AR053987A1 - Derivados de malonamida. proceso de obtencion y composiciones farmaceuticas. - Google Patents
Derivados de malonamida. proceso de obtencion y composiciones farmaceuticas.Info
- Publication number
- AR053987A1 AR053987A1 ARP050105106A ARP050105106A AR053987A1 AR 053987 A1 AR053987 A1 AR 053987A1 AR P050105106 A ARP050105106 A AR P050105106A AR P050105106 A ARP050105106 A AR P050105106A AR 053987 A1 AR053987 A1 AR 053987A1
- Authority
- AR
- Argentina
- Prior art keywords
- lower alkyl
- halogen
- pharmaceutical compositions
- cycloalkyl
- hydroxy
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- WRIRWRKPLXCTFD-UHFFFAOYSA-N malonamide Chemical class NC(=O)CC(N)=O WRIRWRKPLXCTFD-UHFFFAOYSA-N 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 10
- 229910052736 halogen Inorganic materials 0.000 abstract 5
- 125000005843 halogen group Chemical group 0.000 abstract 5
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 3
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 2
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D267/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D267/02—Seven-membered rings
- C07D267/08—Seven-membered rings having the hetero atoms in positions 1 and 4
- C07D267/12—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D267/14—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with one six-membered ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/553—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Hydrogenated Pyridines (AREA)
Abstract
Proceso de obtencion y composiciones farmacéuticas que los comprenden. Reivindicacion 1: Compuestos de la formula general (1) en la que R es halogeno, alquilo inferior o trifluorometilo; R1 es H, alquilo inferior o alquilo inferior sustituido por halogeno o hidroxi o es alquenilo inferior, -(CH2)n-cicloalquilo, -(CH2)n-COR' o es bencilo opcionalmente sustituido por halogeno o R' es alcoxi inferior, hidroxi o amino; R2 es H, alquilo inferior, trifluorometilo o cicloalquilo; R3 es alquilo inferior o alquilo inferior sustituido por halogeno o es bencilo opcionalmente sustituido por dos átomos de halogeno o es -(CH2)n-cicloalquilo o -(CH2)n-piridinilo; X es -CH2-, -CH(R4)-, -C(alquilo inferior)2-, -C(halogeno)(alquilo inferior)- o - CH(R4)-O-; R4 es alquilo, alquilo inferior, alcoxi inferior, hidroxi o -CH2-2-[1,3]dioxalano-; n es 0, 1 o 2; a sales de adicion de ácido farmacéuticamente aceptables de los mismos.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP04106395 | 2004-12-08 | ||
| EP05100816 | 2005-02-07 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR053987A1 true AR053987A1 (es) | 2007-05-30 |
Family
ID=36293585
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP050105106A AR053987A1 (es) | 2004-12-08 | 2005-12-07 | Derivados de malonamida. proceso de obtencion y composiciones farmaceuticas. |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US7211573B2 (es) |
| EP (1) | EP1828151B1 (es) |
| JP (1) | JP4979590B2 (es) |
| KR (1) | KR100890678B1 (es) |
| CN (1) | CN101072760B (es) |
| AR (1) | AR053987A1 (es) |
| AT (1) | ATE504580T1 (es) |
| AU (1) | AU2005313582B8 (es) |
| BR (1) | BRPI0518615A2 (es) |
| CA (1) | CA2589196A1 (es) |
| DE (1) | DE602005027388D1 (es) |
