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DK1361880T3 - 6-substituerede pyrido-pyrimidiner - Google Patents

6-substituerede pyrido-pyrimidiner

Info

Publication number
DK1361880T3
DK1361880T3 DK02726103T DK02726103T DK1361880T3 DK 1361880 T3 DK1361880 T3 DK 1361880T3 DK 02726103 T DK02726103 T DK 02726103T DK 02726103 T DK02726103 T DK 02726103T DK 1361880 T3 DK1361880 T3 DK 1361880T3
Authority
DK
Denmark
Prior art keywords
pyrimidines
substituted pyrido
pyrido
substituted
Prior art date
Application number
DK02726103T
Other languages
English (en)
Inventor
Jian Jeffrey Chen
James Patrick Dunn
David Michael Goldstein
Christoph Martin Stahl
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Application granted granted Critical
Publication of DK1361880T3 publication Critical patent/DK1361880T3/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/06Antipsoriatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D519/00Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Rheumatology (AREA)
  • Immunology (AREA)
  • Dermatology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pulmonology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
DK02726103T 2001-02-12 2002-02-04 6-substituerede pyrido-pyrimidiner DK1361880T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US26837501P 2001-02-12 2001-02-12
US33465401P 2001-11-30 2001-11-30

Publications (1)

Publication Number Publication Date
DK1361880T3 true DK1361880T3 (da) 2006-01-23

Family

ID=26953040

Family Applications (1)

Application Number Title Priority Date Filing Date
DK02726103T DK1361880T3 (da) 2001-02-12 2002-02-04 6-substituerede pyrido-pyrimidiner

Country Status (31)

Country Link
US (3) US6696566B2 (da)
EP (1) EP1361880B1 (da)
JP (1) JP4064818B2 (da)
KR (1) KR100639772B1 (da)
CN (1) CN100376571C (da)
AR (1) AR035854A1 (da)
AT (1) ATE305303T1 (da)
AU (1) AU2002256615B2 (da)
BR (1) BRPI0207172B8 (da)
CA (1) CA2434834C (da)
CZ (1) CZ20032416A3 (da)
DE (1) DE60206363T2 (da)
DK (1) DK1361880T3 (da)
ES (1) ES2249574T3 (da)
HR (1) HRP20030624B1 (da)
HU (1) HU229604B1 (da)
IL (2) IL156872A0 (da)
JO (1) JO2410B1 (da)
MA (1) MA26993A1 (da)
MX (1) MXPA03007166A (da)
MY (1) MY131518A (da)
NO (1) NO326133B1 (da)
NZ (1) NZ526961A (da)
PA (1) PA8539201A1 (da)
PE (1) PE20020976A1 (da)
PL (1) PL366918A1 (da)
RU (1) RU2269527C2 (da)
SK (1) SK11322003A3 (da)
WO (1) WO2002064594A2 (da)
YU (1) YU63703A (da)
ZA (1) ZA200305938B (da)

