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ME01829B - KRISTALNI OBLIK 1-(β-D-GLUKOPIRANOZIL) -4-METIL- 3-[5- (4-FLUORFENIL)-2-TIENILMETIL]BENZEN HEMIHIDRAT - Google Patents

KRISTALNI OBLIK 1-(β-D-GLUKOPIRANOZIL) -4-METIL- 3-[5- (4-FLUORFENIL)-2-TIENILMETIL]BENZEN HEMIHIDRAT

Info

Publication number
ME01829B
ME01829B MEP-2014-45A MEP4514A ME01829B ME 01829 B ME01829 B ME 01829B ME P4514 A MEP4514 A ME P4514A ME 01829 B ME01829 B ME 01829B
Authority
ME
Montenegro
Prior art keywords
thienylmethyl
glucopyranosyl
fluorophenyl
methyl
crystalline form
Prior art date
Application number
MEP-2014-45A
Other languages
English (en)
Inventor
Sumihiro Nomura
Eiji Kawanishi
Original Assignee
Mitsubishi Tanabe Pharma Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38973167&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ME01829(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Mitsubishi Tanabe Pharma Corp filed Critical Mitsubishi Tanabe Pharma Corp
Publication of ME01829B publication Critical patent/ME01829B/me

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H7/00—Compounds containing non-saccharide radicals linked to saccharide radicals by a carbon-to-carbon bond
    • C07H7/04—Carbocyclic radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Endocrinology (AREA)
  • Epidemiology (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Cardiology (AREA)
  • Emergency Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Dermatology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Claims (6)

1.  Kristalni oblik 1-(β-D-glukopiranozil)-4-metil-3-[5-(4-fluorfenil)-2-tienilmetil]benzen hemihidrat, koji ima suštinski isti rendgenski dijagramam praha kao što je dato na slici 1.
2.  Kristalni oblik 1-(β-D-glukopiranozil)-4-metil-3-[5-(4-fluorfenil)-2-tienilmetil]benzen hemihidrat, koji ima suštinski isti infracrveni spektar kao što je dato na slici 2.
3.  Kristalni oblik 1-(β-D-glukopiranozil)-4-metil-3-[5-(4-fluorfenil)-2-tienilmetil]benzen hemihidrat iz zahteva 2, koji ima sledeće glavne makrimume u IC spektru: 1626, 1600, 1549, i 1507 cm-1.
4.  Postupak za dobijanje kristalnog oblika 1-(β-D-glukopiranozil)-4-metil-3-[5-(4-fluorfenil)-2-tienilmetil]benzen hemihidrata iz zahteva 1, 2 ilir 3, koji obuhvata obrazovanje rastvora 1-(β-D-glukopiranozil)-4-metil-3-[5-(4-fluorfenil)-2-tienilmetil]benzena u rastvaraču koji sadrži vodu i kristalizaciju hemihidrata iz rastvora taloženjem ili rekristalizacijom.
5.  Farmaceutska kompozicija koja sadrži delotvornu količinu kristalnog oblika 1-(β-D-glukopiranozil)-4-metil-3-[5-(4-fluorfenil)-2-tienilmetil]benzen hemihidrata iz zahteva 1, 2 ili 3, i njegov farmaceutski prihvatljiv nosač.
6. Kristalni oblik 1-(β-D-glukopiranozil)-4-metil-3-[5-(4-fluorfenil)-2-tienilmetil]benzen hemihidrata iza zahteva 1, 2 ili 3 za upotrebu u lečenju ili odlaganju napredovanja ili početka dijabetes melitusa, dijabetičke retinopatije, dijabetičke neuropatije, dijabetičke nefropatije, usporenog zarastanja rana, insulinske rezistencije, hiperglikemije, hiperinsulinemije, povišenog nivoa masnih kiselina u krvi, povišenog nivoa glicerola u krvi, hiperlipidemije, kliničke gojaznosti, hipertrigliceridemije, sindroma X, dijabetičkih komplikacija, ateroskleroze ili hipertenzije.
MEP-2014-45A 2006-12-04 2007-12-03 KRISTALNI OBLIK 1-(β-D-GLUKOPIRANOZIL) -4-METIL- 3-[5- (4-FLUORFENIL)-2-TIENILMETIL]BENZEN HEMIHIDRAT ME01829B (me)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US86842606P 2006-12-04 2006-12-04
JP2006327019 2006-12-04
PCT/JP2007/073729 WO2008069327A1 (en) 2006-12-04 2007-12-03 CRYSTALLINE FORM OF 1- (β-D-GLUCOPYRANOSYL) -4 -METHYL- 3- [5- (4 -FLUOROPHENYL) -2-THIENYLMETHYL] BENZENE HEMIHYDRATE
EP07850306.7A EP2102224B2 (en) 2006-12-04 2007-12-03 CRYSTALLINE FORM OF 1- (ß-D-GLUCOPYRANOSYL) -4 -METHYL- 3- [5- (4 -FLUOROPHENYL) -2-THIENYLMETHYL]BENZENE HEMIHYDRATE

Publications (1)

Publication Number Publication Date
ME01829B true ME01829B (me) 2014-12-20

Family

ID=38973167

Family Applications (1)

Application Number Title Priority Date Filing Date
MEP-2014-45A ME01829B (me) 2006-12-04 2007-12-03 KRISTALNI OBLIK 1-(β-D-GLUKOPIRANOZIL) -4-METIL- 3-[5- (4-FLUORFENIL)-2-TIENILMETIL]BENZEN HEMIHIDRAT

Country Status (34)

Country Link
US (2) US7943582B2 (me)
EP (1) EP2102224B2 (me)
JP (1) JP5159788B2 (me)
KR (1) KR101146095B1 (me)
CN (3) CN101573368B (me)
AR (4) AR064099A1 (me)
AU (1) AU2007329895C1 (me)
BR (1) BRPI0718882B8 (me)
CA (1) CA2671357C (me)
CL (1) CL2007003487A1 (me)
CO (1) CO6210719A2 (me)
CR (1) CR10861A (me)
DK (1) DK2102224T4 (me)
EA (1) EA017103B1 (me)
EC (1) ECSP099489A (me)
ES (1) ES2456640T5 (me)
GT (1) GT200900151A (me)
IL (1) IL199032A (me)
ME (1) ME01829B (me)
MX (1) MX2009005857A (me)
MY (1) MY153702A (me)
NO (1) NO344354B1 (me)
NZ (1) NZ577545A (me)
PA (1) PA8759401A1 (me)
PE (3) PE20110841A1 (me)
PL (1) PL2102224T5 (me)
PT (1) PT2102224E (me)
RS (1) RS53274B2 (me)
SI (1) SI2102224T2 (me)
SV (1) SV2009003285A (me)
TW (1) TWI403325B (me)
UY (1) UY30730A1 (me)
WO (1) WO2008069327A1 (me)
ZA (1) ZA200903941B (me)

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