NO20072609L - Malonamid-derivater - Google Patents
Malonamid-derivaterInfo
- Publication number
- NO20072609L NO20072609L NO20072609A NO20072609A NO20072609L NO 20072609 L NO20072609 L NO 20072609L NO 20072609 A NO20072609 A NO 20072609A NO 20072609 A NO20072609 A NO 20072609A NO 20072609 L NO20072609 L NO 20072609L
- Authority
- NO
- Norway
- Prior art keywords
- lower alkyl
- halogen
- hydroxy
- substituted
- cycloalkyl
- Prior art date
Links
- WRIRWRKPLXCTFD-UHFFFAOYSA-N malonamide Chemical class NC(=O)CC(N)=O WRIRWRKPLXCTFD-UHFFFAOYSA-N 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 10
- 229910052736 halogen Inorganic materials 0.000 abstract 7
- 150000002367 halogens Chemical group 0.000 abstract 7
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 4
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 3
- 150000002431 hydrogen Chemical class 0.000 abstract 3
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract 1
- 208000024827 Alzheimer disease Diseases 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 125000002757 morpholinyl group Chemical group 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D267/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D267/02—Seven-membered rings
- C07D267/08—Seven-membered rings having the hetero atoms in positions 1 and 4
- C07D267/12—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D267/14—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with one six-membered ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/553—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Abstract
I Oppfinnelsen angår forbindelser med den generelle formel I hvor R er halogen, lavere alkyl eller lavere alkyl substituert med halogen; R1 er hydrogen, lavere alkyl eller lavere alkyl substituert med halogen eller hydroksy eller er lavere alkenyl, -(CH2)n-cykloalkyl, -(CH2)n-COR' eller er benzyl, eventuelt substituert med halogen eller er -(CH2)n-morfolinyl; R' er lavere alkoksy, hydroksy eller amino; R2 er hydrogen, lavere alkyl eller di-lavere alkyl, lavere alkyl substituert med halogen eller hydroksy eller er benzyl eller cykloalkyl; R3 er lavere alkyl eller lavere alkyl substituert med halogen eller er benzyl, eventuelt substituert med to halogenatomer eller er -(CH2)n-cykloalkyl eller -(CH2)n-pyridinyl; X er -CR4R4'- eller - CR4R4'-O-; R4/R4' er uavhengig av hverandre hydrogen, halogen, lavere alkyl, lavere alkoksy, hydroksy eller -CH2-2-[1,3]dioksalan-; n er 0, 1 eller 2; farmasøytisk egnede syreaddisjonssalter derav og alle former av optisk rene enantiomerer, racemater eller diastereomerer og diastereomer-blandinger derav for behandling av Alzheimer's sykdom.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP04106395 | 2004-12-08 | ||
| EP05100816 | 2005-02-07 | ||
| PCT/EP2005/012834 WO2006061136A2 (en) | 2004-12-08 | 2005-12-01 | Malonamide derivatives as inhibitors of gamma-secretase for the treatment of alzheimer’s disease |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NO20072609L true NO20072609L (no) | 2007-06-19 |
Family
ID=36293585
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20072609A NO20072609L (no) | 2004-12-08 | 2007-05-24 | Malonamid-derivater |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US7211573B2 (no) |
| EP (1) | EP1828151B1 (no) |
| JP (1) | JP4979590B2 (no) |
| KR (1) | KR100890678B1 (no) |
