NO20083917L - Malonamidderivater som gammasekretaseinhibitorer - Google Patents
Malonamidderivater som gammasekretaseinhibitorerInfo
- Publication number
- NO20083917L NO20083917L NO20083917A NO20083917A NO20083917L NO 20083917 L NO20083917 L NO 20083917L NO 20083917 A NO20083917 A NO 20083917A NO 20083917 A NO20083917 A NO 20083917A NO 20083917 L NO20083917 L NO 20083917L
- Authority
- NO
- Norway
- Prior art keywords
- lower alkyl
- halogen
- hydrogen
- gamma secretase
- secretase inhibitors
- Prior art date
Links
- WRIRWRKPLXCTFD-UHFFFAOYSA-N malonamide Chemical class NC(=O)CC(N)=O WRIRWRKPLXCTFD-UHFFFAOYSA-N 0.000 title abstract 2
- 239000003540 gamma secretase inhibitor Substances 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 5
- 229910052736 halogen Inorganic materials 0.000 abstract 4
- 150000002367 halogens Chemical class 0.000 abstract 4
- 229910052739 hydrogen Inorganic materials 0.000 abstract 4
- 239000001257 hydrogen Substances 0.000 abstract 4
- 150000002431 hydrogen Chemical class 0.000 abstract 2
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract 1
- 208000024827 Alzheimer disease Diseases 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D223/18—Dibenzazepines; Hydrogenated dibenzazepines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Oppfinnelsen angår malonamid-derivater med formel (I): I hvor A1 er -CHR- eller -C(O)-; A2 er -C(O)-, og R2/R3, uavhengig av hverandre, er hydrogen, lavere alkyl, halogen, hydroksy eller lavere alkoksy; eller A2 er -O-C(O)-, og R2/R3, uavhengig av hverandre, er hydrogen eller lavere alkyl; R er hydrogen eller lavere alkyl substituert med halogen; R1 er hydrogen, lavere alkyl eller -(CH2)n-aryl, eventuelt substituert med halogen; R4 er lavere alkyl substituert med halogen; n er 0, 1 eller 2; og farmasøytisk egnede syreaddisjonssalter, optisk rene enantiomerer, racemater eller diastereomere blandinger derav, for behandling av Alzheimers sykdom.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP06111771 | 2006-03-27 | ||
| PCT/EP2007/052557 WO2007110335A1 (en) | 2006-03-27 | 2007-03-19 | Malonamide derivatives as gamma secretase inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NO20083917L true NO20083917L (no) | 2008-10-23 |
Family
ID=36843221
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20083917A NO20083917L (no) | 2006-03-27 | 2008-09-15 | Malonamidderivater som gammasekretaseinhibitorer |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US7425551B2 (no) |
| EP (1) | EP2018368B1 (no) |
| JP (1) | JP5129231B2 (no) |
| KR (1) | KR101169628B1 (no) |
| CN (1) | CN101410378B (no) |
| AR (1) | AR060125A1 (no) |
| AU (1) | AU2007229550B2 (no) |
| BR (1) | BRPI0709773B8 (no) |
| CA (1) | CA2645756C (no) |
| CL (1) | CL2007000789A1 (no) |
| ES (1) | ES2398531T3 (no) |
| IL (1) | IL194054A (no) |
| MX (1) | MX2008012136A (no) |
| NO (1) | NO20083917L (no) |
| RU (1) | RU2440342C2 (no) |
| TW (1) | TW200740760A (no) |
| WO (1) | WO2007110335A1 (no) |
| ZA (1) | ZA200808190B (no) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008063849A2 (en) * | 2006-11-03 | 2008-05-29 | Northwestern University | Multiple sclerosis therapy |
| WO2008092786A1 (en) * | 2007-02-02 | 2008-08-07 | F. Hoffmann-La Roche Ag | 6-oxo-6,7-dihydro-5h-dibenzo[b,d]azepin-7-yl derivatives |
| FR2913886B1 (fr) | 2007-03-22 | 2012-03-02 | Guerbet Sa | Utilisation de nanoparticules metalliques dans le diagnostique de la maladie d'alzheimer |
| US8309299B2 (en) * | 2010-05-19 | 2012-11-13 | Hoffmann-La Roche Inc. | Combination therapy and method for assessing resistance to treatment |
| TWI530489B (zh) | 2011-03-22 | 2016-04-21 | 必治妥美雅史谷比公司 | 雙（氟烷基）－１，４－苯二氮呯酮化合物 |
| AR087107A1 (es) | 2011-07-27 | 2014-02-12 | Lilly Co Eli | Compuesto inhibidor de la señalizacion de la trayectoria notch |
| JO3491B1 (ar) | 2015-07-07 | 2020-07-05 | Audion Therapeutics | مركبات مثبطة لإشارات مسار notch |
| EP4185306A4 (en) * | 2020-07-23 | 2024-11-06 | Purdue Research Foundation | NOTCH SIGNAL INHIBITORS FOR THE TREATMENT OF OBESITY AND METABOLIC DISEASES |
