[go: up one dir, main page]

NO20072013L - Selv-gelerings alginatsystemer og anvendelser derav - Google Patents

Selv-gelerings alginatsystemer og anvendelser derav

Info

Publication number
NO20072013L
NO20072013L NO20072013A NO20072013A NO20072013L NO 20072013 L NO20072013 L NO 20072013L NO 20072013 A NO20072013 A NO 20072013A NO 20072013 A NO20072013 A NO 20072013A NO 20072013 L NO20072013 L NO 20072013L
Authority
NO
Norway
Prior art keywords
alginate
dispersion
indicated
methods
homogeneous
Prior art date
Application number
NO20072013A
Other languages
English (en)
Other versions
NO341594B1 (no
Inventor
Jan-Egil Melvik
Michael Dornish
Edvar Onsoyen
Astrid B Berge
Terje Svendsen
Original Assignee
Fmc Biopolymer As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fmc Biopolymer As filed Critical Fmc Biopolymer As
Publication of NO20072013L publication Critical patent/NO20072013L/no
Publication of NO341594B1 publication Critical patent/NO341594B1/no

Links

Classifications

    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
    • A23L29/20—Foods or foodstuffs containing additives; Preparation or treatment thereof containing gelling or thickening agents
    • A23L29/206—Foods or foodstuffs containing additives; Preparation or treatment thereof containing gelling or thickening agents of vegetable origin
    • A23L29/256—Foods or foodstuffs containing additives; Preparation or treatment thereof containing gelling or thickening agents of vegetable origin from seaweeds, e.g. alginates, agar or carrageenan
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/729—Agar; Agarose; Agaropectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/734—Alginic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/32—Bones; Osteocytes; Osteoblasts; Tendons; Tenocytes; Teeth; Odontoblasts; Cartilage; Chondrocytes; Synovial membrane
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/20—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/28—Materials for coating prostheses
    • A61L27/34—Macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3641—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the site of application in the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3804—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
    • A61L27/3817—Cartilage-forming cells, e.g. pre-chondrocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3839—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by the site of application in the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3895—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells using specific culture conditions, e.g. stimulating differentiation of stem cells, pulsatile flow conditions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
    • A61L29/08—Materials for coatings
    • A61L29/085—Macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/08—Materials for coatings
    • A61L31/10—Macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/36—Materials or treatment for tissue regeneration for embolization or occlusion, e.g. vaso-occlusive compositions or devices
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/81—Packaged device or kit

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Transplantation (AREA)
  • Dermatology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cell Biology (AREA)
  • Botany (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Vascular Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Dispersion Chemistry (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Immunology (AREA)
  • Surgery (AREA)
  • Organic Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Polymers & Plastics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Food Science & Technology (AREA)
  • Nutrition Science (AREA)
  • Virology (AREA)
  • Biotechnology (AREA)
  • Inorganic Chemistry (AREA)
  • Physical Education & Sports Medicine (AREA)

Abstract

Kit og sammensetninger for fremstilling av en alginatgel er angitt. Kitene og sammensetningene omfatter oppløselig alginat og uoppløselig alginat/gelerings ion partikler. Fremgangsmåter for utlevering av en selv-gelerings alginatdispersjon er angitt. Fremgangsmåtene omfatter å danne en dispersjon av uoppløselig alginat/gelerings ion partikler i en løsning inneholdende oppløselig alginat, og utlevere dispersjonen hvorved dispersjonen danner en alginatgel-matriks. Fremgangsmåtene kan omfatte å utlevere dispersjonen inn i kroppen til et individ. En alginatgel med en tykkelse på mer enn 5 mm og et homogent alginatmatriks nettverk og homogene alginatgeler fri fra én eller flere av: sulfater citrater, fosfater, laktatater, EDTA eller lipider er angitt. Implanterbare anordninger omfattende et homogent alginatgel belegg er angitt. Fremgangsmåter for å forbedre viabiliteten av pankreatiske øyer, eller andre cellulære aggregater eller vev, etter isolering og under lagring og transport er angitt.
NO20072013A 2004-10-12 2007-04-19 Biomedisinsk kit for fremstilling av en biokompatibel alginatgel, sammensetning for fremstilling av slike geler, fremgangsmåte for utlevering av en selv-gelerings alginat dispersjon og en implanterbar anordning samt alginatgeler og implanterbare anordninger omfattende slike NO341594B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US61785204P 2004-10-12 2004-10-12
PCT/US2005/036460 WO2006044342A2 (en) 2004-10-12 2005-10-12 Self-gelling alginate systems and uses thereof

