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EA200900358A1 - Энантиомерно чистые фосфоиндолы в качестве ингибиторов hiv - Google Patents

Энантиомерно чистые фосфоиндолы в качестве ингибиторов hiv

Info

Publication number
EA200900358A1
EA200900358A1 EA200900358A EA200900358A EA200900358A1 EA 200900358 A1 EA200900358 A1 EA 200900358A1 EA 200900358 A EA200900358 A EA 200900358A EA 200900358 A EA200900358 A EA 200900358A EA 200900358 A1 EA200900358 A1 EA 200900358A1
Authority
EA
Eurasian Patent Office
Prior art keywords
nrr
heterocyclyl
aryl
compounds
hydrogen
Prior art date
Application number
EA200900358A
Other languages
English (en)
Other versions
EA016267B1 (ru
Inventor
Ричард Сторер
Франсуа-Рене Александр
Кирил Дуссон
Адел М. Мусса
Эдвард Бриджиз
Original Assignee
Айденикс Фармасьютикалз, Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Айденикс Фармасьютикалз, Инк. filed Critical Айденикс Фармасьютикалз, Инк.
Publication of EA200900358A1 publication Critical patent/EA200900358A1/ru
Publication of EA016267B1 publication Critical patent/EA016267B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/572—Five-membered rings
    • C07F9/5728—Five-membered rings condensed with carbocyclic rings or carbocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Virology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicinal Preparation (AREA)

Abstract

Предложены 3-фосфоиндольные соединения по существу в форме единичного энантиомера, полезные для лечения инфекций, вызванных вирусами семейства Flaviviridae, и, в частности, инфекций HLV. Также предложены фармацевтические композиции, содержащие 3-фосфоиндольные соединения самостоятельно или в комбинации с одним или более чем одним другим противовирусным агентом, способы их получения и способы приготовления лекарственного средства, включающего эти соединения. 3-Фосфоиндольные соединения имеют формулы (А) или (В) и их фармацевтически приемлемые соли, сольваты, гидраты или сложные эфиры. В формулах Х представляет собой атом водорода; арил или гетероциклил; Салкенил, Салкинил или алкил; Y представляет собой водород, -R, -O-R, -NH-R или -NRR; Z представляет собой -OR, -NHR, -NRR, карбоксамидо, амидо, карбоксил, карбонил или остаток аминокислоты; Rпредставляет собой водород, ацил, -S(O)-R, карбоксил, карбонил или остаток аминокислоты; каждый из R, R, Rи Rнезависимо представляет собой водород, Салкенил, Салкинил, арил, гетероциклил, галоген, -CN, -CF, -OR, -NHR, -NRR или -NO; n равно 0, 1 или 2; и каждый R независимо представляет собой водород, алкил, Салкенил, Салкинил, арил или гетероциклил.
EA200900358A 2006-09-29 2007-09-28 Энантиомерно чистые фосфоиндолы в качестве ингибиторов hiv EA016267B1 (ru)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US84858406P 2006-09-29 2006-09-29
US85798006P 2006-11-09 2006-11-09
US90311507P 2007-02-23 2007-02-23
PCT/US2007/020900 WO2008042240A2 (en) 2006-09-29 2007-09-28 Enantiomerically pure phosphoindoles as hiv inhibitors

Publications (2)

Publication Number Publication Date
EA200900358A1 true EA200900358A1 (ru) 2009-10-30
EA016267B1 EA016267B1 (ru) 2012-03-30

Family

ID=39145445

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200900358A EA016267B1 (ru) 2006-09-29 2007-09-28 Энантиомерно чистые фосфоиндолы в качестве ингибиторов hiv

Country Status (18)

Country Link
US (2) US7960428B2 (ru)
EP (1) EP2078029B1 (ru)
JP (1) JP2010504978A (ru)
KR (1) KR20090077813A (ru)
AU (1) AU2007305447A1 (ru)
BR (1) BRPI0717511A2 (ru)
CA (1) CA2664396A1 (ru)
CO (1) CO6190525A2 (ru)
CR (1) CR10693A (ru)
EA (1) EA016267B1 (ru)
ES (1) ES2488922T3 (ru)
IL (1) IL197777A (ru)
MA (1) MA30806B1 (ru)
MX (1) MX2009003410A (ru)
NO (1) NO20091258L (ru)
NZ (1) NZ575831A (ru)
TW (1) TW200821287A (ru)
WO (1) WO2008042240A2 (ru)

Families Citing this family (116)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG155939A1 (en) * 2004-09-17 2009-10-29 Idenix Pharmaceuticals Inc Phosphoindoles as hiv inhibitors
EA016267B1 (ru) 2006-09-29 2012-03-30 Айденикс Фармасьютикалз, Инк. Энантиомерно чистые фосфоиндолы в качестве ингибиторов hiv
TWI384986B (zh) * 2007-01-17 2013-02-11 Lg Life Sciences Ltd 抗病毒劑之順丁烯二酸單鹽以及含有該單鹽之醫藥組成物
TW200946541A (en) 2008-03-27 2009-11-16 Idenix Pharmaceuticals Inc Solid forms of an anti-HIV phosphoindole compound
TW200944537A (en) * 2008-04-03 2009-11-01 Idenix Pharmaceuticals Inc Formulations comprising a phosphoindole compound and one or more second active agents
CN102115452A (zh) * 2009-12-30 2011-07-06 上海特化医药科技有限公司 (e)-3-(3-取代-5-甲基苯基)丙烯腈及其制备方法
EA032868B1 (ru) 2010-01-27 2019-07-31 Вайв Хелткер Компани Комбинация для лечения вич-инфекции
KR101301253B1 (ko) * 2011-12-09 2013-08-28 한국원자력연구원 방사선을 이용한 크로메논 유도체의 제조방법
WO2013142873A2 (en) 2012-03-23 2013-09-26 The Board Of Trustees Of The University Of Illinois Complex and structurally diverse compounds
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