BRPI0417273A - derivados de benzimidazola 5- ou 6-substituìdos como inibidores de replicação do vìrus sincical respiratório - Google Patents
derivados de benzimidazola 5- ou 6-substituìdos como inibidores de replicação do vìrus sincical respiratórioInfo
- Publication number
- BRPI0417273A BRPI0417273A BRPI0417273-6A BRPI0417273A BRPI0417273A BR PI0417273 A BRPI0417273 A BR PI0417273A BR PI0417273 A BRPI0417273 A BR PI0417273A BR PI0417273 A BRPI0417273 A BR PI0417273A
- Authority
- BR
- Brazil
- Prior art keywords
- alkyl
- het
- substituted
- carbonylamino
- hydrogen
- Prior art date
Links
- 230000029812 viral genome replication Effects 0.000 title abstract 3
- -1 6-substituted benzimidazole Chemical class 0.000 title abstract 2
- 241000725643 Respiratory syncytial virus Species 0.000 title abstract 2
- 229940058303 antinematodal benzimidazole derivative Drugs 0.000 title abstract 2
- 239000003112 inhibitor Substances 0.000 title abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 8
- 229910052739 hydrogen Inorganic materials 0.000 abstract 4
- 239000001257 hydrogen Substances 0.000 abstract 4
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
- 125000006297 carbonyl amino group Chemical group [H]N([*:2])C([*:1])=O 0.000 abstract 2
- 150000002431 hydrogen Chemical class 0.000 abstract 2
- 150000001204 N-oxides Chemical class 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000003277 amino group Chemical group 0.000 abstract 1
- JYZIHLWOWKMNNX-UHFFFAOYSA-N benzimidazole Chemical compound C1=C[CH]C2=NC=NC2=C1 JYZIHLWOWKMNNX-UHFFFAOYSA-N 0.000 abstract 1
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 1
- 150000004696 coordination complex Chemical group 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 125000002950 monocyclic group Chemical group 0.000 abstract 1
- 125000003386 piperidinyl group Chemical class 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 125000000719 pyrrolidinyl group Chemical class 0.000 abstract 1
- 230000000241 respiratory effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pulmonology (AREA)
- Virology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
"DERIVADOS DE BENZIMIDAZOLA 5- OU 6-SUBSTITUìDOS COMO INIBIDORES DE REPLICAçãO DO VìRUS SINCICIAL RESPIRATóRIO". A presente invenção refere-se a derivados de benzimidazola 5ou 6-substituídos tendo atividade inibitória sobre a replicação do vírus sincicial respiratório e tendo a fórmula: um pró-fármaco, N-óxido, sal de adição, amina quaternária, complexo de metal ou forma estereoquimicamente isomérica dos mesmos em que Q é Ar¬ 2¬, R¬ 6¬, pirrolidinila substituída por R¬ 6¬, piperidinila substituída por R¬ 6¬ ou ho mopiperidinila substituída por R¬ 6¬, G é uma ligação direta ou opcionalmente substituída C~ 1-10~alcanodiíla; R¬ 1¬ é Ar¬ 1¬ ou um heterociclo monocíclico ou dicíclico; um de R¬ 2a¬ e R¬ 2b¬ é cianoC~ 1-6~alquila, cianoC~ 2-6~alquenila, Ar¬ 3¬C~ 1-6~alquila, Het-C~ 1-6~alquila, N(R¬ 8a¬R¬ 8b¬)C~ 1-6~alquila, Ar¬ 3¬C~ 2-6~alquenila, Het-C~ 2-6~alquenila, Ar¬ 3¬ aminoC~ 1-6~alquila, Het-aminoC~ 1-6~alquila, Ar¬ 3¬tioC~ 1-6~alquila, Het-tioC~ 1-6~alquila, Ar¬ 3¬ sulfonilC~ 1-6~alquila, Het-sulfonilC~ 1-6~alquila, Ar¬ 3¬aminocarbonila, Het-aminocarbonila, Ar¬ 3¬(CH~ 2~)naminocarbonila, Het-(CH~ 2~)naminocarbonila, Ar¬ 3¬ carbonilamino, Het-carbonilamino, Ar¬ 3¬(CH~ 2~)~ n~carbonilamino, Het-(CH~ 2~)~ n~ carbonilamino, e o outro de R¬ 2a¬ e R¬ 2b¬ é hidrogênio; no caso em que R¬ 2a¬ é hidrogênio, então, R¬ 3~ é idrogênio; no caso em que R¬ 2b¬ é hidrogênio, R¬ 3¬ é hidrogênio ou C~ 1-6~ alquila. Ela ainda refere-se a seu preparo e composições compreendendo os mesmos, bem como seu uso como um medicamento.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP03104806 | 2003-12-18 | ||