Publications (2)

Publication Number Publication Date
NO20072013L true NO20072013L (no) 2007-07-06
NO341594B1 NO341594B1 (no) 2017-12-11

Family

ID=36203445

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20072013A NO341594B1 (no) 2004-10-12 2007-04-19 Biomedisinsk kit for fremstilling av en biokompatibel alginatgel, sammensetning for fremstilling av slike geler, fremgangsmåte for utlevering av en selv-gelerings alginat dispersjon og en implanterbar anordning samt alginatgeler og implanterbare anordninger omfattende slike

Country Status (12)

Country Link
US (4) US7790699B2 (no)
EP (1) EP1799232B1 (no)
JP (1) JP5367266B2 (no)
CN (1) CN101227913B (no)
AU (1) AU2005295927B2 (no)
BR (2) BRPI0515973B8 (no)
CA (1) CA2583373C (no)
IL (1) IL182426A0 (no)
MX (1) MX2007004261A (no)
NO (1) NO341594B1 (no)
RU (1) RU2393867C2 (no)
WO (1) WO2006044342A2 (no)

Families Citing this family (104)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8202701B2 (en) * 2004-10-08 2012-06-19 Georgia Tech Research Corporation Microencapsulation of cells in hydrogels using electrostatic potentials
AU2005295927B2 (en) 2004-10-12 2012-02-02 Fmc Biopolymer As Self-gelling alginate systems and uses thereof
DK2347775T3 (da) 2005-12-13 2020-07-13 Harvard College Skabeloner til celletransplantation
WO2008018892A2 (en) * 2005-12-22 2008-02-14 Pluromed, Inc. Methods and kits for treating lacerations and puncture wounds using inverse thermosensitive polymers
BRPI0708422A2 (pt) * 2006-03-01 2011-05-31 Fmc Biopolymer As E Fmc Corp Método para formar um compósito, compósito, métodos para promover a proliferação celular no compósito, para inibir a proliferação celular e para recuperar células do compósito, uso de um compósito, e , métodos para fixar um compósito a um tecido, para remover o crescimento celular, para induzir a geleificação in situ dentro dos poros de uma espuma de alginato, para prevenir a adesão de tecido a tecido adjacene e para formar uma espuma absorvente seca
ITPD20060203A1 (it) * 2006-05-22 2007-11-23 Univ Degli Studi Trieste Idrogeli di miscele di polisaccaridi per l'ingegneria tissutale e la veicolazione di composti attivi
ATE552867T1 (de) * 2006-06-16 2012-04-15 Fmc Biopolymer As Alginatbeschichtete collagenmatrix- zellvorrichtung, herstellungsverfahren dafür und verwendungen davon
WO2007148197A2 (en) * 2006-06-21 2007-12-27 Fmc Biopolymer As Gastro-activated dietary fibers
WO2008006658A1 (en) * 2006-07-14 2008-01-17 Fmc Biopolymer As Hydrogels containing low molecular weight alginates and biostructures made therefrom
AU2007292923B2 (en) * 2006-09-08 2013-10-03 Cardiopolymers, Inc. Intramyocardial patterning for global cardiac resizing and reshaping
EP2081964A4 (en) * 2006-10-12 2012-07-11 Univ Johns Hopkins ALGINATE AND ALGINATLYASE COMPOSITIONS AND USE METHOD
WO2008102340A2 (en) * 2007-02-20 2008-08-28 Svip 1 Llc Kits and methods for determining colon cleanliness
EP2124716A4 (en) * 2007-02-20 2013-01-16 Renew Medical FECAL INCONTINENCE DEVICE, KIT AND METHOD
MX2009008760A (es) 2007-02-21 2009-08-27 Mochida Pharm Co Ltd Composicion para el tratamiento de enfermedades del cartilago.
AU2013204006B2 (en) * 2007-02-21 2015-09-17 Mochida Pharmaceutical Co., Ltd Composition for treatment of cartilage disease
US20100178313A1 (en) * 2007-06-13 2010-07-15 Fmc Corporation Implantable Degradable Biopolymer Fiber Devices
