BG64075B1 - Дозиращ инхалатор за албутерол - Google Patents

Дозиращ инхалатор за албутерол Download PDF

Info

Publication number: BG64075B1
Authority: BG; Bulgaria
Prior art keywords: inhaler according; albuterol; combination; fluorocarbon; propellant
Prior art date: 1995-04-14

Application number

BG102021A

Other languages

Bulgarian (bg)

English (en)

Other versions

BG102021A (en

Inventor

Ian ASHURST

Craig HERMAN

Li Li-Bovet

Michael RIEBE

Original Assignee

Glaxo Wellcome Inc.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-04-14

Filing date

1997-11-05

Publication date

2003-12-31

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27025574&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BG64075(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1997-11-05 Application filed by Glaxo Wellcome Inc. filed Critical Glaxo Wellcome Inc.

1998-07-31 Publication of BG102021A publication Critical patent/BG102021A/xx

2003-12-31 Publication of BG64075B1 publication Critical patent/BG64075B1/bg

Links

NDAUXUAQIAJITI-UHFFFAOYSA-N albuterol Chemical compound CC(C)(C)NCC(O)C1=CC=C(O)C(CO)=C1 NDAUXUAQIAJITI-UHFFFAOYSA-N 0.000 title claims abstract description 27
229960002052 salbutamol Drugs 0.000 title claims abstract description 25
239000003814 drug Substances 0.000 claims abstract description 54
239000000203 mixture Substances 0.000 claims abstract description 47
229940079593 drug Drugs 0.000 claims abstract description 41
229920002313 fluoropolymer Polymers 0.000 claims abstract description 31
239000003380 propellant Substances 0.000 claims abstract description 31
150000003839 salts Chemical class 0.000 claims abstract description 22
239000013543 active substance Substances 0.000 claims abstract description 10
NBVXSUQYWXRMNV-UHFFFAOYSA-N fluoromethane Chemical compound FC NBVXSUQYWXRMNV-UHFFFAOYSA-N 0.000 claims abstract description 10
239000000546 pharmaceutical excipient Substances 0.000 claims abstract description 7
229920000642 polymer Polymers 0.000 claims description 16
229910052782 aluminium Inorganic materials 0.000 claims description 14
XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 claims description 14
239000004812 Fluorinated ethylene propylene Substances 0.000 claims description 11
239000004094 surface-active agent Substances 0.000 claims description 11
239000004813 Perfluoroalkoxy alkane Substances 0.000 claims description 10
229910052751 metal Inorganic materials 0.000 claims description 10
239000002184 metal Substances 0.000 claims description 10
239000000945 filler Substances 0.000 claims description 8
229920006393 polyether sulfone Polymers 0.000 claims description 8
229920002959 polymer blend Polymers 0.000 claims description 8
LVGUZGTVOIAKKC-UHFFFAOYSA-N 1,1,1,2-tetrafluoroethane Chemical group FCC(F)(F)F LVGUZGTVOIAKKC-UHFFFAOYSA-N 0.000 claims description 7
239000004695 Polyether sulfone Substances 0.000 claims description 7
YFMFNYKEUDLDTL-UHFFFAOYSA-N 1,1,1,2,3,3,3-heptafluoropropane Chemical compound FC(F)(F)C(F)C(F)(F)F YFMFNYKEUDLDTL-UHFFFAOYSA-N 0.000 claims description 5
KUVIULQEHSCUHY-XYWKZLDCSA-N Beclometasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(Cl)[C@@H]1[C@@H]1C[C@H](C)[C@@](C(=O)COC(=O)CC)(OC(=O)CC)[C@@]1(C)C[C@@H]2O KUVIULQEHSCUHY-XYWKZLDCSA-N 0.000 claims description 5
229910045601 alloy Inorganic materials 0.000 claims description 5
239000000956 alloy Substances 0.000 claims description 5
239000002260 anti-inflammatory agent Substances 0.000 claims description 5
229950000210 beclometasone dipropionate Drugs 0.000 claims description 5
239000006184 cosolvent Substances 0.000 claims description 5
229920002312 polyamide-imide Polymers 0.000 claims description 5
239000012453 solvate Substances 0.000 claims description 5
239000004952 Polyamide Substances 0.000 claims description 3
239000000043 antiallergic agent Substances 0.000 claims description 3
229940071648 metered dose inhaler Drugs 0.000 claims description 3
229920002647 polyamide Polymers 0.000 claims description 3
239000004642 Polyimide Substances 0.000 claims description 2
239000004734 Polyphenylene sulfide Substances 0.000 claims description 2
229920001721 polyimide Polymers 0.000 claims description 2