| DK (1) | DK1828151T3 (es) |
| IL (1) | IL183293A0 (es) |
| MX (1) | MX2007006504A (es) |
| NO (1) | NO20072609L (es) |
| NZ (1) | NZ555184A (es) |
| PL (1) | PL1828151T3 (es) |
| PT (1) | PT1828151E (es) |
| RU (1) | RU2402538C2 (es) |
| TW (1) | TWI349005B (es) |
| WO (1) | WO2006061136A2 (es) |
| ZA (1) | ZA200705018B (es) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2069317A2 (en) | 2006-09-20 | 2009-06-17 | F. Hoffmann-Roche AG | 4-oxo-2,3,4,5-tetrahydro-benzo[b][1,4]diazepine derivatives |
| WO2008092786A1 (en) * | 2007-02-02 | 2008-08-07 | F. Hoffmann-La Roche Ag | 6-oxo-6,7-dihydro-5h-dibenzo[b,d]azepin-7-yl derivatives |
| CN101909633B (zh) * | 2008-01-11 | 2012-05-30 | 霍夫曼-拉罗奇有限公司 | γ-分泌酶抑制剂用于治疗癌症的应用 |
| US8741889B2 (en) * | 2008-01-11 | 2014-06-03 | Hoffmann-La Roche Inc | Method of treating non-small cell lung cancer and colon cancer with gamma-secretase inhibitor |
| EP3307721B1 (en) | 2015-06-11 | 2020-06-17 | H. Hoffnabb-La Roche Ag | Targeted notch pathway inhibitors |
| US11339157B1 (en) | 2017-10-24 | 2022-05-24 | Bayer Aktiengesellschaft | 4H-pyrrolo[3,2-c]pyridin-4-one derivatives |
| WO2020095983A1 (ja) * | 2018-11-07 | 2020-05-14 | 中外製薬株式会社 | Ｏ－置換セリン誘導体の製造方法 |
| WO2020216773A1 (en) | 2019-04-24 | 2020-10-29 | Bayer Aktiengesellschaft | 4h-pyrrolo[3,2-c]pyridin-4-one compounds |
| BR112021019998B1 (pt) | 2019-04-24 | 2024-01-16 | The Broad Institute, Inc. | 4h-pirrolo[3,2-c]piridin-4-ona, seus usos, composição farmacêutica, e kit de partes |
| WO2020216774A1 (en) | 2019-04-24 | 2020-10-29 | Bayer Aktiengesellschaft | 4h-pyrrolo[3,2-c]pyridin-4-one derivatives |
| CN112300019A (zh) * | 2019-07-31 | 2021-02-02 | 华东师范大学 | 一种邻乙酰氨基苯丁酸类化合物的制备方法 |
| CA3177214A1 (en) | 2020-03-31 | 2021-10-07 | Bayer Aktiengesellschaft | 3-(anilino)-2-[3-(3-alkoxy-pyridin-4-yl]-1,5,6,7-tetrahydro-4h-pyrrolo[3,2-c]pyridin-4-one derivatives as egfr inhibitors for the treatment of cancer |
| CN116940549A (zh) | 2021-03-09 | 2023-10-24 | 巴斯夫欧洲公司 | 丙二酰胺类及其作为除草剂的用途 |
| CN117858619A (zh) * | 2021-08-25 | 2024-04-09 | 巴斯夫欧洲公司 | 除草剂丙二酰胺 |
| CA3229806A1 (en) * | 2021-08-31 | 2023-03-09 | Basf Se | Herbicidal malonamides containing a condensed ring system |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL72523A (en) * | 1983-08-12 | 1988-06-30 | Takeda Chemical Industries Ltd | 3-amino-4-oxo-2,3,4,5-tetrahydro-1,5-benzoxazepine derivatives,their production and pharmaceutical compositions containing them |
| JP2002241368A (ja) * | 1997-02-18 | 2002-08-28 | Shionogi & Co Ltd | 新規ベンゾラクタム誘導体およびそれを含有する医薬組成物 |
| WO1999067219A1 (en) * | 1998-06-22 | 1999-12-29 | Elan Pharmaceuticals, Inc. | Compounds for inhibiting beta-amyloid peptide release and/or its synthesis |
| GB0012671D0 (en) | 2000-05-24 | 2000-07-19 | Merck Sharp & Dohme | Therapeutic agents |
| CA2486380C (en) * | 2002-05-29 | 2011-10-25 | F. Hoffmann-La Roche Ag | N-acylaminobenzene dervatives as selective monoamine oxidase b inhibitors |
| TW200502221A (en) * | 2002-10-03 | 2005-01-16 | Astrazeneca Ab | Novel lactams and uses thereof |
| JP4662914B2 (ja) | 2003-02-04 | 2011-03-30 | エフ．ホフマン−ラ ロシュ アーゲー | ガンマ−セクレターゼ阻害剤としてのマロンアミド誘導体 |
| US7060698B2 (en) | 2003-05-19 | 2006-06-13 | Hoffmann-La Roche Inc. | Benzoxazepinone derivatives |