WO2008157318A2 (en) * 2007-06-13 2008-12-24 Fmc Corporation Alginate coated, polysaccharide gel-containing foam composite, preparative methods, and uses thereof
WO2009002401A2 (en) 2007-06-21 2008-12-31 President And Fellows Of Harvard College Scaffolds for cell collection or elimination
KR20100063744A (ko) * 2007-08-28 2010-06-11 에프엠씨 코포레이션 지연된 자가-겔화 알기네이트 시스템 및 이의 용도
EP2036533A1 (en) * 2007-09-14 2009-03-18 3M Innovative Properties Company Curable Dental Retraction Composition, Method of Production and Use thereof
KR101510494B1 (ko) * 2007-10-24 2015-04-08 모찌다 세이야쿠 가부시끼가이샤 관절 질환 치료용 조성물
PT2268142T (pt) * 2007-11-27 2017-06-02 Algipharma As Utilização de oligómeros alginados no combate aos biofilmes
EP2082755A1 (de) 2008-01-16 2009-07-29 CellMed AG Monolithische in-situ vernetzte Alginatimplantate
US9370558B2 (en) 2008-02-13 2016-06-21 President And Fellows Of Harvard College Controlled delivery of TLR agonists in structural polymeric devices
US10328133B2 (en) 2008-02-13 2019-06-25 President And Fellows Of Harvard College Continuous cell programming devices
US9012399B2 (en) 2008-05-30 2015-04-21 President And Fellows Of Harvard College Controlled release of growth factors and signaling molecules for promoting angiogenesis
US8367637B2 (en) 2008-08-19 2013-02-05 Mochida Pharmaceutical Co., Ltd. Composition for treating arthritic disorder
FR2937857B1 (fr) * 2008-10-30 2015-04-03 Brothier Lab Membrane chirurgicale antiadherence
JP5615804B2 (ja) * 2009-03-23 2014-10-29 公益財団法人函館地域産業振興財団 医療用及び基礎化粧用（スキンケア用）高分子材料並びにその製造方法
EP2416741B1 (en) 2009-04-06 2015-03-11 Bender Analytical Holding B.V. In situ gelling alginate systems
WO2010120749A2 (en) 2009-04-13 2010-10-21 President And Fellow Of Harvard College Harnessing cell dynamics to engineer materials
RU2586253C2 (ru) 2009-06-03 2016-06-10 АльгиФарма АС Обработка акинетобактерий альгинатными олигомерами и антибиотиками
WO2011014871A1 (en) 2009-07-31 2011-02-03 President And Fellows Of Harvard College Programming of cells for tolerogenic therapies
DE102010009475B4 (de) * 2010-02-26 2011-11-24 F. Holzer Gmbh Verfahren zur Herstellung eines dosierbaren applikationsfertigen Präparates
EP2542230A4 (en) 2010-03-05 2013-08-28 Harvard College PROMOTING THE ADHESION OF SKELETAL MUSCLE STEM CELLS BY SIMULTANEOUS ADMINISTRATION OF VEGF AND IGF-1
US8927524B2 (en) 2010-03-11 2015-01-06 Bender Analytical Holding B.V. Sterile alginate-based aqueous composition for medical use and process for the preparation thereof
RU2012145811A (ru) 2010-03-29 2014-05-10 Евоник Корпорейшн Композиции и способы улучшенного удержания фармацевтической композиции на участке местного введения
US9693954B2 (en) 2010-06-25 2017-07-04 President And Fellows Of Harvard College Co-delivery of stimulatory and inhibitory factors to create temporally stable and spatially restricted zones
CN107648668B (zh) 2010-10-06 2021-06-18 哈佛学院董事会 用于基于材料的细胞疗法的可注射的成孔水凝胶
WO2012064697A2 (en) 2010-11-08 2012-05-18 President And Fellows Of Harvard College Materials presenting notch signaling molecules to control cell behavior
WO2012085609A1 (en) 2010-12-20 2012-06-28 Dept. Of Pathobiology Treatment of osteoarthritis by continuous intra-articular injection of alginate gel
WO2012148684A1 (en) 2011-04-27 2012-11-01 President And Fellows Of Harvard College Cell-friendly inverse opal hydrogels for cell encapsulation, drug and protein delivery, and functional nanoparticle encapsulation
US9675561B2 (en) 2011-04-28 2017-06-13 President And Fellows Of Harvard College Injectable cryogel vaccine devices and methods of use thereof
