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UA97619C2 - Гидрогалогенидный комплекс агомелатина и способ его получения - Google Patents

Гидрогалогенидный комплекс агомелатина и способ его получения

Info

Publication number
UA97619C2
UA97619C2 UAA201111232A UAA201111232A UA97619C2 UA 97619 C2 UA97619 C2 UA 97619C2 UA A201111232 A UAA201111232 A UA A201111232A UA A201111232 A UAA201111232 A UA A201111232A UA 97619 C2 UA97619 C2 UA 97619C2
Authority
UA
Ukraine
Prior art keywords
preparation
agomelatine
hydrohalide complex
complex
product
Prior art date
Application number
UAA201111232A
Other languages
English (en)
Ukrainian (uk)
Inventor
Пенг Жанг
Ханбин Шан
Жедонг Йуан
Ксудонг Джианг
Йу Хуанг
Хубо Ванг
Ксуфенг Као
Ксингдонг Ченг
Хонгджуан Пан
Ксионг Йу
Original Assignee
Ле Лаборатуар Сервье
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40878634&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=UA97619(C2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Ле Лаборатуар Сервье filed Critical Ле Лаборатуар Сервье
Publication of UA97619C2 publication Critical patent/UA97619C2/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/16—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
    • C07C233/17—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C07C233/18—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C01—INORGANIC CHEMISTRY
    • C01B—NON-METALLIC ELEMENTS; COMPOUNDS THEREOF; METALLOIDS OR COMPOUNDS THEREOF NOT COVERED BY SUBCLASS C01C
    • C01B7/00—Halogens; Halogen acids
    • C01B7/01—Chlorine; Hydrogen chloride
    • C—CHEMISTRY; METALLURGY
    • C01—INORGANIC CHEMISTRY
    • C01B—NON-METALLIC ELEMENTS; COMPOUNDS THEREOF; METALLOIDS OR COMPOUNDS THEREOF NOT COVERED BY SUBCLASS C01C
    • C01B7/00—Halogens; Halogen acids
    • C01B7/09—Bromine; Hydrogen bromide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Данное изобретение касается гидрогалогенидного комплекса агомелатина и способа его получения. Гидрогалогенидный комплекс агомелатина, полученный с помощью данного способа, является более растворимым, более стабильным и имеет лучшую степень чистоты, чем агомелатин сам по себе, что делает его более пригодным для применения в фармацевтических препаратах. Используя раскрытый способ, продукт с лучшей степенью чистоты могут получать с помощью неосложненного способа без привлечения дополнительных трудных этапов.
UAA201111232A 2009-02-27 2010-02-26 Гидрогалогенидный комплекс агомелатина и способ его получения UA97619C2 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN2009100467821A CN101481321B (zh) 2009-02-27 2009-02-27 阿戈美拉汀卤化氢复合物及其制备方法
PCT/CN2010/070780 WO2010097052A1 (zh) 2009-02-27 2010-02-26 阿戈美拉汀卤化氢复合物及其制备方法

Publications (1)

Publication Number Publication Date
UA97619C2 true UA97619C2 (ru) 2012-02-27

Family

ID=40878634

Family Applications (1)

Application Number Title Priority Date Filing Date
UAA201111232A UA97619C2 (ru) 2009-02-27 2010-02-26 Гидрогалогенидный комплекс агомелатина и способ его получения

Country Status (36)

Country Link
US (1) US8524949B2 (ru)
EP (1) EP2418195B1 (ru)
JP (1) JP5426693B2 (ru)
KR (1) KR101284202B1 (ru)
CN (1) CN101481321B (ru)
AP (1) AP3048A (ru)
AU (1) AU2010217082B2 (ru)
BR (1) BRPI1008767B1 (ru)
CA (1) CA2753449C (ru)
CL (1) CL2011002090A1 (ru)
CO (1) CO6420335A2 (ru)
CR (1) CR20110446A (ru)
CU (1) CU20110163A7 (ru)
CY (1) CY1117100T1 (ru)
DK (1) DK2418195T3 (ru)
EA (1) EA021939B1 (ru)
EC (1) ECSP11011290A (ru)
ES (1) ES2530730T3 (ru)
GE (1) GEP20156221B (ru)
HN (1) HN2011002291A (ru)
HR (1) HRP20150072T1 (ru)
IL (1) IL214682A (ru)
MA (1) MA33063B1 (ru)
MX (1) MX2011008946A (ru)
MY (1) MY154015A (ru)
NI (1) NI201100163A (ru)
NZ (1) NZ594773A (ru)
PE (1) PE20120652A1 (ru)
PL (1) PL2418195T3 (ru)
PT (1) PT2418195E (ru)
RS (1) RS53751B1 (ru)
SG (1) SG173691A1 (ru)
SI (1) SI2418195T1 (ru)
UA (1) UA97619C2 (ru)
WO (1) WO2010097052A1 (ru)
ZA (1) ZA201106048B (ru)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102106806B (zh) * 2009-12-29 2013-04-17 上海中西制药有限公司 一种固体制剂的制备方法及所得固体制剂
CN102190595A (zh) * 2010-03-17 2011-09-21 上海医药工业研究院 阿戈美拉汀溴化氢水合物及其制备方法
CN102190594A (zh) 2010-03-17 2011-09-21 上海医药工业研究院 阿戈美拉汀氯化氢水合物及其制备方法
CN101870662B (zh) * 2010-05-21 2013-03-20 中山大学 结晶型阿戈美拉汀溶剂化物及其制备方法
WO2012046253A2 (en) * 2010-10-08 2012-04-12 Msn Laboratories Limited Process for the preparation of n-[2- (7-methoxy-l-naphthyl) ethyl] acetamide and its novel crystalline forms
PL2517700T3 (pl) * 2011-04-28 2013-12-31 Zentiva Ks Farmaceutyczne dopuszczalne kokryształy n-[2-(7-metoksy-1-naftylo]acetamidu i sposoby ich wytwarzania
EP2551257A1 (en) * 2011-07-28 2013-01-30 Laboratorios Del. Dr. Esteve, S.A. Co-crystals of agomelatine with co-crystal-formers
FR2978916B1 (fr) 2011-08-10 2013-07-26 Servier Lab Composition pharmaceutique solide pour administration buccale d'agomelatine
CN102702008B (zh) * 2012-06-03 2014-05-28 上海右手医药科技开发有限公司 阿戈美拉汀硫酸复合物及其制备方法
CN102702041B (zh) * 2012-05-14 2013-08-14 上海右手医药科技开发有限公司 阿戈美拉汀苯磺酸类复合物及其制备方法
EP2851363B1 (en) * 2012-05-14 2018-01-03 Shanghai Righthand Pharmtech. Co., Ltd. Agomelatine acid radical composite, and preparation method and application thereof
CN102718675B (zh) * 2012-06-07 2015-03-25 上海右手医药科技开发有限公司 阿戈美拉汀甲磺酸复合物及其制备方法
ES2590908T3 (es) * 2012-12-17 2016-11-24 Dr. Reddy's Laboratories Ltd. Cocristal de agomelatina con ácido fosfórico
WO2014096373A1 (en) 2012-12-21 2014-06-26 Laboratorios Lesvi, S. L. Process for prepararing n-(2-(7-methoxy-1-naphthalenyl)ethyl) acetamide and solid forms thereof
FR3001894A1 (fr) 2013-02-08 2014-08-15 Servier Lab Composition pharmaceutique solide pour administration buccale d'agomelatine
EA031237B1 (ru) * 2013-07-29 2018-12-28 Ле Лаборатуар Сервье Новые комплексы агомелатина и сульфокислот, способ их получения и фармацевтические композиции, которые их содержат
MX369301B (es) * 2013-07-31 2019-11-05 Servier Lab Nuevas formas de co-cristales de agomelatina y de acido p-toluenosulfonico, su procedimiento de preparacion y las composiciones farmaceuticas que las contienen.

