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MA26993A1 - 6-pyridopyrimidines substitues - Google Patents

6-pyridopyrimidines substitues

Info

Publication number
MA26993A1
MA26993A1 MA27273A MA27273A MA26993A1 MA 26993 A1 MA26993 A1 MA 26993A1 MA 27273 A MA27273 A MA 27273A MA 27273 A MA27273 A MA 27273A MA 26993 A1 MA26993 A1 MA 26993A1
Authority
MA
Morocco
Prior art keywords
pyridopyrimidines
substituted
substituted pyridopyrimidines
Prior art date
Application number
MA27273A
Other languages
English (en)
Inventor
Jian Jeffrey Chen
James Patrick Dunn
David Michael Goldstein
Christoph Martin Stahl
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of MA26993A1 publication Critical patent/MA26993A1/fr

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/06Antipsoriatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D519/00Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Rheumatology (AREA)
  • Immunology (AREA)
  • Dermatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
MA27273A 2001-02-12 2003-08-11 6-pyridopyrimidines substitues MA26993A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US26837501P 2001-02-12 2001-02-12
US33465401P 2001-11-30 2001-11-30

Publications (1)

Publication Number Publication Date
MA26993A1 true MA26993A1 (fr) 2004-12-20

Family

ID=26953040

Family Applications (1)

Application Number Title Priority Date Filing Date
MA27273A MA26993A1 (fr) 2001-02-12 2003-08-11 6-pyridopyrimidines substitues

Country Status (31)

Country Link
US (3) US6696566B2 (fr)
EP (1) EP1361880B1 (fr)
JP (1) JP4064818B2 (fr)
KR (1) KR100639772B1 (fr)
CN (1) CN100376571C (fr)
AR (1) AR035854A1 (fr)
AT (1) ATE305303T1 (fr)
AU (1) AU2002256615B2 (fr)
BR (1) BRPI0207172B8 (fr)
CA (1) CA2434834C (fr)
CZ (1) CZ20032416A3 (fr)
DE (1) DE60206363T2 (fr)
DK (1) DK1361880T3 (fr)
ES (1) ES2249574T3 (fr)
HR (1) HRP20030624B1 (fr)
HU (1) HU229604B1 (fr)
IL (2) IL156872A0 (fr)
JO (1) JO2410B1 (fr)
MA (1) MA26993A1 (fr)
MX (1) MXPA03007166A (fr)
MY (1) MY131518A (fr)
NO (1) NO326133B1 (fr)
NZ (1) NZ526961A (fr)
PA (1) PA8539201A1 (fr)
PE (1) PE20020976A1 (fr)
PL (1) PL366918A1 (fr)
RU (1) RU2269527C2 (fr)
SK (1) SK11322003A3 (fr)
WO (1) WO2002064594A2 (fr)
YU (1) YU63703A (fr)
ZA (1) ZA200305938B (fr)