WO2012149358A1 (en) 2011-04-28 2012-11-01 President And Fellows Of Harvard College Injectable preformed macroscopic 3-dimensional scaffolds for minimally invasive administration
US8404256B2 (en) 2011-05-06 2013-03-26 The University Of Memphis Research Foundation Biomaterial composite composition and method of use
AU2012261848B2 (en) 2011-06-03 2017-06-15 President And Fellows Of Harvard College In situ antigen-generating cancer vaccine
WO2013039380A1 (en) 2011-09-15 2013-03-21 Bender Analytical Holding B.V. Sterile alginate-based aqueous composition for medical use and process for the preparation thereof
GB201120368D0 (en) 2011-11-24 2012-01-04 Sperm Vital As Methods for the preparation of hydrogels
US8877259B2 (en) 2012-02-09 2014-11-04 Mary Kay Inc. Cosmetic formulation
CN104244929B (zh) 2012-04-16 2017-04-05 哈佛学院董事会 用于调节免疫反应的介孔二氧化硅组合物
HK1215200A1 (zh) * 2012-11-14 2016-08-19 3-D Matrix Ltd. 血管栓塞系统
CN102993330B (zh) * 2012-12-20 2014-12-24 青岛明月海藻集团有限公司 一种齿科印模材料用藻酸盐的制备方法
WO2014127219A1 (en) * 2013-02-14 2014-08-21 The Cleveland Clinic Foundation Methods for induction of cell fates from pluripotent cells
MD669Z (ro) * 2013-03-14 2014-03-31 Ольга ДИМОВА Procedeu de obţinere a alginaţilor din alge brune
RU2535035C1 (ru) * 2013-09-11 2014-12-10 Общество с ограниченной ответственностью "КОЛЕТЕКС" Способ получения стерильной саможелирующейся альгинатной системы
NZ721597A (en) 2013-12-24 2022-07-01 Ares Trading Sa Fgf-18 formulation in alginate/collagen hydrogels
US10682400B2 (en) 2014-04-30 2020-06-16 President And Fellows Of Harvard College Combination vaccine devices and methods of killing cancer cells
CA2948820C (en) * 2014-05-12 2022-03-22 Jonathan Allen Rowley Ready-to-print cells and integrated devices
WO2015191547A1 (en) * 2014-06-09 2015-12-17 Cornell University Implantable therapeutic delivery system and methods thereof
US9295752B1 (en) 2014-09-30 2016-03-29 Covidien Lp Bioadhesive for occluding vessels
WO2016114355A1 (ja) * 2015-01-15 2016-07-21 国立大学法人東京大学 癒着防止用組成物
EP3250250A4 (en) 2015-01-30 2019-05-22 President and Fellows of Harvard College PERITUMORAL AND INTRATUMORAL MATERIALS FOR CANCER THERAPY
WO2016137834A1 (en) * 2015-02-24 2016-09-01 EmboMedics, Inc. Method and system for alleviating joint pain
JP7094533B2 (ja) 2015-04-10 2022-07-04 プレジデント アンド フェローズ オブ ハーバード カレッジ 免疫細胞捕捉デバイスおよびその製造および使用方法
US10376592B2 (en) 2015-06-29 2019-08-13 University of Pittsburgh—of the Commonwealth System of Higher Education Stapled acid-sensitive endosome disrupting alginates
US9655842B1 (en) 2015-12-04 2017-05-23 Covidien Lp Injectable non-aqueous compositions and methods of treating vascular disease
CN105504087B (zh) * 2016-01-28 2017-11-14 杭州德柯医疗科技有限公司 医用级海藻酸钙的制备方法
EP3411475B1 (en) 2016-02-06 2025-08-27 President and Fellows of Harvard College Recapitulating the hematopoietic niche to reconstitute immunity
WO2017139487A1 (en) 2016-02-09 2017-08-17 Northwind Medical, Inc. Methods, agents, and devices for local neuromodulation of autonomic nerves
RU2618435C1 (ru) * 2016-04-15 2017-05-03 Федеральное государственное бюджетное образовательное учреждение высшего образования "Московский государственный университет имени М.В.Ломоносова" (МГУ) Способ микроинкапсулирования стволовых клеток
CN110035754A (zh) 2016-06-29 2019-07-19 图拉维治疗股份有限公司 通过自主神经系统的局部神经调节治疗败血症及相关炎性病况
CN115537372A (zh) 2016-07-13 2022-12-30 哈佛学院院长等 抗原呈递细胞模拟支架及其制备和使用方法
