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EA200200119A1 - β-КАРБОЛИНОВЫЕ ЛЕКАРСТВЕННЫЕ ПРОДУКТЫ - Google Patents

β-КАРБОЛИНОВЫЕ ЛЕКАРСТВЕННЫЕ ПРОДУКТЫ

Info

Publication number
EA200200119A1
EA200200119A1 EA200200119A EA200200119A EA200200119A1 EA 200200119 A1 EA200200119 A1 EA 200200119A1 EA 200200119 A EA200200119 A EA 200200119A EA 200200119 A EA200200119 A EA 200200119A EA 200200119 A1 EA200200119 A1 EA 200200119A1
Authority
EA
Eurasian Patent Office
Prior art keywords
carboline
drugs
compound
solvates
published
Prior art date
Application number
EA200200119A
Other languages
English (en)
Other versions
EA004302B9 (ru
EA004302B1 (ru
Inventor
Нил Р. Андерсон
Керри Дж. Хартоэр
Марта А. Крэл
Грегори А. Стивенсон
Original Assignee
ЛИЛЛИ АЙКОС эЛ-эЛ-Си
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22520112&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA200200119(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by ЛИЛЛИ АЙКОС эЛ-эЛ-Си filed Critical ЛИЛЛИ АЙКОС эЛ-эЛ-Си
Publication of EA200200119A1 publication Critical patent/EA200200119A1/ru
Publication of EA004302B1 publication Critical patent/EA004302B1/ru
Publication of EA004302B9 publication Critical patent/EA004302B9/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Gynecology & Obstetrics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Описано соединение структурной формулы (I)и его фармацевтически приемлемые соли и сольваты, где соединение находится в форме свободного лекарственного средства в виде частиц.Отчет о международном поиске был опубликован 2001.08.16.
EA200200119A 1999-08-03 2000-08-01 β-КАРБОЛИНОВЫЕ ЛЕКАРСТВЕННЫЕ ПРОДУКТЫ EA004302B9 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US14704899P 1999-08-03 1999-08-03
PCT/US2000/020981 WO2001008688A2 (en) 1999-08-03 2000-08-01 Beta-carboline drug products

Publications (3)

Publication Number Publication Date
EA200200119A1 true EA200200119A1 (ru) 2002-06-27
EA004302B1 EA004302B1 (ru) 2004-02-26
EA004302B9 EA004302B9 (ru) 2019-01-31

Family

ID=22520112

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200200119A EA004302B9 (ru) 1999-08-03 2000-08-01 β-КАРБОЛИНОВЫЕ ЛЕКАРСТВЕННЫЕ ПРОДУКТЫ

Country Status (33)