| CN (1) | CN101072760B (no) |
| AR (1) | AR053987A1 (no) |
| AT (1) | ATE504580T1 (no) |
| AU (1) | AU2005313582B8 (no) |
| BR (1) | BRPI0518615A2 (no) |
| CA (1) | CA2589196A1 (no) |
| DE (1) | DE602005027388D1 (no) |
| DK (1) | DK1828151T3 (no) |
| IL (1) | IL183293A0 (no) |
| MX (1) | MX2007006504A (no) |
| NO (1) | NO20072609L (no) |
| NZ (1) | NZ555184A (no) |
| PL (1) | PL1828151T3 (no) |
| PT (1) | PT1828151E (no) |
| RU (1) | RU2402538C2 (no) |
| TW (1) | TWI349005B (no) |
| WO (1) | WO2006061136A2 (no) |
| ZA (1) | ZA200705018B (no) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BRPI0717587A2 (pt) | 2006-09-20 | 2013-10-29 | Hoffmann La Roche | Derivados de 4-oxo-2,3,4,5-tetra-hidro-benzo[b][1,4]diazepina |
| JP2010517954A (ja) * | 2007-02-02 | 2010-05-27 | エフ．ホフマン−ラ ロシュ アーゲー | ６−オキソ−６，７−ジヒドロ−５Ｈ−ジベンゾ［ｂ，ｄ］アゼピン−７−イル誘導体 |
| CN101909633B (zh) * | 2008-01-11 | 2012-05-30 | 霍夫曼-拉罗奇有限公司 | γ-分泌酶抑制剂用于治疗癌症的应用 |
| US8741889B2 (en) * | 2008-01-11 | 2014-06-03 | Hoffmann-La Roche Inc | Method of treating non-small cell lung cancer and colon cancer with gamma-secretase inhibitor |
| CN107438599B (zh) | 2015-06-11 | 2021-12-10 | 豪夫迈·罗氏有限公司 | 靶向Notch通路抑制剂 |
| CA3079786A1 (en) | 2017-10-24 | 2019-05-02 | The Broad Institute, Inc. | 4h-pyrrolo[3,2-c]pyridin-4-one derivatives |
| KR102841441B1 (ko) * | 2018-11-07 | 2025-07-31 | 추가이 세이야쿠 가부시키가이샤 | O-치환 세린 유도체의 제조 방법 |
| WO2020216774A1 (en) | 2019-04-24 | 2020-10-29 | Bayer Aktiengesellschaft | 4h-pyrrolo[3,2-c]pyridin-4-one derivatives |
| CN114127064B (zh) | 2019-04-24 | 2023-12-26 | 拜耳股份有限公司 | 4H-吡咯并[3,2-c]吡啶-4-酮化合物 |
| US20240307362A1 (en) | 2019-04-24 | 2024-09-19 | Bayer Aktiengesellschaft | 4H-PYRROLO[3,2-c]PYRIDIN-4-ONE COMPOUNDS |
| CN112300019A (zh) * | 2019-07-31 | 2021-02-02 | 华东师范大学 | 一种邻乙酰氨基苯丁酸类化合物的制备方法 |
| CA3177214A1 (en) | 2020-03-31 | 2021-10-07 | Bayer Aktiengesellschaft | 3-(anilino)-2-[3-(3-alkoxy-pyridin-4-yl]-1,5,6,7-tetrahydro-4h-pyrrolo[3,2-c]pyridin-4-one derivatives as egfr inhibitors for the treatment of cancer |
| CN116940549A (zh) | 2021-03-09 | 2023-10-24 | 巴斯夫欧洲公司 | 丙二酰胺类及其作为除草剂的用途 |
| AR126867A1 (es) * | 2021-08-25 | 2023-11-22 | Basf Se | Malonamidas herbicidas |
| IL311001A (en) * | 2021-08-31 | 2024-04-01 | Basf Se | Herbicidal malonamides containing a compressed ring system |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL72523A (en) * | 1983-08-12 | 1988-06-30 | Takeda Chemical Industries Ltd | 3-amino-4-oxo-2,3,4,5-tetrahydro-1,5-benzoxazepine derivatives,their production and pharmaceutical compositions containing them |
| JP2002241368A (ja) * | 1997-02-18 | 2002-08-28 | Shionogi & Co Ltd | 新規ベンゾラクタム誘導体およびそれを含有する医薬組成物 |
| WO1999067219A1 (en) * | 1998-06-22 | 1999-12-29 | Elan Pharmaceuticals, Inc. | Compounds for inhibiting beta-amyloid peptide release and/or its synthesis |
| GB0012671D0 (en) | 2000-05-24 | 2000-07-19 | Merck Sharp & Dohme | Therapeutic agents |
| EA009372B1 (ru) * | 2002-05-29 | 2007-12-28 | Ф. Хоффманн-Ля Рош Аг | N-ациламинобензольные производные в качестве селективных ингибиторов моноаминооксидазы в |
| TW200502221A (en) * | 2002-10-03 | 2005-01-16 | Astrazeneca Ab | Novel lactams and uses thereof |
| DE602004015415D1 (de) | 2003-02-04 | 2008-09-11 | Hoffmann La Roche | Malonamidderivate als gamma-secretaseinhibitoren |