229920000069 polyphenylene sulfide Polymers 0.000 claims description 2
TXEYQDLBPFQVAA-UHFFFAOYSA-N tetrafluoromethane Chemical group FC(F)(F)F TXEYQDLBPFQVAA-UHFFFAOYSA-N 0.000 claims description 2
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238000000576 coating method Methods 0.000 description 25
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BNPSSFBOAGDEEL-UHFFFAOYSA-N albuterol sulfate Chemical compound OS(O)(=O)=O.CC(C)(C)NCC(O)C1=CC=C(O)C(CO)=C1.CC(C)(C)NCC(O)C1=CC=C(O)C(CO)=C1 BNPSSFBOAGDEEL-UHFFFAOYSA-N 0.000 description 15
229940057282 albuterol sulfate Drugs 0.000 description 15
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ZFXYFBGIUFBOJW-UHFFFAOYSA-N theophylline Chemical compound O=C1N(C)C(=O)N(C)C2=C1NC=N2 ZFXYFBGIUFBOJW-UHFFFAOYSA-N 0.000 description 4
RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 3
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GIIZNNXWQWCKIB-UHFFFAOYSA-N Serevent Chemical compound C1=C(O)C(CO)=CC(C(O)CNCCCCCCOCCCCC=2C=CC=CC=2)=C1 GIIZNNXWQWCKIB-UHFFFAOYSA-N 0.000 description 2
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QHSJIZLJUFMIFP-UHFFFAOYSA-N ethene;1,1,2,2-tetrafluoroethene Chemical group C=C.FC(F)=C(F)F QHSJIZLJUFMIFP-UHFFFAOYSA-N 0.000 description 2
JYGXADMDTFJGBT-VWUMJDOOSA-N hydrocortisone Chemical compound O=C1CC[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 JYGXADMDTFJGBT-VWUMJDOOSA-N 0.000 description 2
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BQJCRHHNABKAKU-KBQPJGBKSA-N morphine Chemical compound O([C@H]1[C@H](C=C[C@H]23)O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O BQJCRHHNABKAKU-KBQPJGBKSA-N 0.000 description 2
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UCSJYZPVAKXKNQ-HZYVHMACSA-N streptomycin Chemical compound CN[C@H]1[C@H](O)[C@@H](O)[C@H](CO)O[C@H]1O[C@@H]1[C@](C=O)(O)[C@H](C)O[C@H]1O[C@@H]1[C@@H](NC(N)=N)[C@H](O)[C@@H](NC(N)=N)[C@H](O)[C@H]1O UCSJYZPVAKXKNQ-HZYVHMACSA-N 0.000 description 2
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JWZZKOKVBUJMES-UHFFFAOYSA-N (+-)-Isoprenaline Chemical compound CC(C)NCC(O)C1=CC=C(O)C(O)=C1 JWZZKOKVBUJMES-UHFFFAOYSA-N 0.000 description 1
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WRRSFOZOETZUPG-FFHNEAJVSA-N (4r,4ar,7s,7ar,12bs)-9-methoxy-3-methyl-2,4,4a,7,7a,13-hexahydro-1h-4,12-methanobenzofuro[3,2-e]isoquinoline-7-ol;hydrate Chemical compound O.C([C@H]1[C@H](N(CC[C@@]112)C)C3)=C[C@H](O)[C@@H]1OC1=C2C3=CC=C1OC WRRSFOZOETZUPG-FFHNEAJVSA-N 0.000 description 1
UCTWMZQNUQWSLP-VIFPVBQESA-N (R)-adrenaline Chemical compound CNC[C@H](O)C1=CC=C(O)C(O)=C1 UCTWMZQNUQWSLP-VIFPVBQESA-N 0.000 description 1
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FUFLCEKSBBHCMO-UHFFFAOYSA-N 11-dehydrocorticosterone Natural products O=C1CCC2(C)C3C(=O)CC(C)(C(CC4)C(=O)CO)C4C3CCC2=C1 FUFLCEKSBBHCMO-UHFFFAOYSA-N 0.000 description 1
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IVLVTNPOHDFFCJ-UHFFFAOYSA-N fentanyl citrate Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O.C=1C=CC=CC=1N(C(=O)CC)C(CC1)CCN1CCC1=CC=CC=C1 IVLVTNPOHDFFCJ-UHFFFAOYSA-N 0.000 description 1
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BPZSYCZIITTYBL-UHFFFAOYSA-N formoterol Chemical compound C1=CC(OC)=CC=C1CC(C)NCC(O)C1=CC=C(O)C(NC=O)=C1 BPZSYCZIITTYBL-UHFFFAOYSA-N 0.000 description 1
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150000002367 halogens Chemical group 0.000 description 1
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229920001519 homopolymer Polymers 0.000 description 1
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150000004677 hydrates Chemical class 0.000 description 1
150000002430 hydrocarbons Chemical group 0.000 description 1
OROGSEYTTFOCAN-UHFFFAOYSA-N hydrocodone Natural products C1C(N(CCC234)C)C2C=CC(O)C3OC2=C4C1=CC=C2OC OROGSEYTTFOCAN-UHFFFAOYSA-N 0.000 description 1
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238000011065 in-situ storage Methods 0.000 description 1
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238000002483 medication Methods 0.000 description 1
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LMOINURANNBYCM-UHFFFAOYSA-N metaproterenol Chemical compound CC(C)NCC(O)C1=CC(O)=CC(O)=C1 LMOINURANNBYCM-UHFFFAOYSA-N 0.000 description 1
229960005181 morphine Drugs 0.000 description 1
