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MA50589A - Compositions de pyrrolopyrrole en tant qu'activateurs de pyruvate kinase (pkr) - Google Patents

Compositions de pyrrolopyrrole en tant qu'activateurs de pyruvate kinase (pkr)

Info

Publication number
MA50589A
MA50589A MA050589A MA50589A MA50589A MA 50589 A MA50589 A MA 50589A MA 050589 A MA050589 A MA 050589A MA 50589 A MA50589 A MA 50589A MA 50589 A MA50589 A MA 50589A
Authority
MA
Morocco
Prior art keywords
pyrrolopyrrole
pkr
activators
compositions
pyruvate kinase
Prior art date
Application number
MA050589A
Other languages
English (en)
Inventor
Anna Ericsson
Neal Green
Gary Gustafson
Bingsong Han
Jr David R Lancia
Lorna Mitchell
David Richard
Tatiana Shelekhin
Chase C Smith
Zhongguo Wang
Xiaozhang Zheng
Original Assignee
Forma Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Forma Therapeutics Inc filed Critical Forma Therapeutics Inc
Publication of MA50589A publication Critical patent/MA50589A/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/047—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates having two or more hydroxy groups, e.g. sorbitol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pyridine Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicinal Preparation (AREA)
MA050589A 2017-03-20 2018-03-20 Compositions de pyrrolopyrrole en tant qu'activateurs de pyruvate kinase (pkr) MA50589A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201762473751P 2017-03-20 2017-03-20

Publications (1)

Publication Number Publication Date
MA50589A true MA50589A (fr) 2021-09-15

Family

ID=61911726

Family Applications (3)

Application Number Title Priority Date Filing Date
MA44795A MA44795B1 (fr) 2017-03-20 2018-03-20 Compositions de pyrrolopyrrole en tant qu'activateurs de la pyruvate kinase (pkr)
MA45614A MA45614B1 (fr) 2017-03-20 2018-03-20 Compositions de pyrrolopyrrole en tant qu'activateurs de la pyruvate kinase (pkr)
MA050589A MA50589A (fr) 2017-03-20 2018-03-20 Compositions de pyrrolopyrrole en tant qu'activateurs de pyruvate kinase (pkr)

Family Applications Before (2)

Application Number Title Priority Date Filing Date
MA44795A MA44795B1 (fr) 2017-03-20 2018-03-20 Compositions de pyrrolopyrrole en tant qu'activateurs de la pyruvate kinase (pkr)
MA45614A MA45614B1 (fr) 2017-03-20 2018-03-20 Compositions de pyrrolopyrrole en tant qu'activateurs de la pyruvate kinase (pkr)

Country Status (32)

Country Link
US (8) US11014927B2 (fr)
EP (3) EP3448859B1 (fr)
JP (2) JP6594570B2 (fr)
KR (2) KR102296703B1 (fr)
CN (2) CN109311897B (fr)
AR (2) AR111295A1 (fr)
AU (4) AU2018240172C1 (fr)
CA (1) CA3024181C (fr)
CY (2) CY1122393T1 (fr)
DK (2) DK3483164T3 (fr)
EA (1) EA201992215A1 (fr)
ES (2) ES2747768T3 (fr)
HR (2) HRP20191665T1 (fr)
HU (2) HUE049979T2 (fr)
IL (2) IL269447B (fr)
LT (2) LT3448859T (fr)
MA (3) MA44795B1 (fr)
MD (2) MD3448859T2 (fr)
MX (2) MX2020013936A (fr)
NZ (2) NZ763766A (fr)
PL (2) PL3483164T3 (fr)
PT (2) PT3483164T (fr)
RS (2) RS60209B1 (fr)
RU (3) RU2736217C2 (fr)
SA (1) SA519410164B1 (fr)
SG (1) SG11201908670SA (fr)
SI (2) SI3483164T1 (fr)
SM (2) SMT202000243T1 (fr)
TN (2) TN2020000045A1 (fr)
TW (2) TWI887559B (fr)
WO (1) WO2018175474A1 (fr)
ZA (1) ZA201906278B (fr)

