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CN1259135A - 9－肟红霉素衍生物 - Google Patents

9－肟红霉素衍生物 Download PDF

Info

Publication number
CN1259135A
CN1259135A CN98805848A CN98805848A CN1259135A CN 1259135 A CN1259135 A CN 1259135A CN 98805848 A CN98805848 A CN 98805848A CN 98805848 A CN98805848 A CN 98805848A CN 1259135 A CN1259135 A CN 1259135A
Authority
CN
China
Prior art keywords
deoxy
methyl
carbamate
oxoerythronolactone
desosamino
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN98805848A
Other languages
English (en)
Chinese (zh)
Inventor
邬永金
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Products Inc
Original Assignee
Pfizer Products Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Products Inc filed Critical Pfizer Products Inc
Publication of CN1259135A publication Critical patent/CN1259135A/zh
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Genetics & Genomics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Epidemiology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
CN98805848A 1997-06-11 1998-05-15 9－肟红霉素衍生物 Pending CN1259135A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US4934997P 1997-06-11 1997-06-11
US60/049,349 1997-06-11

Publications (1)

Publication Number Publication Date
CN1259135A true CN1259135A (zh) 2000-07-05

Family

ID=21959341

Family Applications (1)

Application Number Title Priority Date Filing Date
CN98805848A Pending CN1259135A (zh) 1997-06-11 1998-05-15 9－肟红霉素衍生物

Country Status (31)

Country Link
EP (1) EP0988308A1 (fr)
JP (1) JP2000513026A (fr)
KR (1) KR20010013660A (fr)
CN (1) CN1259135A (fr)
AP (1) AP9801253A0 (fr)
AR (1) AR012244A1 (fr)
AU (1) AU7226798A (fr)
BG (1) BG103947A (fr)
BR (1) BR9810021A (fr)
CA (1) CA2293335A1 (fr)
CO (1) CO4940506A1 (fr)
CZ (1) CZ9904388A3 (fr)
EA (1) EA199901016A1 (fr)
GT (1) GT199800074A (fr)
HN (1) HN1998000073A (fr)
HR (1) HRP980316A2 (fr)
HU (1) HUP0002252A3 (fr)
ID (1) ID24529A (fr)
IL (1) IL132767A0 (fr)
IS (1) IS5251A (fr)
MA (1) MA26505A1 (fr)
NO (1) NO996108L (fr)
OA (1) OA11225A (fr)
PA (1) PA8451801A1 (fr)
PE (1) PE79899A1 (fr)
PL (1) PL337606A1 (fr)
TN (1) TNSN98083A1 (fr)
TR (1) TR199902995T2 (fr)
TW (1) TW448174B (fr)
WO (1) WO1998056800A1 (fr)
ZA (1) ZA985018B (fr)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HN1998000159A (es) * 1997-10-29 1999-02-09 Monsanto Co Derivados de 9- amino - 3 ceto eritromicina
EP1115732B1 (fr) 1998-09-22 2005-06-29 Pfizer Products Inc. Antibiotiques carbamates et carbazates cetolides
FR2786188B1 (fr) * 1998-11-24 2002-10-31 Hoechst Marion Roussel Inc Nouveaux derives de l'erythromycine, leur procede de preparation et leur applicaion comme medicaments
US6258785B1 (en) 1998-12-02 2001-07-10 Pfizer Inc. Crystalline 9-E-(O-methyl)oxime of 11, 12-dideoxy-3-de(2,6-dideoxy-3-C-methyl-3-O-methyl-α-L-ribohexopyranosyloxy)-6-O-methyl-12,11-(iminocarbonyl-(2-(3-(4-(3-pyridinyl)1H-imadazol-1-yl)propyl)hydrazono))-3-oxoerythromycin
EP1298138B1 (fr) * 1998-12-10 2006-11-02 Pfizer Products Inc. Dérivés anitiobiotiques de Carbamate et de Carbazate Kètolides
US6284732B1 (en) * 1998-12-18 2001-09-04 Bio-Rad Laboratories, Inc. Peptides and peptide analogues designed from HFE protein and their uses in the treatment of iron overload diseases
AU773678B2 (en) * 1999-04-16 2004-06-03 Kosan Biosciences, Inc. Macrolide antiinfective agents
OA11945A (en) 1999-05-24 2006-04-13 Pfizer Prod Inc 13-Methyl erythromycin derivatives.
DE60005334T2 (de) * 1999-06-07 2004-06-24 Abbott Laboratories, Abbott Park 6-o-carbamat ketolide derivate
ID27331A (id) * 1999-09-29 2001-03-29 Pfizer Prod Inc Pembuatan antibiotik-antibiotik ketolida karbamat
EP1439186A3 (fr) * 1999-12-29 2004-11-03 Pfizer Products Inc. Intermédiaires pour macrolides antibactérielles et procinétiques
EP1114826A3 (fr) * 1999-12-29 2001-10-31 Pfizer Products Inc. Macrolides antibactériennes et prokinétiques
US6946446B2 (en) 2000-02-24 2005-09-20 Abbott Laboratories Anti-infective agents useful against multidrug-resistant strains of bacteria
US6403776B1 (en) 2000-07-05 2002-06-11 Pfizer Inc. Synthesis of carbamate ketolide antibiotics
WO2003090761A1 (fr) * 2002-04-25 2003-11-06 Abbott Laboratories Antibacteriens 9-oxime macrolide
US7091196B2 (en) 2002-09-26 2006-08-15 Rib-X Pharmaceuticals, Inc. Bifunctional heterocyclic compounds and methods of making and using same
WO2004080391A2 (fr) * 2003-03-10 2004-09-23 Optimer Pharmaceuticals, Inc. Nouveaux agents antibacteriens
US8202843B2 (en) 2004-02-27 2012-06-19 Rib-X Pharmaceuticals, Inc. Macrocyclic compounds and methods of making and using the same
JP5698979B2 (ja) 2007-10-25 2015-04-08 センプラ ファーマシューティカルズ，インコーポレイテッド マクロライド系抗菌剤の調製プロセス
HRP20160222T1 (hr) 2008-10-24 2016-04-08 Cempra Pharmaceuticals, Inc. Biozaštite uporabom makrolida koji sadrže triazol
US9937194B1 (en) 2009-06-12 2018-04-10 Cempra Pharmaceuticals, Inc. Compounds and methods for treating inflammatory diseases
WO2011032052A1 (fr) 2009-09-10 2011-03-17 Cempra Pharmaceuticals, Inc. Méthodes de traitement du paludisme, de la tuberculose et des maladies à complexe mycobacterium avium (mac)
CN102146085B (zh) * 2010-02-09 2014-03-26 北京理工大学 一种9-肟醚酮内酯衍生物、制备方法及其药物组合物
KR102006200B1 (ko) 2010-03-22 2019-08-01 셈프라 파마슈티컬스, 인크. 매크로라이드의 결정 형태들 및 그 용도들
EP2571506B1 (fr) 2010-05-20 2017-05-10 Cempra Pharmaceuticals, Inc. Procédés de préparation de macrolides et de kétolides et d'intermédiaires de ceux-ci
KR20130120458A (ko) 2010-09-10 2013-11-04 셈프라 파마슈티컬스, 인크. 질환을 치료하기 위한 수소결합 형성 플루오로 케토라이드
WO2013148891A1 (fr) 2012-03-27 2013-10-03 Cempra Pharmaceuticals, Inc. Formulations parentérales pour l'administration d'antibiotiques macrolides
EP2968801B1 (fr) 2013-03-14 2018-09-26 Cempra Pharmaceuticals, Inc. Procédés pour traiter des maladies respiratoires et formulations pour la mise en oeuvre de ceux-ci
CN105188712A (zh) 2013-03-15 2015-12-23 森普拉制药公司 用于制备大环内酯抗菌剂的收敛方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL99995A (en) * 1990-11-21 1997-11-20 Roussel Uclaf Erythromycin derivatives, their preparation and pharmaceutical compositions containing them
US5527780A (en) * 1992-11-05 1996-06-18 Roussel Uclaf Erythromycin derivatives
FR2718450B1 (fr) * 1994-04-08 1997-01-10 Roussel Uclaf Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments.