210000003928 nasal cavity Anatomy 0.000 description 1
229960004398 nedocromil Drugs 0.000 description 1
RQTOOFIXOKYGAN-UHFFFAOYSA-N nedocromil Chemical compound CCN1C(C(O)=O)=CC(=O)C2=C1C(CCC)=C1OC(C(O)=O)=CC(=O)C1=C2 RQTOOFIXOKYGAN-UHFFFAOYSA-N 0.000 description 1
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239000000041 non-steroidal anti-inflammatory agent Substances 0.000 description 1
230000009965 odorless effect Effects 0.000 description 1
229960002657 orciprenaline Drugs 0.000 description 1
150000002960 penicillins Chemical class 0.000 description 1
XDRYMKDFEDOLFX-UHFFFAOYSA-N pentamidine Chemical compound C1=CC(C(=N)N)=CC=C1OCCCCCOC1=CC=C(C(N)=N)C=C1 XDRYMKDFEDOLFX-UHFFFAOYSA-N 0.000 description 1
229960004448 pentamidine Drugs 0.000 description 1
230000000144 pharmacologic effect Effects 0.000 description 1
SONNWYBIRXJNDC-VIFPVBQESA-N phenylephrine Chemical compound CNC[C@H](O)C1=CC=CC(O)=C1 SONNWYBIRXJNDC-VIFPVBQESA-N 0.000 description 1
229960001802 phenylephrine Drugs 0.000 description 1
229960000395 phenylpropanolamine Drugs 0.000 description 1
DLNKOYKMWOXYQA-APPZFPTMSA-N phenylpropanolamine Chemical compound C[C@@H](N)[C@H](O)C1=CC=CC=C1 DLNKOYKMWOXYQA-APPZFPTMSA-N 0.000 description 1
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229920003023 plastic Polymers 0.000 description 1
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229920005862 polyol Polymers 0.000 description 1
150000003077 polyols Chemical class 0.000 description 1
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229960005205 prednisolone Drugs 0.000 description 1
OIGNJSKKLXVSLS-VWUMJDOOSA-N prednisolone Chemical compound O=C1C=C[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 OIGNJSKKLXVSLS-VWUMJDOOSA-N 0.000 description 1
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239000001294 propane Substances 0.000 description 1
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238000004080 punching Methods 0.000 description 1
MIXMJCQRHVAJIO-TZHJZOAOSA-N qk4dys664x Chemical compound O.C1([C@@H](F)C2)=CC(=O)C=C[C@]1(C)[C@@H]1[C@@H]2[C@@H]2C[C@H]3OC(C)(C)O[C@@]3(C(=O)CO)[C@@]2(C)C[C@@H]1O.C1([C@@H](F)C2)=CC(=O)C=C[C@]1(C)[C@@H]1[C@@H]2[C@@H]2C[C@H]3OC(C)(C)O[C@@]3(C(=O)CO)[C@@]2(C)C[C@@H]1O MIXMJCQRHVAJIO-TZHJZOAOSA-N 0.000 description 1
230000009467 reduction Effects 0.000 description 1
229960002720 reproterol Drugs 0.000 description 1
WVLAAKXASPCBGT-UHFFFAOYSA-N reproterol Chemical compound C1=2C(=O)N(C)C(=O)N(C)C=2N=CN1CCCNCC(O)C1=CC(O)=CC(O)=C1 WVLAAKXASPCBGT-UHFFFAOYSA-N 0.000 description 1
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IYMMESGOJVNCKV-SKDRFNHKSA-N rimiterol Chemical compound C([C@@H]1[C@@H](O)C=2C=C(O)C(O)=CC=2)CCCN1 IYMMESGOJVNCKV-SKDRFNHKSA-N 0.000 description 1
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Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/008—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy comprising drug dissolved or suspended in liquid propellant for inhalation via a pressurized metered dose inhaler [MDI]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
- A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/12—Aerosols; Foams
- A61K9/124—Aerosols; Foams characterised by the propellant
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/009—Inhalators using medicine packages with incorporated spraying means, e.g. aerosol cans
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D83/00—Containers or packages with special means for dispensing contents
- B65D83/14—Containers for dispensing liquid or semi-liquid contents by internal gaseous pressure, i.e. aerosol containers comprising propellant
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D83/00—Containers or packages with special means for dispensing contents
- B65D83/14—Containers for dispensing liquid or semi-liquid contents by internal gaseous pressure, i.e. aerosol containers comprising propellant
- B65D83/44—Valves specially adapted for the discharge of contents; Regulating devices
- B65D83/52—Metering valves; Metering devices
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/02—General characteristics of the apparatus characterised by a particular materials
- A61M2205/0222—Materials for reducing friction

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Bioinformatics & Cheminformatics (AREA)
Pulmonology (AREA)
Dispersion Chemistry (AREA)
Heart & Thoracic Surgery (AREA)
Mechanical Engineering (AREA)
Hematology (AREA)
Anesthesiology (AREA)
Biomedical Technology (AREA)
Chemical Kinetics & Catalysis (AREA)
Emergency Medicine (AREA)
Otolaryngology (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicinal Preparation (AREA)
Containers And Packaging Bodies Having A Special Means To Remove Contents (AREA)
Laminated Bodies (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Steroid Compounds (AREA)

BG102021A 1995-04-14 1997-11-05 Дозиращ инхалатор за албутерол BG64075B1 (bg)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US42237195A	1995-04-14	1995-04-14
US58486096A	1996-01-05	1996-01-05
PCT/US1996/005002 WO1996032099A1 (en)	1995-04-14	1996-04-10	Metered dose inhaler for albuterol

Publications (2)

Publication Number	Publication Date
BG102021A BG102021A (en)	1998-07-31
BG64075B1 true BG64075B1 (bg)	2003-12-31

Family

ID=27025574

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BG102021A BG64075B1 (bg)	1995-04-14	1997-11-05	Дозиращ инхалатор за албутерол

Country Status (32)

Country	Link
US (2)	US6131566A (xx)
EP (3)	EP0820279B1 (xx)
JP (1)	JPH11509433A (xx)
KR (1)	KR100496836B1 (xx)
CN (1)	CN1217654C (xx)
AP (1)	AP791A (xx)
AT (2)	ATE219934T1 (xx)
AU (1)	AU710382B2 (xx)
BG (1)	BG64075B1 (xx)
BR (1)	BR9604976A (xx)
CA (3)	CA2361954C (xx)
CY (1)	CY2402B1 (xx)
CZ (1)	CZ292578B6 (xx)
DE (2)	DE69637257T2 (xx)
DK (1)	DK0820279T3 (xx)
EA (1)	EA000890B1 (xx)
EE (1)	EE03997B1 (xx)
ES (2)	ES2292526T3 (xx)
GE (1)	GEP20002254B (xx)
HU (1)	HU219900B (xx)
IS (1)	IS4577A (xx)
NO (1)	NO316588B1 (xx)
NZ (1)	NZ306278A (xx)
OA (1)	OA10627A (xx)
PL (1)	PL180900B1 (xx)
PT (1)	PT820279E (xx)
RO (1)	RO119118B1 (xx)
SI (1)	SI0820279T1 (xx)
SK (1)	SK281746B6 (xx)
TR (1)	TR199701167T1 (xx)
UA (1)	UA50734C2 (xx)
WO (1)	WO1996032099A1 (xx)

