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CA2322164A1 - Inhibiteurs du transport de la glycine - Google Patents

Inhibiteurs du transport de la glycine Download PDF

Info

Publication number
CA2322164A1
CA2322164A1 CA002322164A CA2322164A CA2322164A1 CA 2322164 A1 CA2322164 A1 CA 2322164A1 CA 002322164 A CA002322164 A CA 002322164A CA 2322164 A CA2322164 A CA 2322164A CA 2322164 A1 CA2322164 A1 CA 2322164A1
Authority
CA
Canada
Prior art keywords
formula
butyl
bis
fluorophenyl
piperidinyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002322164A
Other languages
English (en)
Inventor
Ludo Edmond Josephine Kennis
Walter Herman Maria Louis Luyten
Frans Edward Janssens
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Janssen Pharmaceutica NV
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2322164A1 publication Critical patent/CA2322164A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)

Abstract

La présente invention concerne l'utilisation des dérivés [4,4-bis(4-fluorophényl)butyl]-1-(pipérazinyles et pipéridyniles), inhibiteurs du transport de la glycine, pour la préparation de médicaments destinés aux traitements des troubles du système nerveux périphérique et du système nerveux central, en particulier, des psychoses, de la douleur, de l'épilepsie, des maladies neurodégénératives (maladie d'Alzheimer), de l'ictus, du trauma crânien, de la sclérose multiple et des troubles de même genre. La présente invention concerne aussi de nouveaux composés, leur préparation et leurs formes galéniques.
CA002322164A 1998-03-06 1999-02-26 Inhibiteurs du transport de la glycine Abandoned CA2322164A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP98200701.5 1998-03-06
EP98200701 1998-03-06
PCT/EP1999/001309 WO1999044596A2 (fr) 1998-03-06 1999-02-26 Inhibiteurs du transport de la glycine

Publications (1)

Publication Number Publication Date
CA2322164A1 true CA2322164A1 (fr) 1999-09-10

Family

ID=8233444

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002322164A Abandoned CA2322164A1 (fr) 1998-03-06 1999-02-26 Inhibiteurs du transport de la glycine

Country Status (17)