| US56686704P | 2004-04-30 | 2004-04-30 | |
| PCT/EP2004/053618 WO2005058874A1 (en) | 2003-12-18 | 2004-12-20 | 5- or 6-substituted benzimidazole derivatives as inhibitors of respiratory syncytial virus replication |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0417273A true BRPI0417273A (pt) | 2007-03-27 |
Family
ID=43646156
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0417273-6A BRPI0417273A (pt) | 2003-12-18 | 2004-12-20 | derivados de benzimidazola 5- ou 6-substituìdos como inibidores de replicação do vìrus sincical respiratório |
Country Status (19)
| Country | Link |
|---|---|
| US (2) | US20070093502A1 (pt) |
| EP (1) | EP1697347B1 (pt) |
| JP (1) | JP2007514719A (pt) |
| KR (1) | KR101123055B1 (pt) |
| CN (1) | CN1914196B (pt) |
| AR (1) | AR046770A1 (pt) |
| AT (1) | ATE499361T1 (pt) |
| AU (1) | AU2004298459B2 (pt) |
| BR (1) | BRPI0417273A (pt) |
| CA (1) | CA2548793A1 (pt) |
| DE (1) | DE602004031555D1 (pt) |
| DK (1) | DK1697347T3 (pt) |
| HR (1) | HRP20110313T1 (pt) |
| MX (1) | MXPA06007111A (pt) |
| MY (1) | MY142783A (pt) |
| RU (1) | RU2369606C2 (pt) |
| SI (1) | SI1697347T1 (pt) |
| TW (1) | TWI382981B (pt) |
| WO (1) | WO2005058874A1 (pt) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2419613C2 (ru) * | 2005-06-20 | 2011-05-27 | Тиботек Фармасьютикалз Лтд | Гетероциклиламиноалкилзамещенные бензимидазолы |
| RS54936B1 (sr) | 2011-10-14 | 2016-11-30 | Ambit Biosciences Corp | Heterociklična jedinjenja i njihova upotreba kao modulatora receptora tirozin kinaza tipa iii |
| TW201813963A (zh) | 2016-09-23 | 2018-04-16 | 美商基利科學股份有限公司 | 磷脂醯肌醇3-激酶抑制劑 |
| TW201815787A (zh) | 2016-09-23 | 2018-05-01 | 美商基利科學股份有限公司 | 磷脂醯肌醇3-激酶抑制劑 |
| TW201825465A (zh) | 2016-09-23 | 2018-07-16 | 美商基利科學股份有限公司 | 磷脂醯肌醇3-激酶抑制劑 |
| US11014927B2 (en) | 2017-03-20 | 2021-05-25 | Forma Therapeutics, Inc. | Pyrrolopyrrole compositions as pyruvate kinase (PKR) activators |
| EP3697777A1 (en) | 2017-10-19 | 2020-08-26 | eFFECTOR Therapeutics, Inc. | Benzimidazole-indole inhibitors of mnk1 and mnk2 |
| US12053458B2 (en) | 2018-09-19 | 2024-08-06 | Novo Nordisk Health Care Ag | Treating sickle cell disease with a pyruvate kinase R activating compound |
| ES2989438T3 (es) | 2018-09-19 | 2024-11-26 | Novo Nordisk Healthcare Ag | Activación de la piruvato cinasa R |
| EP4031132A4 (en) | 2019-09-19 | 2023-09-13 | Forma Therapeutics, Inc. | Activating pyruvate kinase r |
| US12128035B2 (en) | 2021-03-19 | 2024-10-29 | Novo Nordisk Health Care Ag | Activating pyruvate kinase R |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4025621A (en) * | 1975-01-09 | 1977-05-24 | Purdy Clarence L | Method of curing and providing immunity from viral infections |
| CA1140119A (en) | 1978-04-03 | 1983-01-25 | Joseph Torremans | N-heterocyclyl-4-piperidinamines |
| US4556660A (en) | 1982-07-12 | 1985-12-03 | Janssen Pharmaceutica N.V. | N-(Bicyclic heterocyclyl)-4-piperidinamines |
| US4634704A (en) | 1983-10-06 | 1987-01-06 | Janssen Pharmaceutica, N.V. | Anti-allergic five membered heterocyclic ring containing N-(bicyclic heterocycyl)-4-piperidinamines |
| NZ223654A (en) * | 1987-03-09 | 1990-03-27 | Janssen Pharmaceutica Nv | 1-alkyl-substituted-benzimidazole-4-piperidinamines and pharmaceutical compositions |