Country Link
EP (1) EP1200092B1 (ru)
JP (1) JP4456788B2 (ru)
KR (1) KR20020063842A (ru)
CN (2) CN101134019A (ru)
AR (1) AR033953A1 (ru)
AT (1) ATE264680T1 (ru)
AU (1) AU773666B2 (ru)
BR (1) BR0012901A (ru)
CA (1) CA2380087C (ru)
CO (1) CO5200849A1 (ru)
CZ (1) CZ300151B6 (ru)
DE (1) DE60010089T2 (ru)
DK (1) DK1200092T3 (ru)
DZ (1) DZ3180A1 (ru)
EA (1) EA004302B9 (ru)
ES (1) ES2220506T3 (ru)
HK (1) HK1044278B (ru)
HR (1) HRP20020091B1 (ru)
HU (1) HU229443B1 (ru)
IL (1) IL147642A0 (ru)
MX (1) MXPA02001197A (ru)
MY (1) MY125428A (ru)
NO (1) NO321602B1 (ru)
NZ (1) NZ516613A (ru)
PE (1) PE20010480A1 (ru)
PL (1) PL199469B1 (ru)
PT (1) PT1200092E (ru)
SK (1) SK286365B6 (ru)
SV (1) SV2002000137A (ru)
TW (1) TWI235658B (ru)
UA (1) UA71629C2 (ru)
WO (1) WO2001008688A2 (ru)
ZA (1) ZA200200825B (ru)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1200091B1 (en) * 1999-08-03 2008-07-02 Lilly Icos LLC Pharmaceutical composition comprising tadalafil
US8063214B2 (en) * 2004-10-28 2011-11-22 Dr. Reddy's Laboratories Limited Polymorphic forms of tadalafil
DE602006004694D1 (de) 2006-01-05 2009-02-26 Teva Pharma Feuchtgranulierungsmethode zur Herstellung pharmazeutischer Aripiprazolzusammensetzungen
DE102007028869A1 (de) 2007-06-22 2008-12-24 Ratiopharm Gmbh Verfahren zur Herstellung eines Arzneimittels enthaltend Tadalafil
MD4009C2 (ru) * 2008-07-15 2010-08-31 Институт Химии Академии Наук Молдовы Использование 1-метил-4-(N-метиламинобутил-4)-β-карболина в качестве противотуберкулезного средства
DE102009033396A1 (de) 2009-07-16 2011-01-20 Ratiopharm Gmbh Wässrige Lösung und gelatinierte Zusammensetzung umfassend einen Phosphodiesterase-5-Inhibitor sowie diesbezügliche Verfahren und Verwendung
DE102009035211A1 (de) 2009-07-29 2011-02-17 Ratiopharm Gmbh Copräzipitate umfassend einen Phosphodiesterase-5-Inhibitor (PDE-5-Inhibitor) und einen pharmazeutisch verträglichen Trägerstoff, ihre Herstellung und Verwendung
WO2012085927A2 (en) * 2010-12-02 2012-06-28 Mylan Laboratories, Limited Tadalafil compositions
WO2012095151A1 (en) 2010-12-23 2012-07-19 Zaklady Farmaceutyczne Polpharma Sa Solid pharmaceutical dosage forms comprising tadalafil and methods of preparation thereof
WO2012107092A1 (en) 2011-02-10 2012-08-16 Synthon Bv Pharmaceutical composition comprising tadalafil and a cyclodextrin
WO2012107090A1 (en) 2011-02-10 2012-08-16 Synthon Bv Granulated composition comprising tadalafil and a disintegrant
WO2012107541A1 (en) 2011-02-10 2012-08-16 Synthon Bv Pharmaceutical composition comprising tadalafil and a cyclodextrin
JP5930686B2 (ja) * 2011-12-07 2016-06-08 株式会社トクヤマ 溶解性および安定性の向上した難溶性医薬品原体及びその製造方法
US9871201B2 (en) 2012-03-15 2018-01-16 Merck Patent Gmbh Electronic devices
WO2014003677A1 (en) * 2012-06-28 2014-01-03 Xspray Microparticles Ab Pharmaceutical compositions comprising solid dispersion particles containing tadalafil
WO2014003678A1 (en) * 2012-06-28 2014-01-03 Xspray Microparticles Ab Pharmaceutical compositions comprising ambrisentan and solid dispersion particles containing tadalafil
CN105310984A (zh) * 2014-06-10 2016-02-10 合肥贝霓医药科技有限公司 一种pde5抑制剂的超微粉体及其制备方法
JP6445559B2 (ja) * 2014-06-24 2018-12-26 ウーシン ラボタチ カンパニー, リミテッドWooshin Labottach Co., Ltd. タダラフィルを含む口腔内崩壊フィルム製剤およびその製造方法
WO2016012539A1 (en) 2014-07-23 2016-01-28 Krka, D.D., Novo Mesto A process for the preparation of cgmp-phosphodiesterase inhibitor and oral pharmaceutical formulation comprising tadalafil co-precipitates
JP2016106139A (ja) * 2016-03-07 2016-06-16 株式会社トクヤマ 溶解性および安定性の向上した難溶性医薬品原体及びその製造方法
SG11202006080SA (en) 2017-12-26 2020-07-29 Ftf Pharma Private Ltd Liquid oral formulations for pde v inhibitors
SMT202000546T1 (it) 2018-01-10 2021-01-05 Gap S A Capsule di gelatina molle comprendenti una sospensione di tadalafil
CN110638770B (zh) * 2019-10-25 2022-04-05 株洲千金药业股份有限公司 他达拉非片剂的制备方法及以该方法制得的片剂
EP4531815A1 (en) * 2022-05-27 2025-04-09 Rontis Hellas S.A. Improved pharmaceutical composition containing tadalafil and nanomilling process for the preparation thereof
CN119112817A (zh) * 2024-08-20 2024-12-13 武汉九珑人福药业有限责任公司 一种他达拉非片及其制备方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5618845A (en) * 1994-10-06 1997-04-08 Cephalon, Inc. Acetamide derivative having defined particle size
GB9511220D0 (en) * 1995-06-02 1995-07-26 Glaxo Group Ltd Solid dispersions