EP3493842A4 (en) 2016-08-02 2020-07-29 President and Fellows of Harvard College BIOMATERIALS TO MODULATE IMMUNE RESPONSES
EP3661568A4 (en) * 2017-08-03 2021-04-14 Ortho-Space Ltd. SELF-HEALING BALLOONS
WO2019043699A1 (en) * 2017-08-30 2019-03-07 Hadasit Medical Research Services And Development Ltd. DEVICES, KITS AND METHODS FOR REDUCING AND / OR PREVENTING INTRA-ABDOMINAL ADHESIONS
CN116965534A (zh) * 2017-08-31 2023-10-31 罗利制品有限公司 可食用容器的制作方法
WO2019047954A1 (en) * 2017-09-08 2019-03-14 L'oreal SKIN CARE KIT
EP3501553A1 (en) * 2017-12-21 2019-06-26 Association for the Advancement of Tissue Engineering and Cell based Technologies & Therapies (A4TEC) - Associação Hydrogel comprising manganese, methods and uses thereof
GB201801014D0 (en) * 2018-01-22 2018-03-07 Univ Newcastle Storage and/or transport for multicellular aggregates
WO2019157370A1 (en) 2018-02-09 2019-08-15 Decibel Therapeutics, Inc. Hypertonic pharmaceutical compositions containing an anti-platinum chemoprotectant agent
US11103618B2 (en) * 2018-02-22 2021-08-31 Warsaw Orthopedic, Inc. Demineralized bone matrix having improved handling characteristics
AU2019241458B2 (en) * 2018-03-27 2025-02-27 Laminaria Group Ab Nutritional supplements
US20210315587A1 (en) * 2018-07-02 2021-10-14 Tulavi Therapeutics, Inc. Methods and devices for in situ formed nerve cap with rapid release
AU2019299519B2 (en) 2018-07-02 2025-03-06 Incept Llc Methods and devices for in situ formed nerve cap
WO2020061129A1 (en) 2018-09-19 2020-03-26 President And Fellows Of Harvard College Compositions and methods for labeling and modulation of cells in vitro and in vivo
CN112969479A (zh) * 2018-11-06 2021-06-15 国立癌症中心 海藻酸基注射型凝胶体系
CN109735496A (zh) * 2019-02-22 2019-05-10 深圳市罗湖区人民医院 一种肿瘤细胞化疗药物三维耐药模型及其建立方法
CN113498336A (zh) * 2019-03-08 2021-10-12 莱雅公司 用于皮肤护理的试剂盒
CN109894095B (zh) * 2019-03-28 2022-10-14 北京工业大学 一种含铁锰氧化物的海藻酸钠-壳聚糖复合凝胶微球吸附除砷材料及其制备方法
US10813947B1 (en) 2019-05-31 2020-10-27 Decibel Therapeutics, Inc. Methods of otoprotection against platinum-based antineoplastic agents
WO2021062263A1 (en) * 2019-09-27 2021-04-01 Sigilon Therapeutics, Inc. Methods of evaluating polypeptide-modified polymers in compositions
CN111235921A (zh) * 2020-01-21 2020-06-05 湖北工业大学 有效提高粘度与增稠特性的海藻酸钠溶液及其制备方法与应用
WO2021217560A1 (en) * 2020-04-30 2021-11-04 L'oreal Kit for caring for the skin
CA3190689A1 (en) 2020-08-31 2022-03-03 The Board Of Trustees Of University Of Illinois Alginate-coated mesenchymal stromal and progenitor cells and methods for using the same
CN114430042B (zh) * 2020-10-13 2023-09-29 中国石油化工股份有限公司 一种用于锂电池添加剂的海藻酸锂及其制备方法和应用
US20220174941A1 (en) * 2020-12-08 2022-06-09 Seaspine, Inc. Method of Increasing Bone Cell Viability
WO2022271496A1 (en) 2021-06-23 2022-12-29 Loliware Inc. Bio-based, biodegradable compositions and articles made therefrom
WO2023282247A1 (ja) * 2021-07-05 2023-01-12 国立大学法人滋賀医科大学 組織形成剤
CA3225516A1 (en) * 2021-07-14 2023-01-19 Corinne Bright Methods and devices for nerve regeneration
NO347755B1 (en) 2021-10-21 2024-03-18 Blue Wave Therapeutics Gmbh Peptide-coupled alginate gels comprising radionuclides
KR20250018400A (ko) 2022-06-24 2025-02-05 오사카 유니버시티 알긴산염 및 이를 포함하는 지혈재
CN115260544B (zh) * 2022-07-26 2024-04-26 武汉纺织大学 多重交联的3d凝胶材料的快速成型方法
GB202314592D0 (en) * 2023-09-22 2023-11-08 Polari Group Ltd Faecal barrier device
US12479979B1 (en) 2024-11-25 2025-11-25 Loliware, Inc. Biobased, biodegradable compositions for making articles

