CO5700725A2 - Derivados sustituidos de la ciclohexano-1,4-diamina - Google Patents
Derivados sustituidos de la ciclohexano-1,4-diaminaInfo
- Publication number
- CO5700725A2 CO5700725A2 CO03098857A CO03098857A CO5700725A2 CO 5700725 A2 CO5700725 A2 CO 5700725A2 CO 03098857 A CO03098857 A CO 03098857A CO 03098857 A CO03098857 A CO 03098857A CO 5700725 A2 CO5700725 A2 CO 5700725A2
- Authority
- CO
- Colombia
- Prior art keywords
- substituted
- unsubstituted
- heteroaryl
- cycloalkyl
- aryl
- Prior art date
Links
- 125000003118 aryl group Chemical group 0.000 abstract 8
- 125000001072 heteroaryl group Chemical group 0.000 abstract 8
- 229920006395 saturated elastomer Polymers 0.000 abstract 8
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 abstract 7
- 125000004209 (C1-C8) alkyl group Chemical group 0.000 abstract 5
- 125000002947 alkylene group Chemical group 0.000 abstract 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- VKIRRGRTJUUZHS-UHFFFAOYSA-N cyclohexane-1,4-diamine Chemical class NC1CCC(N)CC1 VKIRRGRTJUUZHS-UHFFFAOYSA-N 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C211/00—Compounds containing amino groups bound to a carbon skeleton
- C07C211/33—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings
- C07C211/34—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of a saturated carbon skeleton
- C07C211/36—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of a saturated carbon skeleton containing at least two amino groups bound to the carbon skeleton
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- A61K31/13—Amines
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/132—Amines having two or more amino groups, e.g. spermidine, putrescine
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- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
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- Pharmacology & Pharmacy (AREA)
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- Orthopedic Medicine & Surgery (AREA)
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Abstract
1.- Derivados sustituidos de la ciclohexano-1,4-diamina con la fórmula general I , , en la queR1 y R2 son independientes enlre sí y se seleccionan enlre H; alquilo C1-8 o cicloalquilo C3-8, cada uno saturado o no saturado, ramificado o no ramificado, sustituido una o más veces o no sustituido; arilo o heteroarilo, cada uno sustituido una o más veces o no sustituido; o bien arilo, cicloalquilo C3-8 o heteroarilo, cada uno sustituido una o más veces o no sustituido, enlazado a través de alquileno C1-3; en la fórmula R1 y R2 no deben ser ambos H,o bien los grupos R1 y R2 forman juntos un anillo y representan CH2CH2OCH2CH2, CH2CH2NR6CH2CH2 o (CH2)3-6,estando R6 seleccionado entre H; alquilo C1-8 o cicloalquilo C3-8, cada uno saturado o no saturado, ramificado o no ramificado, sustituido una o más veces o no sustituido; arilo o heteroarilo, cada uno sustituido una o más veces o no sustituido; o bien arilo, cicloalquilo C3-8 o heteroarilo, cada uno sustituido una o más veces o no sustituido, enlazado a través de alquileno C1-3;R3 se selecciona entre alquilo C1-8 o cicloalquilo C3-8, cada uno saturado o no saturado, ramificado o no ramificado, sustituido una o más veces o no sustituido; arilo o heteroarilo, cada uno no sustituido o sustituido una o más veces; arilo, cicloalquilo C3-8 o heteroarilo, cada uno no sustituido o sustituido una o más veces enlazado a través de un grupo alquilo C1-4 saturado o no saturado, ramificado o no ramificado, sustituido o no sustituido;R4 se selecciona entre H, alquilo C1-8 saturado o no saturado, ramificado o no ramificado, sustituido una o más veces o no sustituido; o bien C(X)R7, C(X)NR7R8, C(X)OR9, C(X)SR9, S(O2)R9siendo X = O o S,estando R7 seleccionado entre H, alquilo C1-8 o cicloalquilo C3-8, cada uno saturado o no saturado, ramificado o no ramificado, sustituido una o más veces o no sustituido; arilo o heteroarilo, cada uno no sustituido o sustituido una o más veces; arilo, cicloalquilo C3-8 o heteroarilo, cada uno no sustituido o sustituido una o más veces, enlazado a través de un grupo alquilo saturado o no saturado, ramificado o no ramificado, sustituido o no sustituido; ...