Also Published As

Publication number Publication date
BG103947A (en) 2000-07-31
HN1998000073A (es) 1999-01-08
OA11225A (en) 2003-07-17
PL337606A1 (en) 2000-08-28
HUP0002252A2 (hu) 2000-12-28
ID24529A (id) 2000-07-20
NO996108L (no) 2000-02-10
EA199901016A1 (ru) 2000-06-26
PE79899A1 (es) 1999-08-25
TR199902995T2 (xx) 2000-02-21
PA8451801A1 (es) 2000-05-24
CO4940506A1 (es) 2000-07-24
NO996108D0 (no) 1999-12-10
HRP980316A2 (en) 1999-04-30
IL132767A0 (en) 2001-03-19
BR9810021A (pt) 2000-09-19
WO1998056800A1 (fr) 1998-12-17
AP9801253A0 (en) 1999-12-04
TW448174B (en) 2001-08-01
EP0988308A1 (fr) 2000-03-29
CA2293335A1 (fr) 1998-12-17
MA26505A1 (fr) 2004-12-20
HUP0002252A3 (en) 2002-01-28
IS5251A (is) 1999-11-16
TNSN98083A1 (fr) 2005-03-15
JP2000513026A (ja) 2000-10-03
KR20010013660A (ko) 2001-02-26
AR012244A1 (es) 2000-09-27
GT199800074A (es) 1999-11-27
CZ9904388A3 (cs) 2002-10-16
ZA985018B (en) 1999-12-10
AU7226798A (en) 1998-12-30

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