Family Cites Families (58)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1814981A (en) 1927-08-06 1931-07-14 Kelco Co Process of preparing alginic acid and compounds thereof
GB399822A (en) 1932-03-12 1933-10-12 British Celanese Improvements in processes and apparatus for the manufacture of artificial filaments and like materials
GB666961A (en) * 1942-07-27 1952-02-20 Kelco Co Improvements in gel-forming compositions and methods of forming the same
US2420308A (en) 1942-07-27 1947-05-13 Kelco Co Gel-forming algin composition and method
GB1399822A (en) * 1971-07-30 1975-07-02 Finch E G Growing medium for application to root-forming plant material
NO153084C (no) * 1979-08-01 1986-01-15 Quaker Oats Ltd Fremgangsmaate for fremstilling av imiterte naeringsmiddelprodukter.
US4792525A (en) * 1982-08-04 1988-12-20 La Jolla Cancer Research Foundation Tetrapeptide
US4988621A (en) * 1985-05-24 1991-01-29 La Jolla Cancer Research Foundation Peptides in cell detachment and aggregation
US4879237A (en) * 1985-05-24 1989-11-07 La Jolla Cancer Research Foundation Use of peptides in control of cell attachment and detachment
US4789734A (en) * 1985-08-06 1988-12-06 La Jolla Cancer Research Foundation Vitronectin specific cell receptor derived from mammalian mesenchymal tissue
GB8813773D0 (en) 1988-06-10 1988-07-13 Kelco Int Ltd Alginate gels
US5175093A (en) * 1989-11-07 1992-12-29 Lehigh University Bioactive cells immobilized in alginate beads containing voids formed with polyethylene glycol
US5318780A (en) * 1991-10-30 1994-06-07 Mediventures Inc. Medical uses of in situ formed gels
JP3534780B2 (ja) 1992-01-31 2004-06-07 テルモ株式会社 血管塞栓剤
US5266326A (en) * 1992-06-30 1993-11-30 Pfizer Hospital Products Group, Inc. In situ modification of alginate
AU5599594A (en) 1992-11-16 1994-06-08 Ciba-Geigy Ag Polyvinyl alcohol/borate ophthalmic drug delivery system
US5709854A (en) * 1993-04-30 1998-01-20 Massachusetts Institute Of Technology Tissue formation by injecting a cell-polymeric solution that gels in vivo
US5531716A (en) * 1993-09-29 1996-07-02 Hercules Incorporated Medical devices subject to triggered disintegration
US6090763A (en) * 1994-02-28 2000-07-18 Stewart; Howard Franklin Hydrogel soap
GB9414304D0 (en) * 1994-07-15 1994-09-07 C V Lab Ltd Fibres, manufacture and use
US6129761A (en) 1995-06-07 2000-10-10 Reprogenesis, Inc. Injectable hydrogel compositions
US6150581A (en) 1995-06-07 2000-11-21 United States Surgical Corporation Chitosan/alginate anti-adhesion barrier
WO1997003710A1 (en) 1995-07-19 1997-02-06 Innovative Technologies Limited Wound treatment composition
JP3984664B2 (ja) * 1995-12-22 2007-10-03 日清紡績株式会社 創傷被覆材
JPH09227412A (ja) * 1996-02-28 1997-09-02 Dai Ichi High Frequency Co Ltd 高分子ゲルの製造方法
US6090938A (en) 1996-05-01 2000-07-18 Collaborative Group, Ltd. Activation of signal transduction by underivatized, aqueous soluble . .beta(1-3)-Glucan
GB9609474D0 (en) * 1996-05-08 1996-07-10 Innovative Tech Ltd Hydrogels
IL118376A0 (en) * 1996-05-22 1996-09-12 Univ Ben Gurion Polysaccharide sponges for cell culture and transplantation
NO305441B1 (no) 1996-07-12 1999-05-31 Norsk Hydro As Anvendelse av G-blokk polysakkarider
JP4335316B2 (ja) 1996-09-19 2009-09-30 ザ・リージェンツ・オブ・ザ・ユニバーシティ・オブ・ミシガン アルギネートまたは修飾アルギネートのようなポリサッカライドを含むポリマー