| SI1711470T1 (sl) | 2003-09-09 | 2009-08-31 | Hoffmann La Roche | Derivati malonamida, ki blokirajo aktivnost gama-sekretaze |
| PL1673347T3 (pl) | 2003-10-06 | 2016-01-29 | Hoffmann La Roche | Podstawione pochodne dibenzo-azepiny i benzo-diazepiny użyteczne jako inhibitory gamma-sekretazy |
-
2005
- 2005-11-30 US US11/289,176 patent/US7211573B2/en not_active Expired - Fee Related
- 2005-12-01 DK DK05811672.4T patent/DK1828151T3/da active
- 2005-12-01 NZ NZ555184A patent/NZ555184A/en not_active IP Right Cessation
- 2005-12-01 MX MX2007006504A patent/MX2007006504A/es active IP Right Grant
- 2005-12-01 PT PT05811672T patent/PT1828151E/pt unknown
- 2005-12-01 CA CA002589196A patent/CA2589196A1/en not_active Abandoned
- 2005-12-01 KR KR1020077015604A patent/KR100890678B1/ko not_active Expired - Fee Related
- 2005-12-01 AU AU2005313582A patent/AU2005313582B8/en not_active Ceased
- 2005-12-01 DE DE602005027388T patent/DE602005027388D1/de not_active Expired - Lifetime
- 2005-12-01 AT AT05811672T patent/ATE504580T1/de active
- 2005-12-01 BR BRPI0518615-3A patent/BRPI0518615A2/pt not_active IP Right Cessation
- 2005-12-01 RU RU2007120211/04A patent/RU2402538C2/ru not_active IP Right Cessation
- 2005-12-01 EP EP05811672A patent/EP1828151B1/en not_active Expired - Lifetime
- 2005-12-01 WO PCT/EP2005/012834 patent/WO2006061136A2/en not_active Ceased
- 2005-12-01 JP JP2007544779A patent/JP4979590B2/ja not_active Expired - Fee Related
- 2005-12-01 CN CN2005800421635A patent/CN101072760B/zh not_active Expired - Fee Related
- 2005-12-01 PL PL05811672T patent/PL1828151T3/pl unknown
- 2005-12-07 AR ARP050105106A patent/AR053987A1/es unknown
- 2005-12-07 TW TW094143269A patent/TWI349005B/zh not_active IP Right Cessation
-
2007
- 2007-05-17 IL IL183293A patent/IL183293A0/en unknown
- 2007-05-24 NO NO20072609A patent/NO20072609L/no not_active Application Discontinuation
- 2007-06-04 ZA ZA200705018A patent/ZA200705018B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| RU2007120211A (ru) | 2009-01-20 |
| DE602005027388D1 (de) | 2011-05-19 |
| PL1828151T3 (pl) | 2011-09-30 |
| ATE504580T1 (de) | 2011-04-15 |
| KR100890678B1 (ko) | 2009-03-26 |
| BRPI0518615A2 (pt) | 2008-11-25 |
| AU2005313582B2 (en) | 2011-06-02 |
| CN101072760B (zh) | 2011-12-28 |
| AU2005313582A8 (en) | 2011-06-16 |
| JP4979590B2 (ja) | 2012-07-18 |
| MX2007006504A (es) | 2007-06-22 |
| EP1828151B1 (en) | 2011-04-06 |
| WO2006061136A2 (en) | 2006-06-15 |
| ZA200705018B (en) | 2010-04-28 |
| AU2005313582B8 (en) | 2011-06-16 |
| DK1828151T3 (da) | 2011-05-16 |
| US20060122168A1 (en) | 2006-06-08 |
| RU2402538C2 (ru) | 2010-10-27 |
| IL183293A0 (en) | 2007-09-20 |
| US7211573B2 (en) | 2007-05-01 |
| NZ555184A (en) | 2010-01-29 |
| TW200626568A (en) | 2006-08-01 |
| AU2005313582A1 (en) | 2006-06-15 |
| NO20072609L (no) | 2007-06-19 |
| CA2589196A1 (en) | 2006-06-15 |
| CN101072760A (zh) | 2007-11-14 |
| TWI349005B (en) | 2011-09-21 |
| KR20070086979A (ko) | 2007-08-27 |
| PT1828151E (pt) | 2011-06-16 |
| JP2008522994A (ja) | 2008-07-03 |
| HK1114840A1 (en) | 2008-11-14 |
| EP1828151A2 (en) | 2007-09-05 |
| WO2006061136A3 (en) | 2006-08-03 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |