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CN109563035A - 9-氨基甲基取代的四环素类化合物的晶型及其制备方法 - Google Patents

9-氨基甲基取代的四环素类化合物的晶型及其制备方法 Download PDF

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Publication number
CN109563035A
CN109563035A CN201780026902.4A CN201780026902A CN109563035A CN 109563035 A CN109563035 A CN 109563035A CN 201780026902 A CN201780026902 A CN 201780026902A CN 109563035 A CN109563035 A CN 109563035A
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CN109563035B (zh
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黄振华
洪梅
姜辰
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KBP Biosciences Co Ltd
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KBP Biosciences Co Ltd
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/65—Tetracyclines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/54—Spiro-condensed
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
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  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Indole Compounds (AREA)

Abstract

本发明属于医药技术领域，涉及9‑氨基甲基取代的四环素类化合物的晶型及其制备方法，具体涉及式(1)所示的化合物晶型、式(1)所示的化合物晶型的制备方法及其晶型在制备治疗和/或预防四环素敏感菌和/或耐药菌引起的感染疾病药物中的应用。

Description

PCT国内申请，说明书已公开。

Claims (10)

  1. PCT国内申请，权利要求书已公开。
CN201780026902.4A 2016-06-22 2017-06-22 9-氨基甲基取代的四环素类化合物的晶型及其制备方法 Active CN109563035B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN201610457261 2016-06-22
CN201610457261.5 2016-06-22
PCT/CN2017/089470 WO2017219994A1 (zh) 2016-06-22 2017-06-22 9-氨基甲基取代的四环素类化合物的晶型及其制备方法

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CN109563035A true CN109563035A (zh) 2019-04-02
CN109563035B CN109563035B (zh) 2021-07-20

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US (1) US10633337B2 (zh)
EP (1) EP3476831B8 (zh)
JP (1) JP6883593B2 (zh)
KR (1) KR102205843B1 (zh)
CN (1) CN109563035B (zh)
AU (1) AU2017282891B2 (zh)
CA (1) CA3028014C (zh)
CL (1) CL2018003739A1 (zh)
CO (1) CO2019000513A2 (zh)
ES (1) ES2906885T3 (zh)
IL (1) IL263868B (zh)
MA (1) MA45461A (zh)
MX (1) MX381701B (zh)
MY (1) MY186900A (zh)
PE (1) PE20190810A1 (zh)
PH (1) PH12018502680A1 (zh)
RU (2) RU2764723C2 (zh)
SG (1) SG11201811499WA (zh)
TW (1) TWI656116B (zh)
WO (1) WO2017219994A1 (zh)
ZA (1) ZA201900274B (zh)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
USD962414S1 (en) 2020-02-28 2022-08-30 Beijing Xiaomi Mobile Software Co., Ltd Fan
WO2021252876A1 (en) * 2020-06-11 2021-12-16 Paratek Pharmaceuticals, Inc. Crystalline forms of omadacycline, methods of synthesis thereof and methods of use thereof

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004064728A2 (en) * 2003-01-16 2004-08-05 Paratek Pharmaceuticals, Inc. Use of specific tetracycline compounds in therapy
CN101248038A (zh) * 2005-05-27 2008-08-20 惠氏公司 替加环素的结晶固体形式及其制备方法
CN102417465A (zh) * 2011-10-27 2012-04-18 宫宁瑞 替加环素新晶型及其制备方法
WO2013013505A1 (zh) * 2011-07-26 2013-01-31 山东亨利医药科技有限责任公司 9-氨基甲基取代的四环素类化合物

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5574967B2 (ja) * 2007-11-14 2014-08-20 サンド・アクチエンゲゼルシヤフト チゲサイクリン塩酸塩の結晶型
EP2252579A2 (en) * 2008-01-23 2010-11-24 Sandoz AG Antibiotic compounds
TW202216656A (zh) * 2008-05-19 2022-05-01 美商Ｐｒｔｋ Ｓｐｖ２公司 四環素化合物之甲苯磺酸鹽及同素異形體

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004064728A2 (en) * 2003-01-16 2004-08-05 Paratek Pharmaceuticals, Inc. Use of specific tetracycline compounds in therapy
CN101248038A (zh) * 2005-05-27 2008-08-20 惠氏公司 替加环素的结晶固体形式及其制备方法
WO2013013505A1 (zh) * 2011-07-26 2013-01-31 山东亨利医药科技有限责任公司 9-氨基甲基取代的四环素类化合物
CN102417465A (zh) * 2011-10-27 2012-04-18 宫宁瑞 替加环素新晶型及其制备方法

Also Published As

Publication number Publication date
EP3476831B8 (en) 2021-12-29
NZ749495A (en) 2020-12-18
JP2019520363A (ja) 2019-07-18
US10633337B2 (en) 2020-04-28
CA3028014A1 (en) 2017-12-28
EP3476831A1 (en) 2019-05-01
EP3476831B1 (en) 2021-11-17
BR112018076726A2 (pt) 2019-04-02
MX381701B (es) 2025-03-13
TW201800393A (zh) 2018-01-01
CO2019000513A2 (es) 2019-04-30
MX2019000086A (es) 2019-05-02
PE20190810A1 (es) 2019-06-13
TWI656116B (zh) 2019-04-11
RU2019101248A (ru) 2020-07-22
JP6883593B2 (ja) 2021-06-09
KR20190024900A (ko) 2019-03-08
PH12018502680A1 (en) 2019-10-14
WO2017219994A1 (zh) 2017-12-28
US20190241515A1 (en) 2019-08-08
CN109563035B (zh) 2021-07-20
RU2019101248A3 (zh) 2020-07-22
CL2018003739A1 (es) 2019-04-05
KR102205843B1 (ko) 2021-01-22
ES2906885T3 (es) 2022-04-20
IL263868B (en) 2022-08-01
MA45461A (fr) 2019-05-01
IL263868A (en) 2019-01-31
ZA201900274B (en) 2020-05-27
RU2764723C2 (ru) 2022-01-19
RU2022100160A (ru) 2022-03-16
AU2017282891B2 (en) 2020-01-02
CA3028014C (en) 2021-09-07
MY186900A (en) 2021-08-26
AU2017282891A1 (en) 2019-01-17
EP3476831A4 (en) 2019-11-27
SG11201811499WA (en) 2019-01-30

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