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ATE305303T1 (de) 2001-02-12 2005-10-15 Hoffmann La Roche 6-substituierte pyridopyrimidine
GEP20063909B (en) * 2002-01-22 2006-08-25 Warner Lambert Co 2-(PYRIDIN-2-YLAMINO)-PYRIDO[2,3d] PYRIMIDIN-7-ONES
PL374544A1 (en) 2002-04-03 2005-10-31 F.Hoffmann-La Roche Ag Imidazo fused compounds
RU2324695C2 (ru) * 2002-08-06 2008-05-20 Ф.Хоффманн-Ля Рош Аг 6-АЛКОКСИПИРИДОПИРИМИДИНЫ И ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ, ОБЛАДАЮЩАЯ АКТИВНОСТЬЮ ИНГИБИТОРОВ КИНАЗЫ МАР р38
JP2006516548A (ja) 2002-12-30 2006-07-06 アンジオテック インターナショナル アクツィエン ゲゼルシャフト 迅速ゲル化ポリマー組成物からの薬物送達法
US7230098B2 (en) * 2003-02-26 2007-06-12 Sugen, Inc. Aminoheteroaryl compounds as protein kinase inhibitors
EP1620105B1 (fr) * 2003-04-16 2007-01-10 F. Hoffmann-La Roche Ag Derives amines de (6-(phenoxy)-pyrido ¬3,4-d| pyrimidin-2-yle) en tant qu'inhibiteurs de la kinase p38 pour le traitement de conditions inflammatoires telles que la polyarthrite rhumatoide
SI1685131T1 (sl) * 2003-11-13 2007-06-30 Hoffmann La Roche Hidroksialkil-substituirani pirido-7-pirimidin-7-oni
WO2006056863A1 (fr) * 2004-11-23 2006-06-01 Ranbaxy Laboratories Limited Pyrido'2, 3-d!pyrimidines utilisees comme agents anti-inflammatoires
US20060142312A1 (en) * 2004-12-23 2006-06-29 Pfizer Inc C6-aryl and heteroaryl substituted pyrido[2,3-D] pyrimidin-7-ones
EP1846403A1 (fr) * 2005-02-02 2007-10-24 Ranbaxy Laboratories Limited Derives azabicyclo utilises comme agents anti-inflammatoires
WO2006119504A2 (fr) * 2005-05-04 2006-11-09 Renovis, Inc. Composes heterocycliques fusionnes, leurs compositions et leurs utilisations
MX2008000885A (es) * 2005-07-21 2008-03-18 Hoffmann La Roche Compuestos de pirido[2,3-d]pirimidin-2,4-diamina como inhibidores de la proteina tirosina fosfatasa 1b.
CA2617359A1 (fr) * 2005-08-09 2007-02-22 Irm Llc Composes et compositions utiles comme inhibiteurs de proteines kinases
WO2007022946A1 (fr) 2005-08-21 2007-03-01 Abbott Gmbh & Co. Kg Composes heterocycliques et leur utilisation en tant que partenaires de liaison des recepteurs 5-ht5
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MX2008014908A (es) * 2006-05-26 2009-05-13 Toyama Chemical Co Ltd Compuesto heterociclico nuevo o sal del mismo e intermedio del mismo.
WO2008150260A1 (fr) * 2007-06-06 2008-12-11 Gpc Biotech, Inc. Inhibiteurs de kinase
WO2008078249A1 (fr) * 2006-12-21 2008-07-03 Ranbaxy Laboratories Limited Agents anti-inflammatoires
US8022085B2 (en) 2007-05-07 2011-09-20 Amgen Inc. Pyrazolo-pyridinone and pyrazolo-pyrazinone compounds as P38 modulators and methods of use thereof
CN101679211A (zh) 2007-06-15 2010-03-24 霍夫曼-拉罗奇有限公司 用于制备3-氨基-戊-1,5-二醇的新方法
US8367671B2 (en) 2008-03-21 2013-02-05 Amgen Inc. Pyrazolo[3.4-B]pyrazine compounds as p38 modulators and methods of use as anti-inflamatory agents
EP2112150B1 (fr) 2008-04-22 2013-10-16 Forma Therapeutics, Inc. Inhibiteurs Raf améliorés
EP2344502A2 (fr) * 2008-10-22 2011-07-20 F. Hoffmann-La Roche AG Inhibiteurs pyrimidinylpyridone de jnk
WO2010071846A2 (fr) 2008-12-19 2010-06-24 Afraxis, Inc. Composés pour traiter des états neuropsychiatriques
JP2013507395A (ja) * 2009-10-09 2013-03-04 アフラクシス・インコーポレイテッド Cns障害治療用の8−エチル−6−(アリール)ピリド[2,3−d]ピリミジン−7(8h)−オン
KR101754664B1 (ko) 2009-12-18 2017-07-06 템플 유니버시티-오브 더 커먼웰쓰 시스템 오브 하이어 에듀케이션 치환된 피리도〔2,3-d〕피리미딘-7(8h)-온스 및 이의 치료 용도
WO2016015597A1 (fr) 2014-07-26 2016-02-04 Sunshine Lake Pharma Co., Ltd. Composés utilisés comme petits molécules inhibitrices de cdk et leurs utilisations
SG11201809882XA (en) 2016-06-08 2018-12-28 Support Venture Gmbh Pharmaceutical combinations for treating cancer
UA124804C2 (uk) 2016-08-15 2021-11-24 Пфайзер Інк. Піридопіримідинонові інгібітори cdk2/4/6
CN109562105A (zh) * 2016-08-17 2019-04-02 企业支持有限责任公司 预防或治疗听力损失的方法
US11117858B2 (en) 2017-01-11 2021-09-14 The General Hospital Corporation Voltage gated sodium channel imaging agents
SG10202110804WA (en) * 2017-04-04 2021-11-29 Kinarus Ag Methods of preventing or treating ophthalmic diseases
CN111032655B (zh) 2017-08-31 2022-09-02 达纳-法伯癌症研究所股份有限公司 Egfr和/或her2抑制剂和使用方法
US10342786B2 (en) 2017-10-05 2019-07-09 Fulcrum Therapeutics, Inc. P38 kinase inhibitors reduce DUX4 and downstream gene expression for the treatment of FSHD
EP3692144A1 (fr) 2017-10-05 2020-08-12 Fulcrum Therapeutics, Inc. Utilisation d'inhibiteurs de p38 pour réduire l'expression de dux4
WO2020006210A1 (fr) * 2018-06-27 2020-01-02 Tufts Medical Center, Inc. Composés pyridopyrimidine et leurs méthodes d'utilisation
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ATE305303T1 (de) * 2001-02-12 2005-10-15 Hoffmann La Roche 6-substituierte pyridopyrimidine
GEP20063909B (en) * 2002-01-22 2006-08-25 Warner Lambert Co 2-(PYRIDIN-2-YLAMINO)-PYRIDO[2,3d] PYRIMIDIN-7-ONES

