate and its pharmaceutically acceptable salts thereof
WO2012070057A1 (en) 2010-11-23 2012-05-31 Matrix Laboratories Ltd Process for the preparation of (3r, 3as, 6ar)-hexahydrofuro [2, 3- b] furan-3-ol
CN105315178B (zh) * 2014-07-09 2018-07-06 浙江九洲药业股份有限公司 达芦那韦相关物质及其制备方法
CN118026896A (zh) * 2020-12-30 2024-05-14 上海飞腾医药科技有限公司 抗hiv类药物中间体晶体的生长方法和所得晶体

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JPH07110846B2 (ja) * 1987-12-23 1995-11-29 アグロカネショウ株式会社 置換ベンジルスルホアミド誘導体、その製法及び選択性除草剤
ES2123065T3 (es) 1992-08-25 1999-01-01 Searle & Co Hidroxietilamino-sulfonamidas utiles como inhibidores de proteasas retroviricas.
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DE69616446T2 (de) 1995-02-03 2002-05-16 Kaneka Corp., Osaka Verfahren zur herstellung von alpha-haloketonen, alpha-halohydrinen und epoxiden
AU7722296A (en) 1995-11-15 1997-06-05 G.D. Searle & Co. Substituted sulfonylalkanoylamino hydroxyethylamino sulfonamide retroviral protease inhibitors
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WO2001046120A1 (en) 1999-12-23 2001-06-28 Aerojet Fine Chemicals Llc Improved preparation of 2s,3s-n-isobutyl-n-(2-hydroxy-3-amino-4-phenylbutyl)-p-nitrobenzenesulfonylamide hydrochloride and other derivatives of 2-hydroxy-1,3-diamines
KR20020046948A (ko) 2000-12-12 2002-06-21 에가시라 구니오 에폭사이드 결정의 제조방법
JP2002332270A (ja) * 2001-03-07 2002-11-22 Ajinomoto Co Inc スルホンアミド誘導体の製造方法
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AU2003275675A1 (en) 2002-12-27 2004-07-29 Sumitomo Chemical Company, Limited Process for producing hexahydrofurofuranol derivative, intermediate thereof and process for producing the same
UA79404C2 (en) * 2003-10-02 2007-06-11 Basf Ag 2-cyanobenzenesulfonamide for controlling pests
AU2004309122B2 (en) * 2003-12-23 2011-07-21 Janssen Sciences Ireland Unlimited Company Process for the preparation of (3R,3aS,6AR)-hexahydrofuro [2,3-b] furan-3-yl (1S,2R)-3-[[(4-aminophenyl) sulfonyl] (isobutyl) amino]-1-benzyl-2-hydroxypropylcarbamate
TWI383975B (zh) 2004-03-31 2013-02-01 悌柏泰克醫藥有限公司 製備（３Ｒ，３ａＳ，６ａＲ）六氫-呋喃并〔２，３-ｂ〕呋喃-３-醇之方法

Also Published As

Publication number Publication date
US8076513B2 (en) 2011-12-13
SI2152667T1 (sl) 2011-06-30
DE602008005012D1 (de) 2011-03-31
IL200811A0 (en) 2010-05-17
HRP20110290T1 (hr) 2011-05-31
ATE498606T1 (de) 2011-03-15
EP2152667B1 (en) 2011-02-16
RU2009143867A (ru) 2011-06-10
EP2152667A1 (en) 2010-02-17
US20100121094A1 (en) 2010-05-13
CA2682616A1 (en) 2008-11-06
PL2152667T3 (pl) 2011-06-30
DK2152667T3 (da) 2011-05-16
AU2008244306A1 (en) 2008-11-06
CN101668734A (zh) 2010-03-10
BRPI0810609A2 (pt) 2014-10-21
JP2010525029A (ja) 2010-07-22
ES2360654T3 (es) 2011-06-08
WO2008132154A1 (en) 2008-11-06
PT2152667E (pt) 2011-04-06
MX2009011574A (es) 2009-11-09

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