NO20034576L - [Dihydro-benzo[b] [1,4] diazepin-2-on-derivater som MGLUR2- antagonister II - Google Patents

[Dihydro-benzo[b] [1,4] diazepin-2-on-derivater som MGLUR2- antagonister II

Info

Publication number: NO20034576L
Authority: NO; Norway
Prior art keywords: diazepin; benzo; dihydro; derivatives; mglur2 antagonists
Prior art date: 2001-04-12

Application number

NO20034576A

Other languages

English (en)

Norwegian (no)

Other versions

NO20034576D0 (no

Inventor

Juergen Wichmann

Geo Adam

Erwin Goetschi

Vincent Mutel

Thomas Johannes Woltering

Original Assignee

Hoffmann La Roche

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-04-12

Filing date

2003-10-10

Publication date

2003-11-12

2003-10-10 Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche

2003-10-10 Publication of NO20034576D0 publication Critical patent/NO20034576D0/no

2003-11-12 Publication of NO20034576L publication Critical patent/NO20034576L/no

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
- C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
- C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
- C07D243/24—Oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Psychiatry (AREA)
Hospice & Palliative Care (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

NO20034576A 2001-04-12 2003-10-10 [Dihydro-benzo[b] [1,4] diazepin-2-on-derivater som MGLUR2- antagonister II NO20034576L (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP01109125		2001-04-12
PCT/EP2002/003644 WO2002083652A1 (en)	2001-04-12	2002-04-02	DIHYDRO-BENZO [b] [1, 4] DIAZEPIN-2-ONE DERIVATIVES AS MGLUR2 ANTAGONISTS II

Publications (2)

Publication Number	Publication Date
NO20034576D0 NO20034576D0 (no)	2003-10-10
NO20034576L true NO20034576L (no)	2003-11-12

Family

ID=8177126

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO20034576A NO20034576L (no)	2001-04-12	2003-10-10	[Dihydro-benzo[b] [1,4] diazepin-2-on-derivater som MGLUR2- antagonister II

Country Status (37)

Country	Link
US (1)	US6544985B2 (sk)
EP (1)	EP1379511B1 (sk)
JP (1)	JP4071115B2 (sk)
KR (1)	KR100566171B1 (sk)
CN (1)	CN1264825C (sk)
AR (1)	AR035816A1 (sk)
AT (1)	ATE299868T1 (sk)
AU (1)	AU2002312788B2 (sk)
BG (1)	BG108254A (sk)
BR (1)	BR0208891A (sk)
CA (1)	CA2442557C (sk)
CZ (1)	CZ20033003A3 (sk)
DE (1)	DE60205100T2 (sk)
DK (1)	DK1379511T3 (sk)
EC (1)	ECSP034797A (sk)
ES (1)	ES2246012T3 (sk)
GT (1)	GT200200073A (sk)
HR (1)	HRP20030792A2 (sk)
HU (1)	HUP0400851A3 (sk)
IL (2)	IL157873A0 (sk)
JO (1)	JO2285B1 (sk)
MA (1)	MA27012A1 (sk)
MX (1)	MXPA03009311A (sk)
MY (1)	MY140271A (sk)
NO (1)	NO20034576L (sk)
NZ (1)	NZ528315A (sk)
PA (1)	PA8543301A1 (sk)
PE (1)	PE20021041A1 (sk)
PL (1)	PL367064A1 (sk)
PT (1)	PT1379511E (sk)
RU (1)	RU2263112C2 (sk)
SI (1)	SI1379511T1 (sk)
SK (1)	SK13682003A3 (sk)
UY (1)	UY27258A1 (sk)
WO (1)	WO2002083652A1 (sk)
YU (1)	YU79003A (sk)
ZA (1)	ZA200307243B (sk)