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10123163A DE10123163A1 (de) | 2001-05-09 | 2001-05-09 | Substituierte Cyclohexan-1,4-diaminderivate |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO5700725A2 true CO5700725A2 (es) | 2006-11-30 |
Family
ID=7684562
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CO03098857A CO5700725A2 (es) | 2001-05-09 | 2003-11-07 | Derivados sustituidos de la ciclohexano-1,4-diamina |
| CO03098846A CO5540300A2 (es) | 2001-05-09 | 2003-11-07 | Derivados sustituidos de la 2-piridina ciclohexano-1,4- diamina |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CO03098846A CO5540300A2 (es) | 2001-05-09 | 2003-11-07 | Derivados sustituidos de la 2-piridina ciclohexano-1,4- diamina |
Country Status (30)
| Country | Link |
|---|---|
| US (3) | US20040229872A1 (es) |
| EP (3) | EP1385825B1 (es) |
| JP (3) | JP2004533439A (es) |
| KR (2) | KR100895778B1 (es) |
| CN (2) | CN1307158C (es) |
| AR (1) | AR035883A1 (es) |
| AT (2) | ATE359260T1 (es) |
| AU (3) | AU2002312883B2 (es) |
| BR (2) | BR0209579A (es) |
| CA (3) | CA2446461C (es) |
| CO (2) | CO5700725A2 (es) |
| CY (2) | CY1106468T1 (es) |
| CZ (2) | CZ20032995A3 (es) |
| DE (3) | DE10123163A1 (es) |
| DK (2) | DK1385825T3 (es) |
| EC (2) | ECSP034830A (es) |
| ES (2) | ES2291486T3 (es) |
| HU (3) | HU228253B1 (es) |
| IL (4) | IL158784A0 (es) |
| MX (3) | MXPA03010201A (es) |
| NO (2) | NO328600B1 (es) |
| NZ (2) | NZ529334A (es) |
| PE (1) | PE20021094A1 (es) |
| PL (3) | PL212887B1 (es) |
| PT (2) | PT1385825E (es) |
| RU (2) | RU2321579C2 (es) |
| SI (2) | SI1392641T1 (es) |
| SK (2) | SK287319B6 (es) |
| WO (3) | WO2002090317A1 (es) |
| ZA (2) | ZA200309522B (es) |
Families Citing this family (48)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10252650A1 (de) * | 2002-11-11 | 2004-05-27 | Grünenthal GmbH | Cyclohexyl-Harnstoff-Derivate |
| DE10252665A1 (de) | 2002-11-11 | 2004-06-03 | Grünenthal GmbH | 4-Aminomethyl-1-aryl-cyclohexylamin-Derivate |
| WO2004043902A1 (de) | 2002-11-12 | 2004-05-27 | Grünenthal GmbH | 4-hydroxymethyl-1-aryl-cyclohexylamin-derivative |
| AP2005003319A0 (en) | 2002-11-19 | 2005-06-30 | Achillion Pharmaceitucals Inc | Substituted aryl thioureas and related compounds; inhibitors of viral replication |
| US7026432B2 (en) | 2003-08-12 | 2006-04-11 | General Electric Company | Electrically conductive compositions and method of manufacture thereof |
| US7354988B2 (en) | 2003-08-12 | 2008-04-08 | General Electric Company | Electrically conductive compositions and method of manufacture thereof |
| US7378409B2 (en) * | 2003-08-21 | 2008-05-27 | Bristol-Myers Squibb Company | Substituted cycloalkylamine derivatives as modulators of chemokine receptor activity |
| US7309727B2 (en) | 2003-09-29 | 2007-12-18 | General Electric Company | Conductive thermoplastic compositions, methods of manufacture and articles derived from such compositions |
| DE10360793A1 (de) * | 2003-12-23 | 2005-07-28 | Grünenthal GmbH | Spirocyclische Cyclohexan-Derivate |
| DE10360792A1 (de) * | 2003-12-23 | 2005-07-28 | Grünenthal GmbH | Spirocyclische Cyclohexan-Derivate |
| DE102004023522A1 (de) | 2004-05-10 | 2005-12-01 | Grünenthal GmbH | Substituierte Cyclohexyl-1,4-diamin-Derivate |
| DE102004023635A1 (de) | 2004-05-10 | 2006-04-13 | Grünenthal GmbH | Heteroarylsubstituierte Cyclohexyl-1,4-diamin-Derivate |
| DE102004023506A1 (de) * | 2004-05-10 | 2005-12-01 | Grünenthal GmbH | Kettenverlängerte substituierte Cyclohexyl-1,4-diamin-Derivate |
| DE102004023507A1 (de) * | 2004-05-10 | 2005-12-01 | Grünenthal GmbH | Substituierte Cyclohexylessigsäure-Derivate |
| DE102004023508A1 (de) | 2004-05-10 | 2005-12-08 | Grünenthal GmbH | Säurederivate substituierter Cyclohexyl-1,4-diamine |
| DE102004023632A1 (de) | 2004-05-10 | 2005-12-08 | Grünenthal GmbH | Substituierte Cyclohexylcarbonsäure-Derivate |
| DE102004023501A1 (de) | 2004-05-10 | 2005-12-01 | Grünenthal GmbH | Oxosubstituierte Cyclohexyl-1,4-diamin-Derivate |
| TW200600492A (en) * | 2004-05-18 | 2006-01-01 | Achillion Pharmaceuticals Inc | Substituted aryl acylthioureas and related compounds; inhibitors of viral replication |
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