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| Total synthesis of spirotryprostatin A, leading to the discovery of some biologically promising analogues S Edmondson, SJ Danishefsky, L Sepp-Lorenzino, N Rosen Journal of the American Chemical Society 121 (10), 2147-2155, 1999 | 571 | 1999 |
| Proteolysis targeting chimeras (PROTACs) in ‘beyond rule-of-five’chemical space: Recent progress and future challenges SD Edmondson, B Yang, C Fallan Bioorganic & Medicinal Chemistry Letters 29 (13), 1555-1564, 2019 | 402 | 2019 |
| The total synthesis of spirotryprostatin A SD Edmondson, SJ Danishefsky Angewandte Chemie International Edition 37 (8), 1138-1140, 1998 | 152 | 1998 |
| Crystal structure of human phosphodiesterase 3B: atomic basis for substrate and inhibitor specificity G Scapin, SB Patel, C Chung, JP Varnerin, SD Edmondson, ... Biochemistry 43 (20), 6091-6100, 2004 | 150 | 2004 |
| (2S,3S)-3-Amino-4-(3,3-difluoropyrrolidin-1-yl)-N,N-dimethyl-4-oxo-2-(4-[1,2,4]triazolo[1,5-a]- pyridin-6-ylphenyl)butanamide: A Selective α-Amino Amide … SD Edmondson, A Mastracchio, RJ Mathvink, J He, B Harper, YJ Park, ... Journal of medicinal chemistry 49 (12), 3614-3627, 2006 | 134 | 2006 |
| Palladium-catalyzed coupling of vinylogous amides with aryl halides: Applications to the synthesis of heterocycles SD Edmondson, A Mastracchio, ER Parmee Organic letters 2 (8), 1109-1112, 2000 | 132 | 2000 |
| Fluoroolefins as amide bond mimics in dipeptidyl peptidase IV inhibitors SD Edmondson, L Wei, J Xu, J Shang, S Xu, J Pang, A Chaudhary, ... Bioorganic & medicinal chemistry letters 18 (7), 2409-2413, 2008 | 127 | 2008 |
| Discovery of 5-{4-[(7-Ethyl-6-oxo-5,6-dihydro-1,5-naphthyridin-3-yl)methyl]piperazin-1-yl}-N-methylpyridine-2-carboxamide (AZD5305): A PARP1–DNA Trapper … JW Johannes, A Balazs, D Barratt, M Bista, MD Chuba, S Cosulich, ... Journal of Medicinal Chemistry 64 (19), 14498-14512, 2021 | 125 | 2021 |
| Discovery of Vibegron: A Potent and Selective β3 Adrenergic Receptor Agonist for the Treatment of Overactive Bladder SD Edmondson, C Zhu, NF Kar, J Di Salvo, H Nagabukuro, ... Journal of Medicinal Chemistry 59 (2), 609-623, 2016 | 124 | 2016 |
| Triazolopiperazine-amides as dipeptidyl peptidase IV inhibitors: Close analogs of JANUVIA™(sitagliptin phosphate) D Kim, JE Kowalchick, SD Edmondson, A Mastracchio, J Xu, GJ Eiermann, ... Bioorganic & medicinal chemistry letters 17 (12), 3373-3377, 2007 | 89 | 2007 |
| Pharmacological characterization of a novel beta 3 adrenergic agonist, vibegron: evaluation of antimuscarinic receptor selectivity for combination therapy for overactive bladder J Di Salvo, H Nagabukuro, LA Wickham, C Abbadie, JA DeMartino, ... The Journal of pharmacology and experimental therapeutics 360 (2), 346-355, 2017 | 68 | 2017 |
| Beta-amino tetrahydroimidazo (1, 2-a) pyrazines and tetrahydrotrioazolo (4, 3-a) pyrazines as dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes SD Edmondson, MH Fisher, D Kim, M MacCoss, ER Parmee, AE Weber, ... US Patent 7,125,873, 2006 | 67 | 2006 |
| Potent and selective proline derived dipeptidyl peptidase IV inhibitors SD Edmondson, A Mastracchio, M Beconi, LF Colwell Jr, B Habulihaz, ... Bioorganic & medicinal chemistry letters 14 (20), 5151-5155, 2004 | 67 | 2004 |
| Discovery of proteolysis-targeting chimera molecules that selectively degrade the IRAK3 pseudokinase SL Degorce, O Tavana, E Banks, C Crafter, L Gingipalli, D Kouvchinov, ... Journal of Medicinal Chemistry 63 (18), 10460-10473, 2020 | 64 | 2020 |
| 4-Amino cyclohexylglycine analogues as potent dipeptidyl peptidase IV inhibitors ER Parmee, J He, A Mastracchio, SD Edmondson, L Colwell, G Eiermann, ... Bioorganic & medicinal chemistry letters 14 (1), 43-46, 2004 | 61 | 2004 |
| Discovery of potent and selective orally bioavailable β-substituted phenylalanine derived dipeptidyl peptidase IV inhibitors SD Edmondson, A Mastracchio, JL Duffy, GJ Eiermann, H He, I Ita, ... Bioorganic & medicinal chemistry letters 15 (12), 3048-3052, 2005 | 60 | 2005 |
| Dipeptidyl peptidase inhibitors for the treatment of diabetes SD Edmondson, E Parmee, AE Weber, J Xu US Patent 7,098,239, 2006 | 54 | 2006 |
| Discovery of a potent and selective tyrosine kinase 2 inhibitor: TAK-279 S Leit, J Greenwood, S Carriero, S Mondal, R Abel, M Ashwell, ... Journal of Medicinal Chemistry 66 (15), 10473-10496, 2023 | 52 | 2023 |
| NanoClick: a high throughput, target-agnostic peptide cell permeability assay A Peier, L Ge, N Boyer, J Frost, R Duggal, K Biswas, S Edmondson, ... ACS Chemical Biology 16 (2), 293-309, 2021 | 52 | 2021 |
