SI1697347T1 - 5- ali 6-substituirani benzimidazolni derivati kot inhibitorji replikacije respiratornega sincicijskega virusa - Google Patents
5- ali 6-substituirani benzimidazolni derivati kot inhibitorji replikacije respiratornega sincicijskega virusaInfo
- Publication number
- SI1697347T1 SI1697347T1 SI200431657T SI200431657T SI1697347T1 SI 1697347 T1 SI1697347 T1 SI 1697347T1 SI 200431657 T SI200431657 T SI 200431657T SI 200431657 T SI200431657 T SI 200431657T SI 1697347 T1 SI1697347 T1 SI 1697347T1
- Authority
- SI
- Slovenia
- Prior art keywords
- inhibitors
- respiratory syncytial
- syncytial virus
- virus replication
- benzimidazole derivatives
- Prior art date
Links
- -1 6-substituted benzimidazole Chemical class 0.000 title 1
- 241000725643 Respiratory syncytial virus Species 0.000 title 1
- 229940058303 antinematodal benzimidazole derivative Drugs 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 230000029812 viral genome replication Effects 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Virology (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP03104806 | 2003-12-18 | ||
| US56686704P | 2004-04-30 | 2004-04-30 | |
| EP04804954A EP1697347B1 (en) | 2003-12-18 | 2004-12-20 | 5- or 6-substituted benzimidazole derivatives as inhibitors of respiratory syncytial virus replication |
| PCT/EP2004/053618 WO2005058874A1 (en) | 2003-12-18 | 2004-12-20 | 5- or 6-substituted benzimidazole derivatives as inhibitors of respiratory syncytial virus replication |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SI1697347T1 true SI1697347T1 (sl) | 2011-06-30 |
Family
ID=43646156
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SI200431657T SI1697347T1 (sl) | 2003-12-18 | 2004-12-20 | 5- ali 6-substituirani benzimidazolni derivati kot inhibitorji replikacije respiratornega sincicijskega virusa |
Country Status (19)
| Country | Link |
|---|---|
| US (2) | US20070093502A1 (sl) |
| EP (1) | EP1697347B1 (sl) |
| JP (1) | JP2007514719A (sl) |
| KR (1) | KR101123055B1 (sl) |
| CN (1) | CN1914196B (sl) |
| AR (1) | AR046770A1 (sl) |
| AT (1) | ATE499361T1 (sl) |
| AU (1) | AU2004298459B2 (sl) |
| BR (1) | BRPI0417273A (sl) |
| CA (1) | CA2548793A1 (sl) |
| DE (1) | DE602004031555D1 (sl) |
| DK (1) | DK1697347T3 (sl) |
| HR (1) | HRP20110313T1 (sl) |
| MX (1) | MXPA06007111A (sl) |
| MY (1) | MY142783A (sl) |
| RU (1) | RU2369606C2 (sl) |
| SI (1) | SI1697347T1 (sl) |
| TW (1) | TWI382981B (sl) |
| WO (1) | WO2005058874A1 (sl) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX2007016311A (es) * | 2005-06-20 | 2008-03-07 | Tibotec Pharm Ltd | Bencimidazoles sustituidos con heterociclilaminoalquilo. |
| IN2014CN03597A (sl) | 2011-10-14 | 2015-10-09 | Ambit Biosciences Corp | |
| TW201815787A (zh) | 2016-09-23 | 2018-05-01 | 美商基利科學股份有限公司 | 磷脂醯肌醇3-激酶抑制劑 |
| TW201825465A (zh) | 2016-09-23 | 2018-07-16 | 美商基利科學股份有限公司 | 磷脂醯肌醇3-激酶抑制劑 |
| TW201813963A (zh) | 2016-09-23 | 2018-04-16 | 美商基利科學股份有限公司 | 磷脂醯肌醇3-激酶抑制劑 |
| DK3448859T3 (da) | 2017-03-20 | 2019-09-23 | Forma Therapeutics Inc | Pyrrolopyrrolsammensætninger som pyruvatkinase- (pkr) aktivatorer |
| AU2018352695A1 (en) | 2017-10-19 | 2020-05-28 | Effector Therapeutics, Inc. | Benzimidazole-indole inhibitors of Mnk1 and Mnk2 |
| WO2020061378A1 (en) | 2018-09-19 | 2020-03-26 | Forma Therapeutics, Inc. | Treating sickle cell disease with a pyruvate kinase r activating compound |
| JP7450610B2 (ja) | 2018-09-19 | 2024-03-15 | ノヴォ・ノルディスク・ヘルス・ケア・アーゲー | ピルビン酸キナーゼｒの活性化 |
| MX2022003254A (es) | 2019-09-19 | 2022-04-18 | Forma Therapeutics Inc | Composiciones activadoras de piruvato cinasa r (pkr). |
| US12128035B2 (en) | 2021-03-19 | 2024-10-29 | Novo Nordisk Health Care Ag | Activating pyruvate kinase R |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4025621A (en) * | 1975-01-09 | 1977-05-24 | Purdy Clarence L | Method of curing and providing immunity from viral infections |