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US7119196B2 (en) *	2002-03-28	2006-10-10	Wisys Technology Foundation, Inc.	Anxiolytic agents with reduced sedative and ataxic effects
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SI1651234T1 (sl) *	2003-07-25	2008-02-29	Hoffmann La Roche	Kombinacija antagonista mglur2 in inhibitorja ache za zdravljenje akutnih in/ali kronicnih nevroloskih motenj
US7329662B2 (en)	2003-10-03	2008-02-12	Hoffmann-La Roche Inc.	Pyrazolo-pyridine
US20060160823A1 (en) *	2004-05-28	2006-07-20	Leonore Witchey-Lakshmanan	Particulate-stabilized injectable pharmaceutical compositions of Posaconazole
MXPA06014809A (es) *	2004-06-21	2007-02-12	Hoffmann La Roche	Derivados de pirazol-pirimidina.
BRPI0607927A2 (pt)	2005-02-11	2009-10-20	Hoffmann La Roche	derivados de pirazol-pirimidina
DK1863818T3 (da)	2005-03-23	2010-05-10	Hoffmann La Roche	Acetylenyl-pyrazolo-pyrimidinderivater som mglur2-antagonister
JP5237798B2 (ja)	2005-06-23	2013-07-17	アレイバイオファーマ、インコーポレイテッド	ベンズイミダゾール化合物の調製方法
KR101121292B1 (ko)	2005-09-27	2012-04-13	에프. 호프만-라 로슈 아게	Ｍｇｌｕｒ2 길항제로서 옥사다이아졸일 피라졸로-피리미딘
GB0600228D0 (en) *	2006-01-06	2006-02-15	Fermentas Uab	Inactivation method
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RU2517181C2 (ru)	2008-10-16	2014-05-27	Орто-Макнейл-Янссен Фармасьютикалз, Инк.	Производные индола и бензоморфолина в качестве модулятора метаботропных глутаматных рецепторов
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RU2015116749A (ru)	2012-10-23	2016-12-20	Ф. Хоффманн-Ля Рош Аг	Антагонисты mglu2/3 для лечения аутических расстройств
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2002
- 2002-04-02 IL IL15787302A patent/IL157873A0/xx active IP Right Grant
- 2002-04-02 BR BR0208891-6A patent/BR0208891A/pt not_active Application Discontinuation
- 2002-04-02 CZ CZ20033003A patent/CZ20033003A3/cs unknown
- 2002-04-02 CN CNB028081811A patent/CN1264825C/zh not_active Expired - Fee Related
- 2002-04-02 EP EP02737911A patent/EP1379511B1/en not_active Expired - Lifetime
- 2002-04-02 NZ NZ528315A patent/NZ528315A/en unknown
- 2002-04-02 PT PT02737911T patent/PT1379511E/pt unknown
- 2002-04-02 CA CA002442557A patent/CA2442557C/en not_active Expired - Fee Related
- 2002-04-02 DE DE60205100T patent/DE60205100T2/de not_active Expired - Lifetime
- 2002-04-02 DK DK02737911T patent/DK1379511T3/da active
- 2002-04-02 AT AT02737911T patent/ATE299868T1/de not_active IP Right Cessation
- 2002-04-02 HR HR20030792A patent/HRP20030792A2/hr not_active Application Discontinuation
- 2002-04-02 RU RU2003130637/04A patent/RU2263112C2/ru not_active IP Right Cessation
- 2002-04-02 WO PCT/EP2002/003644 patent/WO2002083652A1/en not_active Ceased
- 2002-04-02 MX MXPA03009311A patent/MXPA03009311A/es active IP Right Grant
- 2002-04-02 JP JP2002581408A patent/JP4071115B2/ja not_active Expired - Fee Related
- 2002-04-02 KR KR1020037013300A patent/KR100566171B1/ko not_active Expired - Fee Related
- 2002-04-02 AU AU2002312788A patent/AU2002312788B2/en not_active Ceased
- 2002-04-02 SK SK1368-2003A patent/SK13682003A3/sk unknown
- 2002-04-02 ES ES02737911T patent/ES2246012T3/es not_active Expired - Lifetime
- 2002-04-02 HU HU0400851A patent/HUP0400851A3/hu unknown
- 2002-04-02 SI SI200230163T patent/SI1379511T1/xx unknown
- 2002-04-02 YU YU79003A patent/YU79003A/sh unknown
- 2002-04-02 PL PL02367064A patent/PL367064A1/xx not_active Application Discontinuation
- 2002-04-03 US US10/115,826 patent/US6544985B2/en not_active Expired - Fee Related
- 2002-04-09 AR ARP020101290A patent/AR035816A1/es not_active Application Discontinuation
- 2002-04-09 PA PA20028543301A patent/PA8543301A1/es unknown
- 2002-04-10 PE PE2002000291A patent/PE20021041A1/es not_active Application Discontinuation
- 2002-04-10 JO JO200232A patent/JO2285B1/en active
- 2002-04-11 MY MYPI20021345A patent/MY140271A/en unknown
- 2002-04-11 GT GT200200073A patent/GT200200073A/es unknown
- 2002-04-11 UY UY27258A patent/UY27258A1/es not_active Application Discontinuation
2003
- 2003-09-11 IL IL157873A patent/IL157873A/en not_active IP Right Cessation
- 2003-09-16 ZA ZA200307243A patent/ZA200307243B/en unknown
- 2003-10-08 EC EC2003004797A patent/ECSP034797A/es unknown
- 2003-10-08 MA MA27346A patent/MA27012A1/fr unknown
- 2003-10-10 BG BG108254A patent/BG108254A/bg unknown
- 2003-10-10 NO NO20034576A patent/NO20034576L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
CA2442557C (en)	2008-12-23
JP4071115B2 (ja)	2008-04-02
AU2002312788B2 (en)	2005-11-10
MA27012A1 (fr)	2004-12-20
PL367064A1 (en)	2005-02-21
YU79003A (sh)	2006-05-25
HUP0400851A2 (hu)	2004-07-28
PE20021041A1 (es)	2002-11-19
IL157873A (en)	2008-11-26
MY140271A (en)	2009-12-31
CN1535266A (zh)	2004-10-06
EP1379511B1 (en)	2005-07-20
CN1264825C (zh)	2006-07-19
DE60205100T2 (de)	2006-06-01
ZA200307243B (en)	2004-12-16
ECSP034797A (es)	2003-12-01
HUP0400851A3 (en)	2010-03-29
ES2246012T3 (es)	2006-02-01
GT200200073A (es)	2002-11-07
DK1379511T3 (da)	2005-11-07
KR20030087076A (ko)	2003-11-12
HRP20030792A2 (en)	2005-10-31
NZ528315A (en)	2005-04-29
RU2263112C2 (ru)	2005-10-27
US6544985B2 (en)	2003-04-08
UY27258A1 (es)	2002-10-31
JP2004529925A (ja)	2004-09-30
AR035816A1 (es)	2004-07-14
US20020193367A1 (en)	2002-12-19
CA2442557A1 (en)	2002-10-24
RU2003130637A (ru)	2005-04-10
CZ20033003A3 (cs)	2004-05-12
PA8543301A1 (es)	2003-01-24
IL157873A0 (en)	2004-03-28
EP1379511A1 (en)	2004-01-14
BR0208891A (pt)	2004-04-20
PT1379511E (pt)	2005-10-31
MXPA03009311A (es)	2004-02-12
WO2002083652A1 (en)	2002-10-24
SI1379511T1 (en)	2005-10-31
HK1068888A1 (en)	2005-05-06
NO20034576D0 (no)	2003-10-10
SK13682003A3 (sk)	2004-07-07
BG108254A (bg)	2004-09-30
KR100566171B1 (ko)	2006-03-29
JO2285B1 (en)	2005-09-12
DE60205100D1 (de)	2005-08-25
ATE299868T1 (de)	2005-08-15