GB2320502B (en) 1996-12-20 2000-09-20 Johnson & Johnson Medical Bioresorbable alginate derivatives
US6656508B2 (en) * 1997-04-17 2003-12-02 Amgen Inc. Sustained-release alginate gels
NO305033B1 (no) 1997-05-09 1999-03-22 Algipharma As Fremgangsmate for fremstilling av uronsyreblokker fra alginat
US5965997A (en) * 1997-08-20 1999-10-12 Benchmarq Microelectronics Battery monitoring circuit with storage of charge and discharge accumulation values accessible therefrom
EP1009317A4 (en) * 1997-08-28 2001-01-24 Boston Scient Corp SYSTEM FOR IMPLANTING CROSSLINKED POLYSACCHARIDE FIBER AND METHODS OF FORMING AND INSERTING THE SAME
US6146655A (en) * 1997-08-29 2000-11-14 Softy-Flex Inc. Flexible intra-oral bandage and drug delivery system
WO1999015211A1 (en) 1997-09-19 1999-04-01 Reprogenesis, Inc. Improved hydrogel for tissue engineering
AT409228B (de) * 1997-11-07 2002-06-25 Siemens Ag Verfahren und einrichtung zum schneiden beim kontinuierlichen warmwalzen
US6911212B2 (en) * 1998-02-27 2005-06-28 Musculoskeletal Transplant Foundation Malleable putty and flowable paste with allograft bone having residual calcium for filling bone defects
US6432449B1 (en) 1998-05-18 2002-08-13 Amgen Inc. Biodegradable sustained-release alginate gels
DE19836960A1 (de) 1998-08-14 2000-02-17 Ulrich Zimmermann Verfahren zur Gewinnung hochgereinigter Alginate
EP1135418A1 (en) * 1998-11-13 2001-09-26 CP Kelco U.S., Inc. Biopolymer salts with low endotoxin levels, biopolymer compositions thereof and methods of making the same
US6309380B1 (en) * 1999-01-27 2001-10-30 Marian L. Larson Drug delivery via conformal film
US6495161B1 (en) * 1999-03-09 2002-12-17 Vivorx, Inc. Cytoprotective biocompatible containment systems for biologically active materials and methods of making same
JP2000288018A (ja) * 1999-04-02 2000-10-17 Alcare Co Ltd 肛門部用ドレッシング
KR20010010151A (ko) 1999-07-16 2001-02-05 김윤 수용성 알긴산염과 카르복시메틸 셀룰로오스를 주성분으로 하는 유착방지제 및 그의 제조방법
US6497902B1 (en) * 1999-12-01 2002-12-24 The Regents Of The University Of Michigan Ionically crosslinked hydrogels with adjustable gelation time
EP1248640B1 (en) * 2000-01-20 2006-10-04 Diabcell Pty Limited Preparation and xenotransplantation of porcine islets
US6592566B2 (en) * 2000-02-03 2003-07-15 Arizona Board Of Regents Method for forming an endovascular occlusion
US6638917B1 (en) * 2000-02-25 2003-10-28 Scimed Life Systems, Inc. Reducing adhesion
SE0103827D0 (sv) 2001-11-16 2001-11-16 Mikael Wiberg Nerve repair unit and method of producing it
CN1665458A (zh) 2002-05-01 2005-09-07 维里根股份公司 可注射软骨细胞植入物
NO20023581D0 (no) 2002-07-26 2002-07-26 Fmc Biopolymer As Nye mutantstammer av Pseudomonas fluorescens og varianter derav, metoder for produksjon og bruk derav til produksjon avalginat
SI21300A (sl) 2002-10-08 2004-04-30 Krka, Tovarna Zdravil, D.D., Novo Mesto Farmacevtske formulacije z alginati
EP1663326B1 (en) * 2003-09-08 2010-03-03 FMC Biopolymer AS Gelled biopolymer based foam
CN1897890B (zh) * 2003-12-23 2012-01-25 Fmc生物聚合物联合股份有限公司 用藻酸盐基质控制细胞生长
AU2005295927B2 (en) * 2004-10-12 2012-02-02 Fmc Biopolymer As Self-gelling alginate systems and uses thereof
JO2630B1 (en) 2006-04-13 2012-06-17 نوفارتيس ايه جي Organic compounds