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DE60303009T2 (de) 2002-01-22 2006-07-13 Warner-Lambert Co. Llc 2-(pyridin-2-ylamino)-pyrido[2,3-d]pyrimidin-7-one
RU2310657C2 (ru) 2002-04-03 2007-11-20 Ф.Хоффманн-Ля Рош Аг Имидазоконденсированные соединения и фармацевтическая композиция, содержащая их
ES2293064T3 (es) 2002-08-06 2008-03-16 F. Hoffmann-La Roche Ag 6-alcoxi-pirido-pirimidinas como inhibidores de la p-38 map quinasa.
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DK2476667T3 (da) * 2003-02-26 2014-09-15 Sugen Inc Aminoheteroaryl-forbindelser som proteinkinase-inhibitorer
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RU2348632C2 (ru) * 2003-11-13 2009-03-10 Ф.Хоффманн-Ля Рош Аг Гидроксиалкилзамещенные пиридо-7-пиримидин-7-оны
EP1831215A1 (en) * 2004-11-23 2007-09-12 Ranbaxy Laboratories Limited Pyrido[2,3-d]pyrimidines as anti-inflamatory agents
US20060142312A1 (en) * 2004-12-23 2006-06-29 Pfizer Inc C6-aryl and heteroaryl substituted pyrido[2,3-D] pyrimidin-7-ones
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AU2007268749B2 (en) * 2006-05-26 2012-07-26 Taisho Pharmaceutical Co., Ltd. Novel heterocyclic compound or salt thereof and intermediate thereof
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CN101679211A (zh) 2007-06-15 2010-03-24 霍夫曼-拉罗奇有限公司 用于制备3-氨基-戊-1,5-二醇的新方法
US8367671B2 (en) 2008-03-21 2013-02-05 Amgen Inc. Pyrazolo[3.4-B]pyrazine compounds as p38 modulators and methods of use as anti-inflamatory agents
EP2112150B1 (en) 2008-04-22 2013-10-16 Forma Therapeutics, Inc. Improved raf inhibitors
CA2734037A1 (en) * 2008-10-22 2010-04-29 F. Hoffmann-La Roche Ag Pyrimidinyl pyridone inhibitors of jnk
US8674095B2 (en) 2008-12-19 2014-03-18 Afraxis Holdings, Inc. Compounds for treating neuropsychiatric conditions
CN102648200A (zh) * 2009-10-09 2012-08-22 亚弗克希斯公司 用于治疗cns病症的8-乙基-6-(芳基)吡啶并[2,3-d]嘧啶-7(8h)-酮
JP5797664B2 (ja) * 2009-12-18 2015-10-21 テンプル・ユニバーシティ−オブ・ザ・コモンウェルス・システム・オブ・ハイアー・エデュケイションTemple University−Of The Commonwealth System Of Higher Education 置換ピリド[2,3−d]ピリミジン−7(8H)−オン及びそれらの治療用の使用
WO2016015597A1 (en) 2014-07-26 2016-02-04 Sunshine Lake Pharma Co., Ltd. Compounds as cdk small-molecule inhibitors and uses thereof
AU2017277478B2 (en) 2016-06-08 2023-03-16 Support-Venture Gmbh Pharmaceutical combinations for treating cancer
AU2017311645B2 (en) 2016-08-15 2021-05-27 Pfizer Inc. Pyridopyrimdinone CDK2/4/6 inhibitors
SG11201900776TA (en) * 2016-08-17 2019-03-28 Support Venture Gmbh Method of preventing or treating hearing loss
US11117858B2 (en) 2017-01-11 2021-09-14 The General Hospital Corporation Voltage gated sodium channel imaging agents
JP7356352B2 (ja) 2017-04-04 2023-10-04 キナラス アーゲー 眼疾患の予防方法又は処置方法
CN115322193A (zh) * 2017-08-31 2022-11-11 达纳-法伯癌症研究所股份有限公司 Egfr和/或her2抑制剂和使用方法
US10342786B2 (en) 2017-10-05 2019-07-09 Fulcrum Therapeutics, Inc. P38 kinase inhibitors reduce DUX4 and downstream gene expression for the treatment of FSHD
CN111601593B (zh) 2017-10-05 2022-04-15 弗尔康医疗公司 P38激酶抑制剂降低dux4和下游基因表达以用于治疗fshd
WO2020006210A1 (en) * 2018-06-27 2020-01-02 Tufts Medical Center, Inc. Pyridopyrimidine compounds and methods of their use
JP2021524493A (ja) 2018-07-13 2021-09-13 キナラス アーゲー 線維性疾患を予防または処置するためのPPARアゴニストおよびp38キナーゼ阻害剤の組合せ物
TW202112368A (zh) 2019-06-13 2021-04-01 荷蘭商法西歐知識產權股份有限公司 用於治療有關dux4表現之疾病的抑制劑組合
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Also Published As

Publication number Publication date
NO20033540D0 (no) 2003-08-11
US6696566B2 (en) 2004-02-24
CZ20032416A3 (cs) 2004-07-14
IL156872A (en) 2009-07-20
YU63703A (sh) 2006-05-25
US20070135458A1 (en) 2007-06-14
MA26993A1 (fr) 2004-12-20
PE20020976A1 (es) 2002-10-29
US7169794B2 (en) 2007-01-30
HK1066170A1 (en) 2005-03-18
KR100639772B1 (ko) 2006-10-30
HUP0303458A2 (hu) 2004-01-28
CN1503672A (zh) 2004-06-09
JP2004525896A (ja) 2004-08-26
RU2269527C2 (ru) 2006-02-10
PA8539201A1 (es) 2004-08-31
ATE305303T1 (de) 2005-10-15
BRPI0207172B8 (pt) 2021-05-25
BR0207172A (pt) 2004-03-30
JO2410B1 (en) 2007-06-17
CA2434834A1 (en) 2002-08-22
BRPI0207172B1 (pt) 2019-04-09
EP1361880B1 (en) 2005-09-28
NZ526961A (en) 2005-03-24
AU2002256615B2 (en) 2007-09-13
HRP20030624B1 (en) 2007-03-31
ES2249574T3 (es) 2006-04-01
ZA200305938B (en) 2005-01-26
DE60206363T2 (de) 2006-07-06
US20030171584A1 (en) 2003-09-11
HRP20030624A2 (en) 2005-06-30
MY131518A (en) 2007-08-30
NO326133B1 (no) 2008-10-06
HUP0303458A3 (en) 2012-12-28
US20040116698A1 (en) 2004-06-17
CN100376571C (zh) 2008-03-26
US7449581B2 (en) 2008-11-11
CA2434834C (en) 2010-09-14
DE60206363D1 (de) 2006-02-09
SK11322003A3 (en) 2004-10-05
AR035854A1 (es) 2004-07-21
IL156872A0 (en) 2004-02-08
RU2003125887A (ru) 2005-03-20
HU229604B1 (en) 2014-02-28
JP4064818B2 (ja) 2008-03-19
MXPA03007166A (es) 2003-11-18
KR20040018254A (ko) 2004-03-02
WO2002064594A2 (en) 2002-08-22
PL366918A1 (en) 2005-02-07
WO2002064594A3 (en) 2003-01-09
EP1361880A2 (en) 2003-11-19
NO20033540L (no) 2003-08-11

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