| Interconnected microphysiological systems for quantitative biology and pharmacology studies CD Edington, WLK Chen, E Geishecker, T Kassis, LR Soenksen, ... Scientific reports 8 (1), 4530, 2018 | 511 | 2018 |
| A portable and reconfigurable multi-organ platform for drug development with onboard microfluidic flow control JR Coppeta, MJ Mescher, BC Isenberg, AJ Spencer, ES Kim, AR Lever, ... Lab on a Chip 17 (1), 134-144, 2017 | 113 | 2017 |
| Discovery of AZD4573, a potent and selective inhibitor of CDK9 that enables short duration of target engagement for the treatment of hematological malignancies B Barlaam, R Casella, J Cidado, C Cook, C De Savi, A Dishington, ... Journal of medicinal chemistry 63 (24), 15564-15590, 2020 | 108 | 2020 |
| Metabolite profiling and pharmacokinetic evaluation of hydrocortisone in a perfused three-dimensional human liver bioreactor U Sarkar, D Rivera-Burgos, EM Large, DJ Hughes, KC Ravindra, RL Dyer, ... Drug metabolism and disposition 43 (7), 1091-1099, 2015 | 102 | 2015 |
| Cytotoxic and pathogenic properties of Klebsiella oxytoca isolated from laboratory animals A Darby, K Lertpiriyapong, U Sarkar, U Seneviratne, DS Park, ... PloS one 9 (7), e100542, 2014 | 89 | 2014 |
| Synthesis and biological evaluation of new 2-arylcarbonyl-3-trifluoromethylquinoxaline 1, 4-di-N-oxide derivatives and their reduced analogues B Solano, V Junnotula, S Dutta, U Sarkar, KS Gates, A Marín, R Villar, ... Journal of medicinal chemistry 50 (22), 5485-5492, 2007 | 89 | 2007 |
| Integrated assessment of diclofenac biotransformation, pharmacokinetics, and omics-based toxicity in a three-dimensional human liver-immunocompetent coculture system U Sarkar, KC Ravindra, E Large, CL Young, D Rivera-Burgos, J Yu, ... Drug Metabolism and Disposition 45 (7), 855-866, 2017 | 85 | 2017 |
| DNA Strand Cleavage by the Phenazine Di-N-oxide Natural Product Myxin under Both Aerobic and Anaerobic Conditions G Chowdhury, U Sarkar, S Pullen, WR Wilson, A Rajapakse, ... Chemical research in toxicology 25 (1), 197-206, 2012 | 81 | 2012 |
| Mechanism-based triarylphosphine-ester probes for capture of endogenous RSNOs U Seneviratne, LC Godoy, JS Wishnok, GN Wogan, SR Tannenbaum Journal of the American Chemical Society 135 (20), 7693-7704, 2013 | 74 | 2013 |
| Initiation of DNA strand cleavage by 1, 2, 4-benzotriazine 1, 4-dioxide antitumor agents: mechanistic insight from studies of 3-methyl-1, 2, 4-benzotriazine 1, 4-dioxide V Junn, U Sarkar, S Sinha, KS Gates Journal of the American Chemical Society 131 (3), 1015-1024, 2008 | 66* | 2008 |
| Quantitative systems pharmacology approaches applied to microphysiological systems (MPS): data interpretation and multi‐MPS integration J Yu, NA Cilfone, EM Large, U Sarkar, JS Wishnok, SR Tannenbaum, ... CPT: pharmacometrics & systems pharmacology 4 (10), 585-594, 2015 | 55 | 2015 |
| Dirichlet Boundary Conditions and Effect of Confinement on Chemical Reactivity S Giri, U Sarkar, PK Chattaraj The Journal of Physical Chemistry A 113 (40), 10759-10766, 2009 | 49 | 2009 |
| Development of a quantification method for adenosine in tumors by LC-MS/MS with dansyl chloride derivatization KJ Goodwin, E Gangl, U Sarkar, P Pop-Damkov, N Jones, A Borodovsky, ... Analytical Biochemistry 568, 78-88, 2019 | 37 | 2019 |
| CPT: pharmacometrics Syst J Yu, NA Cilfone, EM Large, U Sarkar, JS Wishnok, SR Tannenbaum, ... Pharmacol 4 (585), 10.1002, 2015 | 31 | 2015 |
| Antimicrobial drug use in primary health care R Uppal, U Sarkar, CR Giriyappanavar, V Kacker Journal of Clinical epidemiology 46 (7), 671-673, 1993 | 28 | 1993 |
| Enzymatic conversion of 6-nitroquinoline to the fluorophore 6-aminoquinoline selectively under hypoxic conditions A Rajapakse, C Linder, RD Morrison, U Sarkar, ND Leigh, CL Barnes, ... Chemical research in toxicology 26 (4), 555-563, 2013 | 26 | 2013 |
| Discovery of a series of 7-azaindoles as potent and highly selective CDK9 inhibitors for transient target engagement B Barlaam, C De Savi, A Dishington, L Drew, AD Ferguson, D Ferguson, ... Journal of Medicinal Chemistry 64 (20), 15189-15213, 2021 | 21 | 2021 |
| Exploiting the inherent photophysical properties of the major tirapazamine metabolite in the development of profluorescent substrates for enzymes that catalyze the bioreductive … X Shen, CH Laber, U Sarkar, F Galazzi, KM Johnson, NG Mahieu, ... The Journal of organic chemistry 83 (6), 3126-3131, 2018 | 21 | 2018 |
| Stabilities and spin distributions of benzannulated benzyl radicals Y Sui, U Sarkar, R Glaser, K Gates Journal of Chemical Theory and Computation 3 (3), 1091-1099, 2007 | 18 | 2007 |
| Chemical reactivity dynamics in ground and excited electronic states PK Chattaraj, U Sarkar Theoretical and Computational Chemistry 19, 269-286, 2007 | 18 | 2007 |
Linda GriffithProfessor of Biological Engineering, Massachusetts Institute of TechnologyVerified email at mit.edu