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DE69631476T2 (de) *	1995-04-14	2005-01-13	Smithkline Beecham Corp.	Vorrichtung zur dosierten inhalierung von beclomethason-diproprionat
EP1908488A3 (en) *	1995-04-14	2008-04-16	SmithKline Beecham Corporation	Metered dose inhaler for salmeterol
BR9604976A (pt) *	1995-04-14	1998-06-09	Glaxo Wellcome Inc	Inalador de dose medida sistema inalador de dose medida e uso do mesmo
WO1996032151A1 (en) *	1995-04-14	1996-10-17	Glaxo Wellcome Inc.	Metered dose inhaler for fluticasone propionate
GB9526392D0 (en)	1995-12-22	1996-02-21	Glaxo Group Ltd	Medicaments
US6120752A (en) *	1997-05-21	2000-09-19	3M Innovative Properties Company	Medicinal aerosol products containing formulations of ciclesonide and related steroids
TW533865U (en) *	1997-06-10	2003-05-21	Glaxo Group Ltd	Dispenser for dispensing medicament and actuation indicating device
US20010031244A1 (en) *	1997-06-13	2001-10-18	Chiesi Farmaceutici S.P.A.	Pharmaceutical aerosol composition
GB2328932B (en) *	1997-09-03	1999-10-13	Bespak Plc	Improvements in or relating to metering valves for pressurised dispensing containers
US20030103906A1 (en) *	1997-10-14	2003-06-05	Smithkline Beecham Corporation	Metered dose inhaler having internal surfaces coated with fluorocarbon polymer
US6086376A (en) *	1998-01-30	2000-07-11	Rtp Pharma Inc.	Dry aerosol suspension of phospholipid-stabilized drug microparticles in a hydrofluoroalkane propellant
GB9814717D0 (en) *	1998-02-23	1998-09-02	Bespak Plc	Improvements in drug delivery devices
DE69901813T3 (de) †	1998-02-23	2008-08-28	Glaxo Group Ltd., Greenford	Unter Druck gesetzte Spenderbehälter
GB9805938D0 (en) *	1998-03-19	1998-05-13	Glaxo Group Ltd	Valve for aerosol container
EP1102579B1 (de) *	1998-08-04	2003-03-19	Jago Research Ag	Medizinische aerosolformulierungen
GB2340759B (en) *	1998-08-26	2003-05-07	Bespak Plc	Improvements in drug delivery devices
GB9820937D0 (en) *	1998-09-26	1998-11-18	Glaxo Group Ltd	Inhalation device
IT1303788B1 (it) *	1998-11-25	2001-02-23	Chiesi Farma Spa	Formulazioni di aerosol medicinali.
DZ2947A1 (fr) *	1998-11-25	2004-03-15	Chiesi Farma Spa	Inhalateur à compteur de dose sous pression.
US6390291B1 (en)	1998-12-18	2002-05-21	Smithkline Beecham Corporation	Method and package for storing a pressurized container containing a drug
WO2001097888A2 (en)	2000-06-22	2001-12-27	Glaxo Group Limited	Method and package for storing a pressurized container containing a drug
US6352152B1 (en)	1998-12-18	2002-03-05	Smithkline Beecham Corporation	Method and package for storing a pressurized container containing a drug
US6315112B1 (en)	1998-12-18	2001-11-13	Smithkline Beecham Corporation	Method and package for storing a pressurized container containing a drug
US6315985B1 (en)	1999-06-18	2001-11-13	3M Innovative Properties Company	C-17/21 OH 20-ketosteroid solution aerosol products with enhanced chemical stability
IT1313553B1 (it)	1999-07-23	2002-09-09	Chiesi Farma Spa	Formulazioni ottimizzate costituite da soluzioni di steroidi dasomministrare per inalazione.
GB9918573D0 (en) *	1999-08-07	1999-10-06	Glaxo Group Ltd	Valve
AU2509901A (en) *	1999-12-11	2001-06-18	Glaxo Group Limited	Medicament dispenser
CO5270018A1 (es) *	1999-12-11	2003-04-30	Glaxo Group Ltd	Distribuidor de medicamento