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NO20034496D0 (no)	2003-10-08	Dihydro-benzo[b][1,4]diazepin-2-on-derivater som MGLUR2- antagonister I
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FR14C0066I2 (fr)	2015-05-22	2,3-dihydro-6-nitroimidazo[2,1-b]oxazoles
NO20014412L (no)	2001-09-11	Forbindelser nyttige som anti-inflammatoriske midler
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NO20021251D0 (no)	2002-03-13	Tienoisoksazolyl- og tienylpyrrazolyl-fenoksysubstituerte propylderivater anvendelige som D4antagonister
NO20015668D0 (no)	2001-11-20	Substituerte imidazotiazoler som antidepressive midler
DK1181288T3 (da)	2003-11-17	Bicycliske oxazolidinoner som antibakterielle midler
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DE50107988D1 (de)	2005-12-15	Substituierte 1,2,3,4-tetrahydrochinolin-2-carbonsäurederivate
PT1351959E (pt)	2005-09-30	Novos derivados de pleuromutilina
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DK1294729T3 (da)	2005-01-17	2-aminoalkyl-thieno[2,3-d]pyrimidiner
PT1326866E (pt)	2005-08-31	3,4-di-hidropirido[1,2-a]pirimidinas substituidas
NO20011309D0 (no)	2001-03-15	Benzotieno [3,2-c]pyridiner som<alfa>2-antagonister
DK1380585T3 (da)	2005-03-07	Pyrazolopyridinon som mellemprodukt
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ES1047631Y (es)	2001-09-01	Dispositivo para la fabricacion de piezas modulares para la construccion.
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