BR9907951A - Inibidores de transporte de glicina - Google Patents
Inibidores de transporte de glicinaInfo
- Publication number
- BR9907951A BR9907951A BR9907951-8A BR9907951A BR9907951A BR 9907951 A BR9907951 A BR 9907951A BR 9907951 A BR9907951 A BR 9907951A BR 9907951 A BR9907951 A BR 9907951A
- Authority
- BR
- Brazil
- Prior art keywords
- transport inhibitors
- glycine transport
- transport
- glycin
- epilepsy
- Prior art date
Links
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 title abstract 6
- 239000004471 Glycine Substances 0.000 title abstract 2
- 239000003112 inhibitor Substances 0.000 title abstract 2
- 238000002360 preparation method Methods 0.000 abstract 2
- 125000001255 4-fluorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1F 0.000 abstract 1
- 208000024827 Alzheimer disease Diseases 0.000 abstract 1
- 206010019196 Head injury Diseases 0.000 abstract 1
- 208000012902 Nervous system disease Diseases 0.000 abstract 1
- 208000002193 Pain Diseases 0.000 abstract 1
- 208000028017 Psychotic disease Diseases 0.000 abstract 1
- 208000006011 Stroke Diseases 0.000 abstract 1
- 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 206010015037 epilepsy Diseases 0.000 abstract 1
- 201000006417 multiple sclerosis Diseases 0.000 abstract 1
- 230000004770 neurodegeneration Effects 0.000 abstract 1
- 208000015122 neurodegenerative disease Diseases 0.000 abstract 1
- 230000002093 peripheral effect Effects 0.000 abstract 1
- 125000004193 piperazinyl group Chemical group 0.000 abstract 1
- 125000003386 piperidinyl group Chemical group 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Epidemiology (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP98200701 | 1998-03-06 | ||
| PCT/EP1999/001309 WO1999044596A2 (fr) | 1998-03-06 | 1999-02-26 | Inhibiteurs du transport de la glycine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR9907951A true BR9907951A (pt) | 2001-01-30 |
Family
ID=8233444
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR9907951-8A BR9907951A (pt) | 1998-03-06 | 1999-02-26 | Inibidores de transporte de glicina |
Country Status (17)
| Country | Link |
|---|---|
| EP (1) | EP1059922A2 (fr) |
| JP (1) | JP2002505277A (fr) |
| KR (1) | KR20010032968A (fr) |
| CN (1) | CN1292698A (fr) |
| AU (1) | AU3408999A (fr) |
| BG (1) | BG104685A (fr) |
| BR (1) | BR9907951A (fr) |
| CA (1) | CA2322164A1 (fr) |
| EE (1) | EE200000482A (fr) |
| HR (1) | HRP20000523A2 (fr) |
| HU (1) | HUP0101048A2 (fr) |
| IL (1) | IL138228A0 (fr) |
| NO (1) | NO20004431L (fr) |
| PL (1) | PL343435A1 (fr) |
| SK (1) | SK13082000A3 (fr) |
| TR (1) | TR200002567T2 (fr) |
| WO (1) | WO1999044596A2 (fr) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CZ20014573A3 (cs) | 1999-06-28 | 2002-05-15 | Janssen Pharmaceutica N. V. | Inhibitory replikace respiračně syncyciálního viru |
| UA73749C2 (en) * | 1999-11-01 | 2005-09-15 | Diarylenines | |
| WO2001081308A2 (fr) * | 2000-04-20 | 2001-11-01 | Nps Allelix Corp. | Aminopiperidines |
| DE10040016A1 (de) * | 2000-08-16 | 2002-02-28 | Boehringer Ingelheim Pharma | Neue beta-Amyloid Inhibitoren, Verfahren zu deren Herstellung und deren Verwendung als Arzneimittel |
| WO2002019967A2 (fr) | 2000-09-08 | 2002-03-14 | Gliatech, Inc. | Derives hydraziniques substitues |
| WO2002022581A1 (fr) * | 2000-09-14 | 2002-03-21 | Gliatech, Inc. | Composes azotes et leur utilisation comme inhibiteurs de transport de la glycine |
| AR032653A1 (es) | 2001-02-09 | 2003-11-19 | Telik Inc | Inhibidores heterociclicos del trasportador de glicina 2 composiciones farmaceuticas, uso y metodos. |
| US7030150B2 (en) | 2001-05-11 | 2006-04-18 | Trimeris, Inc. | Benzimidazole compounds and antiviral uses thereof |
| RU2355683C2 (ru) * | 2003-09-09 | 2009-05-20 | Ф.Хоффманн-Ля Рош Аг | Производные 1-бензоилпиперазина в качестве ингибиторов поглощения глицина для лечения психозов |
| EP1663232B1 (fr) * | 2003-09-09 | 2007-10-03 | F. Hoffmann-La Roche Ag | Derives de 1-(2-amino-benzol)-piperazine en tant qu'inhibiteurs de l'absorption du glycocolle pour traiter des psychoses |
| WO2005058885A2 (fr) * | 2003-12-18 | 2005-06-30 | Glaxo Group Limited | Composes |
| TW200630337A (en) | 2004-10-14 | 2006-09-01 | Euro Celtique Sa | Piperidinyl compounds and the use thereof |
| MX2007006429A (es) * | 2004-12-09 | 2007-07-19 | Hoffmann La Roche | Derivados de fenil-piperazin-metanona. |
| ES2338139T3 (es) * | 2004-12-15 | 2010-05-04 | F. Hoffmann-La Roche Ag | Fenil-metanonas bi- y triciclicas sustituidas como inhibidores del transportador de la glicina i (glyt-1) para el tratamiento de la enfermedad de alzheimer. |
| PE20061156A1 (es) | 2004-12-23 | 2006-12-16 | Glaxo Group Ltd | Derivados de benzamida como agentes inhibidores del transportador de glicina |
| GB0428233D0 (en) * | 2004-12-23 | 2005-01-26 | Glaxo Group Ltd | Compounds |
| US7485637B2 (en) | 2005-01-04 | 2009-02-03 | Hoffmann-La Roche Inc. | Benzoyl-tetrahydropiperidine derivatives |
| EP1836178A1 (fr) * | 2005-01-06 | 2007-09-26 | F. Hoffmann-Roche AG | Phenyl methanones sulfanyl substituees utilisees comme inhibiteurs du transporteur de glycine 1 (glyt-1) pour le traitement de troubles neurologiques et neuropsychiatriques |
| BRPI0519794A2 (pt) * | 2005-01-07 | 2009-03-17 | Hoffmann La Roche | derivados de [4-(heteroaril)piperazin-1-il]-(fenil 2,5-substituìdo)metanona como inibidores de transportador de glicina 1 (glyt-1) para o tratamento de distúrbios neurológicos e neuropsiquiátricos |
| AU2006207650B2 (en) * | 2005-01-18 | 2011-01-27 | F. Hoffmann-La Roche Ag | 2, 5-disubstituted phenyl methanone derivatives as glycine transporter 1 (GlyT-I) inhibitors for the treatment of neurological and neuropsychiatry disorders |
| AU2006208547B2 (en) | 2005-01-26 | 2011-02-10 | F. Hoffmann-La Roche Ag | Phenyl methanone derivatives and their use as glycine transporter 1 inhibitors |
| DK1848694T3 (da) * | 2005-02-07 | 2010-01-25 | Hoffmann La Roche | Heterocykliske substituerede phenylmethanoner som inhibitorer af glycintransporter |
| CN100341871C (zh) * | 2005-06-03 | 2007-10-10 | 复旦大学 | 含哌啶结构的有机硫化合物，制备方法和应用 |
| US8247442B2 (en) | 2006-03-29 | 2012-08-21 | Purdue Pharma L.P. | Benzenesulfonamide compounds and their use |
| US8791264B2 (en) | 2006-04-13 | 2014-07-29 | Purdue Pharma L.P. | Benzenesulfonamide compounds and their use as blockers of calcium channels |
| TW200812963A (en) | 2006-04-13 | 2008-03-16 | Euro Celtique Sa | Benzenesulfonamide compounds and the use thereof |
| KR20120031245A (ko) * | 2006-11-01 | 2012-03-30 | 퍼듀 퍼머 엘피 | 페닐프로피온아미드 화합물 및 그의 용도 |
| FR2910321B1 (fr) | 2006-12-21 | 2009-07-10 | Galderma Res & Dev S N C Snc | Gel creme comprenant au moins un retinoide et du peroxyde de benzole |
| FR2910320B1 (fr) * | 2006-12-21 | 2009-02-13 | Galderma Res & Dev S N C Snc | Emulsion comprenant au moins un retinoide et du peroxyde de benzole |
| WO2008124118A1 (fr) | 2007-04-09 | 2008-10-16 | Purdue Pharma L.P. | Composés benzènesulfonylés et leur utilisation |
| US8765736B2 (en) | 2007-09-28 | 2014-07-01 | Purdue Pharma L.P. | Benzenesulfonamide compounds and the use thereof |
| EP2231601B1 (fr) * | 2007-12-12 | 2014-06-18 | Amgen Inc. | Inhibiteurs du transporteur de glycine 1 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1140119A (fr) * | 1978-04-03 | 1983-01-25 | Joseph Torremans | Nouvelles n-heterocycle-4-piperidinamines |
| US4219559A (en) * | 1979-01-10 | 1980-08-26 | Janssen Pharmaceutica N.V. | N-Heterocyclyl-4-piperidinamines |
| US4695575A (en) * | 1984-11-13 | 1987-09-22 | Janssen Pharmaceutica, N.V. | 4-[(bicycle heterocyclyl)-methyl and -hetero]-piperidines |
| PH23995A (en) * | 1984-01-09 | 1990-02-09 | Janssen Pharmaceutica Nv | 4((bicycle heterocyclyl)-methyl and hetero)piperidines |
| WO1999025353A1 (fr) * | 1997-11-13 | 1999-05-27 | Merck Sharp & Dohme Limited | Utilisations therapeutiques de derives de triazolopyridazine |
-
1999
- 1999-02-26 TR TR2000/02567T patent/TR200002567T2/xx unknown
- 1999-02-26 AU AU34089/99A patent/AU3408999A/en not_active Abandoned
- 1999-02-26 PL PL99343435A patent/PL343435A1/xx not_active Application Discontinuation
- 1999-02-26 BR BR9907951-8A patent/BR9907951A/pt not_active Application Discontinuation
- 1999-02-26 IL IL13822899A patent/IL138228A0/xx unknown
- 1999-02-26 EE EEP200000482A patent/EE200000482A/xx unknown
- 1999-02-26 HU HU0101048A patent/HUP0101048A2/hu unknown
- 1999-02-26 HR HR20000523A patent/HRP20000523A2/hr not_active Application Discontinuation
- 1999-02-26 JP JP2000534198A patent/JP2002505277A/ja not_active Withdrawn
- 1999-02-26 WO PCT/EP1999/001309 patent/WO1999044596A2/fr not_active Ceased
- 1999-02-26 EP EP99915541A patent/EP1059922A2/fr not_active Withdrawn
- 1999-02-26 CA CA002322164A patent/CA2322164A1/fr not_active Abandoned
- 1999-02-26 SK SK1308-2000A patent/SK13082000A3/sk unknown
- 1999-02-26 KR KR1020007006315A patent/KR20010032968A/ko not_active Withdrawn
- 1999-02-26 CN CN998036471A patent/CN1292698A/zh active Pending
-
2000
- 2000-08-11 BG BG104685A patent/BG104685A/xx unknown
- 2000-09-05 NO NO20004431A patent/NO20004431L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| NO20004431L (no) | 2000-10-30 |
| AU3408999A (en) | 1999-09-20 |
| BG104685A (en) | 2001-04-30 |
| HRP20000523A2 (en) | 2001-02-28 |
| PL343435A1 (en) | 2001-08-13 |
| SK13082000A3 (sk) | 2001-03-12 |
| NO20004431D0 (no) | 2000-09-05 |
| TR200002567T2 (tr) | 2000-11-21 |
| WO1999044596A2 (fr) | 1999-09-10 |
| CN1292698A (zh) | 2001-04-25 |
| HUP0101048A2 (hu) | 2001-10-28 |
| CA2322164A1 (fr) | 1999-09-10 |
| EP1059922A2 (fr) | 2000-12-20 |
| IL138228A0 (en) | 2001-10-31 |
| EE200000482A (et) | 2002-02-15 |
| KR20010032968A (ko) | 2001-04-25 |
| WO1999044596A3 (fr) | 2000-02-17 |
| JP2002505277A (ja) | 2002-02-19 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA10 | Dismissal: dismissal - article 33 of industrial property law | ||
| B11Y | Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette] |