| CA1140119A (en) | 1978-04-03 | 1983-01-25 | Joseph Torremans | N-heterocyclyl-4-piperidinamines |
| US4556660A (en) | 1982-07-12 | 1985-12-03 | Janssen Pharmaceutica N.V. | N-(Bicyclic heterocyclyl)-4-piperidinamines |
| US4634704A (en) | 1983-10-06 | 1987-01-06 | Janssen Pharmaceutica, N.V. | Anti-allergic five membered heterocyclic ring containing N-(bicyclic heterocycyl)-4-piperidinamines |
| NZ223654A (en) * | 1987-03-09 | 1990-03-27 | Janssen Pharmaceutica Nv | 1-alkyl-substituted-benzimidazole-4-piperidinamines and pharmaceutical compositions |
| KR100190299B1 (ko) | 1990-07-19 | 1999-06-01 | 디르크 반테 | 신규한 옥사졸릴 유도체 |
| TR200103806T2 (tr) * | 1999-06-28 | 2002-06-21 | Janssen Pharmaceutica N. V. | Solunum sistemi sinsitiyal virüsünün replikasyonunu inhibe edici maddeler. |
| PT1196408E (pt) * | 1999-06-28 | 2005-01-31 | Janssen Pharmaceutica Nv | Inibidores da replicacao do virus sincicial respiratorio |
| BR0011997A (pt) * | 1999-06-28 | 2002-03-05 | Janssen Pharmaceutica Nv | Inibidores da replicação do vìrus sincicial respiratório |
| JP2004532856A (ja) * | 2001-04-30 | 2004-10-28 | 藤沢薬品工業株式会社 | アポリポタンパク質ｂ阻害剤としてのビアリールカルボキサミド化合物 |
| US7030150B2 (en) * | 2001-05-11 | 2006-04-18 | Trimeris, Inc. | Benzimidazole compounds and antiviral uses thereof |
| FR2833948B1 (fr) * | 2001-12-21 | 2004-02-06 | Sod Conseils Rech Applic | Nouveaux derives de benzimidazole et leur utilisation en tant que medicament |
-
2004
- 2004-12-20 MY MYPI20045258A patent/MY142783A/en unknown
- 2004-12-20 MX MXPA06007111A patent/MXPA06007111A/es active IP Right Grant
- 2004-12-20 BR BRPI0417273-6A patent/BRPI0417273A/pt not_active Application Discontinuation
- 2004-12-20 JP JP2006544465A patent/JP2007514719A/ja active Pending
- 2004-12-20 US US10/596,521 patent/US20070093502A1/en not_active Abandoned
- 2004-12-20 RU RU2006125727/04A patent/RU2369606C2/ru not_active IP Right Cessation
- 2004-12-20 AU AU2004298459A patent/AU2004298459B2/en not_active Ceased
- 2004-12-20 AT AT04804954T patent/ATE499361T1/de not_active IP Right Cessation
- 2004-12-20 CA CA002548793A patent/CA2548793A1/en not_active Abandoned
- 2004-12-20 CN CN2004800416543A patent/CN1914196B/zh not_active Expired - Lifetime
- 2004-12-20 DE DE602004031555T patent/DE602004031555D1/de not_active Expired - Lifetime
- 2004-12-20 TW TW093139735A patent/TWI382981B/zh not_active IP Right Cessation
- 2004-12-20 EP EP04804954A patent/EP1697347B1/en not_active Expired - Lifetime
- 2004-12-20 AR ARP040104808A patent/AR046770A1/es not_active Application Discontinuation
- 2004-12-20 KR KR1020067014248A patent/KR101123055B1/ko not_active Expired - Fee Related
- 2004-12-20 DK DK04804954.8T patent/DK1697347T3/da active
- 2004-12-20 HR HR20110313T patent/HRP20110313T1/hr unknown
- 2004-12-20 WO PCT/EP2004/053618 patent/WO2005058874A1/en not_active Ceased
- 2004-12-20 SI SI200431657T patent/SI1697347T1/sl unknown
-
2008
- 2008-10-17 US US12/253,450 patent/US8278455B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP1697347A1 (en) | 2006-09-06 |
| RU2006125727A (ru) | 2008-01-27 |
| EP1697347B1 (en) | 2011-02-23 |
| BRPI0417273A (pt) | 2007-03-27 |
| AU2004298459A1 (en) | 2005-06-30 |
| US20090062278A1 (en) | 2009-03-05 |
| CN1914196B (zh) | 2012-01-25 |
| AR046770A1 (es) | 2005-12-21 |
| HRP20110313T1 (hr) | 2011-05-31 |
| DE602004031555D1 (de) | 2011-04-07 |
| MY142783A (en) | 2010-12-31 |
| RU2369606C2 (ru) | 2009-10-10 |
| US8278455B2 (en) | 2012-10-02 |
| CA2548793A1 (en) | 2005-06-30 |
| TWI382981B (zh) | 2013-01-21 |
| DK1697347T3 (da) | 2011-06-06 |
| JP2007514719A (ja) | 2007-06-07 |
| ATE499361T1 (de) | 2011-03-15 |
| CN1914196A (zh) | 2007-02-14 |
| MXPA06007111A (es) | 2006-08-23 |
| WO2005058874A1 (en) | 2005-06-30 |
| KR20060127047A (ko) | 2006-12-11 |
| KR101123055B1 (ko) | 2012-04-12 |
| AU2004298459B2 (en) | 2011-03-17 |
| TW200531970A (en) | 2005-10-01 |
| US20070093502A1 (en) | 2007-04-26 |
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