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PL2861566T3 (pl) 2012-06-13 2017-06-30 F.Hoffmann-La Roche Ag Nowy diazaspirocykloalkan i azaspirocykloalkan
PL2900669T3 (pl) 2012-09-25 2020-01-31 F. Hoffmann-La Roche Ag Pochodne heksahydropirolo[3,4-C]pirolu i związki pokrewne jako inhibitory autotaksyny (ATX) oraz inhibitory produkcji kwasu lizofosfatydowego (LPA) do leczenia np. chorób nerek
AR095079A1 (es) 2013-03-12 2015-09-16 Hoffmann La Roche Derivados de octahidro-pirrolo[3,4-c]-pirrol y piridina-fenilo
HUE036117T2 (hu) 2013-11-26 2018-06-28 Hoffmann La Roche Oktahidro-ciklobuta[1,2-C;3,4-C']dipirrol származékok, mint autotaxin inhibitorok
JP6554481B2 (ja) 2014-03-26 2019-07-31 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ オートタキシン（ａｔｘ）及びリゾホスファチジン酸（ｌｐａ）産生の阻害剤としての縮合［１，４］ジアゼピン化合物
EA037928B1 (ru) 2014-03-26 2021-06-08 Ф. Хоффманн-Ля Рош Аг Бициклические соединения в качестве ингибиторов продукции аутотаксина (atx) и лизофосфатидиловой кислоты (lpa)
MA41898A (fr) 2015-04-10 2018-02-13 Hoffmann La Roche Dérivés de quinazolinone bicyclique
CR20180058A (es) 2015-09-04 2018-02-26 Hoffmann La Roche Nuevos derivados de fenoximetilo
CN107922412B (zh) 2015-09-24 2021-02-23 豪夫迈·罗氏有限公司 作为atx抑制剂的二环化合物
EP3353178B1 (fr) * 2015-09-24 2021-07-14 F. Hoffmann-La Roche AG Composés bicycliques comme inhibiteurs mixtes de atx/ca
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RU2019132254A (ru) 2017-03-16 2021-04-16 Ф. Хоффманн-Ля Рош Аг Гетероциклические соединения, пригодные в качестве дуальных ингибиторов atx/ca
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JP6594570B2 (ja) * 2017-03-20 2019-10-23 フォーマ セラピューティクス，インコーポレイテッド ピルビン酸キナーゼ（ｐｋｒ）活性化剤としてのピロロピロール組成物
WO2020061378A1 (fr) * 2018-09-19 2020-03-26 Forma Therapeutics, Inc. Traitement de la drépanocytose avec un composé activant la pyruvate kinase r
WO2020061252A1 (fr) * 2018-09-19 2020-03-26 Forma Therapeutics, Inc. Inhibition de la peptidase 9x spécifique de l'ubiquitine
WO2020061255A1 (fr) * 2018-09-19 2020-03-26 Forma Therapeutics, Inc. Activation de la pyruvate kinase r
SG11202102526QA (en) * 2018-09-19 2021-04-29 Forma Therapeutics Inc Inhibiting ubiquitin specific peptidase 9x
WO2020191022A1 (fr) * 2019-03-18 2020-09-24 Forma Therapeutics, Inc. Inhibition de la peptidase 9x spécifique de l'ubiquitine
AU2020350763A1 (en) * 2019-09-19 2022-04-07 Novo Nordisk Health Care Ag Pyruvate kinase R (PKR) activating compositions
WO2021055863A1 (fr) * 2019-09-19 2021-03-25 Forma Therapeutics, Inc. Compositions d'activation de la pyruvate kinase r (pkr)
JP7660102B2 (ja) * 2019-09-29 2025-04-10 正大天晴▲藥▼▲業▼集▲団▼股▲フン▼有限公司 Ｎヘテロ五員環含有カプシドタンパク質集合阻害剤の結晶形及びその使用
WO2021202796A1 (fr) * 2020-04-01 2021-10-07 Global Blood Therapeutics, Inc. Pyrrolidine-pyrazoles en tant qu'activateurs de la pyruvate kinase
US20220087983A1 (en) * 2020-09-18 2022-03-24 Forma Therapeutics, Inc. Activating pyruvate kinase r
US12128035B2 (en) 2021-03-19 2024-10-29 Novo Nordisk Health Care Ag Activating pyruvate kinase R
EP4455136A4 (fr) * 2021-12-21 2025-11-05 Scinnohub Pharmaceutical Co Ltd Composé contenant une structure bis(azanylylidène) sulfonyle et son utilisation en médecine
WO2024112764A1 (fr) 2022-11-21 2024-05-30 Novo Nordisk Health Care Ag Synthèse de pyrrolo [3,4-c] pyrroles
CN115957219B (zh) * 2022-12-27 2024-04-19 北京大学 M2亚型丙酮酸激酶凝聚体的解聚剂在制备抗衰老药物中的应用
WO2024230586A1 (fr) * 2023-05-05 2024-11-14 赛诺哈勃药业（成都）有限公司 Nouvelle utilisation d'un composé contenant une structure de diazépine sulfonyle en tant qu'agoniste de pkm2
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DK3483164T3 (da) 2020-03-23
EP3448859A1 (fr) 2019-03-06
US20190218221A1 (en) 2019-07-18
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MX2018014032A (es) 2019-08-21
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HRP20200752T1 (hr) 2020-07-24
SG11201908670SA (en) 2019-10-30
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TWI887559B (zh) 2025-06-21
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KR20190092597A (ko) 2019-08-07
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EA201992215A1 (ru) 2020-02-06
EP3448859B1 (fr) 2019-07-10
TW202244048A (zh) 2022-11-16
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DK3448859T3 (da) 2019-09-23
RU2019137023A3 (fr) 2020-04-30
US11649242B2 (en) 2023-05-16
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US11396513B2 (en) 2022-07-26
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SA519410164B1 (ar) 2022-03-10
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US12071440B2 (en) 2024-08-27
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US11014927B2 (en) 2021-05-25
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US20200069643A1 (en) 2020-03-05
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PL3448859T3 (pl) 2020-02-28
AR111295A1 (es) 2019-06-26
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EP3680241A1 (fr) 2020-07-15
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IL269447A (en) 2019-11-28
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IL289175A (en) 2022-02-01
US20210246143A1 (en) 2021-08-12
US20240391922A1 (en) 2024-11-28
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US10836771B2 (en) 2020-11-17
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MD3448859T2 (ro) 2020-03-31
IL269447B (en) 2022-01-01
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AU2018240172A1 (en) 2018-11-29
AU2021201244B2 (en) 2022-10-20
RU2707751C1 (ru) 2019-11-29
EP3483164A1 (fr) 2019-05-15
MD3483164T2 (ro) 2020-07-31
HUE045261T2 (hu) 2019-12-30
LT3483164T (lt) 2020-05-11
LT3448859T (lt) 2019-10-25
TN2019000290A1 (en) 2021-05-07
CN109311897A (zh) 2019-02-05
AR115993A2 (es) 2021-03-17
US20200031839A1 (en) 2020-01-30
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KR102296703B1 (ko) 2021-09-01
AU2021201244A1 (en) 2021-03-11

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