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CL2018003739A1 - Formas cristalinas de un compuesto de tetraciclina sustituida con 9-aminometilo y un método para su preparación. - Google Patents

Formas cristalinas de un compuesto de tetraciclina sustituida con 9-aminometilo y un método para su preparación.

Info

Publication number
CL2018003739A1
CL2018003739A1 CL2018003739A CL2018003739A CL2018003739A1 CL 2018003739 A1 CL2018003739 A1 CL 2018003739A1 CL 2018003739 A CL2018003739 A CL 2018003739A CL 2018003739 A CL2018003739 A CL 2018003739A CL 2018003739 A1 CL2018003739 A1 CL 2018003739A1
Authority
CL
Chile
Prior art keywords
preparation
crystalline forms
aminomethyl
tetracycline compound
compound substituted
Prior art date
Application number
CL2018003739A
Other languages
English (en)
Inventor
Zhenhua Huang
Mei Hong
Chen Jiang
Original Assignee
Kbp Biosciences Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kbp Biosciences Co Ltd filed Critical Kbp Biosciences Co Ltd
Publication of CL2018003739A1 publication Critical patent/CL2018003739A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/65—Tetracyclines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/54—Spiro-condensed
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Indole Compounds (AREA)

Abstract

LA PRESENTE INVENCIÓN SE REFIERE A LAS FORMAS CRISTALINAS DE UN COMPUESTO DE TETRACICLINA SUSTITUIDA CON 9-AMINOMETILO Y UN PROCESO PARA SU PREPARACIÓN. ESPECÍFICAMENTE, LA INVENCIÓN SE REFIERE A FORMAS CRISTALINAS DEL COMPUESTO DE FÓRMULA (1), UN PROCESO PARA PREPARAR DICHAS FORMAS CRISTALINAS Y AL USO DE LAS MISMAS EN LA PREPARACIÓN DE MEDICAMENTOS PARA TRATAR Y/O PREVENIR UNA ENFERMEDAD INFECCIOSA CAUSADA POR BACTERIAS SENSIBLES A LA TETRACICLINA Y/O BACTERIAS RESISTENTES A LA TETRACICLINA.
CL2018003739A 2016-06-22 2018-12-21 Formas cristalinas de un compuesto de tetraciclina sustituida con 9-aminometilo y un método para su preparación. CL2018003739A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201610457261 2016-06-22

Publications (1)

Publication Number Publication Date
CL2018003739A1 true CL2018003739A1 (es) 2019-04-05

Family

ID=60783195

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2018003739A CL2018003739A1 (es) 2016-06-22 2018-12-21 Formas cristalinas de un compuesto de tetraciclina sustituida con 9-aminometilo y un método para su preparación.

Country Status (21)

Country Link
US (1) US10633337B2 (es)
EP (1) EP3476831B8 (es)
JP (1) JP6883593B2 (es)
KR (1) KR102205843B1 (es)
CN (1) CN109563035B (es)
AU (1) AU2017282891B2 (es)
CA (1) CA3028014C (es)
CL (1) CL2018003739A1 (es)
CO (1) CO2019000513A2 (es)
ES (1) ES2906885T3 (es)
IL (1) IL263868B (es)
MA (1) MA45461A (es)
MX (1) MX381701B (es)
MY (1) MY186900A (es)
PE (1) PE20190810A1 (es)
PH (1) PH12018502680A1 (es)
RU (2) RU2764723C2 (es)
SG (1) SG11201811499WA (es)
TW (1) TWI656116B (es)
WO (1) WO2017219994A1 (es)
ZA (1) ZA201900274B (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
USD962414S1 (en) 2020-02-28 2022-08-30 Beijing Xiaomi Mobile Software Co., Ltd Fan
AU2021288202A1 (en) * 2020-06-11 2022-12-08 Paratek Pharmaceuticals Inc. Crystalline forms of omadacycline, methods of synthesis thereof and methods of use thereof

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004064728A2 (en) * 2003-01-16 2004-08-05 Paratek Pharmaceuticals, Inc. Use of specific tetracycline compounds in therapy
AR057649A1 (es) * 2005-05-27 2007-12-12 Wyeth Corp Formas solidas cristalinas de tigeciclina y metodos para preparar las mismas
US8252946B2 (en) * 2007-11-14 2012-08-28 Sandoz Ag Crystalline forms of tigecycline hydrochloride
US20110124893A1 (en) * 2008-01-23 2011-05-26 Sandoz Ag Antibiotic compounds
TW202021946A (zh) * 2008-05-19 2020-06-16 美商派洛泰克藥物股份有限公司 四環素化合物之甲苯磺酸鹽及同素異形體
WO2013013505A1 (zh) 2011-07-26 2013-01-31 山东亨利医药科技有限责任公司 9-氨基甲基取代的四环素类化合物
CN102417465B (zh) * 2011-10-27 2014-03-12 宫宁瑞 替加环素新晶型及其制备方法

Also Published As

Publication number Publication date
PH12018502680A1 (en) 2019-10-14
KR102205843B1 (ko) 2021-01-22
EP3476831B1 (en) 2021-11-17
BR112018076726A2 (pt) 2019-04-02
CA3028014A1 (en) 2017-12-28
RU2022100160A (ru) 2022-03-16
MX2019000086A (es) 2019-05-02
CO2019000513A2 (es) 2019-04-30
KR20190024900A (ko) 2019-03-08
TW201800393A (zh) 2018-01-01
MX381701B (es) 2025-03-13
MA45461A (fr) 2019-05-01
RU2019101248A3 (es) 2020-07-22
RU2019101248A (ru) 2020-07-22
PE20190810A1 (es) 2019-06-13
IL263868B (en) 2022-08-01
JP6883593B2 (ja) 2021-06-09
MY186900A (en) 2021-08-26
CA3028014C (en) 2021-09-07
US10633337B2 (en) 2020-04-28
WO2017219994A1 (zh) 2017-12-28
US20190241515A1 (en) 2019-08-08
SG11201811499WA (en) 2019-01-30
NZ749495A (en) 2020-12-18
ES2906885T3 (es) 2022-04-20
AU2017282891B2 (en) 2020-01-02
JP2019520363A (ja) 2019-07-18
EP3476831A1 (en) 2019-05-01
EP3476831A4 (en) 2019-11-27
EP3476831B8 (en) 2021-12-29
ZA201900274B (en) 2020-05-27
CN109563035B (zh) 2021-07-20
IL263868A (en) 2019-01-31
AU2017282891A1 (en) 2019-01-17
CN109563035A (zh) 2019-04-02
RU2764723C2 (ru) 2022-01-19
TWI656116B (zh) 2019-04-11

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