| CA3229806A1 (en) * | 2021-08-31 | 2023-03-09 | Basf Se | Herbicidal malonamides containing a condensed ring system |
| TW202508595A (zh) | 2023-05-04 | 2025-03-01 | 美商銳新醫藥公司 | 用於ｒａｓ相關疾病或病症之組合療法 |
| WO2025034702A1 (en) | 2023-08-07 | 2025-02-13 | Revolution Medicines, Inc. | Rmc-6291 for use in the treatment of ras protein-related disease or disorder |
| WO2025080946A2 (en) | 2023-10-12 | 2025-04-17 | Revolution Medicines, Inc. | Ras inhibitors |
| WO2025171296A1 (en) | 2024-02-09 | 2025-08-14 | Revolution Medicines, Inc. | Ras inhibitors |
| WO2025240847A1 (en) | 2024-05-17 | 2025-11-20 | Revolution Medicines, Inc. | Ras inhibitors |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SU1404505A1 (ru) * | 1987-01-22 | 1988-06-23 | Томский политехнический институт им.С.М.Кирова | Способ получени 6,7-дигидро-5н-дибенз (с, @ )азепин-7-она |
| JP2004500419A (ja) * | 2000-04-11 | 2004-01-08 | デュポン ファーマシューティカルズ カンパニー | Ａβタンパク質産生阻害剤としての置換ラクタム |
| WO2001092235A1 (en) * | 2000-06-01 | 2001-12-06 | Bristol-Myers Squibb Pharma Company | LACTAMS SUBSTITUTED BY CYCLIC SUCCINATES AS INHIBITORS OF Aβ PROTEIN PRODUCTION |
| TW200502221A (en) * | 2002-10-03 | 2005-01-16 | Astrazeneca Ab | Novel lactams and uses thereof |
| JP4662914B2 (ja) | 2003-02-04 | 2011-03-30 | エフ．ホフマン−ラ ロシュ アーゲー | ガンマ−セクレターゼ阻害剤としてのマロンアミド誘導体 |
| SI1711470T1 (sl) * | 2003-09-09 | 2009-08-31 | Hoffmann La Roche | Derivati malonamida, ki blokirajo aktivnost gama-sekretaze |
| PL1673347T3 (pl) * | 2003-10-06 | 2016-01-29 | Hoffmann La Roche | Podstawione pochodne dibenzo-azepiny i benzo-diazepiny użyteczne jako inhibitory gamma-sekretazy |
-
2007
- 2007-03-19 CA CA2645756A patent/CA2645756C/en active Active
- 2007-03-19 BR BRPI0709773A patent/BRPI0709773B8/pt active IP Right Grant
- 2007-03-19 ES ES07727035T patent/ES2398531T3/es active Active
- 2007-03-19 AU AU2007229550A patent/AU2007229550B2/en active Active
- 2007-03-19 EP EP07727035A patent/EP2018368B1/en active Active
- 2007-03-19 KR KR1020087023614A patent/KR101169628B1/ko active Active
- 2007-03-19 RU RU2008142361/04A patent/RU2440342C2/ru not_active IP Right Cessation
- 2007-03-19 WO PCT/EP2007/052557 patent/WO2007110335A1/en not_active Ceased
- 2007-03-19 CN CN2007800103966A patent/CN101410378B/zh active Active
- 2007-03-19 MX MX2008012136A patent/MX2008012136A/es active IP Right Grant
- 2007-03-19 JP JP2009502013A patent/JP5129231B2/ja active Active
- 2007-03-22 US US11/726,639 patent/US7425551B2/en active Active
- 2007-03-23 TW TW096110174A patent/TW200740760A/zh unknown
- 2007-03-26 CL CL2007000789A patent/CL2007000789A1/es unknown
- 2007-03-26 AR ARP070101236A patent/AR060125A1/es not_active Application Discontinuation
-
2008
- 2008-09-11 IL IL194054A patent/IL194054A/en active IP Right Grant
- 2008-09-15 NO NO20083917A patent/NO20083917L/no not_active Application Discontinuation
- 2008-09-23 ZA ZA200808190A patent/ZA200808190B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| MX2008012136A (es) | 2008-10-03 |
| US7425551B2 (en) | 2008-09-16 |
| WO2007110335A1 (en) | 2007-10-04 |
| JP2009531369A (ja) | 2009-09-03 |
| CA2645756A1 (en) | 2007-10-04 |
| CL2007000789A1 (es) | 2008-01-18 |
| RU2008142361A (ru) | 2010-05-10 |
| EP2018368B1 (en) | 2012-12-05 |
| AR060125A1 (es) | 2008-05-28 |
| BRPI0709773A2 (pt) | 2011-07-26 |
| CN101410378A (zh) | 2009-04-15 |
| BRPI0709773B8 (pt) | 2021-05-25 |
| IL194054A (en) | 2013-05-30 |
| TW200740760A (en) | 2007-11-01 |
| JP5129231B2 (ja) | 2013-01-30 |
| EP2018368A1 (en) | 2009-01-28 |
| BRPI0709773B1 (pt) | 2020-09-15 |
| CA2645756C (en) | 2013-12-31 |
| AU2007229550B2 (en) | 2012-03-08 |
| US20070225273A1 (en) | 2007-09-27 |
| CN101410378B (zh) | 2012-12-05 |
| KR20080098441A (ko) | 2008-11-07 |
| RU2440342C2 (ru) | 2012-01-20 |
| KR101169628B1 (ko) | 2012-07-30 |
| ZA200808190B (en) | 2009-08-26 |
| AU2007229550A1 (en) | 2007-10-04 |
| ES2398531T3 (es) | 2013-03-20 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC2A | Withdrawal, rejection or dismissal of laid open patent application |