Country Link
EP (1) EP1059922A2 (fr)
JP (1) JP2002505277A (fr)
KR (1) KR20010032968A (fr)
CN (1) CN1292698A (fr)
AU (1) AU3408999A (fr)
BG (1) BG104685A (fr)
BR (1) BR9907951A (fr)
CA (1) CA2322164A1 (fr)
EE (1) EE200000482A (fr)
HR (1) HRP20000523A2 (fr)
HU (1) HUP0101048A2 (fr)
IL (1) IL138228A0 (fr)
NO (1) NO20004431L (fr)
PL (1) PL343435A1 (fr)
SK (1) SK13082000A3 (fr)
TR (1) TR200002567T2 (fr)
WO (1) WO1999044596A2 (fr)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CZ20014573A3 (cs) 1999-06-28 2002-05-15 Janssen Pharmaceutica N. V. Inhibitory replikace respiračně syncyciálního viru
UA73749C2 (en) * 1999-11-01 2005-09-15 Diarylenines
WO2001081308A2 (fr) * 2000-04-20 2001-11-01 Nps Allelix Corp. Aminopiperidines
DE10040016A1 (de) * 2000-08-16 2002-02-28 Boehringer Ingelheim Pharma Neue beta-Amyloid Inhibitoren, Verfahren zu deren Herstellung und deren Verwendung als Arzneimittel
WO2002019967A2 (fr) 2000-09-08 2002-03-14 Gliatech, Inc. Derives hydraziniques substitues
WO2002022581A1 (fr) * 2000-09-14 2002-03-21 Gliatech, Inc. Composes azotes et leur utilisation comme inhibiteurs de transport de la glycine
AR032653A1 (es) 2001-02-09 2003-11-19 Telik Inc Inhibidores heterociclicos del trasportador de glicina 2 composiciones farmaceuticas, uso y metodos.
US7030150B2 (en) 2001-05-11 2006-04-18 Trimeris, Inc. Benzimidazole compounds and antiviral uses thereof
RU2355683C2 (ru) * 2003-09-09 2009-05-20 Ф.Хоффманн-Ля Рош Аг Производные 1-бензоилпиперазина в качестве ингибиторов поглощения глицина для лечения психозов
EP1663232B1 (fr) * 2003-09-09 2007-10-03 F. Hoffmann-La Roche Ag Derives de 1-(2-amino-benzol)-piperazine en tant qu'inhibiteurs de l'absorption du glycocolle pour traiter des psychoses
WO2005058885A2 (fr) * 2003-12-18 2005-06-30 Glaxo Group Limited Composes
TW200630337A (en) 2004-10-14 2006-09-01 Euro Celtique Sa Piperidinyl compounds and the use thereof
MX2007006429A (es) * 2004-12-09 2007-07-19 Hoffmann La Roche Derivados de fenil-piperazin-metanona.
ES2338139T3 (es) * 2004-12-15 2010-05-04 F. Hoffmann-La Roche Ag Fenil-metanonas bi- y triciclicas sustituidas como inhibidores del transportador de la glicina i (glyt-1) para el tratamiento de la enfermedad de alzheimer.
PE20061156A1 (es) 2004-12-23 2006-12-16 Glaxo Group Ltd Derivados de benzamida como agentes inhibidores del transportador de glicina
GB0428233D0 (en) * 2004-12-23 2005-01-26 Glaxo Group Ltd Compounds
US7485637B2 (en) 2005-01-04 2009-02-03 Hoffmann-La Roche Inc. Benzoyl-tetrahydropiperidine derivatives
EP1836178A1 (fr) * 2005-01-06 2007-09-26 F. Hoffmann-Roche AG Phenyl methanones sulfanyl substituees utilisees comme inhibiteurs du transporteur de glycine 1 (glyt-1) pour le traitement de troubles neurologiques et neuropsychiatriques
BRPI0519794A2 (pt) * 2005-01-07 2009-03-17 Hoffmann La Roche derivados de [4-(heteroaril)piperazin-1-il]-(fenil 2,5-substituìdo)metanona como inibidores de transportador de glicina 1 (glyt-1) para o tratamento de distúrbios neurológicos e neuropsiquiátricos
AU2006207650B2 (en) * 2005-01-18 2011-01-27 F. Hoffmann-La Roche Ag 2, 5-disubstituted phenyl methanone derivatives as glycine transporter 1 (GlyT-I) inhibitors for the treatment of neurological and neuropsychiatry disorders
AU2006208547B2 (en) 2005-01-26 2011-02-10 F. Hoffmann-La Roche Ag Phenyl methanone derivatives and their use as glycine transporter 1 inhibitors
DK1848694T3 (da) * 2005-02-07 2010-01-25 Hoffmann La Roche Heterocykliske substituerede phenylmethanoner som inhibitorer af glycintransporter
CN100341871C (zh) * 2005-06-03 2007-10-10 复旦大学 含哌啶结构的有机硫化合物，制备方法和应用
US8247442B2 (en) 2006-03-29 2012-08-21 Purdue Pharma L.P. Benzenesulfonamide compounds and their use
US8791264B2 (en) 2006-04-13 2014-07-29 Purdue Pharma L.P. Benzenesulfonamide compounds and their use as blockers of calcium channels
TW200812963A (en) 2006-04-13 2008-03-16 Euro Celtique Sa Benzenesulfonamide compounds and the use thereof
KR20120031245A (ko) * 2006-11-01 2012-03-30 퍼듀 퍼머 엘피 페닐프로피온아미드 화합물 및 그의 용도
FR2910321B1 (fr) 2006-12-21 2009-07-10 Galderma Res & Dev S N C Snc Gel creme comprenant au moins un retinoide et du peroxyde de benzole
FR2910320B1 (fr) * 2006-12-21 2009-02-13 Galderma Res & Dev S N C Snc Emulsion comprenant au moins un retinoide et du peroxyde de benzole
WO2008124118A1 (fr) 2007-04-09 2008-10-16 Purdue Pharma L.P. Composés benzènesulfonylés et leur utilisation
US8765736B2 (en) 2007-09-28 2014-07-01 Purdue Pharma L.P. Benzenesulfonamide compounds and the use thereof
EP2231601B1 (fr) * 2007-12-12 2014-06-18 Amgen Inc. Inhibiteurs du transporteur de glycine 1

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1140119A (fr) * 1978-04-03 1983-01-25 Joseph Torremans Nouvelles n-heterocycle-4-piperidinamines
US4219559A (en) * 1979-01-10 1980-08-26 Janssen Pharmaceutica N.V. N-Heterocyclyl-4-piperidinamines
US4695575A (en) * 1984-11-13 1987-09-22 Janssen Pharmaceutica, N.V. 4-[(bicycle heterocyclyl)-methyl and -hetero]-piperidines
PH23995A (en) * 1984-01-09 1990-02-09 Janssen Pharmaceutica Nv 4((bicycle heterocyclyl)-methyl and hetero)piperidines
WO1999025353A1 (fr) * 1997-11-13 1999-05-27 Merck Sharp & Dohme Limited Utilisations therapeutiques de derives de triazolopyridazine

Also Published As

Publication number Publication date
NO20004431L (no) 2000-10-30
AU3408999A (en) 1999-09-20
BG104685A (en) 2001-04-30
HRP20000523A2 (en) 2001-02-28
PL343435A1 (en) 2001-08-13
SK13082000A3 (sk) 2001-03-12
NO20004431D0 (no) 2000-09-05
TR200002567T2 (tr) 2000-11-21
WO1999044596A2 (fr) 1999-09-10
CN1292698A (zh) 2001-04-25
BR9907951A (pt) 2001-01-30
HUP0101048A2 (hu) 2001-10-28
EP1059922A2 (fr) 2000-12-20
IL138228A0 (en) 2001-10-31
EE200000482A (et) 2002-02-15
KR20010032968A (ko) 2001-04-25
WO1999044596A3 (fr) 2000-02-17
JP2002505277A (ja) 2002-02-19

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Legal Events

Date Code Title Description
FZDE Discontinued