| Molecular Genetics and Epidemiology of the NAT1 and NAT2 Acetylation Polymorphisms DW Hein, MA Doll, AJ Fretland, MA Leff, SJ Webb, GH Xiao, ... Cancer Epidemiology Biomarkers & Prevention 9 (1), 29-42, 2000 | 968 | 2000 |
| Epoxide hydrolases: biochemistry and molecular biology AJ Fretland, CJ Omiecinski Chemico-biological interactions 129 (1-2), 41-59, 2000 | 391 | 2000 |
| Functional characterization of human N-acetyltransferase 2 (NAT2) single nucleotide polymorphisms AJ Fretland, MA Leff, MA Doll, DW Hein Pharmacogenetics and Genomics 11 (3), 207-215, 2001 | 186 | 2001 |
| Genetic polymorphisms in heterocyclic amine metabolism and risk of colorectal adenomas N Ishibe, R Sinha, DW Hein, M Kulldorff, P Strickland, AJ Fretland, ... Pharmacogenetics and Genomics 12 (2), 145-150, 2002 | 137 | 2002 |
| Improving the accuracy of predicted human pharmacokinetics: lessons learned from the AstraZeneca drug pipeline over two decades M Davies, RDO Jones, K Grime, R Jansson-Löfmark, AJ Fretland, ... Trends in pharmacological sciences 41 (6), 390-408, 2020 | 127 | 2020 |
| Evaluation of Various Static In Vitro–In Vivo Extrapolation Models for Risk Assessment of the CYP3A Inhibition Potential of an Investigational Drug MLT Vieira, B Kirby, I Ragueneau‐Majlessi, A Galetin, JYL Chien, ... Clinical Pharmacology & Therapeutics 95 (2), 189-198, 2014 | 114 | 2014 |
| Utility of intersystem extrapolation factors in early reaction phenotyping and the quantitative extrapolation of human liver microsomal intrinsic clearance using recombinant … Y Chen, L Liu, K Nguyen, AJ Fretland Drug metabolism and disposition 39 (3), 373-382, 2011 | 107 | 2011 |
| Novel human N-acetyltransferase 2 alleles that differ in mechanism for slow acetylator phenotype MA Leff, AJ Fretland, MA Doll, DW Hein Journal of Biological Chemistry 274 (49), 34519-34522, 1999 | 98 | 1999 |
| Camonsertib in DNA damage response-deficient advanced solid tumors: phase 1 trial results TA Yap, E Fontana, EK Lee, DR Spigel, M Højgaard, S Lheureux, ... Nature medicine 29 (6), 1400-1411, 2023 | 91 | 2023 |
| Rodent models of the human acetylation polymorphism: comparisons of recombinant acetyltransferases DW Hein, MA Doll, AJ Fretland, K Gray, AC Deitz, Y Feng, W Jiang, ... Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 376 (1 …, 1997 | 90 | 1997 |
| Dietary selenium reduces the formation of aberrant crypts in rats administered 3, 2′-dimethyl-4-aminobiphenyl Y Feng, JW Finley, CD Davis, WK Becker, AJ Fretland, DW Hein Toxicology and applied pharmacology 157 (1), 36-42, 1999 | 86 | 1999 |
| Functional characterization of nucleotide polymorphisms in the coding region of N-acetyltransferase 1 AJ Fretland, MA Doll, MA Leff, DW Hein Pharmacogenetics and Genomics 11 (6), 511-520, 2001 | 81 | 2001 |
| Determination of HumanNAT2Acetylator Genotype by Restriction Fragment-Length Polymorphism and Allele-Specific Amplification MA Doll, AJ Fretland, AC Deitz, DW Hein Analytical biochemistry 231 (2), 413-420, 1995 | 79 | 1995 |
| Discovery of highly selective and orally active lysophosphatidic acid receptor-1 antagonists with potent activity on human lung fibroblasts Y Qian, M Hamilton, A Sidduri, S Gabriel, Y Ren, R Peng, R Kondru, ... Journal of medicinal chemistry 55 (17), 7920-7939, 2012 | 70 | 2012 |
| Prostate-specific human N-acetyltransferase 2 (NAT2) expression in the mouse MA Leff, PN Epstein, MA Doll, AJ Fretland, US Devanaboyina, TD Rustan, ... The Journal of pharmacology and experimental therapeutics 290 (1), 182-187, 1999 | 68 | 1999 |
| Acetylator phenotype and genotype in patients infected with HIV: discordance between methods for phenotype determination and genotype WM O'Neil, RK Drobitch, RD MacArthur, MJ Farrough, MA Doll, ... Pharmacogenetics and Genomics 10 (2), 171-182, 2000 | 65 | 2000 |
| Determination of time-dependent inactivation of CYP3A4 in cryopreserved human hepatocytes and assessment of human drug-drug interactions Y Chen, L Liu, M Monshouwer, AJ Fretland Drug metabolism and disposition 39 (11), 2085-2092, 2011 | 64 | 2011 |
| Cloning, Sequencing, and Recombinant Expression ofNAT1, NAT2, andNAT3Derived from the C3H/HeJ (Rapid) and A/HeJ (Slow) Acetylator Inbred Mouse: Functional Characterization of … AJ Fretland, MA Doll, K Gray, Y Feng, DW Hein Toxicology and applied pharmacology 142 (2), 360-366, 1997 | 61 | 1997 |
| Tissue distribution of N‐acetyltransferase 1 and 2 catalyzing the N‐acetylation of 4‐aminobiphenyl and O‐acetylation of N‐hydroxy‐4‐aminobiphenyl in the … DW Hein, MA Doll, DE Nerland, AJ Fretland Molecular Carcinogenesis: Published in cooperation with the University of …, 2006 | 59 | 2006 |
| Effects of single nucleotide polymorphisms in human N‐acetyltransferase 2 on metabolic activation (O‐acetylation) of heterocyclic amine carcinogens DW Hein, AJ Fretland, MA Doll International journal of cancer 119 (5), 1208-1211, 2006 | 56 | 2006 |