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2658818B1 (fr) * 1990-02-27 1993-12-31 Adir Cie Nouveaux derives a structure naphtalenique, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
FR2778662B1 (fr) * 1998-05-12 2000-06-16 Adir Nouveaux composes cycliques substitues, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR2795326B1 (fr) * 1999-06-28 2001-08-31 Adir Composition pharmaceutique solide thermoformable a liberation controlee
JP4522851B2 (ja) 2002-05-24 2010-08-11 バイエル・クロツプサイエンス・アクチエンゲゼルシヤフト チオアルキルアミン誘導体の調製方法
WO2005068413A1 (ja) * 2004-01-15 2005-07-28 Tosoh Corporation フルオレン基を母核とするアミン化合物、該アミン化合物の製造方法及び該アミン化合物の用途
FR2866335B1 (fr) 2004-02-13 2006-05-26 Servier Lab Nouveau procede de synthese de l'agomelatine
FR2889523B1 (fr) * 2005-08-03 2007-12-28 Servier Lab Nouvelle forme cristalline v de l'agomelatine, son procede de preparation et les compositions pharmaceutiques qui la contiennent
FR2899472B1 (fr) * 2006-04-07 2008-09-12 Servier Lab Utilisation de l'agomelatine pour l'obtention de medicaments destines au traitement du trouble anxiete generalisee

Also Published As

Publication number Publication date
AP2011005845A0 (en) 2011-08-31
JP2012519155A (ja) 2012-08-23
CA2753449C (en) 2014-01-07
HRP20150072T1 (xx) 2015-03-13
PT2418195E (pt) 2014-12-26
MY154015A (en) 2015-04-30
ECSP11011290A (es) 2011-09-30
HN2011002291A (es) 2014-04-07
CY1117100T1 (el) 2017-04-05
KR101284202B1 (ko) 2013-07-09
WO2010097052A1 (zh) 2010-09-02
CA2753449A1 (en) 2010-09-02
ES2530730T3 (es) 2015-03-05
BRPI1008767B1 (pt) 2021-06-15
AU2010217082B2 (en) 2012-05-03
NZ594773A (en) 2013-03-28
EP2418195A4 (en) 2013-01-16
DK2418195T3 (en) 2015-03-02
MX2011008946A (es) 2011-09-27
CN101481321B (zh) 2012-04-18
KR20110117721A (ko) 2011-10-27
RS53751B1 (sr) 2015-06-30
NI201100163A (es) 2011-12-12
JP5426693B2 (ja) 2014-02-26
PL2418195T3 (pl) 2015-04-30
ZA201106048B (en) 2012-10-31
PE20120652A1 (es) 2012-06-14
US20110313198A1 (en) 2011-12-22
MA33063B1 (fr) 2012-02-01
CR20110446A (es) 2011-10-18
EP2418195A1 (en) 2012-02-15
CU20110163A7 (es) 2012-02-15
AU2010217082A1 (en) 2011-09-08
CL2011002090A1 (es) 2012-02-03
EA201101208A1 (ru) 2012-04-30
AP3048A (en) 2014-11-30
SG173691A1 (en) 2011-09-29
GEP20156221B (en) 2015-01-26
CO6420335A2 (es) 2012-04-16
EA021939B1 (ru) 2015-10-30
CN101481321A (zh) 2009-07-15
IL214682A0 (en) 2011-11-30
US8524949B2 (en) 2013-09-03
BRPI1008767A2 (pt) 2016-06-28
EP2418195B1 (en) 2014-11-19
SI2418195T1 (sl) 2015-03-31
IL214682A (en) 2015-10-29

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