| US7060698B2 (en) | 2003-05-19 | 2006-06-13 | Hoffmann-La Roche Inc. | Benzoxazepinone derivatives |
| DE602004020680D1 (de) | 2003-09-09 | 2009-05-28 | Hoffmann La Roche | Die aktivität von gamma-secretase blockierende malonamidderivate |
| DK1673347T3 (en) | 2003-10-06 | 2015-10-12 | Hoffmann La Roche | SUBSTITUTED DIBENZO-AZEPINE AND BENZO-DIAZEPINE DERIVATIVES USED AS GAMMA SECRETASE INHIBITORS |
-
2005
- 2005-11-30 US US11/289,176 patent/US7211573B2/en not_active Expired - Fee Related
- 2005-12-01 AT AT05811672T patent/ATE504580T1/de active
- 2005-12-01 CN CN2005800421635A patent/CN101072760B/zh not_active Expired - Fee Related
- 2005-12-01 DE DE602005027388T patent/DE602005027388D1/de not_active Expired - Lifetime
- 2005-12-01 KR KR1020077015604A patent/KR100890678B1/ko not_active Expired - Fee Related
- 2005-12-01 MX MX2007006504A patent/MX2007006504A/es active IP Right Grant
- 2005-12-01 NZ NZ555184A patent/NZ555184A/en not_active IP Right Cessation
- 2005-12-01 RU RU2007120211/04A patent/RU2402538C2/ru not_active IP Right Cessation
- 2005-12-01 EP EP05811672A patent/EP1828151B1/en not_active Expired - Lifetime
- 2005-12-01 AU AU2005313582A patent/AU2005313582B8/en not_active Ceased
- 2005-12-01 DK DK05811672.4T patent/DK1828151T3/da active
- 2005-12-01 JP JP2007544779A patent/JP4979590B2/ja not_active Expired - Fee Related
- 2005-12-01 WO PCT/EP2005/012834 patent/WO2006061136A2/en not_active Ceased
- 2005-12-01 PL PL05811672T patent/PL1828151T3/pl unknown
- 2005-12-01 BR BRPI0518615-3A patent/BRPI0518615A2/pt not_active IP Right Cessation
- 2005-12-01 CA CA002589196A patent/CA2589196A1/en not_active Abandoned
- 2005-12-01 PT PT05811672T patent/PT1828151E/pt unknown
- 2005-12-07 AR ARP050105106A patent/AR053987A1/es unknown
- 2005-12-07 TW TW094143269A patent/TWI349005B/zh not_active IP Right Cessation
-
2007
- 2007-05-17 IL IL183293A patent/IL183293A0/en unknown
- 2007-05-24 NO NO20072609A patent/NO20072609L/no not_active Application Discontinuation
- 2007-06-04 ZA ZA200705018A patent/ZA200705018B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JP4979590B2 (ja) | 2012-07-18 |
| RU2402538C2 (ru) | 2010-10-27 |
| US20060122168A1 (en) | 2006-06-08 |
| JP2008522994A (ja) | 2008-07-03 |
| TWI349005B (en) | 2011-09-21 |
| DK1828151T3 (da) | 2011-05-16 |
| TW200626568A (en) | 2006-08-01 |
| CN101072760B (zh) | 2011-12-28 |
| US7211573B2 (en) | 2007-05-01 |
| EP1828151B1 (en) | 2011-04-06 |
| EP1828151A2 (en) | 2007-09-05 |
| AU2005313582A8 (en) | 2011-06-16 |
| ATE504580T1 (de) | 2011-04-15 |
| AR053987A1 (es) | 2007-05-30 |
| CN101072760A (zh) | 2007-11-14 |
| KR20070086979A (ko) | 2007-08-27 |
| DE602005027388D1 (de) | 2011-05-19 |
| AU2005313582B2 (en) | 2011-06-02 |
| HK1114840A1 (en) | 2008-11-14 |
| CA2589196A1 (en) | 2006-06-15 |
| AU2005313582A1 (en) | 2006-06-15 |
| IL183293A0 (en) | 2007-09-20 |
| RU2007120211A (ru) | 2009-01-20 |
| PL1828151T3 (pl) | 2011-09-30 |
| MX2007006504A (es) | 2007-06-22 |
| WO2006061136A2 (en) | 2006-06-15 |
| ZA200705018B (en) | 2010-04-28 |
| AU2005313582B8 (en) | 2011-06-16 |
| PT1828151E (pt) | 2011-06-16 |
| BRPI0518615A2 (pt) | 2008-11-25 |
| NZ555184A (en) | 2010-01-29 |
| KR100890678B1 (ko) | 2009-03-26 |
| WO2006061136A3 (en) | 2006-08-03 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC2A | Withdrawal, rejection or dismissal of laid open patent application |