Also Published As

Publication number Publication date
SK286365B6 (sk) 2008-08-05
EP1200092B1 (en) 2004-04-21
HK1044278A1 (en) 2002-10-18
ZA200200825B (en) 2003-04-30
EP1200092A2 (en) 2002-05-02
SV2002000137A (es) 2002-06-07
DE60010089T2 (de) 2004-10-14
AU6508400A (en) 2001-02-19
CN1377270A (zh) 2002-10-30
KR20020063842A (ko) 2002-08-05
SK1722002A3 (en) 2002-05-09
BR0012901A (pt) 2002-04-16
UA71629C2 (en) 2004-12-15
AR033953A1 (es) 2004-01-21
TWI235658B (en) 2005-07-11
HK1044278B (en) 2004-10-08
DE60010089D1 (de) 2004-05-27
CN101134019A (zh) 2008-03-05
NO20020531L (no) 2002-04-03
CZ300151B6 (cs) 2009-02-25
ES2220506T3 (es) 2004-12-16
DK1200092T3 (da) 2004-08-16
HUP0202781A2 (hu) 2002-12-28
NZ516613A (en) 2003-08-29
CA2380087C (en) 2007-05-01
ATE264680T1 (de) 2004-05-15
EA004302B9 (ru) 2019-01-31
DZ3180A1 (fr) 2001-02-08
IL147642A0 (en) 2002-08-14
PL199469B1 (pl) 2008-09-30
CO5200849A1 (es) 2002-09-27
HU229443B1 (en) 2013-12-30
PE20010480A1 (es) 2001-05-26
NO321602B1 (no) 2006-06-12
PT1200092E (pt) 2004-07-30
AU773666B2 (en) 2004-06-03
HRP20020091A2 (en) 2004-02-29
JP4456788B2 (ja) 2010-04-28
HRP20020091B1 (en) 2006-02-28
NO20020531D0 (no) 2002-02-01
PL353268A1 (en) 2003-11-03
WO2001008688A3 (en) 2001-08-16
MY125428A (en) 2006-07-31
CZ2002387A3 (cs) 2002-10-16
WO2001008688A2 (en) 2001-02-08
CA2380087A1 (en) 2001-02-08
JP2003505510A (ja) 2003-02-12
MXPA02001197A (es) 2003-02-12
HUP0202781A3 (en) 2003-10-28
EA004302B1 (ru) 2004-02-26

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Legal Events

Date Code Title Description
PC4A Registration of transfer of a eurasian patent by assignment
QB4A Registration of a licence in a contracting state
MH4A Revocation of a eurasian patent in part
TH4A Publication of the corrected specification to eurasian patent
TK4A Corrections in published eurasian patents
MF4A Revocation of a eurasian patent as invalid entirely

Designated state(s): RU

MK4A Patent expired

Designated state(s): AM AZ BY KZ KG MD TJ TM