IT1317720B1 (it) *	2000-01-07	2003-07-15	Chiesi Farma Spa	Dispositivo per la somministrazione di aerosol dosati pressurizzati inpropellenti idrofluoroalcani.
IT1317846B1 (it)	2000-02-22	2003-07-15	Chiesi Farma Spa	Formulazioni contenenti un farmaco anticolinergico per il trattamentodella broncopneumopatia cronica ostruttiva.
AU2001234005B2 (en)	2000-02-28	2006-01-19	Pharmakodex Limited	Improvements in or relating to the delivery of oral drugs
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1996
- 1996-04-10 BR BR9604976A patent/BR9604976A/pt not_active Application Discontinuation
- 1996-04-10 EE EE9700280A patent/EE03997B1/xx unknown
- 1996-04-10 PT PT96911710T patent/PT820279E/pt unknown
- 1996-04-10 SK SK1388-97A patent/SK281746B6/sk not_active IP Right Cessation
- 1996-04-10 SI SI9630514T patent/SI0820279T1/xx unknown
- 1996-04-10 KR KR1019970707247A patent/KR100496836B1/ko not_active Expired - Lifetime
- 1996-04-10 CA CA002361954A patent/CA2361954C/en not_active Expired - Lifetime
- 1996-04-10 ES ES01202061T patent/ES2292526T3/es not_active Expired - Lifetime
- 1996-04-10 EA EA199700231A patent/EA000890B1/ru not_active IP Right Cessation
- 1996-04-10 EP EP96911710A patent/EP0820279B1/en not_active Revoked
- 1996-04-10 CZ CZ19973259A patent/CZ292578B6/cs not_active IP Right Cessation
- 1996-04-10 PL PL96322778A patent/PL180900B1/pl unknown
- 1996-04-10 RO RO97-01883A patent/RO119118B1/ro unknown
- 1996-04-10 CN CN961944110A patent/CN1217654C/zh not_active Expired - Lifetime
- 1996-04-10 CA CA002391617A patent/CA2391617A1/en not_active Abandoned
- 1996-04-10 CA CA002217950A patent/CA2217950C/en not_active Expired - Lifetime
- 1996-04-10 GE GEAP19963925A patent/GEP20002254B/en unknown
- 1996-04-10 DE DE69637257T patent/DE69637257T2/de not_active Expired - Lifetime
- 1996-04-10 HU HU9801526A patent/HU219900B/hu unknown
- 1996-04-10 DK DK96911710T patent/DK0820279T3/da active
- 1996-04-10 WO PCT/US1996/005002 patent/WO1996032099A1/en not_active Ceased
- 1996-04-10 EP EP07018138A patent/EP1870122A3/en not_active Withdrawn
- 1996-04-10 AU AU54809/96A patent/AU710382B2/en not_active Expired
- 1996-04-10 ES ES96911710T patent/ES2179192T3/es not_active Expired - Lifetime
- 1996-04-10 AP APAP/P/1997/001114A patent/AP791A/en active
- 1996-04-10 NZ NZ306278A patent/NZ306278A/xx not_active IP Right Cessation
- 1996-04-10 EP EP01202061A patent/EP1157749B1/en not_active Revoked
- 1996-04-10 AT AT96911710T patent/ATE219934T1/de not_active IP Right Cessation
- 1996-04-10 JP JP8531178A patent/JPH11509433A/ja active Pending
- 1996-04-10 TR TR97/01167T patent/TR199701167T1/xx unknown
- 1996-04-10 AT AT01202061T patent/ATE373613T1/de not_active IP Right Cessation
- 1996-04-10 DE DE69622166T patent/DE69622166T2/de not_active Expired - Fee Related
- 1996-10-04 UA UA97104953A patent/UA50734C2/uk unknown
1997
- 1997-03-31 US US08/831,268 patent/US6131566A/en not_active Expired - Fee Related
- 1997-10-03 IS IS4577A patent/IS4577A/is unknown
- 1997-10-10 OA OA70105A patent/OA10627A/en unknown
- 1997-10-13 NO NO974737A patent/NO316588B1/no unknown
- 1997-11-05 BG BG102021A patent/BG64075B1/bg unknown
2000
- 2000-05-15 US US09/570,789 patent/US6532955B1/en not_active Expired - Fee Related
2004
- 2004-01-02 CY CY0400002A patent/CY2402B1/xx unknown