Also Published As

Publication number Publication date
US20130288998A1 (en) 2013-10-31
US20100303914A1 (en) 2010-12-02
IL182426A0 (en) 2007-09-20
BRPI0515973B1 (pt) 2018-11-21
WO2006044342A2 (en) 2006-04-27
CN101227913B (zh) 2013-08-14
US20060159823A1 (en) 2006-07-20
CA2583373A1 (en) 2006-04-27
BRPI0515973B8 (pt) 2021-07-27
WO2006044342A3 (en) 2007-12-06
BR122018068450B8 (pt) 2021-07-27
AU2005295927A1 (en) 2006-04-27
JP5367266B2 (ja) 2013-12-11
MX2007004261A (es) 2007-06-18
US8741872B2 (en) 2014-06-03
US7790699B2 (en) 2010-09-07
EP1799232A4 (en) 2008-07-16
RU2393867C2 (ru) 2010-07-10
NO341594B1 (no) 2017-12-11
BR122018068450B1 (pt) 2020-12-01
EP1799232B1 (en) 2015-10-07
AU2005295927B2 (en) 2012-02-02
JP2008515927A (ja) 2008-05-15
CN101227913A (zh) 2008-07-23
BRPI0515973A (pt) 2008-08-12
RU2007117702A (ru) 2008-11-20
US8481695B2 (en) 2013-07-09
EP1799232A2 (en) 2007-06-27
US20140271576A1 (en) 2014-09-18
US9463162B2 (en) 2016-10-11
CA2583373C (en) 2013-09-03

Similar Documents

Publication Publication Date Title
NO20072013L (no) Selv-gelerings alginatsystemer og anvendelser derav
Zhang et al. Highly dynamic nanocomposite hydrogels self‐assembled by metal ion‐ligand coordination
Hunt et al. Encapsulation of fibroblasts causes accelerated alginate hydrogel degradation
MX2010002328A (es) Sistema de alginato de auto-gelatinizacion retardada y uso de los mismos.
Huang et al. Fabrication and in vitro testing of polymeric delivery system for condensed DNA
Oh et al. Injectable, interconnected, high‐porosity macroporous biocompatible gelatin scaffolds made by surfactant‐free emulsion templating
Day et al. Immunoisolating poly (ethylene glycol) based capsules support ovarian tissue survival to restore endocrine function
US20210079170A1 (en) Preparation method of 4d chitosan-based thermosensitive hydrogel
Martínez‐Ramos et al. Three‐dimensional constructs using hyaluronan cell carrier as a tool for the study of cancer stem cells
WO2011009106A2 (en) Methods and compositions for in vitro and in vivo chondrogenesis
Castaño et al. Protein patterning on hydrogels by direct microcontact printing: application to cardiac differentiation
EP2120546A2 (en) Scaffolding for tissue regeneration or repair
CN114276562B (zh) 基于金属配位物理混合制备水凝胶的方法及水凝胶
JP7515718B2 (ja) 筋肉幹細胞培養用架橋型ハイドロゲルの調製方法及びその使用
JP2018531021A5 (no)
Lee et al. Evaluation of in vitro spermatogenesis using poly (D, L‐lactic‐co‐glycolic acid)(PLGA)‐based macroporous biodegradable scaffolds
WO2022236998A1 (zh) 一种产物具有粘性的微生物自修复剂及其应用
CN108530653A (zh) 一种聚乙烯醇磁性水凝胶的制备方法
Liu et al. Synthetic niches for differentiation of human embryonic stem cells bypassing embryoid body formation
Guarino et al. Improving surface and transport properties of macroporous hydrogels for bone regeneration
CN105536069B (zh) 一种羟基磷灰石-石墨烯-壳聚糖三元交联还原复合材料及其制备方法
Chaterji et al. Enhanced osteoblast‐like cell adhesion and proliferation using sulfonate‐bearing polymeric scaffolds
CN112354004A (zh) 医用水凝胶及其制备方法和应用
CN114032529B (zh) 一种晶圆级封装产品的化学镀镍溶液及其化学镀镍工艺
CN114591520B (zh) 一种人工模拟骨髓微环境的复合支架及其制备方法与应用