Also Published As

Publication number Publication date
MXPA03007166A (es) 2003-11-18
HRP20030624B1 (en) 2007-03-31
RU2003125887A (ru) 2005-03-20
KR20040018254A (ko) 2004-03-02
NO20033540D0 (no) 2003-08-11
US6696566B2 (en) 2004-02-24
CN1503672A (zh) 2004-06-09
YU63703A (sh) 2006-05-25
EP1361880B1 (fr) 2005-09-28
JP2004525896A (ja) 2004-08-26
PL366918A1 (en) 2005-02-07
BRPI0207172B8 (pt) 2021-05-25
PA8539201A1 (es) 2004-08-31
IL156872A (en) 2009-07-20
ZA200305938B (en) 2005-01-26
SK11322003A3 (en) 2004-10-05
WO2002064594A2 (fr) 2002-08-22
US7449581B2 (en) 2008-11-11
ATE305303T1 (de) 2005-10-15
BRPI0207172B1 (pt) 2019-04-09
NZ526961A (en) 2005-03-24
US20070135458A1 (en) 2007-06-14
BR0207172A (pt) 2004-03-30
MY131518A (en) 2007-08-30
CZ20032416A3 (cs) 2004-07-14
HRP20030624A2 (en) 2005-06-30
CA2434834A1 (fr) 2002-08-22
JP4064818B2 (ja) 2008-03-19
US20030171584A1 (en) 2003-09-11
AU2002256615B2 (en) 2007-09-13
WO2002064594A3 (fr) 2003-01-09
DE60206363D1 (de) 2006-02-09
US7169794B2 (en) 2007-01-30
JO2410B1 (en) 2007-06-17
US20040116698A1 (en) 2004-06-17
EP1361880A2 (fr) 2003-11-19
HU229604B1 (en) 2014-02-28
NO20033540L (no) 2003-08-11
AR035854A1 (es) 2004-07-21
CN100376571C (zh) 2008-03-26
NO326133B1 (no) 2008-10-06
CA2434834C (fr) 2010-09-14
HK1066170A1 (en) 2005-03-18
ES2249574T3 (es) 2006-04-01
RU2269527C2 (ru) 2006-02-10
IL156872A0 (en) 2004-02-08
KR100639772B1 (ko) 2006-10-30
DE60206363T2 (de) 2006-07-06
HUP0303458A3 (en) 2012-12-28
DK1361880T3 (da) 2006-01-23
HUP0303458A2 (hu) 2004-01-28
PE20020976A1 (es) 2002-10-29

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