Also Published As

Publication number	Publication date
EP0820279B1 (en)	2002-07-03
CN1186430A (zh)	1998-07-01
EE9700280A (et)	1998-04-15
TR199701167T1 (xx)	1998-03-21
SI0820279T1 (en)	2002-12-31
UA50734C2 (uk)	2002-11-15
SK138897A3 (en)	1998-05-06
IS4577A (is)	1997-10-03
KR100496836B1 (ko)	2005-10-21
ES2179192T3 (es)	2003-01-16
BG102021A (en)	1998-07-31
MX9707863A (es)	1997-11-29
JPH11509433A (ja)	1999-08-24
PL180900B1 (pl)	2001-04-30
CZ292578B6 (cs)	2003-10-15
DE69637257T2 (de)	2008-06-12
RO119118B1 (ro)	2004-04-30
ATE219934T1 (de)	2002-07-15
PT820279E (pt)	2002-11-29
ES2292526T3 (es)	2008-03-16
EP1870122A3 (en)	2008-03-12
EA199700231A1 (ru)	1998-02-26
AP791A (en)	1999-12-17
US6532955B1 (en)	2003-03-18
DK0820279T3 (da)	2002-10-07
DE69622166D1 (de)	2002-08-08
WO1996032099A1 (en)	1996-10-17
EP1157749A2 (en)	2001-11-28
CN1217654C (zh)	2005-09-07
PL322778A1 (en)	1998-02-16
CA2217950C (en)	2001-12-25
CY2402B1 (en)	2004-09-10
AP9701114A0 (en)	1997-10-31
CA2361954C (en)	2003-07-08
CZ325997A3 (cs)	1998-03-18
HU219900B (hu)	2001-09-28
US6131566A (en)	2000-10-17
GEP20002254B (en)	2000-10-25
NO974737D0 (no)	1997-10-13
EE03997B1 (et)	2003-04-15
DE69637257D1 (de)	2007-10-31
OA10627A (en)	2001-04-24
CA2391617A1 (en)	1996-10-17
EA000890B1 (ru)	2000-06-26
HUP9801526A3 (en)	2000-03-28
SK281746B6 (sk)	2001-07-10
EP1157749A3 (en)	2003-11-26
NZ306278A (en)	1999-07-29
CA2361954A1 (en)	1996-10-17
HK1009398A1 (en)	1999-09-17
DE69622166T2 (de)	2003-04-03
CA2217950A1 (en)	1996-10-17
ATE373613T1 (de)	2007-10-15
EP1157749B1 (en)	2007-09-19
EP0820279A1 (en)	1998-01-28
AU5480996A (en)	1996-10-30
NO316588B1 (no)	2004-03-01
AU710382B2 (en)	1999-09-16
HUP9801526A2 (hu)	1998-10-28
NO974737L (no)	1997-12-11
KR19980703847A (ko)	1998-12-05
EP1870122A2 (en)	2007-12-26
BR9604976A (pt)	1998-06-09

Publication	Publication Date	Title
BG64075B1 (bg)	2003-12-31	Дозиращ инхалатор за албутерол
JP3573213B2 (ja)	2004-10-06	ベクロメタゾンジプロピオネート用計量投与用吸入器
KR100394299B1 (ko)	2003-10-22	플루티카손프로피오네이트용정량흡입기
KR100403899B1 (ko)	2004-03-20	살메테롤용정량흡입기
US20040223919A1 (en)	2004-11-11	Metered dose inhaler having internal surfaces coated with fluorocarbon polymer
MXPA97007878A (en)	1998-07-03	Inhaler of measured dose for dipropionate of beclometasone
MXPA97007863A (en)	1998-07-03	Inhaler of dose measured for albute
CA2467462A1 (en)	1996-10-17	Metered dose inhaler for salmeterol