| KR100190299B1 (ko) | 1990-07-19 | 1999-06-01 | 디르크 반테 | 신규한 옥사졸릴 유도체 |
| ATE259796T1 (de) * | 1999-06-28 | 2004-03-15 | Janssen Pharmaceutica Nv | Respiratorisches syncytialvirus replikation inhibitoren |
| IL147327A0 (en) * | 1999-06-28 | 2002-08-14 | Janssen Pharmaceutica Nv | Respiratory syncytial virus replication inhibitors |
| AU779516B2 (en) * | 1999-06-28 | 2005-01-27 | Janssen Pharmaceutica N.V. | Respiratory syncytial virus replication inhibitors |
| US20040157866A1 (en) * | 2001-04-30 | 2004-08-12 | Hisashi Takasugi | Amide compounds |
| US7030150B2 (en) * | 2001-05-11 | 2006-04-18 | Trimeris, Inc. | Benzimidazole compounds and antiviral uses thereof |
| FR2833948B1 (fr) * | 2001-12-21 | 2004-02-06 | Sod Conseils Rech Applic | Nouveaux derives de benzimidazole et leur utilisation en tant que medicament |
-
2004
- 2004-12-20 KR KR1020067014248A patent/KR101123055B1/ko not_active Expired - Fee Related
- 2004-12-20 EP EP04804954A patent/EP1697347B1/en not_active Expired - Lifetime
- 2004-12-20 RU RU2006125727/04A patent/RU2369606C2/ru not_active IP Right Cessation
- 2004-12-20 WO PCT/EP2004/053618 patent/WO2005058874A1/en not_active Ceased
- 2004-12-20 BR BRPI0417273-6A patent/BRPI0417273A/pt not_active Application Discontinuation
- 2004-12-20 AT AT04804954T patent/ATE499361T1/de not_active IP Right Cessation
- 2004-12-20 DE DE602004031555T patent/DE602004031555D1/de not_active Expired - Lifetime
- 2004-12-20 TW TW093139735A patent/TWI382981B/zh not_active IP Right Cessation
- 2004-12-20 AR ARP040104808A patent/AR046770A1/es not_active Application Discontinuation
- 2004-12-20 HR HR20110313T patent/HRP20110313T1/hr unknown
- 2004-12-20 CN CN2004800416543A patent/CN1914196B/zh not_active Expired - Lifetime
- 2004-12-20 CA CA002548793A patent/CA2548793A1/en not_active Abandoned
- 2004-12-20 US US10/596,521 patent/US20070093502A1/en not_active Abandoned
- 2004-12-20 AU AU2004298459A patent/AU2004298459B2/en not_active Ceased
- 2004-12-20 MX MXPA06007111A patent/MXPA06007111A/es active IP Right Grant
- 2004-12-20 MY MYPI20045258A patent/MY142783A/en unknown
- 2004-12-20 DK DK04804954.8T patent/DK1697347T3/da active
- 2004-12-20 JP JP2006544465A patent/JP2007514719A/ja active Pending
- 2004-12-20 SI SI200431657T patent/SI1697347T1/sl unknown
-
2008
- 2008-10-17 US US12/253,450 patent/US8278455B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| SI1697347T1 (sl) | 2011-06-30 |
| CN1914196B (zh) | 2012-01-25 |
| DE602004031555D1 (de) | 2011-04-07 |
| DK1697347T3 (da) | 2011-06-06 |
| MXPA06007111A (es) | 2006-08-23 |
| MY142783A (en) | 2010-12-31 |
| CN1914196A (zh) | 2007-02-14 |
| TW200531970A (en) | 2005-10-01 |
| EP1697347A1 (en) | 2006-09-06 |
| HRP20110313T1 (hr) | 2011-05-31 |
| RU2369606C2 (ru) | 2009-10-10 |
| AU2004298459A1 (en) | 2005-06-30 |
| KR20060127047A (ko) | 2006-12-11 |
| AR046770A1 (es) | 2005-12-21 |
| WO2005058874A1 (en) | 2005-06-30 |
| TWI382981B (zh) | 2013-01-21 |
| ATE499361T1 (de) | 2011-03-15 |
| RU2006125727A (ru) | 2008-01-27 |
| US20090062278A1 (en) | 2009-03-05 |
| EP1697347B1 (en) | 2011-02-23 |
| CA2548793A1 (en) | 2005-06-30 |
| AU2004298459B2 (en) | 2011-03-17 |
| JP2007514719A (ja) | 2007-06-07 |
| KR101123055B1 (ko) | 2012-04-12 |
| US20070093502A1 (en) | 2007-04-26 |
| US8278455B2 (en) | 2012-10-02 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B11E | Dismissal acc. art. 34 of ipl - requirements for examination incomplete | ||
| B11T | Dismissal of application maintained [chapter 11.20 patent gazette] |